A mathematic model of two-phase flow and a physical model of two-dimensional (2D) vertical section for the plate-type structured packing Mellapak 250.Y were set up and verified. The models were used to study the influ...A mathematic model of two-phase flow and a physical model of two-dimensional (2D) vertical section for the plate-type structured packing Mellapak 250.Y were set up and verified. The models were used to study the influence of packing’s surface microstructure on the continuity of liquid film and the amount of liquid holdup. Simulation results show that the round corner shape and micro wavy structure are favorable in remaining the continuity of liquid film and increasing the amount of liquid holdup. The appropriate liquid flow rate was determined by investigating different liquid loadings to obtain an unbroken liquid film on the packing surface. The pressure difference between inlet and outlet for gas phase allowed gas and liquid to flow countercurrently in a 2D computational domain. The direction change of gas flow occurred near the phase interface area.展开更多
The seasonal variations of several main water masses in the southern Yellow Sea (SYS) and East China Sea (ECS) in 2011 were analyzed using the in-situ data collected on four cruises.There was something special in the ...The seasonal variations of several main water masses in the southern Yellow Sea (SYS) and East China Sea (ECS) in 2011 were analyzed using the in-situ data collected on four cruises.There was something special in the observations for the Yellow Sea Warm Current (YSWC) ,the Yellow Sea Cold Water Mass (YSCWM) and the Changjiang Diluted Water (CDW) during that year.The YSWC was confirmed to be a seasonal current and its source was closely associated with the Kuroshio onshore intrusion and the northerly wind.It was also found that the YSCWM in the summer of 2011 occupied a more extensive area in comparison with the climatologically-mean case due to the abnormally powerful wind prevailing in the winter of 2010 and decaying gradually thereafter.Resulting from the reduced Changjiang River discharge,the CDW spreading toward the Cheju Island in the summer of 2011 was weaker than the long-term mean and was confined to flow southward in the other seasons.The other water masses seemed normal without noticeable anomalies in 2011.The Yellow Sea Coastal Current (YSCC) water,driven by the northerly wind,flowed southeastward as a whole except for its northeastward surface layer in summer.The Taiwan Warm Current (TWC) was the strongest in summer and the weakest in winter in its northward movement.The Kuroshio water with an enhanced onshore intrusion in autumn was stable in hydrographic features apart from the seasonal variation of its surface layer.展开更多
A simple SI epidemic model with age of vaccination is discussed in this paper.Both vexing birth rate, the mortality rate caused by disease and vaccine waning rate areconsidered in this model. We prove that the global ...A simple SI epidemic model with age of vaccination is discussed in this paper.Both vexing birth rate, the mortality rate caused by disease and vaccine waning rate areconsidered in this model. We prove that the global dynamics is completely determined bythe basic reproductive number R(ψ)(ψ denotes per capita vaccination rate). If R(0) 〈 1,the disease-free equilibrium is a global attractor; If R(ψ) 〈: 1, the disease-free equilibriumis locally asymptotically stable; If R(ψ) :〉 1, an unique endemic equilibrium exists and islocally asymptotically stable under certain condition.展开更多
In this paper, we prove the existence in H+^2, an incomplete metric subspace of H^2×H^2×H^2, of global solutions to the system for a one-dimensional non-monotone fluid in bounded domainΩ=(0,1). The resul...In this paper, we prove the existence in H+^2, an incomplete metric subspace of H^2×H^2×H^2, of global solutions to the system for a one-dimensional non-monotone fluid in bounded domainΩ=(0,1). The results in this paper have improved those previously related results.展开更多
The stability of the Newton-like algorithm in optimization flow control is considered in this paper. This algorithm is proved to be globally stable under a general network topology by means of Lyapunov stability theor...The stability of the Newton-like algorithm in optimization flow control is considered in this paper. This algorithm is proved to be globally stable under a general network topology by means of Lyapunov stability theory,without considering the round trip time of each source. While the stability of this algorithm with considering the round trip time is analyzed as well. The analysis shows that the algorithm with only one bottleneck link accessed by several sources is also globally stable,and all trajectories described by this algorithm ultimately converge to the equilibrium point.展开更多
Characterizing the complex two-phase hydrodynamics in structured packed columns requires a power- ful modeling tool. The traditional two-dimensional model exhibits limitations when one attempts to model the de- tailed...Characterizing the complex two-phase hydrodynamics in structured packed columns requires a power- ful modeling tool. The traditional two-dimensional model exhibits limitations when one attempts to model the de- tailed two-phase flow inside the columns. The present paper presents a three-dimensional computational fluid dy- namics (CFD) model to simulate the two-phase flow in a representative unit of the column. The unit consists of an CFD calculations on column packed with Flexipak 1Y were implemented within the volume of fluid (VOF) mathe- matical framework. The CFD model was validated by comparing the calculated thickness of liquid film with the available experimental data. Special attention was given to quantitative analysis of the effects of gravity on the hy- drodynamics. Fluctuations in the liquid mass flow rate and the calculated pressure drop loss were found to be quali- tatively in agreement with the experimental observations.展开更多
We study the global umbilic submanifolds with parallel mean curvature vector fields in a Riemannian manifold with quasi constant curvature and get a local pinching theorem about the length of the second fundamental form.
