To investigate the involvement of central serotonergic system in behavioral sensitization to morphine in mice. Male Kunming mice were treated (i.p.) with saline or morphine 10 mg/kg twice daily for 3 d and then drug...To investigate the involvement of central serotonergic system in behavioral sensitization to morphine in mice. Male Kunming mice were treated (i.p.) with saline or morphine 10 mg/kg twice daily for 3 d and then drug manipulation was suspended for 5 d. On day 9, a challenge dose of morphine (10 mg/kg) was given and the locomotor activity was measured for 60 rain to confkrm the establishment of behavioral sensitization in mice. Moreover, 5-hydroxytryptophan (5-HTP), a precursor of serotonin, at the doses of 20-80 mg/kg was given i.p. in combination with daily morphine treatment (induction), during the morphine treatment suspension (transfer) or prior to the challenge dose of morphine (expression) and locomotor activity was measured on day 9 after the challenge dose of morphine. Twice daily of morphine injection induced robust behavioral sensitization in mice as evidenced by significantly higher locomotion on day 9 for multiple treatment with morphine than saline in mice. 5-HTP treatment selec- tively and dose-dependently blocked the induction, but not the transfer nor the expression of morphine induced behavioral sensitization. This study provides clear evidence that up-regulation of central serotonergic system may suppress the induction of morphine sensitization in mice.展开更多
The received signal of the polarization sensitive array is proved to have trilinear model characteristics. The blind parallel factor(PARAFAC) signal detection algorithm for the polarization sensitive array is propos...The received signal of the polarization sensitive array is proved to have trilinear model characteristics. The blind parallel factor(PARAFAC) signal detection algorithm for the polarization sensitive array is proposed. The trilinear alternating least square (TALS) algorithm is used to abtain the source matrix, and then the matrix is judged. Simulation results show that the bit error rate (BER) of the detection algorithm is close to that of the non-blind decorrelating method and the algorithm works well under the array error condition. BER difference between the non-blind method and this algorithm is less than 2 dB under a high SNR. The algorithm is blind and robust. The channel fading, the direction of arrive(DOA) imformation and the polarization information are needless in the algorithm.展开更多
The tensile and fracture behaviors of AA6061 alloy were investigated in order to provide quantitative data about this alloy at cryogenic temperatures.Specimens of AA6061 alloy were solution heat treated before tensile...The tensile and fracture behaviors of AA6061 alloy were investigated in order to provide quantitative data about this alloy at cryogenic temperatures.Specimens of AA6061 alloy were solution heat treated before tensile tests at 298,173 and 77 K and tested at strain rates in the range from 0.1 to 0.0001 s^(−1).The results indicate the suppression of the Portevin−Le Chatelier(PLC)effect and dynamic strain aging(DSA)at 77 K.In contrast,at 298 K,a remarkable serrated flow,characteristic of the PLC effect,is observed.Furthermore,the tensile behavior at 77 K,compared with that observed at 173 and 298 K,shows a simultaneous increase in strength,uniform elongation,modulus of toughness,strain-hardening exponent and strain rate sensitivity,which is related to a decrease in the dynamic recovery rate at low temperature.These responses are reflected on the fracture morphology,since the dimple size decreases at 77 K,while the area covered by dimples increases.Comparisons of the Johnson−Cook model show that a good agreement can be obtained for tests at 173 and 77 K,in which DSA is suppressed.展开更多
Celiac disease (CD) is a common autoimmune disorder characterized by an immune response to ingested gluten and has a strong HLA association with HLA- DQ2 and HLA-DQ8 molecules, but human HLA-DQ risk factors do not exp...Celiac disease (CD) is a common autoimmune disorder characterized by an immune response to ingested gluten and has a strong HLA association with HLA- DQ2 and HLA-DQ8 molecules, but human HLA-DQ risk factors do not explain the entire genetic susceptibility to gluten intolerance. CD is caused by the lack of immune tolerance (oral tolerance) to wheat gluten. In this sense, the expression of soluble HLA-G in CD is of special interest because the molecule plays an important role in the induction of immune tolerance. The enhanced expression of soluble HLA-G found in CD may be part of a mechanism to restore the gluten intolerance. In this editorial, we review recent progress in understanding CD in relation to its prevalence, diagnosis and possible mechanisms of pathogenesis.展开更多
