两种方法在治疗食管支架置入术后再狭窄的效-价分析

目的比较内镜下食管支架再置入治疗及射频烧灼治疗食管支架置入术后再狭窄的临床疗效及平均住院费用差别,探索一种效-价比高的治疗方法。方法将食管支架置入术后再狭窄患者纳入治疗范围,随机分为两组,射频治疗组及支架再置入治疗组,分别采用内镜下射频烧灼治疗及食管支架再置入治疗,观察各组有效率、半年存活率及平均住院费用,分别计算其效-价比。结果射频治疗组总有效率96.4%,无效率3.6%,半年存活率82.1%,且无重大并发症,平均住院费用2169元,疗效100%的费用为2250元。支架置入治疗组总有效率100%,半年存活率83.3%,平均住院费用4008元,疗效100%的费用为4008元。两组有效率及半年存活率比较差异无显著性,P>0.05。但前者效-价比明显高于后者。结论内镜下射频治疗和支架再置入治疗都是食管支架置入术后再狭窄有效的姑息治疗方法,疗效相当;但射频治疗价格更低廉,可反复进行,效-价比高。

A Ship Officer Performance Evaluation Model Using Fuzzy-AHP

A ship＇s crew plays an important role in the maritime transportation sector and their performance is paramont in the shipping industry. On this account, an impartial evaluation of the crew＇s performance is an important issue. In this paper, the ship officer＇s performance evaluation problem is studied. The performance evaluation criteria that shipping companies take into account are determined and a performance evaluation process is modelled by using the FAHP （Fuzzy Analytic Hierarchy Process） based on Chang＇s Algorithm. Linguistic variables and fuzzy numbers are used in the assessment process. The results of the proposed model demonstrate that the FAHP method is effective and helps managers make better and more reliable decisions under fuzzy circumstances.

Empirical Study on the Measurement of the High-Tech Industry Efficiency in China--Based on the Data of China＇s 31 Provinces （Including Municipalities and Autonomous Regions）

To evaluate the relative effectiveness of the input and output of the high-tech industry in China＇s 31 provinces （including municipalities and autonomous regions）, DEA evaluation model was constructed using data envelopment analysis （DEA）, and DEA evaluation model was solved using Deap2.1 software, for the purpose of obtaining the DEA efficiency and the non-DEA efficiency in all the provinces （including municipalities and autonomous regions）. Then, the comprehensive efficiency, technical efficiency, scale efficiency, scale return, and projection analysis were analyzed. Finally, the provinces of the non-DEA efficiency are sorted according to three efficiencies, and also a goal of improvement is proposed for the purpose of expanding technology investment in the provinces of the DEA efficiency.

Application of fuzzy integrated evaluation in the safety of coal industry of China

Based on fuzzy integrated evaluation theory, the safety of coal industry was analyzed, the factors affecting the safety of coal industry was considered, and its fuzzy in- tegrated estimating theory and results were given. Finally this paper proposed a new method of industry safety estimation. According to this method, we can integrate the fac- tors affecting coal industry and deal with the parameters and targets of evaluating factors by quantitative analysis, thus give a scientific and reasonable safety degree analyzing evaluation.

Analysis on the Effective Management and Enterprise Value Based on Employee and Customer Value

Value is the internal driving force for any corporate to obtain profits. The key issue of making profit lies on whether the corporate can truly appreciate the needs and combination of stakeholders＇ value, and establish a successful management of value exchange system. This paper starts with the theories of the employee and customer value measurement and management, followed by the value exchange system of employee-customer-organization. Therefore, it explains the status and role of employee-customer-organization in terms of value exchange. This work concludes that customers＇ satisfaction is determined by employees＇ satisfaction, and on that basis, customers would provide the promoted value to the organization.

A Preliminary Evaluation of Global and East Asian Cloud Radiative Effects in Reanalyses