The actual situation of the Tisza Valley traditionally used for land farming is basically determined by the consequences of the river regulation of the nineteenth century which aimed at the extension of the intensive ...The actual situation of the Tisza Valley traditionally used for land farming is basically determined by the consequences of the river regulation of the nineteenth century which aimed at the extension of the intensive agriculture, by the extreme water regime of alternating periods of flood showing a deteriorating trend and drought related to the climatic change; and by several environmental problems induced mainly by the land use. The objective of the article is to prove the regional advantages of a proposed technical solution to mitigate the flood risk with a special regard to the land cover. Hydrodynamic modeling results prove that the best technical solution is given by a combination of different strategies containing the inundation of deep floodplains-areas regularly covered by water before the river regulation works and, globally, by an important mitigation of flood damages, the costs of solution would be surely covered in the longterm. By means of its natural-resembling operation, the regular water cover would allow a multiple use of water, contributing to the solution of the simultaneously existing aridity problem, and, the development of the floodplain landscape management would help improve the ecological and the economical upgrading of the region.展开更多
A three-dimensional geometric model was set up for the oxidative coupling of methane(OCM) fixed bed reactor loaded with Na_3PO_4-Mn/SiO_2/cordierite monolithic catalyst,and an improved Stansch kinetic model was establ...A three-dimensional geometric model was set up for the oxidative coupling of methane(OCM) fixed bed reactor loaded with Na_3PO_4-Mn/SiO_2/cordierite monolithic catalyst,and an improved Stansch kinetic model was established to calculate the OCM reactions using the computational fluid dynamics method and Fluent software.The simulation conditions were completely the same with the experimental conditions that the volume velocity of the reactant is 80 ml·min^(-1) under standard state,the CH_4/O_2 ratio is 3 and the temperature and pressure is800 ℃ and 1 atm,respectively.The contour of the characteristic parameters in the catalyst bed was analyzed,such as the species mass fractions,temperature,the heat flux on side wall surface,pressure,fluid density and velocity.The results showed that the calculated values matched well with the experimental values on the conversion of CH4 and the selectivity of products(C_2H_6,C_2H_4,CO,CO_2 and H_2) in the reactor outlet with an error range of±4%.The mass fractions of CH_4 and O_2 decreased from 0.600 and 0.400 at the catalyst bed inlet to 0.445 and0.120 at the outlet,where the mass fractions of C_2H_6,C_2H_4,CO and CO_2 were 0.0245,0.0460,0.0537 and 0.116,respectively.Due to the existence of laminar boundary layer,the mass fraction contours of each species bent upwards in the vicinity of the boundary layer.The volume of OCM reaction was changing with the proceeding of reaction,and the total moles of products were greater than reactants.The flow field in the catalyst bed maintained constant temperature and pressure.The fluid density decreased gradually from 2.28 kg·m^(-3) at the inlet of the catalyst bed to 2.18 kg·m^(-3) at the outlet of the catalyst bed,while the average velocity magnitude increased from 0.108 m·s-1 to 0.120 m·s^(-1).展开更多
This paper presents a new design of a probe adjusting device intended to position pressure and temperature probes in a flow field. 5-hole, 3-hole and temperature probes can be moved in radial direction and freely rota...This paper presents a new design of a probe adjusting device intended to position pressure and temperature probes in a flow field. 