Rainfall induced landslides are a common threat to the communities living on dangerous hillslopes in Chittagong Metropolitan Area, Bangladesh. Extreme population pressure, indiscriminate hill cutting, increased precip...Rainfall induced landslides are a common threat to the communities living on dangerous hillslopes in Chittagong Metropolitan Area, Bangladesh. Extreme population pressure, indiscriminate hill cutting, increased precipitation events due to global warming and associated unplanned urbanization in the hills are exaggerating landslide events. The aim of this article is to prepare a scientifically accurate landslide susceptibility map by combining landslide initiation and runout maps. Land cover, slope, soil permeability, surface geology, precipitation, aspect, and distance to hill cut, road cut, drainage and stream network factor maps were selected by conditional independence test. The locations of 56 landslides were collected by field surveying. A weight of evidence(Wo E) method was applied to calculate the positive(presence of landslides) and negative(absence of landslides) factor weights. A combination of analytical hierarchical process(AHP) and fuzzymembership standardization(weighs from 0 to 1) was applied for performing a spatial multi-criteria evaluation. Expert opinion guided the decision rule for AHP. The Flow-R tool that allows modeling landslide runout from the initiation sources was applied. The flow direction was calculated using the modified Holmgren's algorithm. The AHP landslide initiation and runout susceptibility maps were used to prepare a combined landslide susceptibility map. The relative operating characteristic curve was used for model validation purpose. The accuracy of Wo E, AHP, and combined susceptibility map was calculated 96%, 97%, and 98%, respectively.展开更多
Inter-phase mass transfer is important to the design and performance of airlift loop reactors for either chemical or biochemical applications, and a good measurement technique is crucial for studying mass transfer in ...Inter-phase mass transfer is important to the design and performance of airlift loop reactors for either chemical or biochemical applications, and a good measurement technique is crucial for studying mass transfer in multiphase systems. According to the model of macro-scale mass transfer in airlift loop reactors, it was proved that the airlift loop reactor can be regarded as a continuous stirred tank reactor for measuring mass transfer coefficient. The calculated mass transfer coefficient on such a basis is different from the volumetric mass transfer coefficient in the macro-scale model and the difference is discussed. To describe the time delay of the probe response to the change of oxygen concentration in the liquid phase, a model taking into account the time constant of response is es-tablished. Sensitivity analysis shows that this model can be used to measure the volumetric mass transfer coefficient. Applying this model to the measurement of volumetric mass transfer coefficient in the loop reactor, results that co-incide with the turbulence theory in the literate were obtained.展开更多
The effect of small changes in sintering temperature on microstructure, electrical properties, dielectric characteristics, and degradation behavior of V-Mn-Nb-Gd co-doped zinc oxide ceramics was investigated. With the...The effect of small changes in sintering temperature on microstructure, electrical properties, dielectric characteristics, and degradation behavior of V-Mn-Nb-Gd co-doped zinc oxide ceramics was investigated. With the increase of sintering temperature, the densities of the sintered pellets decreased from 5.54 to 5.42 g/cm3 and the average grain size increased from 4.1 to 11.7 μm. The breakdown field(E1 m A) decreased noticeably from 7138 to 920 V/cm with the increase of sintering temperature. The varistor ceramics sintered at 900 ℃ exhibited excellent nonohmic properties, which were 66 for the nonohmic coefficient and 77 μA/cm2 for the leakage current density. Concerning stability, the varistors sintered at 900 ℃ exhibited the strongest accelerated degradation characteristics, with ΔE1 mA =-9.2% for DC accelerated degradation stress of 0.85 E1 m A at 85 °C for 24 h.展开更多
In order to investigate the hot deformation behavior of superalloy GH696, isothermal compression experiments were carried out at deformation temperatures of 880?1120 °C and strain rates of 0.01?10 s?1. And the de...In order to investigate the hot deformation behavior of superalloy GH696, isothermal compression experiments were carried out at deformation temperatures of 880?1120 °C and strain rates of 0.01?10 s?1. And the deformation amount of all the samples was 50%. The strain rate sensitivity exponent (m) and strain hardening exponent (n) under different deformation conditions were calculated, meanwhile the effects of the processing parameters on the values ofm andn were analyzed. The results show that the flow stress increases with the increase of strain rate and the decrease of deformation temperature. The value ofm increases with the increase of deformation temperature and decreases with the increase of strain rate, while the value ofn decreases with the increase of deformation temperature. A novel flow stress model during hot deformation of superalloy GH696 was also established. And the calculated flow stress of the alloy is in good agreement with the experimental one.展开更多
