针对现有无后端数据库RFID(radio frequency identification)认证协议存在的安全隐私以及效率低的问题,在Deng等人方案的基础上提出了改进方案。采用组身份标识共享技术,防止读写器穷举搜索,降低读写器搜索时间复杂度;改进读写器成功认...针对现有无后端数据库RFID(radio frequency identification)认证协议存在的安全隐私以及效率低的问题,在Deng等人方案的基础上提出了改进方案。采用组身份标识共享技术,防止读写器穷举搜索,降低读写器搜索时间复杂度;改进读写器成功认证标签后更新共享密钥的方式,实现阅读器和标签密钥的同步更新;引入阅读器和标签产生的随机数种子作为密钥更新的参数,确保密钥的新鲜性和随机性,以保护位置隐私。通过安全性分析和实验分析可知,改进方案有效增强了原协议的安全性,并且提高了读写器的搜索效率,降低了读写器搜索耗时和一轮完整通信所需时间,因此改进方案的实用性更佳。展开更多
AIM:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care databases.METHODS:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvem...AIM:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care databases.METHODS:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement Project(NSQIP,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal pancreatectomy.Utilization of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIP by the exploratory laparoscopy or unlisted procedure current procedural terminology codes.In SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER Program Code Manual,third edition procedure codes.We analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative resection.RESULTS:NIS,NSQIP and SEER identified 4242,2681 and 11 082 DP resections,respectively.Overall,laparoscopy was utilized in 15%(NIS) and 27%(NSQIP).No significant increase was seen over the course of the study.Resection was performed for malignancy in 59%(NIS) and 66%(NSQIP).Neither patient Body mass index nor comorbidities were associated with operative approach(P = 0.95 and P = 0.96,respectively).Mortality(3% vs 2%,P = 0.05) and reoperation(4% vs 4%,P = 1.0) was not different between laparoscopy and open groups.Overall complications(10% vs 15%,P < 0.001),hospital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,P = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,P < 0.001) were less when laparoscopy was utilized.One and two year survival after resection for malignancy were unchanged over the course of the study(ductal adenocarinoma 1-year 63.6% and 2-year 35.1%,P = 0.53;intraductal papillary mucinous neoplasm and nueroendocrine 1-year 90% and 2-year 84%,P = 0.25).The majority of resections were performed in teaching hospitals(77% NIS and 85% NSQIP),but minimally invasive surgery(MIS) was not more likely to be used in teaching hospitals(15% vs 14%,P = 0.26).Hospitals in the top decile for volume were more likely to be teaching hospitals than lower volume deciles(88% vs 43%,P < 0.001),but were no more likely to utilize MIS at resection.Complication rate in teaching and the top decile hospitals was not significantly decreased when compared to non-teaching(15% vs 14%,P = 0.72) and lower volume hospitals(14% vs 15%,P = 0.99).No difference was seen in the median number of lymph nodes and lymph node ratio in N1 disease when compared by year(P = 0.17 and P = 0.96,respectively).CONCLUSION:There appears to be an overall underutilization of laparoscopy for DP.Centralization does not appear to be occurring.Survival and lymph node harvest have not changed.展开更多
Prophenol oxidase isoform A1 was isolated from Drosophila melanogaster （The sequence has been deposited in GenBank data base under accession number AB557586） PHOX-S strain, and its characteristics and activation mec...Prophenol oxidase isoform A1 was isolated from Drosophila melanogaster （The sequence has been deposited in GenBank data base under accession number AB557586） PHOX-S strain, and its characteristics and activation mechanism were determined. The NH2-terminal region of PHOX-S A1 was determined to be comprised of 15 amino acids with the following sequence MTNMKMKMKAMMR. Comparison of an alignment in the known prophenol oxidase protein sequences from Drosophila melanogaster strains showed high homology in the copper-binding sequences at the Cu （A） site of the active center. Limited proteolysis takes place between Arg-50 and Val-51. Therefore, it is concluded that prophenol oxidase PHOX-S protein was evolved at the upstream, but no evolved at the central site in Drosophila melanogaster.展开更多
Distributed secure quantum machine learning （DSQML） enables a classical client with little quantum technology to delegate a remote quantum machine learning to the quantum server with the privacy data preserved. More...Distributed secure quantum machine learning （DSQML） enables a classical client with little quantum technology to delegate a remote quantum machine learning to the quantum server with the privacy data preserved. Moreover, DSQML can be extended to a more general case that the client does not have enough data, and resorts both the remote quantum server and remote databases to perform the secure machi~ learning. Here we propose a DSQML protocol that the client can classify two-dimensional vectors to dif- ferent clusters, resorting to a remote small-scale photon quantum computation processor. The protocol is secure without leaking any relevant information to the Eve. Any eavesdropper who attempts to intercept and disturb the learning process can be noticed. In principle, this protocol can be used to classify high dimensional vectors and may provide a new viewpoint and application for future ＂big data＂.展开更多
