The shape optimization is studied by adopting the domain integrated method which is based on the calculus of variations during the shape design sensitivity analysis. A new method of improving the efficiency of the de...The shape optimization is studied by adopting the domain integrated method which is based on the calculus of variations during the shape design sensitivity analysis. A new method of improving the efficiency of the design velocity field analysis and the quality of the finite element method (FEM) mesh is put forward. The sensitivity analysis which is based on the calculus of variations is used in the shape optimization. The design velocity field is solved by Herrmann method. An example shows that both the quality of the FEM mesh and the efficiency of the computing of the design velocity field are improved by Herrmann method. So the effect and the efficiency of the shape optimization are guaranteed. If using sensitivity analysis which is based on the calculus of variations in the shape optimization, the sensitivity analysis can be a relatively independent module. The efficiency of computing the design velocity field and the quality of mesh will be improved by using Herrmann method.展开更多
For complicated geometries, it is ineflicient to integrate over the entire domain. A new approach for optimization is presented here, based on sensitivity analysis of local do- main and deformation of full domain. Acc...For complicated geometries, it is ineflicient to integrate over the entire domain. A new approach for optimization is presented here, based on sensitivity analysis of local do- main and deformation of full domain. Accurate results of design sensitivity analysis are ob- tained with this approach in shape optimization. This method is shown to be efficient when used in optimization programs and results in less distortion of the mesh.展开更多
To sensitize polyaniline with dyes by electrochemical polymerization, HClO 4 is employed as the dopant and oxidant, and the polyaniline with different sensitive properties is synthesized. The effect of sensitized emer...To sensitize polyaniline with dyes by electrochemical polymerization, HClO 4 is employed as the dopant and oxidant, and the polyaniline with different sensitive properties is synthesized. The effect of sensitized emeraldine salt on the absorption spectrum is discussed in details. The maximum conductivity of sensitized films reaches 1.22 S/cm, and investigation on dye sensitizing of the polymer reveals that C.I. Direct Blue 71, C.I. Direct Blue 84, C.I. Direct Black 19 and CuPc-(COOH) 4 may enhance the photoconductivity of polyaniline greatly.展开更多
Objective： To evaluate correlation between chemosensitivity of tumor cells in vitro and their clinical responsiveness in vivo by comparing the difference of curative effect between chemotherapy of cerebral gliomas di...Objective： To evaluate correlation between chemosensitivity of tumor cells in vitro and their clinical responsiveness in vivo by comparing the difference of curative effect between chemotherapy of cerebral gliomas directed by chemosensitivity test in vitro and its routine chemotherapy. Methods： Sixty-two patients with cerebral gliomas were recruited as the experiment group, who had received total resection or subtotal resection of the tumor. The resected tumor cells were cultured in vitro, followed by chemosensitivity test using colorimetric MTT assay. Finally, chemotherapeutic protocol was made based on the results of the chemosensitivity test. Fifty patients with cerebral gliomas subjected to the routine chemotherapeutic protocol were simultaneously recruited as the control group, whose age, gender, survival functional status and operational fashion were matched with the experiment group. The two groups were equally followed up for the survival functional status, recurrence and death. All data were analyzed using SPSS 10.0 software. Results： At the time of evaluation, KPS values of 64.52 ± 35.84 were seen in the experiment group, and 33.60 ± 36.24 in the control group, showing statistical difference between the two groups （t = 4.5163, P = 0.000）. During 2-4 years of follow up, a recurrence rate of 32.26% was seen in the experimental group, and 60.00% in the control group, showing a statistical difference between the two groups （X^2 = 8.620, P = 0.003）. The fatality was 22.58% in the experiment group, and 48.00% in the control group, showing a statistical difference between the two groups （X^2 = 7.978, P = 0.005）. The survival rate of the experimental group was higher than that of the control group, showing a statistical differences between the two groups （X^2= 7.29, P = 0.0069）. Conclusion： Chemotherapy of glio- mas under the guidance of chemosensitivity test in vitro contributes to obvious improvement on the current survival functional status, a clear decline of the recurrence rates and fatality rate, and raised survival rates of the patients. A close correlation between the chemosensitivity in vitro and clinical responsiveness in vivo is observed.展开更多
AIM： To investigate potential antitumor effects of rAd-p53 by determining if it enhanced sensitivity of gastric cancer cells to chemotherapy. METHODS： Three gastric cancer cell lines with distinct levels of differen...AIM： To investigate potential antitumor effects of rAd-p53 by determining if it enhanced sensitivity of gastric cancer cells to chemotherapy. METHODS： Three gastric cancer cell lines with distinct levels of differentiation were treated with various doses of rAd-p53 alone, oxaliplatin （OXA） alone, or a combination of both. Cell growth was assessed with an 3-（4,5）-dimethylthiahiazo （-z-yl）-3,5-diphenytetrazoli- umromide assay and the expression levels of p53, Bax and Bcl-2 were determined by immunohistochemistry. The presence of apoptosis and the expression of caspase-3 were determined using flow cytometry. RESULTS： Treatment with rAd-p53 or OXA alone inhibited gastric cancer cell growth in a time- and dose- dependent manner; moreover, significant synergistic effects were observed when these treatments were combined. Immunohistochemical analysis demonstrated that treatment with rAd-p53 alone, OXA alone or combined treatment led to decreased Bcl-2 expression and increased Bax expression in gastric cancer cells.Furthermore, flow cytometry showed that rAd-p53 alone, OXA alone or combination treatment induced apoptosis of gastric cancer cells, which was accompa- nied by increased expression of caspase-3. CONCLUSION： rAd-p53 enhances the sensitivity of gastric cancer cells to chemotherapy by promoting apoptosis. Thus, our results suggest that p53 gene therapy combined with chemotherapy represents a novel avenue for gastric cancer treatment.展开更多