The free-piston engine generator(FPEG)is regarded as the next generation of energy conversion system which may replace traditional engines in the future.The effect of key operational parameters like excess air ratio o...The free-piston engine generator(FPEG)is regarded as the next generation of energy conversion system which may replace traditional engines in the future.The effect of key operational parameters like excess air ratio of input mixture and ignition position on the engine performance of a dual-cylinder FPEG was investigated,and their sensitivity was analyzed in this paper.The operating compression ratio of the system is susceptible to changes in excess air ratio and ignition position.At the same time,it decreases from 15.8 to 6.6 when excess air ratio increases from 0.85 to 1.15,but it increases from 6.1 to 13.3 as ignition position increases from 15 mm to 20 mm.The operating frequency and indicated power are more sensitive to changes in excess air ratio than ignition position.But it is the opposite for the indicated thermal efficiency and friction loss.Excess air ratio and ignition position have a quite similar influence on heat transfer.Therefore,from the perspective of system operation and performance,it is preferable to keep excess air coefficient slightly below 1.0.In contrast,when selecting ignition position,it is of great importance to comprehensively consider the risk of structural damage caused by the increase in the compression ratio and in-cylinder gas pressure.展开更多
A more efficient mine ventilation system, the ventilation-on-demand (VOD) system, has been proposed and tested in Canadian mines recently. In order to supply the required air volumes to the production areas of a min...A more efficient mine ventilation system, the ventilation-on-demand (VOD) system, has been proposed and tested in Canadian mines recently. In order to supply the required air volumes to the production areas of a mine, operators need to know the cause and effect of any changes requested from the VOD system. The sensitivity analysis is developed through generating a cause and effect matrix of sensitivity factors on given parameter changes in a ventilation system. This new utility, which was incorporated in the 3D-CANVENT mine ventilation simulator, is able to predict the airflow distributions in a ventilation network when underground conditions and ventilation controls are changed. For a primary ventilation system, the software can determine the optimal operating speed of the main fans to satisfy the airflow requirements in underground workings without necessarily using booster fans and regulators locally. An optimized fan operating speed time-table would assure variable demand-based fresh air delivery to the production areas effectively, while generating significant savings in energy consumption and operating cost.展开更多
In view of the extensive bone damage in rheumatoid arthritis, we used a commonly utilized animal model to detect behavioral changes in pain-related and the bone damage during the early disease, and to explore the corr...In view of the extensive bone damage in rheumatoid arthritis, we used a commonly utilized animal model to detect behavioral changes in pain-related and the bone damage during the early disease, and to explore the correlation between bone damage and pain-related behavioral changes. Methods: Arthritis were induced in Sprague-Dawley (SD) male rats by injecting complete Freund's adjuvant (CFA) into the tails. Pain-related behavior changes were studied using the Hargreaves, VonFrey, and acetone tests on the 0, 7, 14, day and 28 day after CFA injection. The rats were sacrificed according the same schedule. The bone damage of the right proximal tibia was studied by microCT scan and bone histological slices. Results: Animals developed soft tissue inflammation and polyarthritis on 7 days after CFA injection, and arthritic score proved obvious arthritis were established within the study period. Mechanical hyperalgesia and cold allodynia were present in the affected hind paw from the 7 day through the 28 day, but the heat hyperalgesia and the mechanical allodynia lasted a short time after CFA injection. Trabecular bone number (Tb.N), Tissue Mineral Content (TMC) and Bone Volume to Tissue Volume (BV/TV) in the proximal tibia by microCT scan were also reduced after induction, especial 14 days after CFA injection. The bone histologicalslices showed the trabecular bone and proteoglycan diminished, the bone damage severity scores became more severely on the 7 day after CFA injection. Using analysis of covariance, these changes had statistical significance compared with baseline. By linear regression analysis demonstrated mechanical hyperalgesia and cold allodynia correlated well with arthritic score, bone damage parameters and bone damage severity scores. Conclusion: Adjuvant-induced arthritis (AA) were observed after CFA injection and lasted within the later experimental period. Pain-related behavioral changes were observed in the early time of AA. Bone damage was also occurred with arthritis development. Pain-related behavioral change correlated well with arthritic score and bone damage parameters展开更多