5-hole, 3-hole and temperature probes can be moved in radial direction and freely rotated about their axis. The high actuation accuracy of 3.9 ktm in radial direction and 0.09~ in angular position is validated in a 2-stage-turbine test rig which is installed at the Institute of Power Plant Technology, Steam and Gas Turbines, RWTH Aachen University. To meet the challenge to calculate the efficiency of a turbo machine which is mainly influenced by the temperature, all probe adjusting devices are positioned simultaneously and controlled by the MAS (measuring acquisition system) so that the same radial position in each stage is measured at the same time. For this purpose a new program has been developed to synchronize actuation and measurement. The slim design of 60 mm width allows measurement between the stages of turbo machines with small axial distances between vane and blade. In addition a CFD/FEA shows how the design and combination of materials compensate the thermal expansion of the engine during operation. This allows a minimal safety distance of 0.2 mm between rotor and probe to enable measurement as close to the physical boundary as possible. The actuation accuracy is demonstrated with pressure, temperature and angle distribution plots. It is also shown that the resolution of the measuring points, and therefore the actuation distances, has a large impact on the flow field analysis and should be set as high as possible. However the measuring time has to be taken into account.展开更多
This paper presents new beam test results for O^+ beam on a high current Integral Split Ring Radio Frequency Quadruple(ISR RFQ)accelerator.After the upgrading,a new designed 2.45GHz O^+ ECR Ion Source can provide a be...This paper presents new beam test results for O^+ beam on a high current Integral Split Ring Radio Frequency Quadruple(ISR RFQ)accelerator.After the upgrading,a new designed 2.45GHz O^+ ECR Ion Source can provide a beam with macro-puise peak current of 4mA at the injection point behind a 15ram diaphragm,whose O^+ factor is 60%—80% varied with gas flow rate and the normalized rms emittance is less than 0.15πmm·mrad.The accelerated O^+ beam current goes up to 2mA with the transmission of about 80% at 45kW RF power with duty factor 1/6(pulse duration of 1ms and repetition frequency of 166Hz).The upgraded RF power system includes low level RF pulse modulation amplifier,AGC,3W and 20W preamplifiers,1kW driver and 30kW final amplifier,which can output nearly 50kW in pulsed mode.The vacuum has been improved,too.The upgraded 1MeV ISR RFQ can be used as the beam injector of a new designed SFRFQ accelerating system,which is under the construction at Peking University.展开更多
Strongly swirl flow simulation are still under deve1oping. In this paper, ε equation based on the Renormalization. Group theory is used into algebraic stress model. Standard κ-ε model, algebraic stress model by Jia...Strongly swirl flow simulation are still under deve1oping. In this paper, ε equation based on the Renormalization. Group theory is used into algebraic stress model. Standard κ-ε model, algebraic stress model by Jiang Zhang[5]. and present model (RNG-ASM) are applied simultaneously to simulating the confined strongly swirling flow. The Simulating results by RNG-ASM model are compared to the results by other two model, it is shown that the predictions by this model display reasonable agreement with experimental data, and lead to gnater improvement than Zhang’s ASM turbulence model[5].展开更多
We recently reported that zacopride is a selective inward rectifier potassium current (IK1 ) channel agonist, suppressing ventricular arrhythmias without affecting atrial arrhythmias. The present study aimed to invest...We recently reported that zacopride is a selective inward rectifier potassium current (IK1 ) channel agonist, suppressing ventricular arrhythmias without affecting atrial arrhythmias. The present study aimed to investigate the unique pharmacological properties of zacopride. The whole-cell patch-clamp technique was used to study IK1 currents in rat atrial myocytes and Kir2.x currents in human embryonic kidney (HEK)-293 cells transfected with inward rectifier potassium channel (Kir)2.1, Kir2.2, Kir2.3, or mutated Kir2.1 (at phosphorylation site S425L). Western immunoblots were performed to estimate the relative protein expression levels of Kir2.x in rat atria and ventricles. Results showed that zacopride did not affect the IK1 and transmembrane potential of atrial myocytes. In HEK293 cells, zacopride increased Kir2.1 homomeric channels by 40.7%±9.7% at 50 mV, but did not affect Kir2.2 and Kir2.3 homomeric channels, and Kir2.1-Kir2.2, Kir2.1-Kir2.3 and Kir2.2-Kir2.3 heteromeric channels. Western immunoblots showed that similar levels of Kir2.3 protein were expressed in rat atria and ventricles, but atrial Kir2.1 protein level was only 25% of that measured in the ventricle. In addition, 5-hydroxytryptamine (5-HT) 3 receptor was undetectable, whereas 5-HT 4 receptor was weakly expressed in HEK293 cells. The Kir2.1-activating effect of zacopride in these cells was abolished by inhibition of protein kinase A (PKA), but not PKC or PKG. Furthermore, zacopride did not activate the mutant Kir2.1 channel in HEK293 cells but selectively activated the Kir2.1 homomeric channel via a PKA-dependent pathway, independent to that of the 5-HT receptor.展开更多