Glacier area changes in the Qangtang Plateau are analyzed during 1970-2000 using air photos,relevant photogrammetric maps and satellite images based on the multi-temporal grid method.The results indicate that the melt...Glacier area changes in the Qangtang Plateau are analyzed during 1970-2000 using air photos,relevant photogrammetric maps and satellite images based on the multi-temporal grid method.The results indicate that the melting of glaciers accelerated,only a few of glaciers in an advancing state during 1970-2000 in the whole Qangtang Plateau.However,the glaciers seemed still more stable in the study area than in most areas of western China.We estimate that glacier retreat was likely due to air temperature warming during 1970-2000 in the Qangtang Plateau.Furthermore,the functional model of glacier system is applied to study climate sensitivity of glacier area changes,which indicates that glacier lifespan mainly depends on the heating rate,secondly the precipitation,and precipitation increasing can slow down glacier retreat and make glacier lifespan prolonged.展开更多
The sensitivity analysis functions on globularized fraction ofαlamellae were established using a physically-based microstructure model and gradient method.These functions were applied to the sensitivity analysis on g...The sensitivity analysis functions on globularized fraction ofαlamellae were established using a physically-based microstructure model and gradient method.These functions were applied to the sensitivity analysis on globularized fraction ofαlamellae in TC17 alloy.The material constants in these functions are determined using the genetic algorithm-based objective optimization technique.The globularized fraction ofαlamellae during isothermal compression of TC17 alloy was quantitatively analyzed based on scanning electron microscopy(SEM)observation.The results show thatαlamellae mostly change to equiaxedαgrains at a deformation temperature of 1083 K,a strain rate of 0.01 s^-1 and a strain of 1.2.The globularized fraction decreases with increasing strain rate because lower strain rate provides enough time for the spheroidization.The effect of deformation temperature on the globularized fraction is controlled by the strain rate.And,the predicted derivations of globularized fraction with respect to processing parameters show good agreement with the experimental values.展开更多
Data regarding the role of neoadjuvant chemotherapy(NACT) are not definitive. Several randomized trials and meta-analyses demonstrate that this chemotherapy regimen decreases the morbidity and mortality rates and incr...Data regarding the role of neoadjuvant chemotherapy(NACT) are not definitive. Several randomized trials and meta-analyses demonstrate that this chemotherapy regimen decreases the morbidity and mortality rates and increases complete cytoreduction rates. If combined with hyperthermic intraperitoneal chemotherapy(HIPEC), NACT could potentially further improve upon these already promising results. Moreover the use of NACT could help in evaluating the chemo-sensitivity of the cancer, thus preventing unnecessary HIPEC procedures in chemo-resistant patients. NACT should definitely be considered as a preferred regimen in the management of advanced ovarian cancer, especially in association with cytoreductive surgery + HIPEC procedure in the context of a multidisciplinary team management in an experienced cancer centre.展开更多
The electromagnetically induced reflection(EIR)effect of graphene metamaterials has been investigated by finite difference time domain(FDTD)method.In this study,a metamaterial sandwich structure composed of silica(SiO...The electromagnetically induced reflection(EIR)effect of graphene metamaterials has been investigated by finite difference time domain(FDTD)method.In this study,a metamaterial sandwich structure composed of silica(SiO2),gold and graphene on terahertz band is designed.By changing the width of the two ribbons of graphene length and the incident angle of electromagnetic wave,the EIR effect of the structure is discussed,and it can be found that SiO2 is a kind of excellent dielectric material.The simulation results show that graphene metamaterial is not sensitive to polarized incident electromagnetic wave.Therefore,such EIR phenomena as insensitive polarization and large incident angle can be applied to optical communication filters and terahertz devices.展开更多
文摘The shape optimization is studied by adopting the domain integrated method which is based on the calculus of variations during the shape design sensitivity analysis. A new method of improving the efficiency of the design velocity field analysis and the quality of the finite element method (FEM) mesh is put forward. The sensitivity analysis which is based on the calculus of variations is used in the shape optimization. The design velocity field is solved by Herrmann method. An example shows that both the quality of the FEM mesh and the efficiency of the computing of the design velocity field are improved by Herrmann method. So the effect and the efficiency of the shape optimization are guaranteed. If using sensitivity analysis which is based on the calculus of variations in the shape optimization, the sensitivity analysis can be a relatively independent module. The efficiency of computing the design velocity field and the quality of mesh will be improved by using Herrmann method.