A 1.8-V 64-kb four-way set-associative CMOS cache memory implemented by 0.18μm/1.8V 1P6M logic CMOS technology for a super performance 32-b RISC microprocessor is presented.For comparison,a conventional parallel acce...A 1.8-V 64-kb four-way set-associative CMOS cache memory implemented by 0.18μm/1.8V 1P6M logic CMOS technology for a super performance 32-b RISC microprocessor is presented.For comparison,a conventional parallel access cache with the same storage and organization is also designed and simulated using the same technology.Simulation results indicate that by using sequential access,power reduction of 26% on a cache hit and 35% on a cache miss is achieved.High-speed approaches including modified current-mode sense amplifier and split dynamic tag comparators are adopted to achieve fast data access.Simulation results indicate that a typical clock to data access of 2.7ns is achieved...展开更多
The present manuscript aims to examine the impact of art on the cultivation of personality and sensitivity. The author suggests that education in art contributes to evolving sensibility towards the surrounding world. ...The present manuscript aims to examine the impact of art on the cultivation of personality and sensitivity. The author suggests that education in art contributes to evolving sensibility towards the surrounding world. The artistic knowledge or attitude helps us perceive and feel the quotidian with affection, imagination, and creativity. It functions as a complement to a rational understanding of reality. This paper retakes Aristotelian category of poiesis, considering it a creative act and delves into John Dewey's view of relations between education and art. Dewey f'mds in the aesthetic-artistic experience of the quotidian a way to engage with the other and to treat life as something with deep aesthetic sense. The discussion shown in this article follows four main threads under the scope of the Deweynian notion of art as experience, They are the education for art, education by art, education in art, and the creative act of the quotidian.展开更多
The existing hydraulic system always have problems of temperature rise,runningstability and anti-interference of the implementation components,reliability of hydrauliccomponents,maintenance difficulties,and other issu...The existing hydraulic system always have problems of temperature rise,runningstability and anti-interference of the implementation components,reliability of hydrauliccomponents,maintenance difficulties,and other issues.With high efficiency,energysaving,reliability,easy operating,stable running,anti-interference ability,and other advantages,the load-sensitive hydraulic system is more suitable for coal mine all-hydrauliccore rig.Therefore,for the technical development of the coal mine all-hydraulic core rig,the load-sensitive technology employed by the rig should be of great significance.展开更多
The sensitivity of precipitation was studied by conducting control aqua-planet experiments(APEs) with a model to determine atmospheric general circulation.The model includes two versions: that with a spectral dynamica...The sensitivity of precipitation was studied by conducting control aqua-planet experiments(APEs) with a model to determine atmospheric general circulation.The model includes two versions: that with a spectral dynamical core(SAMIL) and that with a finite-volume dynamical core(FAMIL).Three factors were investigated including dynamical core,time-step length,and horizontal resolution.Numerical results show that the dynamical core significantly affects the structure of zonal averaged precipitation.FAMIL exhibited an equatorial precipitation belt with a single narrow peak,and SAMIL showed a broader belt with double peaks.Moreover,the time step of the model physics is shown to affect the zonal-averaged tropical convective precipitation ratio such that a longer time step leads to more production and consumption of convective available potential energy and convection initiated away from the equator,which corresponds to equatorial double peaks of precipitation.Further,precipitation is determined to be sensitive to horizontal resolution such that higher horizontal resolution allows for more small-scale kinetic energy to be resolved and leads to a broader probability distribution of low-level vertical velocity.This process results in heavier rainfall and convective precipitation extremes in the tropics.Abstract The sensitivity of precipitation was studied by conducting control aqua-planet