Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole genomes.While the discipline has been successful with respect to identifying specific...Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole genomes.While the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors involved in oncogenesis,it is also challenging our approach to managing patients suffering from this deadly disease.Specifically cancer genomics is driving clinical oncology to take a more molecular approach to diagnosis,prognostication,and treatment selection.We review here recent work undertaken in cancer genomics with an emphasis on translation of genomic findings.Finally,we discuss scientific challenges and research opportunities emerging from findings derived through analysis of tumors with high-depth sequencing.展开更多
Classical Chinese poems（CCP） is regarded as the inheritance and treasure of Chinese culture. CCP translation, on one hand, makes us have access to explore the linguistic charming and the cultural value of classical ...Classical Chinese poems（CCP） is regarded as the inheritance and treasure of Chinese culture. CCP translation, on one hand, makes us have access to explore the linguistic charming and the cultural value of classical Chinese poems; on the other hand, it provides an opportunity to transmit Chinese classical culture into western culture. While translatability of CCP translation, coupled with its untranslatability is considered a contentious topic in translation circle. Admittedly, in the process of CCP translation, some problems or barriers turn out to be our stumbling stone. But generally speaking, most of the poetry are translatable and untranslatability can be transformed into translatability with certain strategies. This thesis have compared the similarities and differences between Chinese and western poems to analyze the reasons why CCP can or cannot be translated and lays much emphasis on untranslatability as well as the compensation of untranslatability. Lastly, foreignization and domestication are recommended as two strategies in CCP translation when untranslatability occurs.展开更多
基金supported in part by the National Institutes of Health through MD Anderson's Cancer Center Support Grant CA016672
文摘Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole genomes.While the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors involved in oncogenesis,it is also challenging our approach to managing patients suffering from this deadly disease.Specifically cancer genomics is driving clinical oncology to take a more molecular approach to diagnosis,prognostication,and treatment selection.We review here recent work undertaken in cancer genomics with an emphasis on translation of genomic findings.Finally,we discuss scientific challenges and research opportunities emerging from findings derived through analysis of tumors with high-depth sequencing.
文摘Classical Chinese poems（CCP） is regarded as the inheritance and treasure of Chinese culture. CCP translation, on one hand, makes us have access to explore the linguistic charming and the cultural value of classical Chinese poems; on the other hand, it provides an opportunity to transmit Chinese classical culture into western culture. While translatability of CCP translation, coupled with its untranslatability is considered a contentious topic in translation circle. Admittedly, in the process of CCP translation, some problems or barriers turn out to be our stumbling stone. But generally speaking, most of the poetry are translatable and untranslatability can be transformed into translatability with certain strategies. This thesis have compared the similarities and differences between Chinese and western poems to analyze the reasons why CCP can or cannot be translated and lays much emphasis on untranslatability as well as the compensation of untranslatability. Lastly, foreignization and domestication are recommended as two strategies in CCP translation when untranslatability occurs.