文摘For complicated geometries, it is ineflicient to integrate over the entire domain. A new approach for optimization is presented here, based on sensitivity analysis of local do- main and deformation of full domain. Accurate results of design sensitivity analysis are ob- tained with this approach in shape optimization. This method is shown to be efficient when used in optimization programs and results in less distortion of the mesh.
文摘To sensitize polyaniline with dyes by electrochemical polymerization, HClO 4 is employed as the dopant and oxidant, and the polyaniline with different sensitive properties is synthesized. The effect of sensitized emeraldine salt on the absorption spectrum is discussed in details. The maximum conductivity of sensitized films reaches 1.22 S/cm, and investigation on dye sensitizing of the polymer reveals that C.I. Direct Blue 71, C.I. Direct Blue 84, C.I. Direct Black 19 and CuPc-(COOH) 4 may enhance the photoconductivity of polyaniline greatly.
文摘Objective： To evaluate correlation between chemosensitivity of tumor cells in vitro and their clinical responsiveness in vivo by comparing the difference of curative effect between chemotherapy of cerebral gliomas directed by chemosensitivity test in vitro and its routine chemotherapy. Methods： Sixty-two patients with cerebral gliomas were recruited as the experiment group, who had received total resection or subtotal resection of the tumor. The resected tumor cells were cultured in vitro, followed by chemosensitivity test using colorimetric MTT assay. Finally, chemotherapeutic protocol was made based on the results of the chemosensitivity test. Fifty patients with cerebral gliomas subjected to the routine chemotherapeutic protocol were simultaneously recruited as the control group, whose age, gender, survival functional status and operational fashion were matched with the experiment group. The two groups were equally followed up for the survival functional status, recurrence and death. All data were analyzed using SPSS 10.0 software. Results： At the time of evaluation, KPS values of 64.52 ± 35.84 were seen in the experiment group, and 33.60 ± 36.24 in the control group, showing statistical difference between the two groups （t = 4.5163, P = 0.000）. During 2-4 years of follow up, a recurrence rate of 32.26% was seen in the experimental group, and 60.00% in the control group, showing a statistical difference between the two groups （X^2 = 8.620, P = 0.003）. The fatality was 22.58% in the experiment group, and 48.00% in the control group, showing a statistical difference between the two groups （X^2 = 7.978, P = 0.005）. The survival rate of the experimental group was higher than that of the control group, showing a statistical differences between the two groups （X^2= 7.29, P = 0.0069）. Conclusion： Chemotherapy of glio- mas under the guidance of chemosensitivity test in vitro contributes to obvious improvement on the current survival functional status, a clear decline of the recurrence rates and fatality rate, and raised survival rates of the patients. A close correlation between the chemosensitivity in vitro and clinical responsiveness in vivo is observed.