experiments(APEs)with a model to determine atmospheric general circulation.The model includes two versions:that with a spectral dynamical core(SAMIL)and that with a finite-volume dynamical core(FAMIL).Three factors were investigated including dynamical core,time-step length,and horizontal resolution.Numerical results show that the dynamical core significantly affects the structure of zonal averaged precipitation.FAMIL exhibited an equatorial precipitation belt with a single narrow peak,and SAMIL showed a broader belt with double peaks.Moreover,the time step of the model physics is shown to affect the zonal-averaged tropical convective precipitation ratio such that a longer time step leads to more production and consumption of convective available potential energy and convection initiated away from the equator,which corresponds to equatorial double peaks of precipitation.Further,precipitation is determined to be sensitive to horizontal resolution such that higher horizontal resolution allows for more small-scale kinetic energy to be resolved and leads to a broader probability distribution of low-level vertical velocity.This process results in heavier rainfall and convective precipitation extremes in the tropics.展开更多
基金National Natural Science Foundation of China (Grant No. 30570653)National Basic Research Program of China (Grant No. 2003CB515400)985 Program of China Ministry of Education
文摘To investigate the involvement of central serotonergic system in behavioral sensitization to morphine in mice. Male Kunming mice were treated (i.p.) with saline or morphine 10 mg/kg twice daily for 3 d and then drug manipulation was suspended for 5 d. On day 9, a challenge dose of morphine (10 mg/kg) was given and the locomotor activity was measured for 60 rain to confkrm the establishment of behavioral sensitization in mice. Moreover, 5-hydroxytryptophan (5-HTP), a precursor of serotonin, at the doses of 20-80 mg/kg was given i.p. in combination with daily morphine treatment (induction), during the morphine treatment suspension (transfer) or prior to the challenge dose of morphine (expression) and locomotor activity was measured on day 9 after the challenge dose of morphine. Twice daily of morphine injection induced robust behavioral sensitization in mice as evidenced by significantly higher locomotion on day 9 for multiple treatment with morphine than saline in mice. 5-HTP treatment selec- tively and dose-dependently blocked the induction, but not the transfer nor the expression of morphine induced behavioral sensitization. This study provides clear evidence that up-regulation of central serotonergic system may suppress the induction of morphine sensitization in mice.
文摘The received signal of the polarization sensitive array is proved to have trilinear model characteristics. The blind parallel factor(PARAFAC) signal detection algorithm for the polarization sensitive array is proposed. The trilinear alternating least square (TALS) algorithm is used to abtain the source matrix, and then the matrix is judged. Simulation results show that the bit error rate (BER) of the detection algorithm is close to that of the non-blind decorrelating method and the algorithm works well under the array error condition. BER difference between the non-blind method and this algorithm is less than 2 dB under a high SNR. The algorithm is blind and robust. The channel fading, the direction of arrive(DOA) imformation and the polarization information are needless in the algorithm.
基金We would like to acknowledge the Sao Paulo Research Foundation(FAPESP)(Grant No.2014/15091-7 and 2016/10997-0)the Conselho Nacional de Desenvolvimento Científico e Tecnológico-Brazil(CNPq)(Grant No.449009/2014-9)This study was financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brazil(CAPES)-Finance Code 001.Danielle Cristina Camilo MAGALHÃES acknowledges CNPq for her PhD scholarship(Grant No.153181/2013-3).
文摘The tensile and fracture behaviors of AA6061 alloy were investigated in order to provide quantitative data about this alloy at cryogenic temperatures.Specimens of AA6061 alloy were solution heat treated before tensile tests at 298,173 and 77 K and tested at strain rates in the range from 0.1 to 0.0001 s^(−1).The results indicate the suppression of the Portevin−Le Chatelier(PLC)effect and dynamic strain aging(DSA)at 77 K.In contrast,at 298 K,a remarkable serrated flow,characteristic of the PLC effect,is observed.Furthermore,the tensile behavior at 77 K,compared with that observed at 173 and 298 K,shows a simultaneous increase in strength,uniform elongation,modulus of toughness,strain-hardening exponent and strain rate sensitivity,which is related to a decrease in the dynamic recovery rate at low temperature.These responses are reflected on the fracture morphology,since the dimple size decreases at 77 K,while the area covered by dimples increases.Comparisons of the Johnson−Cook model show that a good agreement can be obtained for tests at 173 and 77 K,in which DSA is suppressed.
