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温度敏感瞬时受体电位通道参与化疗引起的外周神经病变的研究进展 被引量:2
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作者 陈晓博 曹鹏 +1 位作者 于锋 王大为 《药学与临床研究》 2014年第2期144-148,共5页
化疗所引起的外周神经病变(CIPN)是临床抗肿瘤治疗过程中常见的剂量限制性毒性。外周神经系统中所分布的温度敏感瞬时受体电位通道(thermoTRPs)在CIPN的发生发展中发挥了关键的作用,参与了CIPN神经性痛觉过敏等症状形成。化疗药物可通... 化疗所引起的外周神经病变(CIPN)是临床抗肿瘤治疗过程中常见的剂量限制性毒性。外周神经系统中所分布的温度敏感瞬时受体电位通道(thermoTRPs)在CIPN的发生发展中发挥了关键的作用,参与了CIPN神经性痛觉过敏等症状形成。化疗药物可通过多种途径激活thermoTRPs或导致其异常表达。研究thermoTRPs在CIPN中的作用及其机制具有重要意义。本文综述了近年来有关于thermoTRPs参与CIPN的相关研究以及临床治疗进展。 展开更多
关键词 化疗引起的外周神经病变 痛觉过敏 温度敏感瞬时受体电位通道 氧化应激
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Fe-Cr-Ni合金碱性应力腐蚀破裂 被引量:5
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作者 黄春波 吕战鹏 杨武 《腐蚀与防护》 CAS 2002年第6期239-244,共6页
介绍了核电站蒸汽发生器传热管Fe Cr Ni合金、特别是 80 0合金的碱性应力腐蚀破裂 ,总结了材质成分、热处理、应力、冷加工、环境和电化学等因素对Fe Cr Ni合金的碱性应力腐蚀破裂的影响 ,并归纳了预测应力腐蚀破裂敏感电位的方法。
关键词 FE-CR-NI合金 蒸汽发生器 碱性应力腐蚀破裂 影响因素 敏感电位 传热管 核反应堆
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Detection performance of azimuthal electromagnetic logging while drilling tool in anisotropic media 被引量:4
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作者 Wu Zhen-Guan Wang Lei +3 位作者 Fan Yi-Ren Deng Shao-Gui Huang Rui Xing Tao 《Applied Geophysics》 SCIE CSCD 2020年第1期1-12,167,共13页
Azimuthal electromagnetic(EM)logging while drilling(LWD)has been extensively used in high-angle and horizontal(HA/HZ)wells.However,due to the effects of formation anisotropy,accurate geosteering decision and formation... Azimuthal electromagnetic(EM)logging while drilling(LWD)has been extensively used in high-angle and horizontal(HA/HZ)wells.However,due to the effects of formation anisotropy,accurate geosteering decision and formation evaluations have become increasingly difficult.To quantitatively analyze the effect of anisotropy on tool responses and data processing,this paper investigates the sensitivity of EM LWD measurements to electric anisotropy and inversion accuracy via forward modeling and inversion.First,a sensitivity factor is defined to quantitatively analyze the sensitivity of the magnetic field components and synthetic signals to electric anisotropy.Then,azimuthal EM LWD responses in anisotropic layered formations are simulated,and the sensitivities to formation parameters for compensated and uncompensated tool configurations are comparatively analyzed.Finally,we discuss the effects of the inversion model on bed boundary inversion in anisotropic formations.Numerical simulation and inversion results show that azimuthal EM LWD can be significantly affected by electric anisotropy.Fortunately,by using a symmetrical compensation configuration,the sensitivity of the geosignals to electric anisotropy can be suppressed,and the boundary detection capability can be further enhanced.Anisotropy normally gives rise to separated resistivity curves and abnormal"horns";moreover,complicated nonlinear distortion can also arise in geosignals as the tool approaches a bed boundary.If anisotropy effects are ignored in the inversion process,the estimated bed boundary and formation resistivity are usually unreliable,which may mislead geosteering decisions. 展开更多
关键词 ANISOTROPY azimuthal electromagnetic LWD sensitivity INVERSION
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Novel Method for Optimal Location of STATCOM in Distribution Systems Using Sensitivity Analysis by DIgSILENT Software
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作者 Abouzar Samimi Masoud Aliakbar Golkar 《Journal of Energy and Power Engineering》 2012年第7期1170-1176,共7页
In this paper a new method has been proposed to decide optimal placement and best sizing of STATCOM (static synchronous compensator). The best place of STATCOM is found using the sensitivity analysis and optimum siz... In this paper a new method has been proposed to decide optimal placement and best sizing of STATCOM (static synchronous compensator). The best place of STATCOM is found using the sensitivity analysis and optimum sizing of STATCOM is managed using the genetic algorithm. The average model can account for the high-frequency effects and power electronic losses, and more accurately predict the active and reactive power outputs of the STATCOM. This paper employs the DIgSILENT simulator and DPL (DIgSILENT programming language) as a programming tool of the DIgSILENT to show the validity of the proposed method. The effectiveness of suggested approach has been tested on part of the distribution network of Iran, Khoramdarreh city in Zanjan province. 展开更多
关键词 Average model optimal placement genetic algorithm sensitivity analysis STATCOM.