基金Supported by Xuzhou Science and Technology Development Fund,No. XM07C039
文摘AIM： To investigate potential antitumor effects of rAd-p53 by determining if it enhanced sensitivity of gastric cancer cells to chemotherapy. METHODS： Three gastric cancer cell lines with distinct levels of differentiation were treated with various doses of rAd-p53 alone, oxaliplatin （OXA） alone, or a combination of both. Cell growth was assessed with an 3-（4,5）-dimethylthiahiazo （-z-yl）-3,5-diphenytetrazoli- umromide assay and the expression levels of p53, Bax and Bcl-2 were determined by immunohistochemistry. The presence of apoptosis and the expression of caspase-3 were determined using flow cytometry. RESULTS： Treatment with rAd-p53 or OXA alone inhibited gastric cancer cell growth in a time- and dose- dependent manner; moreover, significant synergistic effects were observed when these treatments were combined. Immunohistochemical analysis demonstrated that treatment with rAd-p53 alone, OXA alone or combined treatment led to decreased Bcl-2 expression and increased Bax expression in gastric cancer cells.Furthermore, flow cytometry showed that rAd-p53 alone, OXA alone or combination treatment induced apoptosis of gastric cancer cells, which was accompa- nied by increased expression of caspase-3. CONCLUSION： rAd-p53 enhances the sensitivity of gastric cancer cells to chemotherapy by promoting apoptosis. Thus, our results suggest that p53 gene therapy combined with chemotherapy represents a novel avenue for gastric cancer treatment.
基金supported by the National Natural Science Foundation of China (Nos.40871043,40801025)the Project of National Scientific Basic Special Fund on the Ministry of Science and Technology of China (No.2006FY110200)the Key Construction Disciplines of Hunan Province (No.40652001)
文摘Glacier area changes in the Qangtang Plateau are analyzed during 1970-2000 using air photos,relevant photogrammetric maps and satellite images based on the multi-temporal grid method.The results indicate that the melting of glaciers accelerated,only a few of glaciers in an advancing state during 1970-2000 in the whole Qangtang Plateau.However,the glaciers seemed still more stable in the study area than in most areas of western China.We estimate that glacier retreat was likely due to air temperature warming during 1970-2000 in the Qangtang Plateau.Furthermore,the functional model of glacier system is applied to study climate sensitivity of glacier area changes,which indicates that glacier lifespan mainly depends on the heating rate,secondly the precipitation,and precipitation increasing can slow down glacier retreat and make glacier lifespan prolonged.
基金Project(51575446) supported by the National Natural Science Foundation of ChinaProject(2016JQ5070) supported by the Natural Science Basis Research Plan of Shaanxi Province,China+1 种基金Project(2017KJXX-27) supported by the Youth Science and Technology New Star Plan of Shaanxi Province,ChinaProject(3102017AX003) supported by the Fundamental Research Funds for the Central Universities,China
文摘The sensitivity analysis functions on globularized fraction ofαlamellae were established using a physically-based microstructure model and gradient method.These functions were applied to the sensitivity analysis on globularized fraction ofαlamellae in TC17 alloy.The material constants in these functions are determined using the genetic algorithm-based objective optimization technique.The globularized fraction ofαlamellae during isothermal compression of TC17 alloy was quantitatively analyzed based on scanning electron microscopy(SEM)observation.The results show thatαlamellae mostly change to equiaxedαgrains at a deformation temperature of 1083 K,a strain rate of 0.01 s^-1 and a strain of 1.2.The globularized fraction decreases with increasing strain rate because lower strain rate provides enough time for the spheroidization.The effect of deformation temperature on the globularized fraction is controlled by the strain rate.And,the predicted derivations of globularized fraction with respect to processing parameters show good agreement with the experimental values.
文摘Data regarding the role of neoadjuvant chemotherapy(NACT) are not definitive. Several randomized trials and meta-analyses demonstrate that this chemotherapy regimen decreases the morbidity and mortality rates and increases complete cytoreduction rates. If combined with hyperthermic intraperitoneal chemotherapy(HIPEC), NACT could potentially further improve upon these already promising results. Moreover the use of NACT could help in evaluating the chemo-sensitivity of the cancer, thus preventing unnecessary HIPEC procedures in chemo-resistant patients. NACT should definitely be considered as a preferred regimen in the management of advanced ovarian cancer, especially in association with cytoreductive surgery + HIPEC procedure in the context of a multidisciplinary team management in an experienced cancer centre.
基金Research Project of Anhui Province Education Department(No.KJ2020A0684)Innovation and Entrepreneurship Training Program for College Students(Nos.S201910375072,201910375050,201910375052,202010375030)。
文摘The electromagnetically induced reflection(EIR)effect of graphene metamaterials has been investigated by finite difference time domain(FDTD)method.In this study,a metamaterial sandwich structure composed of silica(SiO2),gold and graphene on terahertz band is designed.By changing the width of the two ribbons of graphene length and the incident angle of electromagnetic wave,the EIR effect of the structure is discussed,and it can be found that SiO2 is a kind of excellent dielectric material.The simulation results show that graphene metamaterial is not sensitive to polarized incident electromagnetic wave.Therefore,such EIR phenomena as insensitive polarization and large incident angle can be applied to optical communication filters and terahertz devices.