文摘Celiac disease (CD) is a common autoimmune disorder characterized by an immune response to ingested gluten and has a strong HLA association with HLA- DQ2 and HLA-DQ8 molecules, but human HLA-DQ risk factors do not explain the entire genetic susceptibility to gluten intolerance. CD is caused by the lack of immune tolerance (oral tolerance) to wheat gluten. In this sense, the expression of soluble HLA-G in CD is of special interest because the molecule plays an important role in the induction of immune tolerance. The enhanced expression of soluble HLA-G found in CD may be part of a mechanism to restore the gluten intolerance. In this editorial, we review recent progress in understanding CD in relation to its prevalence, diagnosis and possible mechanisms of pathogenesis.
基金funded by the Center for Spatial Information Science and Systems at George Mason University, USABayes Ahmed is a Commonwealth Scholar funded by the UK govt
文摘Rainfall induced landslides are a common threat to the communities living on dangerous hillslopes in Chittagong Metropolitan Area, Bangladesh. Extreme population pressure, indiscriminate hill cutting, increased precipitation events due to global warming and associated unplanned urbanization in the hills are exaggerating landslide events. The aim of this article is to prepare a scientifically accurate landslide susceptibility map by combining landslide initiation and runout maps. Land cover, slope, soil permeability, surface geology, precipitation, aspect, and distance to hill cut, road cut, drainage and stream network factor maps were selected by conditional independence test. The locations of 56 landslides were collected by field surveying. A weight of evidence(Wo E) method was applied to calculate the positive(presence of landslides) and negative(absence of landslides) factor weights. A combination of analytical hierarchical process(AHP) and fuzzymembership standardization(weighs from 0 to 1) was applied for performing a spatial multi-criteria evaluation. Expert opinion guided the decision rule for AHP. The Flow-R tool that allows modeling landslide runout from the initiation sources was applied. The flow direction was calculated using the modified Holmgren's algorithm. The AHP landslide initiation and runout susceptibility maps were used to prepare a combined landslide susceptibility map. The relative operating characteristic curve was used for model validation purpose. The accuracy of Wo E, AHP, and combined susceptibility map was calculated 96%, 97%, and 98%, respectively.
基金Supported by the Specialized Research Fund for the Program of Higher Education (No.20050003030) and byTsinghua-Zhongda Postdoctoral Fellowship Program (No.20283600131).
文摘Inter-phase mass transfer is important to the design and performance of airlift loop reactors for either chemical or biochemical applications, and a good measurement technique is crucial for studying mass transfer in multiphase systems. According to the model of macro-scale mass transfer in airlift loop reactors, it was proved that the airlift loop reactor can be regarded as a continuous stirred tank reactor for measuring mass transfer coefficient. The calculated mass transfer coefficient on such a basis is different from the volumetric mass transfer coefficient in the macro-scale model and the difference is discussed. To describe the time delay of the probe response to the change of oxygen concentration in the liquid phase, a model taking into account the time constant of response is es-tablished. Sensitivity analysis shows that this model can be used to measure the volumetric mass transfer coefficient. Applying this model to the measurement of volumetric mass transfer coefficient in the loop reactor, results that co-incide with the turbulence theory in the literate were obtained.
文摘The effect of small changes in sintering temperature on microstructure, electrical properties, dielectric characteristics, and degradation behavior of V-Mn-Nb-Gd co-doped zinc oxide ceramics was investigated. With the increase of sintering temperature, the densities of the sintered pellets decreased from 5.54 to 5.42 g/cm3 and the average grain size increased from 4.1 to 11.7 μm. The breakdown field(E1 m A) decreased noticeably from 7138 to 920 V/cm with the increase of sintering temperature. The varistor ceramics sintered at 900 ℃ exhibited excellent nonohmic properties, which were 66 for the nonohmic coefficient and 77 μA/cm2 for the leakage current density. Concerning stability, the varistors sintered at 900 ℃ exhibited the strongest accelerated degradation characteristics, with ΔE1 mA =-9.2% for DC accelerated degradation stress of 0.85 E1 m A at 85 °C for 24 h.