OBJECTIVE: To observe the effects of serum containing Mahuang(Herba Ephedra Sinica) or Wuweizi(Fructus Schisandrae Chinensis) on the migration of alveolar macrophages(AM) and interstitial macrophages(IM) from normal r...OBJECTIVE: To observe the effects of serum containing Mahuang(Herba Ephedra Sinica) or Wuweizi(Fructus Schisandrae Chinensis) on the migration of alveolar macrophages(AM) and interstitial macrophages(IM) from normal rats, and to analyze and compare the mechanisms leading to cell migration differences.METHODS: Rats were randomly divided into three groups: Mahuang(Herba Ephedra Sinica), Wuweizi(Fructus Schisandrae Chinensis), and blank serum. After treatment with the herbs, serum was extracted from the rats. AM and IM were isolated from normal rats and cultured. The effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on normal rat AM and IM chemotactic migration were determined by transwell assays. The CC chemokine receptor(CCR) 2, CCR5, voltage-gated Kvl. 3 K^+channel(Kv1. 3), and voltage-gated Kvl. 5 K^+channel(Kv1. 5) protein levels were analyzed by western blotting.RESULTS: The migration quantities of AM and IM in the Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum groups were significantly higher than those in the blank serum group(P < 0.01). Compared with the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group, the migration quantity of cultured rat AM in the Mahuang(Herba Ephedra Sinica) medicated serum group was significantly increased(P <0.01). Meanwhile, compared with the Mahuang(Herba Ephedra Sinica) medicated serum group, the migration quantity of cultured rat IM in the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group was significantly increased(P < 0.01).CCR2, CCR5, Kv1. 3, and Kv1. 5 proteins were expressed on the AM cell surface, and showed significantly higher expression in the Mahuang(Herba Ephedra Sinica) medicated serum group compared with the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group. In contrast, CCR5, Kv1.3,and Kv1.5 proteins were expressed on the IM cell surface, and showed significantly higher expression in the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group compared with the Mahuang(Herba Ephedra Sinica) medicated serum group.CONCLUSION: Mahuang(Herba Ephedra Sinica)and Wuweizi(Fructus Schisandrae Chinensis) can promote AM and IM migration ability, with Mahuang(Herba Ephedra Sinica) targeting AM more apparently and Wuweizi(Fructus Schisandrae Chinensis) targeting IM more apparently. The mechanism may be that, by stimulating cells, Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) promote expression of CCR2 and CCR5 receptors on the AM and IM cell surface,which pass signals to Kvl.3 and Kvl.5 ion channels,leading to changes in the cytoskeleton, and ultimately promoting chemotactic cell migration.展开更多
This work deals with the dissipative generalized Korteweg-de Vries (gKdV) equations of the formu t + u 2u x + u xxx-bu xx+ ru = f, t≥0, u(0,x) = u 0(x)∈V = H 2 2π,with periodic boundary conditions. It is proved tha...This work deals with the dissipative generalized Korteweg-de Vries (gKdV) equations of the formu t + u 2u x + u xxx-bu xx+ ru = f, t≥0, u(0,x) = u 0(x)∈V = H 2 2π,with periodic boundary conditions. It is proved that there exists an inertial manifold for the semiflow generated by this equation in space V. Since such a manifold is finite dimensional, positively invariant, and exponentially attracting of all the solution trajectories, the long-time dynamics of the dissipative gKdV equations are determined by a finite number of modes without the soliton phenomena.展开更多
