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黄芩苷及其含药血清在大鼠体内的药动学、药效学相关性研究 被引量:22
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作者 宋珏 路通 +2 位作者 谢林 王广基 刘晓东 《中国临床药理学与治疗学》 CAS CSCD 2006年第12期1350-1354,共5页
目的:以黄芩苷含药血清对PC12细胞氧化损伤的保护作用为药效指标,研究黄芩苷的体内药动学及药效学过程的相关性。方法:大鼠灌胃后,测定不同取血点血清样本中的黄芩苷含量,运用血清药理学方法,观察血清样本对H2O2诱导PC12细胞氧化... 目的:以黄芩苷含药血清对PC12细胞氧化损伤的保护作用为药效指标,研究黄芩苷的体内药动学及药效学过程的相关性。方法:大鼠灌胃后,测定不同取血点血清样本中的黄芩苷含量,运用血清药理学方法,观察血清样本对H2O2诱导PC12细胞氧化损伤模型的保护作用,对浓度.时间、效应.时间曲线进行相关分析,建立药动.药效结合模型;观察不同浓度黄芩苷溶液的保护作用,获得黄芩苷体外抗氧化作用的量效关系。结果:黄芩苷含药血清对PC12细胞氧化损伤有明显保护作用,且具有时间依赖性。效应-时间曲线的Emax为98%,fmax为15min;浓度-时间曲线的Cmax为9.39μg·ml^-1,fmax亦为15min,以Log(AUC)-AUE作图,图形近似呈“S”形。体外实验中,黄芩苷浓度在0.16~10μg·ml^-1范围内有抑制作用,且作用随剂量增加而增大。结论:黄芩苷体内、外均具有抗氧化作用,且效应的时效关系与血清中黄芩苷的时量关系呈正相关。 展开更多
关键词 黄芩苷 PC12细胞 血清药理学 药动-药 效结合模型
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Nonlinear dynamic characteristics of magneto-rheological visco-elastomers 被引量:4
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作者 YING ZuGuang NI YiQing SAJJADI Masoud 《Science China(Technological Sciences)》 SCIE EI CAS 2013年第4期878-883,共6页
The smart magneto-rheological visco-elastomer (MRVE) has a promising application to vibration control.Its dynamic characteristics are described by complex moduli which are applicable to linear dynamics.However,experim... The smart magneto-rheological visco-elastomer (MRVE) has a promising application to vibration control.Its dynamic characteristics are described by complex moduli which are applicable to linear dynamics.However,experimental results show remarkable nonlinear relations between force and deformation for certain large deformations,and the nonlinear dynamic modeling needs to be developed.The present study focuses on the nonlinear dynamic characteristics of MRVE.The MRVE was fabricated and specimens were tested to show nonlinear mechanical properties and dynamic behaviors.The nonlinear effect induced by applied magnetic fields was investigated.A phenomenological model for the dynamic behaviors of MRVE was proposed to describe the nonlinear elasticity,linear damping and hysteretic effect,and the corresponding equivalent linear model in the frequency domain was also given for small deformations.The proposed model is applicable to the dynamics and control analysis of composite structures with MRVE. 展开更多
关键词 nonlinear hysteresis dynamic modeling magneto-rheological visco-elastomer complex stiffness
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