Chandrasekran-paul (1982) made an equation of drug release from matrix system as follows:In this paper a simplified expression has been deduced from it within ordinary range of experimental time and with appropriate v...Chandrasekran-paul (1982) made an equation of drug release from matrix system as follows:In this paper a simplified expression has been deduced from it within ordinary range of experimental time and with appropriate values of K. The cumulative amount of drug release may vary in directproportion to the square root of time with an intercept,that is,The release behaviour of both nifedipine patch and propranolol patch has fit the expression with good correlation coefficient.The re0lease data of hydrocortisone creams (Shah,1989)also can be described by the same expression.Compared with Higuchi’s equation,the presence of the intercept,A〃,may be relative to drug dissolution characteristics展开更多
In this paper, a generalized limit equilibrium method of solving the active earth pressure problem behind a retaining wall is proposed.Differing from other limit equilibrium methods, an arbitrary slip surface shape wi...In this paper, a generalized limit equilibrium method of solving the active earth pressure problem behind a retaining wall is proposed.Differing from other limit equilibrium methods, an arbitrary slip surface shape without any assumptions of pre-defined shapes is needed in the current framework, which is verified to find the most probable failure slip surface. Based on the current computational framework, numerical comparisons with experiment, discrete element method and other methods are carried out. In addition, the influences of the inclination of the wall, the soil cohesion, the angle of the internal friction of the soil, the slope inclination of the backfill soil on the critical pressure coefficient of the soil, the point of application of the resultant earth pressure and the shape of the slip surface are also carefully investigated. The results demonstrate that limit equilibrium solution from predefined slip plane assumption, including Coulomb solution, is a special case of current computational framework. It is well illustrated that the current method is feasible to evaluate the characteristics of earth pressure problem.展开更多
Utilization of carbon dioxide(CO_(2))has become a crucial and anticipated solution to address environmental and ecological issues.Enzymes such as carbonic anhydrase(CA)can efficiently convert CO_(2) into various platf...Utilization of carbon dioxide(CO_(2))has become a crucial and anticipated solution to address environmental and ecological issues.Enzymes such as carbonic anhydrase(CA)can efficiently convert CO_(2) into various platform chemicals under ambient conditions,which offers a promising way for CO_(2) utilization.Herein,we constructed a Pickering interfacial biocatalytic system(PIBS)stabilized by CA‐embedded MOFs(ZIF‐8 and ZIF‐L)for CO_(2) mineralization.Through structure engineering of MOFs and incorporation of Pickering emulsion,the internal and external diffusion processes of CO_(2) during the enzymatic mineralization were greatly intensified.When CO_(2) was ventilated at a flow rate of 50 mL min^(–1) for 1 h,the pH value of PIBS dropped from~8.00 to~6.50,while the average pH value of free system only dropped to~7.15,indicating that the initial reaction rate of CO_(2) mineralization of PIBS is nearly twice that of the free system.After the 8^(th) cycle reaction,PIBS can still produce more than 9.8 mg of CaCO_(3) in 5 min,realizing efficient and continuous mineralization of CO_(2).展开更多
Residues of tetracycline antibiotics(TCs) in environments may be harmful to human.Due to their high polarities,it is extremely challenging to efficiently enrich TCs with low concentrations in natural waters for analys...Residues of tetracycline antibiotics(TCs) in environments may be harmful to human.Due to their high polarities,it is extremely challenging to efficiently enrich TCs with low concentrations in natural waters for analysis.In this work,a magnetic metal-organic framework Fe_(3)O_(4)@[Cu_(3)(btc)_(2)]was synthesized and applied as a dispersive micro-solid phase extraction adsorbent for TCs enrichment.Effects of dispersive micro-solid phase extraction conditions including extraction time,solution p H,and elution solvent on the extraction efficiencies of TCs were investigated.Results show that TCs could be enriched efficiently by Fe_(3)O_(4)@[Cu_(3)(btc)_(2)],and electrostatic interaction between TCs and Fe_(3)O_(4)@[Cu_(3)(btc)_(2)]dominated this process.Combined with liquid chromatography-tandem mass spectrometry,four TCs residues (oxytetracycline,tetracycline,chlortetracycline,and doxycycline) in natural waters were determined.The detection limits (LOD,S/N=3) of the four antibiotics were 0.01-0.02μg/L,and the limits of quantitation (LOQ,S/N=10)were 0.04-0.07μg/L.The recoveries obtained from river water and aquaculture water spiked with three TCs concentration levels ranged from 70.3%to 96.5%with relative standard deviations of 3.8%-12.8%.Results indicate that the magnetic metal-organic framework based dispersive micro-solid phase extraction is simple,rapid and high-loading for antibiotics enrichment from water,which further expand the practical application of metal-organic frameworks in sample pretreatment for environmental pollutant analysis.展开更多