Global existence of weak and strong solutions to the quasi-hydrostatic primitive equations is studied in this paper. This model, that derives from the full non-hydrostatic model for geophysical fluid dynamics in the z...Global existence of weak and strong solutions to the quasi-hydrostatic primitive equations is studied in this paper. This model, that derives from the full non-hydrostatic model for geophysical fluid dynamics in the zero-limit of the aspect ratio, is more realistic than the classical hydrostatic model, since the traditional approximation that consists in neglecting a part of the Coriolis force is relaxed. After justifying the derivation of the model, the authors provide a rigorous proof of global existence of weak solutions, and well-posedness for strong solutions in dimension three.展开更多
基金Supported by the National Key Basic R&D Program ("973" Program, No. 2009CB219905 and 2009CB219907)the Program for Changjiang Scholars and Innovative Research Teams in Universities (No. IRT0936)
文摘A mathematic model of two-phase flow and a physical model of two-dimensional (2D) vertical section for the plate-type structured packing Mellapak 250.Y were set up and verified. The models were used to study the influence of packing’s surface microstructure on the continuity of liquid film and the amount of liquid holdup. Simulation results show that the round corner shape and micro wavy structure are favorable in remaining the continuity of liquid film and increasing the amount of liquid holdup. The appropriate liquid flow rate was determined by investigating different liquid loadings to obtain an unbroken liquid film on the packing surface. The pressure difference between inlet and outlet for gas phase allowed gas and liquid to flow countercurrently in a 2D computational domain. The direction change of gas flow occurred near the phase interface area.
基金supported by National Basic Research Program of China(973 Program,2010CB428904)
文摘The seasonal variations of several main water masses in the southern Yellow Sea (SYS) and East China Sea (ECS) in 2011 were analyzed using the in-situ data collected on four cruises.There was something special in the observations for the Yellow Sea Warm Current (YSWC) ,the Yellow Sea Cold Water Mass (YSCWM) and the Changjiang Diluted Water (CDW) during that year.The YSWC was confirmed to be a seasonal current and its source was closely associated with the Kuroshio onshore intrusion and the northerly wind.It was also found that the YSCWM in the summer of 2011 occupied a more extensive area in comparison with the climatologically-mean case due to the abnormally powerful wind prevailing in the winter of 2010 and decaying gradually thereafter.Resulting from the reduced Changjiang River discharge,the CDW spreading toward the Cheju Island in the summer of 2011 was weaker than the long-term mean and was confined to flow southward in the other seasons.The other water masses seemed normal without noticeable anomalies in 2011.The Yellow Sea Coastal Current (YSCC) water,driven by the northerly wind,flowed southeastward as a whole except for its northeastward surface layer in summer.The Taiwan Warm Current (TWC) was the strongest in summer and the weakest in winter in its northward movement.The Kuroshio water with an enhanced onshore intrusion in autumn was stable in hydrographic features apart from the seasonal variation of its surface layer.
基金Supported by the NSF of China(10371105) Supported by the Youth Science Foundation of Xinyang Normal University(20060202)
文摘A simple SI epidemic model with age of vaccination is discussed in this paper.Both vexing birth rate, the mortality rate caused by disease and vaccine waning rate areconsidered in this model. We prove that the global dynamics is completely determined bythe basic reproductive number R(ψ)(ψ denotes per capita vaccination rate). If R(0) 〈 1,the disease-free equilibrium is a global attractor; If R(ψ) 〈: 1, the disease-free equilibriumis locally asymptotically stable; If R(ψ) :〉 1, an unique endemic equilibrium exists and islocally asymptotically stable under certain condition.
文摘In this paper, we prove the existence in H+^2, an incomplete metric subspace of H^2×H^2×H^2, of global solutions to the system for a one-dimensional non-monotone fluid in bounded domainΩ=(0,1). The results in this paper have improved those previously related results.
基金the National Outstanding Youth Foundation of China (Grant No.60525303)the NNSF of China( Grant No.60404022 and 60604004)+2 种基金the NSF of Hebei Province (Grant No.102160)the Special Projects in Mathematics Funded by Natural Science Foundation of Hebei Prov-ince(Grant No.07M005)the NS of Education Office in Hebei Province (Grant No.2004123).
