以Web of Science为数据源,应用文献统计分析软件CiteSpace绘制蜥蜴与气候变化研究领域的知识图谱,对该领域的年度发文统计、主要研究力量、合作关系、学科、期刊、研究前沿与知识基础、研究热点与发展趋势进行系统分析。结果表明:1)蜥...以Web of Science为数据源,应用文献统计分析软件CiteSpace绘制蜥蜴与气候变化研究领域的知识图谱,对该领域的年度发文统计、主要研究力量、合作关系、学科、期刊、研究前沿与知识基础、研究热点与发展趋势进行系统分析。结果表明:1)蜥蜴与气候变化研究领域的发文量不断增加,发展速度迅猛。2)发达国家是蜥蜴与气候变化领域的主要研究力量,美国与澳大利亚发文量最高,占据主要地位;澳大利亚詹姆斯库克大学是主要研究机构;同时,各个国家、机构间的合作不断增强。3)蜥蜴与气候变化研究领域文献涉及多个学科,已有的学科主要涉及生命科学领域。4)当前该领域的7个研究热点分别为体温调节、系统发育与物种进化、生物多样性、脆弱性、评估与模型、保护管理以及气候变化;其中体温调节、系统发育、物种进化与脆弱性方面依旧是国际上该领域的研究热点。展开更多
Objective： To describe the characteristics of short interfering double stranded RNA （dsRNA） against hepatitis C virus （HCV） and to fred out the determining factors in design for desirable inhibitory efficacy. Met...Objective： To describe the characteristics of short interfering double stranded RNA （dsRNA） against hepatitis C virus （HCV） and to fred out the determining factors in design for desirable inhibitory efficacy. Methods： The data were collected and analyzed by retrieval of 229 published short dsRNAs designed for degradation ofHCV RNA. Results： Statistical analyses showed that the most frequently involved short dsRNAs were directing against 5＇NTR/core and genotype lb, accounting for 64.2% and 69.9%, respectively. Inhibitory efficacy varied with the structural characteristics of short dsRNAs, of which the most potential were those directed against HCV core region with inhibitory efficacy of 70.2%. Moreover, the mean inhibitory efficacy of short dsRNAs with GC contents from 30% to 52% was higher than that of those with GC contents out of this range. Conclusion： Based on this pooled data in a relatively large sample, the present results provided clues to design for short dsRNAs with more potent inhibitory efficacy.展开更多
文摘以Web of Science为数据源,应用文献统计分析软件CiteSpace绘制蜥蜴与气候变化研究领域的知识图谱,对该领域的年度发文统计、主要研究力量、合作关系、学科、期刊、研究前沿与知识基础、研究热点与发展趋势进行系统分析。结果表明:1)蜥蜴与气候变化研究领域的发文量不断增加,发展速度迅猛。2)发达国家是蜥蜴与气候变化领域的主要研究力量,美国与澳大利亚发文量最高,占据主要地位;澳大利亚詹姆斯库克大学是主要研究机构;同时,各个国家、机构间的合作不断增强。3)蜥蜴与气候变化研究领域文献涉及多个学科,已有的学科主要涉及生命科学领域。4)当前该领域的7个研究热点分别为体温调节、系统发育与物种进化、生物多样性、脆弱性、评估与模型、保护管理以及气候变化;其中体温调节、系统发育、物种进化与脆弱性方面依旧是国际上该领域的研究热点。
基金Supported by Grants from the Committee of Science and Technology of Shanghai, China (No.10ZR1413100, and No.114119a1400)
文摘Objective： To describe the characteristics of short interfering double stranded RNA （dsRNA） against hepatitis C virus （HCV） and to fred out the determining factors in design for desirable inhibitory efficacy. Methods： The data were collected and analyzed by retrieval of 229 published short dsRNAs designed for degradation ofHCV RNA. Results： Statistical analyses showed that the most frequently involved short dsRNAs were directing against 5＇NTR/core and genotype lb, accounting for 64.2% and 69.9%, respectively. Inhibitory efficacy varied with the structural characteristics of short dsRNAs, of which the most potential were those directed against HCV core region with inhibitory efficacy of 70.2%. Moreover, the mean inhibitory efficacy of short dsRNAs with GC contents from 30% to 52% was higher than that of those with GC contents out of this range. Conclusion： Based on this pooled data in a relatively large sample, the present results provided clues to design for short dsRNAs with more potent inhibitory efficacy.