The research presented in this paper deals with the seismic protection of existing frame structures by means of passive energy dissipation. An iterative displacement-based procedure, based on capacity spectrum, to des...The research presented in this paper deals with the seismic protection of existing frame structures by means of passive energy dissipation. An iterative displacement-based procedure, based on capacity spectrum, to design dissipative bracings for seismic retrofitting of the frame structures is described, and some applications are discussed. The procedure can be used with any typology of dissipative device and for different performance targets. In this work, the procedure has been applied, with both traditional pushover (load profile proportional to first mode) and multimodal pushover, to an existing RC (reinforced concrete) frame building. In the application, the buckling restrained braces have been used in order to prevent damages to both the structure and non structural elements. The use of multimodal pushover proves to be more effective than pushover based on single mode in case of medium rise RC frame building (higher than 30 m) but, once this building is retrofitted, and therefore regularized, with a bracing system, the difference between using monomodal or multimodal pushover becomes insignificant.展开更多
Polymer dispersants are widely used as grinding aids to reduce the viscosity of mineral particle suspensions and to improve energy efficiency during fine grinding. The authors studied here the effects of polymer dispe...Polymer dispersants are widely used as grinding aids to reduce the viscosity of mineral particle suspensions and to improve energy efficiency during fine grinding. The authors studied here the effects of polymer dispersants of different molecular structure on limestone suspension properties in wet stirred media milling. The polymers differed in their molecular weight and PDI (polydispersity index). Two traditionally fractionated polymer dispersants having a high PDI (over 2) and one made by controlled radical polymerization having a low PDI (1.2) were tested. It was noticed that these dispersants worked as electrosteric stabilizers and prevented the agglomeration of ground limestone particles. Their addition allowed increased solids concentrations to be used in the grinding experiments and at the same time lowered the particle size and specific energy consumption. The particle sizes obtained were about 1 μm regardless of the dispersant or its dose. The dispersant with a low PDI reduced the viscosity more than did the high PDI dispersants. The results indicate that higher solids concentrations can be used at the same dispersant dose when a low PDI dispersant is used, leading to energy savings via increased throughput. Alternatively, a lower dose of low PDI polymer dispersant than of a high PDI polymer dispersant can be used at the same solids concentration.展开更多
The applications of numerical simulation in demolition blasting were reviewed.Several methods of numerical simulation in demolition blasting were introduced.The strength and weakness of the numerical methods mentioned...The applications of numerical simulation in demolition blasting were reviewed.Several methods of numerical simulation in demolition blasting were introduced.The strength and weakness of the numerical methods mentioned in this paper were also indicated,respectively.Furthermore,the solid lattice model in the frame of discrete element method(DEM),which was developed by the author and his team,was detailedly described.The existed problems in the current numerical simulation methods of demolition blasting were presented and the future trend of the numerical simulation is finally prospected.展开更多
Consider a finite absorbing Markov generator, irreducible on the non-absorbing states. PerronFrobenius theory ensures the existence of a corresponding positive eigenvector ψ. The goal of the paper is to give bounds o...Consider a finite absorbing Markov generator, irreducible on the non-absorbing states. PerronFrobenius theory ensures the existence of a corresponding positive eigenvector ψ. The goal of the paper is to give bounds on the amplitude max ψ/ min ψ. Two approaches are proposed: One using a path method and the other one, restricted to the reversible situation, based on spectral estimates. The latter approach is extended to denumerable birth and death processes absorbing at 0 for which infinity is an entrance boundary. The interest of estimating the ratio is the reduction of the quantitative study of convergence to quasi-stationarity to the convergence to equilibrium of related ergodic processes, as seen by Diaconis and Miclo(2014).展开更多