文摘The stability of the Newton-like algorithm in optimization flow control is considered in this paper. This algorithm is proved to be globally stable under a general network topology by means of Lyapunov stability theory,without considering the round trip time of each source. While the stability of this algorithm with considering the round trip time is analyzed as well. The analysis shows that the algorithm with only one bottleneck link accessed by several sources is also globally stable,and all trajectories described by this algorithm ultimately converge to the equilibrium point.
基金Supported by the Major State Basic Research Development Program of China(2011CB706501)the National Natural Science Foundation of China(51276157)
文摘Characterizing the complex two-phase hydrodynamics in structured packed columns requires a power- ful modeling tool. The traditional two-dimensional model exhibits limitations when one attempts to model the de- tailed two-phase flow inside the columns. The present paper presents a three-dimensional computational fluid dy- namics (CFD) model to simulate the two-phase flow in a representative unit of the column. The unit consists of an CFD calculations on column packed with Flexipak 1Y were implemented within the volume of fluid (VOF) mathe- matical framework. The CFD model was validated by comparing the calculated thickness of liquid film with the available experimental data. Special attention was given to quantitative analysis of the effects of gravity on the hy- drodynamics. Fluctuations in the liquid mass flow rate and the calculated pressure drop loss were found to be quali- tatively in agreement with the experimental observations.
基金Supported by the Directing Research Subject of Jiangsu Education Bureau(03103146)
文摘We study the global umbilic submanifolds with parallel mean curvature vector fields in a Riemannian manifold with quasi constant curvature and get a local pinching theorem about the length of the second fundamental form.
文摘The actual situation of the Tisza Valley traditionally used for land farming is basically determined by the consequences of the river regulation of the nineteenth century which aimed at the extension of the intensive agriculture, by the extreme water regime of alternating periods of flood showing a deteriorating trend and drought related to the climatic change; and by several environmental problems induced mainly by the land use. The objective of the article is to prove the regional advantages of a proposed technical solution to mitigate the flood risk with a special regard to the land cover. Hydrodynamic modeling results prove that the best technical solution is given by a combination of different strategies containing the inundation of deep floodplains-areas regularly covered by water before the river regulation works and, globally, by an important mitigation of flood damages, the costs of solution would be surely covered in the longterm. By means of its natural-resembling operation, the regular water cover would allow a multiple use of water, contributing to the solution of the simultaneously existing aridity problem, and, the development of the floodplain landscape management would help improve the ecological and the economical upgrading of the region.
基金Supported by the National Basic Research Program of China(2005CB221405)
文摘A three-dimensional geometric model was set up for the oxidative coupling of methane(OCM) fixed bed reactor loaded with Na_3PO_4-Mn/SiO_2/cordierite monolithic catalyst,and an improved Stansch kinetic model was established to calculate the OCM reactions using the computational fluid dynamics method and Fluent software.The simulation conditions were completely the same with the experimental conditions that the volume velocity of the reactant is 80 ml·min^(-1) under standard state,the CH_4/O_2 ratio is 3 and the temperature and pressure is800 ℃ and 1 atm,respectively.The contour of the characteristic parameters in the catalyst bed was analyzed,such as the species mass fractions,temperature,the heat flux on side wall surface,pressure,fluid density and velocity.The results showed that the calculated values matched well with the experimental values on the conversion of CH4 and the selectivity of products(C_2H_6,C_2H_4,CO,CO_2 and H_2) in the reactor outlet with an error range of±4%.The mass fractions of CH_4 and O_2 decreased from 0.600 and 0.400 at the catalyst bed inlet to 0.445 and0.120 at the outlet,where the mass fractions of C_2H_6,C_2H_4,CO and CO_2 were 0.0245,0.0460,0.0537 and 0.116,respectively.Due to the existence of laminar boundary layer,the mass fraction contours of each species bent upwards in the vicinity of the boundary layer.The volume of OCM reaction was changing with the proceeding of reaction,and the total moles of products were greater than reactants.The flow field in the catalyst bed maintained constant temperature and pressure.The fluid density decreased gradually from 2.28 kg·m^(-3) at the inlet of the catalyst bed to 2.18 kg·m^(-3) at the outlet of the catalyst bed,while the average velocity magnitude increased from 0.108 m·s-1 to 0.120 m·s^(-1).