文摘In order to investigate the hot deformation behavior of superalloy GH696, isothermal compression experiments were carried out at deformation temperatures of 880?1120 °C and strain rates of 0.01?10 s?1. And the deformation amount of all the samples was 50%. The strain rate sensitivity exponent (m) and strain hardening exponent (n) under different deformation conditions were calculated, meanwhile the effects of the processing parameters on the values ofm andn were analyzed. The results show that the flow stress increases with the increase of strain rate and the decrease of deformation temperature. The value ofm increases with the increase of deformation temperature and decreases with the increase of strain rate, while the value ofn decreases with the increase of deformation temperature. A novel flow stress model during hot deformation of superalloy GH696 was also established. And the calculated flow stress of the alloy is in good agreement with the experimental one.
基金Projects(51675043,52005038)supported by the National Natural Science Foundation of China。
文摘The free-piston engine generator(FPEG)is regarded as the next generation of energy conversion system which may replace traditional engines in the future.The effect of key operational parameters like excess air ratio of input mixture and ignition position on the engine performance of a dual-cylinder FPEG was investigated,and their sensitivity was analyzed in this paper.The operating compression ratio of the system is susceptible to changes in excess air ratio and ignition position.At the same time,it decreases from 15.8 to 6.6 when excess air ratio increases from 0.85 to 1.15,but it increases from 6.1 to 13.3 as ignition position increases from 15 mm to 20 mm.The operating frequency and indicated power are more sensitive to changes in excess air ratio than ignition position.But it is the opposite for the indicated thermal efficiency and friction loss.Excess air ratio and ignition position have a quite similar influence on heat transfer.Therefore,from the perspective of system operation and performance,it is preferable to keep excess air coefficient slightly below 1.0.In contrast,when selecting ignition position,it is of great importance to comprehensively consider the risk of structural damage caused by the increase in the compression ratio and in-cylinder gas pressure.
文摘A more efficient mine ventilation system, the ventilation-on-demand (VOD) system, has been proposed and tested in Canadian mines recently. In order to supply the required air volumes to the production areas of a mine, operators need to know the cause and effect of any changes requested from the VOD system. The sensitivity analysis is developed through generating a cause and effect matrix of sensitivity factors on given parameter changes in a ventilation system. This new utility, which was incorporated in the 3D-CANVENT mine ventilation simulator, is able to predict the airflow distributions in a ventilation network when underground conditions and ventilation controls are changed. For a primary ventilation system, the software can determine the optimal operating speed of the main fans to satisfy the airflow requirements in underground workings without necessarily using booster fans and regulators locally. An optimized fan operating speed time-table would assure variable demand-based fresh air delivery to the production areas effectively, while generating significant savings in energy consumption and operating cost.
文摘In view of the extensive bone damage in rheumatoid arthritis, we used a commonly utilized animal model to detect behavioral changes in pain-related and the bone damage during the early disease, and to explore the correlation between bone damage and pain-related behavioral changes. Methods: Arthritis were induced in Sprague-Dawley (SD) male rats by injecting complete Freund's adjuvant (CFA) into the tails. Pain-related behavior changes were studied using the Hargreaves, VonFrey, and acetone tests on the 0, 7, 14, day and 28 day after CFA injection. The rats were sacrificed according the same schedule. The bone damage of the right proximal tibia was studied by microCT scan and bone histological slices. Results: Animals developed soft tissue inflammation and polyarthritis on 7 days after CFA injection, and arthritic score proved obvious arthritis were established within the study period. Mechanical hyperalgesia and cold allodynia were present in the affected hind paw from the 7 day through the 28 day, but the heat hyperalgesia and the mechanical allodynia lasted a short time after CFA injection. Trabecular bone number (Tb.N), Tissue Mineral Content (TMC) and Bone Volume to Tissue Volume (BV/TV) in the proximal tibia by microCT scan were also reduced after induction, especial 14 days after CFA injection. The bone histologicalslices showed the trabecular bone and proteoglycan diminished, the bone damage severity scores became more severely on the 7 day after CFA injection. Using analysis of covariance, these changes had statistical significance compared with baseline. By linear regression analysis demonstrated mechanical hyperalgesia and cold allodynia correlated well with arthritic score, bone damage parameters and bone damage severity scores. Conclusion: Adjuvant-induced arthritis (AA) were observed after CFA injection and lasted within the later experimental period. Pain-related behavioral changes were observed in the early time of AA. Bone damage was also occurred with arthritis development. Pain-related behavioral change correlated well with arthritic score and bone damage parameters
文摘A 1.8-V 64-kb four-way set-associative CMOS cache memory implemented by 0.18μm/1.8V 1P6M logic CMOS technology for a super performance 32-b RISC microprocessor is presented.For comparison,a conventional parallel access cache with the same storage and organization is also designed and simulated using the same technology.Simulation results indicate that by using sequential access,power reduction of 26% on a cache hit and 35% on a cache miss is achieved.High-speed approaches including modified current-mode sense amplifier and split dynamic tag comparators are adopted to achieve fast data access.Simulation results indicate that a typical clock to data access of 2.7ns is achieved...