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冷敏感TRP蛋白表达于神经元及血管内皮的概述
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作者 王新娜 刘立明 +3 位作者 牛萍 赵鸿飞 马春玉 赵德喜 《重庆医学》 CAS 2020年第24期4206-4211,共6页
瞬时受体电位(TRP)离子通道蛋白作为传递细胞内外重要的传感器,对于人类健康非常重要。目前,公认的冷敏感TRP蛋白有TRPA1、TRPM8,可以被冷刺激激活,参与机体多种生理反应及病理进程,包括温度传导和疼痛感应等,在多种神经性、血管性及离... 瞬时受体电位(TRP)离子通道蛋白作为传递细胞内外重要的传感器,对于人类健康非常重要。目前,公认的冷敏感TRP蛋白有TRPA1、TRPM8,可以被冷刺激激活,参与机体多种生理反应及病理进程,包括温度传导和疼痛感应等,在多种神经性、血管性及离子通道疾病的研究具有必要性和可行性。本文主要就TRPA1、TRPM8离子通道蛋白在神经元、血管内皮细胞的表达作用,以及在一些疾病中的调控机制和未来展望进行综述,以期为相关领域提供参考和思路。 展开更多
关键词 敏感瞬时受体电位蛋白 神经元 血管内皮 研究概述
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诺贝尔生理学或医学奖获奖者大卫·朱利叶斯(David Julius)和阿登·帕塔普蒂安(Ardem Patapoutian)对温度和触觉感受器研究的贡献 被引量:2
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作者 张健 《中华疼痛学杂志》 2022年第3期398-413,共16页
David Julius利用辣椒辣素来识别皮肤神经末梢上对热/冷刺激做出反应的感受器,Ardem Patapoutian利用压力敏感细胞发现了一种对皮肤和内部器官的机械刺激作出反应的新型感受器。两位学者对感受器受体的分型、结构特点、作用及调控机制... David Julius利用辣椒辣素来识别皮肤神经末梢上对热/冷刺激做出反应的感受器,Ardem Patapoutian利用压力敏感细胞发现了一种对皮肤和内部器官的机械刺激作出反应的新型感受器。两位学者对感受器受体的分型、结构特点、作用及调控机制进行了深入的探讨,这使我们对热、冷、机械刺激以及疼痛的认识更为深入。 展开更多
关键词 辣椒辣素受体 温度敏感型瞬时受体电位通道 Piezo离子通道 默克尔细胞
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Individual aortic baroreceptors are sensitive to different ranges of blood pressures 被引量:2
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作者 CHEN MengJiao YANG MingHao +4 位作者 HAN WenJuan AN ShuCheng LIU YiHui LIU ZhiQiang REN Wei 《Science China(Life Sciences)》 SCIE CAS 2014年第5期502-509,共8页
Many receptors,including thermal receptors and mechanical receptors,are only activated by stimuli within a clearly defined range of intensities.Differences in the receptive ranges enable individual receptors and their... Many receptors,including thermal receptors and mechanical receptors,are only activated by stimuli within a clearly defined range of intensities.Differences in the receptive ranges enable individual receptors and their sensory centers to precisely detect the intensity of the stimulus and changes in intensity.Baroreceptors are the sensory terminals of the baroreflex.It is well understood that an increasing number of baroreceptors are recruited to produce afferent action potentials as the blood pressure increases,indicating that individual baroreceptors have different pressure thresholds.The present study revealed that individual baroreceptors could stop their afferent signals when the blood pressure exceeds a certain level,indicating that individual baroreceptors are sensitive to a specific range of blood pressure.The receptive ranges of individual baroreceptors differ in terms of the total range,the lower threshold,and the upper threshold.Of 85 baroreceptors examined in this study,the upper thresholds for about half were within the physiological blood pressure range.These results indicate that supraphysiological blood pressure is unlikely to be encoded by the recruitment of more baroreceptors.Instead,supraphysiological blood pressure levels might be signaled by an increase in the frequency of action potentials or by other mechanisms.In conclusion,our results indicate that rabbit baroreceptors are activated by blood pressure levels within specific receptive ranges.These findings should encourage further studies to examine the role of population coding of blood pressure by baroreceptors in the baroreflex. 展开更多
关键词 depolarization block receptive range rabbit depressor nerve single fiber recording
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