Cloud radiative effects （CREs） at the top of the atmosphere （TOA） in three reanalysis datasets （the Eur- opean Center for Medium-Range Weather Forecasts In- terim Reanalysis （ERA-Interim）, the Japanese 55-yr Re- analysis Project （JRA-55）, and the Modem-Era Retro- spective Analysis for Research and Applications （MERRA）） are evaluated using recent satellite-based observations. The reanalyses can basically capture the spatial pattern of the annual mean shortwave CRE, but the global mean longwave CRE in ERA-interim and JRA55 is weaker than observed, leading to overestimations of the net CRE. Moreover, distinct CRE biases of the reanalyses occur in the Intertropical Convergence Zone （ITCZ）, coastal Pa- cific and Atlantic regions, and East Asia. Quantitative examination further indicates that the spatial correlations of CREs and TOA upward radiation fluxes with corre- sponding observations in ERA-Interim are better than in the other two reanalyses. Although MERRA has certain abilities in producing the magnitudes of global mean CREs, its performance in terms of spatial correlations in winter and summer are worse than for the other two re- analyses. The ability of JRA55 in reflecting CREs lies between the other two datasets. Compared to the global mean results, the spatial correlations of shortwave CRE in East Asia decrease and the biases of regional mean CREs increase in the three reanalyses. This implies that, cur- rently, it is still difficult to reproduce East Asian CREs based on these reanalyses. Relatively, ERA-Interim de- scribes the seasonal variation of East Asian CREs well, albeit weaker than observed. The present study also sug- gests that in-depth exploration of the ability of reanalysis data to describe aspects relating to cloud properties and rad- iation is needed usin~ more comprehensive observations.

The Bruce Highway Action Plan Program Evaluation

The BHAP （Bruce Highway Action Plan） Program Evaluation was a momentous task conducted in most part by the TMR （Transport and Main Roads） CBA （cost benefit analysis） team. The evaluation included 189 overtaking lanes, 404 km of road widening and shoulder sealing in various places between Brisbane and Cairns, 56 capacity focused projects and 16 flood immunity focused projects. The total projected capital costs of all projects proposed as part of the BHAP amounted to over 16 billion dollars. The program evaluation conducted, due to the short timeframes, lack of available data and strategic nature of the plan, has been ＂coined＂ a strategic evaluation. This paper focuses on the methodology applied to the projects proposed in the BHAP. A TMR designed project/program evaluation model （CARP （Concise Analysis of Road Programs） V1.0） was used to evaluate the majority of the proposed BHAP projects. The model produces streams of discounted benefits and costs of the projects and program using limited and incomplete data. The large scale of work and the close proximity of projects allowed for an integrated approach to the analysis, which considered the impact projects have on each other. The result of the program, if all evaluated projects are included, is a BCR （benefit cost ratio） of approximately 0.7l at a discount rate of 7%. If the less viable projects are removed from the program, the program can obtain a benefit cost ratio of greater than 1 with a sufficiently large number of projects remaining.

Pros and Cons in Therapeutic Evaluation of Paraoxonase 1 in Nerve Agent Toxicity

PON 1 （Paraoxonase 1） has been proposed as an efficient catalytic bioscavenger to combat against OP （organophosphate） and CWNA （chemical warfare nerve agent） toxicity. Unlike stoichiometric bioscavengers such as butyrylcholinesterase, catalytic bioscavengers are cost effective with the advantage of eliminating all the OPs/CWNAs at low doses. Analysis of catalytic bioscavenger efficacy of PONI showed promising results by various group of researchers. Still, there are large numbers of grey areas which are not addressed so far. One of the major areas of interest is the pharmacokinetic analysis of infused PON 1 in multiple animal models. It is shown that previous studies in mice significantly increased half-life of PONI, while recent studies in guinea pigs from our group showed reduced half-life of PON1. Similar results were reported by other research groups in guinea pigs and non-human primates. The short half-life of exogenously administered PON1 in multiple animal models may be due to poor association of PON1 with its endogenous carrier, high density lipoprotein or lower doses of PON 1 or a reflection of species difference. These observations warrant the significance of thorough pharmacokinetic analysis of infused PON 1 and the development of alternative approaches for successful utility of PON 1 as an efficient medical countermeasure against OP/CWNA toxicity.

Research on the Model of Performance Evaluation of the Industry Cluster Brand

Firstly, this article carry on the theory research combined with the related theories of cluster brand and the relevant theories of performance evaluation, and distill four main indicators factors of performance evaluation of the cluster brand. Then proceed analysts survey and questionnaire investigation, and then use SPSS software to process date for statistical analysis; use AMOS software to formulate the second-order model, at last, establish structure relationship model of performance evaluation of the cluster brand. Build the model of the cluster brand performance evaluation with fuzzy-synthetic evaluation model.