文摘The present manuscript aims to examine the impact of art on the cultivation of personality and sensitivity. The author suggests that education in art contributes to evolving sensibility towards the surrounding world. The artistic knowledge or attitude helps us perceive and feel the quotidian with affection, imagination, and creativity. It functions as a complement to a rational understanding of reality. This paper retakes Aristotelian category of poiesis, considering it a creative act and delves into John Dewey's view of relations between education and art. Dewey f'mds in the aesthetic-artistic experience of the quotidian a way to engage with the other and to treat life as something with deep aesthetic sense. The discussion shown in this article follows four main threads under the scope of the Deweynian notion of art as experience, They are the education for art, education by art, education in art, and the creative act of the quotidian.
基金Supported by the Youth Innovation Fund of China Coal Research Institute(2007QN50)
文摘The existing hydraulic system always have problems of temperature rise,runningstability and anti-interference of the implementation components,reliability of hydrauliccomponents,maintenance difficulties,and other issues.With high efficiency,energysaving,reliability,easy operating,stable running,anti-interference ability,and other advantages,the load-sensitive hydraulic system is more suitable for coal mine all-hydrauliccore rig.Therefore,for the technical development of the coal mine all-hydraulic core rig,the load-sensitive technology employed by the rig should be of great significance.
基金supported by the Chinese Academy of Sciences (XDA11010402 and XDA05110303)the National Basic Research Program of China (973 Program,2012CB417203 and 2013CB955803)and the National Natural Science Foundation of China (91337110 and 41023002)
文摘The sensitivity of precipitation was studied by conducting control aqua-planet experiments(APEs) with a model to determine atmospheric general circulation.The model includes two versions: that with a spectral dynamical core(SAMIL) and that with a finite-volume dynamical core(FAMIL).Three factors were investigated including dynamical core,time-step length,and horizontal resolution.Numerical results show that the dynamical core significantly affects the structure of zonal averaged precipitation.FAMIL exhibited an equatorial precipitation belt with a single narrow peak,and SAMIL showed a broader belt with double peaks.Moreover,the time step of the model physics is shown to affect the zonal-averaged tropical convective precipitation ratio such that a longer time step leads to more production and consumption of convective available potential energy and convection initiated away from the equator,which corresponds to equatorial double peaks of precipitation.Further,precipitation is determined to be sensitive to horizontal resolution such that higher horizontal resolution allows for more small-scale kinetic energy to be resolved and leads to a broader probability distribution of low-level vertical velocity.This process results in heavier rainfall and convective precipitation extremes in the tropics.Abstract The sensitivity of precipitation was studied by conducting control aqua-planet experiments(APEs)with a model to determine atmospheric general circulation.The model includes two versions:that with a spectral dynamical core(SAMIL)and that with a finite-volume dynamical core(FAMIL).Three factors were investigated including dynamical core,time-step length,and horizontal resolution.Numerical results show that the dynamical core significantly affects the structure of zonal averaged precipitation.FAMIL exhibited an equatorial precipitation belt with a single narrow peak,and SAMIL showed a broader belt with double peaks.Moreover,the time step of the model physics is shown to affect the zonal-averaged tropical convective precipitation ratio such that a longer time step leads to more production and consumption of convective available potential energy and convection initiated away from the equator,which corresponds to equatorial double peaks of precipitation.Further,precipitation is determined to be sensitive to horizontal resolution such that higher horizontal resolution allows for more small-scale kinetic energy to be resolved and leads to a broader probability distribution of low-level vertical velocity.This process results in heavier rainfall and convective precipitation extremes in the tropics.