Given L, N, M ∈ N and an NZ-periodic set S in Z, let l2(S) be the closed subspace of l2(Z) consisting of sequences vanishing outside S. For f = { fl : 0≤l≤L-1 }l2(Z), we denote by G(f, N, M) the Gabor system genera...Given L, N, M ∈ N and an NZ-periodic set S in Z, let l2(S) be the closed subspace of l2(Z) consisting of sequences vanishing outside S. For f = { fl : 0≤l≤L-1 }l2(Z), we denote by G(f, N, M) the Gabor system generated by f, and by L(f, N, M) the closed linear subspace generated by G(f, N, M). This paper addresses density results, frame conditions for a Gabor system G(g, N, M) in l2(S), and Gabor duals of the form G(a, N, M) in some L(h, N, M) for a frame G(g, N, M) in l2(S) (so-called oblique duals). We obtain a density theorem for a Gabor system G(g, N, M) in l2(S), and show that such condition is suficient for theexistence of g={XE1:0≤l≤L-1} with G(g,N,m) We characterize g with G(g,N,m) being respectively a frame for L(g,N,m) being a tight frame for l2(S).and G(h, N, M ) in L(h, N, M ), we establish a criterion for the existence of an oblique Gabor dual of g in L(h, N, M), study the uniqueness of oblique Gabor dual, and derive an explicit expression of a class of oblique Gabor duals (among which the one with the smallest norm is obtained). Some examples are also provided.展开更多
Dear Editor,Actins are a family of essential cytoskeletal proteins involved in nearly all cellular processes(Lambrechts et al.,2004).Of the six human genes that encode actins,only ACTG1and ACTB are ubiquitously expr...Dear Editor,Actins are a family of essential cytoskeletal proteins involved in nearly all cellular processes(Lambrechts et al.,2004).Of the six human genes that encode actins,only ACTG1and ACTB are ubiquitously expressed.ACTG1(OMIM#604717),which is linked to the DFNA20/26 locus,wasidentified in autosomal dominant, non-syndromic hearing loss (NSHL) cases (Baek et al., 2012; Liu et al., 2008; Park et al., 2013; Yuan et al., 2016). In addition, some ACTG1 (OMIM #614583) mutations are associated with Baraitser-Winter syndrome, which is characterized by developmental delay, facial dysmorphologies, brain malformations, colobomas, and variable hearing loss (Riviere et al., 2012).展开更多
文摘Chandrasekran-paul (1982) made an equation of drug release from matrix system as follows:In this paper a simplified expression has been deduced from it within ordinary range of experimental time and with appropriate values of K. The cumulative amount of drug release may vary in directproportion to the square root of time with an intercept,that is,The release behaviour of both nifedipine patch and propranolol patch has fit the expression with good correlation coefficient.The re0lease data of hydrocortisone creams (Shah,1989)also can be described by the same expression.Compared with Higuchi’s equation,the presence of the intercept,A〃,may be relative to drug dissolution characteristics
基金Financial support from the Key Research Program of Chinese Academy of Sciences (Grant No. KZZD-EW-05-01)the NSFC (Grant Nos. 41101008, 41272346)the Youth Talent Team Program of the Institute of Mountain Hazards and Environment, Chinese Academy of Sciences, Opening Fund of State Key Laboratory of Geohazard Prevention and Geoenvironment Protection (Chengdu University of Technology) (Grant No. SKLGP2011K010)
文摘In this paper, a generalized limit equilibrium method of solving the active earth pressure problem behind a retaining wall is proposed.Differing from other limit equilibrium methods, an arbitrary slip surface shape without any assumptions of pre-defined shapes is needed in the current framework, which is verified to find the most probable failure slip surface. Based on the current computational framework, numerical comparisons with experiment, discrete element method and other methods are carried out. In addition, the influences of the inclination of the wall, the soil cohesion, the angle of the internal friction of the soil, the slope inclination of the backfill soil on the critical pressure coefficient of the soil, the point of application of the resultant earth pressure and the shape of the slip surface are also carefully investigated. The results demonstrate that limit equilibrium solution from predefined slip plane assumption, including Coulomb solution, is a special case of current computational framework. It is well illustrated that the current method is feasible to evaluate the characteristics of earth pressure problem.