文摘This paper presents a new design of a probe adjusting device intended to position pressure and temperature probes in a flow field. 5-hole, 3-hole and temperature probes can be moved in radial direction and freely rotated about their axis. The high actuation accuracy of 3.9 ktm in radial direction and 0.09~ in angular position is validated in a 2-stage-turbine test rig which is installed at the Institute of Power Plant Technology, Steam and Gas Turbines, RWTH Aachen University. To meet the challenge to calculate the efficiency of a turbo machine which is mainly influenced by the temperature, all probe adjusting devices are positioned simultaneously and controlled by the MAS (measuring acquisition system) so that the same radial position in each stage is measured at the same time. For this purpose a new program has been developed to synchronize actuation and measurement. The slim design of 60 mm width allows measurement between the stages of turbo machines with small axial distances between vane and blade. In addition a CFD/FEA shows how the design and combination of materials compensate the thermal expansion of the engine during operation. This allows a minimal safety distance of 0.2 mm between rotor and probe to enable measurement as close to the physical boundary as possible. The actuation accuracy is demonstrated with pressure, temperature and angle distribution plots. It is also shown that the resolution of the measuring points, and therefore the actuation distances, has a large impact on the flow field analysis and should be set as high as possible. However the measuring time has to be taken into account.
文摘This paper presents new beam test results for O^+ beam on a high current Integral Split Ring Radio Frequency Quadruple(ISR RFQ)accelerator.After the upgrading,a new designed 2.45GHz O^+ ECR Ion Source can provide a beam with macro-puise peak current of 4mA at the injection point behind a 15ram diaphragm,whose O^+ factor is 60%—80% varied with gas flow rate and the normalized rms emittance is less than 0.15πmm·mrad.The accelerated O^+ beam current goes up to 2mA with the transmission of about 80% at 45kW RF power with duty factor 1/6(pulse duration of 1ms and repetition frequency of 166Hz).The upgraded RF power system includes low level RF pulse modulation amplifier,AGC,3W and 20W preamplifiers,1kW driver and 30kW final amplifier,which can output nearly 50kW in pulsed mode.The vacuum has been improved,too.The upgraded 1MeV ISR RFQ can be used as the beam injector of a new designed SFRFQ accelerating system,which is under the construction at Peking University.
文摘Strongly swirl flow simulation are still under deve1oping. In this paper, ε equation based on the Renormalization. Group theory is used into algebraic stress model. Standard κ-ε model, algebraic stress model by Jiang Zhang[5]. and present model (RNG-ASM) are applied simultaneously to simulating the confined strongly swirling flow. The Simulating results by RNG-ASM model are compared to the results by other two model, it is shown that the predictions by this model display reasonable agreement with experimental data, and lead to gnater improvement than Zhang’s ASM turbulence model[5].
基金supported by the National Natural Science Foundation of China (81170145 to Zhao ZhiQing, 31200864 to Liu QingHua, 31171088 to Cao JiMin)a Science and Technology Program fund from the Health Department of Shanxi Province (2011055 to Zhang Li)
文摘We recently reported that zacopride is a selective inward rectifier potassium current (IK1 ) channel agonist, suppressing ventricular arrhythmias without affecting atrial arrhythmias. The present study aimed to investigate the unique pharmacological properties of zacopride. The whole-cell patch-clamp technique was used to study IK1 currents in rat atrial myocytes and Kir2.x currents in human embryonic kidney (HEK)-293 cells transfected with inward rectifier potassium channel (Kir)2.1, Kir2.2, Kir2.3, or mutated Kir2.1 (at phosphorylation site S425L). Western immunoblots were performed to estimate the relative protein expression levels of Kir2.x in rat atria and ventricles. Results showed that zacopride did not affect the IK1 and transmembrane potential of atrial myocytes. In HEK293 cells, zacopride increased Kir2.1 homomeric channels by 40.7%±9.7% at 50 mV, but did not affect Kir2.2 and Kir2.3 homomeric channels, and Kir2.1-Kir2.2, Kir2.1-Kir2.3 and Kir2.2-Kir2.3 heteromeric channels. Western immunoblots showed that similar levels of Kir2.3 protein were expressed in rat atria and ventricles, but atrial Kir2.1 protein level was only 25% of that measured in the ventricle. In addition, 5-hydroxytryptamine (5-HT) 3 receptor was undetectable, whereas 5-HT 4 receptor was weakly expressed in HEK293 cells. The Kir2.1-activating effect of zacopride in these cells was abolished by inhibition of protein kinase A (PKA), but not PKC or PKG. Furthermore, zacopride did not activate the mutant Kir2.1 channel in HEK293 cells but selectively activated the Kir2.1 homomeric channel via a PKA-dependent pathway, independent to that of the 5-HT receptor.