文摘针对现有无后端数据库RFID(radio frequency identification)认证协议存在的安全隐私以及效率低的问题,在Deng等人方案的基础上提出了改进方案。采用组身份标识共享技术,防止读写器穷举搜索,降低读写器搜索时间复杂度;改进读写器成功认证标签后更新共享密钥的方式,实现阅读器和标签密钥的同步更新;引入阅读器和标签产生的随机数种子作为密钥更新的参数,确保密钥的新鲜性和随机性,以保护位置隐私。通过安全性分析和实验分析可知,改进方案有效增强了原协议的安全性,并且提高了读写器的搜索效率,降低了读写器搜索耗时和一轮完整通信所需时间,因此改进方案的实用性更佳。
文摘AIM:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care databases.METHODS:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement Project(NSQIP,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal pancreatectomy.Utilization of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIP by the exploratory laparoscopy or unlisted procedure current procedural terminology codes.In SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER Program Code Manual,third edition procedure codes.We analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative resection.RESULTS:NIS,NSQIP and SEER identified 4242,2681 and 11 082 DP resections,respectively.Overall,laparoscopy was utilized in 15%(NIS) and 27%(NSQIP).No significant increase was seen over the course of the study.Resection was performed for malignancy in 59%(NIS) and 66%(NSQIP).Neither patient Body mass index nor comorbidities were associated with operative approach(P = 0.95 and P = 0.96,respectively).Mortality(3% vs 2%,P = 0.05) and reoperation(4% vs 4%,P = 1.0) was not different between laparoscopy and open groups.Overall complications(10% vs 15%,P < 0.001),hospital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,P = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,P < 0.001) were less when laparoscopy was utilized.One and two year survival after resection for malignancy were unchanged over the course of the study(ductal adenocarinoma 1-year 63.6% and 2-year 35.1%,P = 0.53;intraductal papillary mucinous neoplasm and nueroendocrine 1-year 90% and 2-year 84%,P = 0.25).The majority of resections were performed in teaching hospitals(77% NIS and 85% NSQIP),but minimally invasive surgery(MIS) was not more likely to be used in teaching hospitals(15% vs 14%,P = 0.26).Hospitals in the top decile for volume were more likely to be teaching hospitals than lower volume deciles(88% vs 43%,P < 0.001),but were no more likely to utilize MIS at resection.Complication rate in teaching and the top decile hospitals was not significantly decreased when compared to non-teaching(15% vs 14%,P = 0.72) and lower volume hospitals(14% vs 15%,P = 0.99).No difference was seen in the median number of lymph nodes and lymph node ratio in N1 disease when compared by year(P = 0.17 and P = 0.96,respectively).CONCLUSION:There appears to be an overall underutilization of laparoscopy for DP.Centralization does not appear to be occurring.Survival and lymph node harvest have not changed.
文摘Prophenol oxidase isoform A1 was isolated from Drosophila melanogaster （The sequence has been deposited in GenBank data base under accession number AB557586） PHOX-S strain, and its characteristics and activation mechanism were determined. The NH2-terminal region of PHOX-S A1 was determined to be comprised of 15 amino acids with the following sequence MTNMKMKMKAMMR. Comparison of an alignment in the known prophenol oxidase protein sequences from Drosophila melanogaster strains showed high homology in the copper-binding sequences at the Cu （A） site of the active center. Limited proteolysis takes place between Arg-50 and Val-51. Therefore, it is concluded that prophenol oxidase PHOX-S protein was evolved at the upstream, but no evolved at the central site in Drosophila melanogaster.
基金supported by the National Natural Science Foundation of China(11474168 and 61401222)the Natural Science Foundation of Jiangsu Province(BK20151502)+1 种基金the Qing Lan Project in Jiangsu Provincea Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Distributed secure quantum machine learning （DSQML） enables a classical client with little quantum technology to delegate a remote quantum machine learning to the quantum server with the privacy data preserved. Moreover, DSQML can be extended to a more general case that the client does not have enough data, and resorts both the remote quantum server and remote databases to perform the secure machi~ learning. Here we propose a DSQML protocol that the client can classify two-dimensional vectors to dif- ferent clusters, resorting to a remote small-scale photon quantum computation processor. The protocol is secure without leaking any relevant information to the Eve. Any eavesdropper who attempts to intercept and disturb the learning process can be noticed. In principle, this protocol can be used to classify high dimensional vectors and may provide a new viewpoint and application for future ＂big data＂.