文摘Utilization of carbon dioxide(CO_(2))has become a crucial and anticipated solution to address environmental and ecological issues.Enzymes such as carbonic anhydrase(CA)can efficiently convert CO_(2) into various platform chemicals under ambient conditions,which offers a promising way for CO_(2) utilization.Herein,we constructed a Pickering interfacial biocatalytic system(PIBS)stabilized by CA‐embedded MOFs(ZIF‐8 and ZIF‐L)for CO_(2) mineralization.Through structure engineering of MOFs and incorporation of Pickering emulsion,the internal and external diffusion processes of CO_(2) during the enzymatic mineralization were greatly intensified.When CO_(2) was ventilated at a flow rate of 50 mL min^(–1) for 1 h,the pH value of PIBS dropped from~8.00 to~6.50,while the average pH value of free system only dropped to~7.15,indicating that the initial reaction rate of CO_(2) mineralization of PIBS is nearly twice that of the free system.After the 8^(th) cycle reaction,PIBS can still produce more than 9.8 mg of CaCO_(3) in 5 min,realizing efficient and continuous mineralization of CO_(2).
基金supported by the National Natural Science Foundation of China(No.21607003).
文摘Residues of tetracycline antibiotics(TCs) in environments may be harmful to human.Due to their high polarities,it is extremely challenging to efficiently enrich TCs with low concentrations in natural waters for analysis.In this work,a magnetic metal-organic framework Fe_(3)O_(4)@[Cu_(3)(btc)_(2)]was synthesized and applied as a dispersive micro-solid phase extraction adsorbent for TCs enrichment.Effects of dispersive micro-solid phase extraction conditions including extraction time,solution p H,and elution solvent on the extraction efficiencies of TCs were investigated.Results show that TCs could be enriched efficiently by Fe_(3)O_(4)@[Cu_(3)(btc)_(2)],and electrostatic interaction between TCs and Fe_(3)O_(4)@[Cu_(3)(btc)_(2)]dominated this process.Combined with liquid chromatography-tandem mass spectrometry,four TCs residues (oxytetracycline,tetracycline,chlortetracycline,and doxycycline) in natural waters were determined.The detection limits (LOD,S/N=3) of the four antibiotics were 0.01-0.02μg/L,and the limits of quantitation (LOQ,S/N=10)were 0.04-0.07μg/L.The recoveries obtained from river water and aquaculture water spiked with three TCs concentration levels ranged from 70.3%to 96.5%with relative standard deviations of 3.8%-12.8%.Results indicate that the magnetic metal-organic framework based dispersive micro-solid phase extraction is simple,rapid and high-loading for antibiotics enrichment from water,which further expand the practical application of metal-organic frameworks in sample pretreatment for environmental pollutant analysis.
文摘The research presented in this paper deals with the seismic protection of existing frame structures by means of passive energy dissipation. An iterative displacement-based procedure, based on capacity spectrum, to design dissipative bracings for seismic retrofitting of the frame structures is described, and some applications are discussed. The procedure can be used with any typology of dissipative device and for different performance targets. In this work, the procedure has been applied, with both traditional pushover (load profile proportional to first mode) and multimodal pushover, to an existing RC (reinforced concrete) frame building. In the application, the buckling restrained braces have been used in order to prevent damages to both the structure and non structural elements. The use of multimodal pushover proves to be more effective than pushover based on single mode in case of medium rise RC frame building (higher than 30 m) but, once this building is retrofitted, and therefore regularized, with a bracing system, the difference between using monomodal or multimodal pushover becomes insignificant.