基金Supported by The National Natural Science Foundation of China(No.81373887)The Traditional Chinese Medicine Standardization Project of the State Administration of Traditional Chinese Medicine(No.ZYXX-2014)The Beijing Municipal Administration of Traditional Chinese Medicine"Generation 3+3"Project-Jin Shiyuan the Well-Known Old Man Chinese Medicine Studio Station(Beijing University of Chinese Medicine)Construction Project
文摘OBJECTIVE: To observe the effects of serum containing Mahuang(Herba Ephedra Sinica) or Wuweizi(Fructus Schisandrae Chinensis) on the migration of alveolar macrophages(AM) and interstitial macrophages(IM) from normal rats, and to analyze and compare the mechanisms leading to cell migration differences.METHODS: Rats were randomly divided into three groups: Mahuang(Herba Ephedra Sinica), Wuweizi(Fructus Schisandrae Chinensis), and blank serum. After treatment with the herbs, serum was extracted from the rats. AM and IM were isolated from normal rats and cultured. The effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on normal rat AM and IM chemotactic migration were determined by transwell assays. The CC chemokine receptor(CCR) 2, CCR5, voltage-gated Kvl. 3 K^+channel(Kv1. 3), and voltage-gated Kvl. 5 K^+channel(Kv1. 5) protein levels were analyzed by western blotting.RESULTS: The migration quantities of AM and IM in the Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum groups were significantly higher than those in the blank serum group(P < 0.01). Compared with the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group, the migration quantity of cultured rat AM in the Mahuang(Herba Ephedra Sinica) medicated serum group was significantly increased(P <0.01). Meanwhile, compared with the Mahuang(Herba Ephedra Sinica) medicated serum group, the migration quantity of cultured rat IM in the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group was significantly increased(P < 0.01).CCR2, CCR5, Kv1. 3, and Kv1. 5 proteins were expressed on the AM cell surface, and showed significantly higher expression in the Mahuang(Herba Ephedra Sinica) medicated serum group compared with the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group. In contrast, CCR5, Kv1.3,and Kv1.5 proteins were expressed on the IM cell surface, and showed significantly higher expression in the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group compared with the Mahuang(Herba Ephedra Sinica) medicated serum group.CONCLUSION: Mahuang(Herba Ephedra Sinica)and Wuweizi(Fructus Schisandrae Chinensis) can promote AM and IM migration ability, with Mahuang(Herba Ephedra Sinica) targeting AM more apparently and Wuweizi(Fructus Schisandrae Chinensis) targeting IM more apparently. The mechanism may be that, by stimulating cells, Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) promote expression of CCR2 and CCR5 receptors on the AM and IM cell surface,which pass signals to Kvl.3 and Kvl.5 ion channels,leading to changes in the cytoskeleton, and ultimately promoting chemotactic cell migration.
文摘This work deals with the dissipative generalized Korteweg-de Vries (gKdV) equations of the formu t + u 2u x + u xxx-bu xx+ ru = f, t≥0, u(0,x) = u 0(x)∈V = H 2 2π,with periodic boundary conditions. It is proved that there exists an inertial manifold for the semiflow generated by this equation in space V. Since such a manifold is finite dimensional, positively invariant, and exponentially attracting of all the solution trajectories, the long-time dynamics of the dissipative gKdV equations are determined by a finite number of modes without the soliton phenomena.
基金supported by the ANR (No. ANR-06-BLAN0306-01)the National Science Foundation (No.NSF-DMS-0906440) and the Research Fund of Indiana University
文摘Global existence of weak and strong solutions to the quasi-hydrostatic primitive equations is studied in this paper. This model, that derives from the full non-hydrostatic model for geophysical fluid dynamics in the zero-limit of the aspect ratio, is more realistic than the classical hydrostatic model, since the traditional approximation that consists in neglecting a part of the Coriolis force is relaxed. After justifying the derivation of the model, the authors provide a rigorous proof of global existence of weak solutions, and well-posedness for strong solutions in dimension three.