Autoimmune hepatitis(AIH) has rarely been described as an autoimmune paraneoplastic syndrome of thymoma.This case is the seventh case of AIH revealed by cholestasis few years after the diagnosis of thymoma and the fir...Autoimmune hepatitis(AIH) has rarely been described as an autoimmune paraneoplastic syndrome of thymoma.This case is the seventh case of AIH revealed by cholestasis few years after the diagnosis of thymoma and the first case treated with chemotherapy alone.We report in this paper a new approach to this rare severe condition.A 29 year-old man presented with chest pain and dyspnea with a history of thymoma surgically removed 4 years ago.CT scan showed the recurrence of an anterior mediastinal mass.Biology showed elevated liver enzymes and profound cholestasis.No sign of viral or toxic hepatitis or bile duct abnormalities were observed.Autoimmune antibodies,except for the anti-nuclear antibody,were negative.Liver biopsy showed active chronic AIH.The patient was diagnosed with recurrent thymoma with AIH and underwent 6 cycles of chemotherapy.A complete response on thymoma and cholestasis was obtained after 10 months of follow-up.Steroids and immunosuppressors are the standard treatment for AIH.The effect of chemotherapy as a specific treatment of this paraneoplastic syndrome needs to be considered.展开更多
During 1970s, the residential remains of the Yangshao Period were discovered at the Dadiwan site in Qin＇an County, Gansu Province, China. With carbon-14 dating, scanning electron microscope （SEM）, thermal expansion...During 1970s, the residential remains of the Yangshao Period were discovered at the Dadiwan site in Qin＇an County, Gansu Province, China. With carbon-14 dating, scanning electron microscope （SEM）, thermal expansion analyzer, polarizing microscope （PLM）, and X ray diffraction （XRD）, the microstructures and chemical compositions of the pottery shard, floor materials of the housing site, kunkur, calcined kunkur, ginger nut （calcium concretion） from the Dadiwan site were analyzed and re- searched. Analysis and simulation tests were also carried out to study the hydratability of calcined ginger nut and calcined kunkur, and the manufacturing process of the residential floors. The research shows that the floor was made of a light concrete formed by the mixture of aggregate of calcinated ginger nut （locally deposited）, red clay and kunkur. The dicalcium silicate （C2S） from the floor material of the housing site is one of the main constituents of modem cement, and the floor is also similar to modem concrete in nature. Therefore, the floor material of the housing site at the Dadiwan site was the earliest man-made concrete in the world ever discovered.展开更多
文摘Autoimmune hepatitis(AIH) has rarely been described as an autoimmune paraneoplastic syndrome of thymoma.This case is the seventh case of AIH revealed by cholestasis few years after the diagnosis of thymoma and the first case treated with chemotherapy alone.We report in this paper a new approach to this rare severe condition.A 29 year-old man presented with chest pain and dyspnea with a history of thymoma surgically removed 4 years ago.CT scan showed the recurrence of an anterior mediastinal mass.Biology showed elevated liver enzymes and profound cholestasis.No sign of viral or toxic hepatitis or bile duct abnormalities were observed.Autoimmune antibodies,except for the anti-nuclear antibody,were negative.Liver biopsy showed active chronic AIH.The patient was diagnosed with recurrent thymoma with AIH and underwent 6 cycles of chemotherapy.A complete response on thymoma and cholestasis was obtained after 10 months of follow-up.Steroids and immunosuppressors are the standard treatment for AIH.The effect of chemotherapy as a specific treatment of this paraneoplastic syndrome needs to be considered.
文摘During 1970s, the residential remains of the Yangshao Period were discovered at the Dadiwan site in Qin＇an County, Gansu Province, China. With carbon-14 dating, scanning electron microscope （SEM）, thermal expansion analyzer, polarizing microscope （PLM）, and X ray diffraction （XRD）, the microstructures and chemical compositions of the pottery shard, floor materials of the housing site, kunkur, calcined kunkur, ginger nut （calcium concretion） from the Dadiwan site were analyzed and re- searched. Analysis and simulation tests were also carried out to study the hydratability of calcined ginger nut and calcined kunkur, and the manufacturing process of the residential floors. The research shows that the floor was made of a light concrete formed by the mixture of aggregate of calcinated ginger nut （locally deposited）, red clay and kunkur. The dicalcium silicate （C2S） from the floor material of the housing site is one of the main constituents of modem cement, and the floor is also similar to modem concrete in nature. Therefore, the floor material of the housing site at the Dadiwan site was the earliest man-made concrete in the world ever discovered.