文摘Polymer dispersants are widely used as grinding aids to reduce the viscosity of mineral particle suspensions and to improve energy efficiency during fine grinding. The authors studied here the effects of polymer dispersants of different molecular structure on limestone suspension properties in wet stirred media milling. The polymers differed in their molecular weight and PDI (polydispersity index). Two traditionally fractionated polymer dispersants having a high PDI (over 2) and one made by controlled radical polymerization having a low PDI (1.2) were tested. It was noticed that these dispersants worked as electrosteric stabilizers and prevented the agglomeration of ground limestone particles. Their addition allowed increased solids concentrations to be used in the grinding experiments and at the same time lowered the particle size and specific energy consumption. The particle sizes obtained were about 1 μm regardless of the dispersant or its dose. The dispersant with a low PDI reduced the viscosity more than did the high PDI dispersants. The results indicate that higher solids concentrations can be used at the same dispersant dose when a low PDI dispersant is used, leading to energy savings via increased throughput. Alternatively, a lower dose of low PDI polymer dispersant than of a high PDI polymer dispersant can be used at the same solids concentration.
文摘The applications of numerical simulation in demolition blasting were reviewed.Several methods of numerical simulation in demolition blasting were introduced.The strength and weakness of the numerical methods mentioned in this paper were also indicated,respectively.Furthermore,the solid lattice model in the frame of discrete element method(DEM),which was developed by the author and his team,was detailedly described.The existed problems in the current numerical simulation methods of demolition blasting were presented and the future trend of the numerical simulation is finally prospected.
基金supported by Agence Nationale de la Recherche(Grant Nos.ANR-11-LABX-0040-CIMIANR-11-IDEX-0002-02 and ANR-12-BS01-0019)
文摘Consider a finite absorbing Markov generator, irreducible on the non-absorbing states. PerronFrobenius theory ensures the existence of a corresponding positive eigenvector ψ. The goal of the paper is to give bounds on the amplitude max ψ/ min ψ. Two approaches are proposed: One using a path method and the other one, restricted to the reversible situation, based on spectral estimates. The latter approach is extended to denumerable birth and death processes absorbing at 0 for which infinity is an entrance boundary. The interest of estimating the ratio is the reduction of the quantitative study of convergence to quasi-stationarity to the convergence to equilibrium of related ergodic processes, as seen by Diaconis and Miclo(2014).
基金supported by National Natural Science Foundation of China (Grant Nos. 10901013, 10671008)Beijing Natural Science Foundation (Grant No. 1092001)+1 种基金the Scientific Research Common Program of Beijing Municipal Commission of Education (Grant No. KM201110005030)the Project Sponsored by SRF for ROCS, SEM of China
文摘Given L, N, M ∈ N and an NZ-periodic set S in Z, let l2(S) be the closed subspace of l2(Z) consisting of sequences vanishing outside S. For f = { fl : 0≤l≤L-1 }l2(Z), we denote by G(f, N, M) the Gabor system generated by f, and by L(f, N, M) the closed linear subspace generated by G(f, N, M). This paper addresses density results, frame conditions for a Gabor system G(g, N, M) in l2(S), and Gabor duals of the form G(a, N, M) in some L(h, N, M) for a frame G(g, N, M) in l2(S) (so-called oblique duals). We obtain a density theorem for a Gabor system G(g, N, M) in l2(S), and show that such condition is suficient for theexistence of g={XE1:0≤l≤L-1} with G(g,N,m) We characterize g with G(g,N,m) being respectively a frame for L(g,N,m) being a tight frame for l2(S).and G(h, N, M ) in L(h, N, M ), we establish a criterion for the existence of an oblique Gabor dual of g in L(h, N, M), study the uniqueness of oblique Gabor dual, and derive an explicit expression of a class of oblique Gabor duals (among which the one with the smallest norm is obtained). Some examples are also provided.
基金supported by the National Natural Science Foundation of China(81530032)the National Key Basic Research Program of China(2014CB943001)
文摘Dear Editor,Actins are a family of essential cytoskeletal proteins involved in nearly all cellular processes(Lambrechts et al.,2004).Of the six human genes that encode actins,only ACTG1and ACTB are ubiquitously expressed.ACTG1(OMIM#604717),which is linked to the DFNA20/26 locus,wasidentified in autosomal dominant, non-syndromic hearing loss (NSHL) cases (Baek et al., 2012; Liu et al., 2008; Park et al., 2013; Yuan et al., 2016). In addition, some ACTG1 (OMIM #614583) mutations are associated with Baraitser-Winter syndrome, which is characterized by developmental delay, facial dysmorphologies, brain malformations, colobomas, and variable hearing loss (Riviere et al., 2012).