Meta-analysis of effectiveness of moxibustion in treatment of postoperative urinary retention

Objective To provide objective basis for clinical decision through efficacy evaluation of randomized controlled trial on moxibustion in treatment of urinary retention.Methods Chinese National knowledge Infrastructure（CNKI）,China Biology Medicine disc（CBM）,VIP,Wanfang Data,and Sciencedirect were retrieved.The objects screened were from January 1,1990 to June 30,2013.Irrelevant,repeated and non-randomized controlled trials were excluded,and randomized controlled trials on moxibustion in treatment of urinary retention conforming to the inclusive criteria were selected.The quality of randomized controlled trials conforming to the inclusive criteria was evaluated using Jadad Scale,and the trials were analyzed statistically via RevMan5.2software.The randomized controlled trials on moxibustion in treatment of urinary retention were evaluated systematically through Cochrane systematic review.Results Nineteen references with better homogeneity were included into the study.Based on Meta-analysis result,the consolidated effect size OR=6.95,95%C/（5.12,9.44）,consolidated effect size test Z=12.43,P〈0.000 01,and the difference was statistically significant,indicating that the moxibustion group might be superior to control group,and the efficacy of moxibustion in treatment of urinary retention was better.It was shown from funnel plot that the subjects distributed symmetrically,indicating small bias of study.Conclusion Moxibustion in treatment of urinary retention has a certain efficacy but there are some small sample size and low-quality literature in the study,big sample size and high-quality and formal randomized controlled trials are needed to study in the futher.

Systematic evaluation on the clinical efficacy of acupoint stimulation therapy for treatment of premature ovarian insufficiency on the basis of network Meta-analysis

Objective To systematically evaluate the effectiveness and safety of acupoint stimulation therapy for treatment of premature ovarian insufficiency（POI）. Methods Computer retrieval was carried out in such databases as Pub Med, Embase, Cochrane Library, web of science, Chinese biomedicine database（CBM）, China National Knowledge Infrastructure（CNKI）, Wan Fang and VIP in order to collect the randomized controlled trials（RCT） concerning acupoint stimulation therapy for treatment of POI. Software R 3.40 and stata 14.0 were used for Meta-analysis and network Meta-analysis, and Rev Man 5.3 was used for plotting the risk bias diagrams. Results Fortythree RCTs were included in total, involving 3046 POI patients and 18 acupoint stimulation therapies and comprehensive therapies. Metaanalysis showed：（1） The curative effects of acupoint stimulation therapy（RR=1.25, 95%CI [1.07,1.45]）, acupoint stimulation therapy＋Chinese herbal medicine（RR=1.25, 95%CI [1.18,1.32]） and acupoint stimulation therapy＋ hormone replacement therapy（HRT）（RR=1.20, 95%CI [1.12,1.29]） were all superior to that of HRT, indicating that the differences were statistically significant（Z=2.90, P=0.04; Z=7.56, P〈0.000 01; Z=4.06, P〈0.000 01）.（2） Compared with HRT, the occurrence rate of adverse effect of acupoint stimulation therapy was lower, and the safety was superior to that of HRT（RR=0.18, 95%CI [0.08,0.41]）, indicating that the differences were statistically significant（Z=4.08, P〈0.000 1）. Forty-two direct comparisons and 110 indirect comparisons were generated according to network Meta-analysis, among which, 38 comparisons were statistically significant. Network Metaanalysis results with HRT as control showed： the therapeutic measures ranking top 3 according to the curative effect sequence were catgut embedment in acupoint, moxibustion and warming-needle moxibustion, successively, and all the 3 measures were monotherapies without reflecting the advantages of comprehensive therapy. HRT ranked 17 th among the 18 included therapeutic measures. Conclusion On the basis of current evidences, acupoint stimulation therapy has a better clinical efficacy and safety for treatment of POI when compared with HRT. The acupoint stimulation therapies ranking the top 3 have more significant curative effects, but the long-term efficacy and the effect on the ovarian function still need to be further explored. In addition, the conclusion of this study still needs to be verified through a large number of RCTs with reasonable designs and appropriate methods.

Comprehensive evaluation methods for dam service status

More than 87000 dams have been built in China,and about one third of them are risky projects.A number of high and ultra-high dams are being constructed in China's western region.The current dam construction practice tends to focus on socio-economic benefits and neglect the environment and ecology.Furthermore,periodic examinations are intended to ensure the structural safety of dams.This paper proposes a general evaluation principle for dam service.This principle stipulates that dam projects should have maximum socio-economic benefits and minimum negative effects on the environment and ecology.To satisfy the general principle of mutual harmony,socio-economic benefits,dam safety,environment,and ecology are analyzed,and the evaluation methods for dam service status are discussed.Then,a fusion algorithm of interlayer assessment is proposed on the basis of evidence theory and the fuzzy comprehensive analysis method.Finally,a comprehensive evaluation model is established.Example analysis shows that the proposed theories and methods can fulfill scientific assessment of the service status of dams.