The Applications of CRISPR Screening in Aging Research

The advancement of Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)gene editing technology has revolutionized the comprehension of human genome,propelling molecular and cellular biology research into unexplored realms and accelerating progress in life sciences and medicine.CRISPR-based gene screening,recognized for its efficiency and practicality,is widely utilized across diverse biological fields.Aging is a multifaceted process governed by a myriad of genetic and epigenetic factors.Unraveling the genes regulating aging holds promise for understanding this intricate phenomenon and devising strategies for its assessment and intervention.This review provides a comprehensive overview of the progress in CRISPR screening and its applications in aging research,while also offering insights into future directions.CRISPR-based genetic-manipulation tools are positioned as indispensable instruments for mitigating aging and managing age-related diseases.

天地一骚客 世间一怀沙——近访国学大师文怀沙

中国文人一直有着一种内心的放达与超脱情结,但是在大多数条件下,这仅仅只是一种愿景,真正能超脱的文人并不多,大多都艰难地徘徊于对现实的纠缠与对理想的精神寄托之中。而文老是一个真正能够超脱于世外的人,这种超脱并不是说对于此生此世的漠不关心,而是对于俗世与俗事的一种泰然自若。在我看来,文老是一个真正既有救世情怀、又有超脱情怀的文人,理想与现实能够在他身上得到完美的统一。

Context-Oriented Multi-RAT User Association and Resource Allocation with Triple Decision in 5G Heterogeneous Networks

In the upcoming 5 G heterogeneous networks, leveraging multiple radio access technologies(RATs) shows to be a crucial issue in achieving RAT multiplexing gain to meet the explosive traffic demand. For always best connection(ABC), users tend to activate parallel transmission across all available RATs. However from a system-wide perspective, this might not be optimal given the context of network load, interference and diverse service requirements. To intelligently determine how to use these multi-RAT access resources concurrently, this paper proposes a joint multi-RAT user association and resource allocation strategy with triple decision and integrated context awareness of users and networks. A dynamic game based ant colony algorithm(GACA) is designed to simultaneously maximize the system utility and the fairness of resource allocation. Simulation results show that it's more reasonable to make multi-RAT association decision from a system-wide viewpoint than from an individual one. Compared to max-SNR based and ABC based strategies, the proposed method alleviates network congestion and optimizes resource allocation. It obtains 39%~70% performance improvement.

Discourse Intonation and Teacher Cognition

This study examines the relationship between discourse intonation （henceforth DI） and teacher cognition. Drawing on the rich literature on the teacher cognition in grammar, this study borrows some relevant insights for a better understanding of the relationship between teacher cognition and DI. Following a qualitative treatment, the study concludes that instruction on D1 is a dynamic debate fed by both teacher training and teachers＇ experience of teaching and learning in general, which leads into suggesting the need for any teacher training on DI to take into account both DI knowledge as well as teacher core and peripheral belief. The contribution of the study lies in its tapping of a relatively poorly investigated area and offering advances on the many negative or simplistic teacher attitudes regarding intonation instruction as expressed in the literature, as well as in bringing to the surfaces something which teachers sometimes are not explicitly aware of.

Globalization and Transformation of Family Care

The effect of globalization on family care traditions has emerged as a significant issue of academic debate in recent years. Globalization and the growth of liberal market economy in local areas has rapidly transformed the traditional pattern of family structure, livelihood strategies of the family members, and care giving practices to the elderly in Nepal. Traditionally, the older people used to live in joint family comprised of their mamed son and their children. The reciprocal exchange of care between the parents and children was associated with the religious conception of virtue and vice. If the oft-springs would not take care for their parents, it was considered as a great sin. This tradition has been gradually eroding with the migration of youths to different destination in search of opportunities for their education and employment. This migratory process has weakened the traditional role of families as care giving institutions to old parents and disable member in the family. The old parents are now increasingly shelter to care homes for their caring. The children maintain their ties with their parents mainly by economic support for their maintenance. The old people have been unable to receive any moral care and support from other members of their family. This article examines the changes on the traditional responsibility of family as a care giving unit for the old people. It discusses the issues based on data gathered fllrough in-depfll interviews and case study of 37 senior citizens living in Siddhi Shaligram Senior Citizens Home （SSSCH） at Bhaktapur district. The secondary sources of information have also been used to shin-pen the conceptual issues related to this field

Research on spirit and culture of the elderly life under the multiple responsibility

With the transformation of population age structure and the extension of life expectancy, China has entered a rapid aging period. With development of social economy and the social security systcn~ the elderly spiritual and cultural needs is becoming more and more importantly. To the government, enterprise, society community, family and themselves, enriching the spirit and culture of the elderly life is a higher level of challenge.

The Endowment Culture Construction under the Perspective of Government

As the aging population increasingly accelerates, the construction of the endowment culture has been putting on the agenda. In fact, the endowment culture plays an irreplaceable part in the social old-age care system. In the period of social transition, the excellent traditional old-age pension culture is destroyed, which makes the cultivation of the old-age social fashion imminent. The atmosphere of respecting the old and establishing a harmonious generation relationship is an important cultural guarantee to establish ＂five old＂ and build a harmonious society, in which our country or government bears inescapable responsibilities.

Literature Review of Multi-illar Multi-level Old-age Security System

Since the 1970s, according to the international pension system reform trend for old-age social security system, no single institutional arrangement can ensure the functions of endowment security system to achieve the optimal.Therefore,how to based on the present situation of development, and to accurately, thus promote the resources integration, comprehensive build multi-level old-age security system, has important policy and practice significance.

Cecal volvulus:Report of a case and review of Japanese literature

A 78-year-old woman presented with fever, severe abdominal pain, and distension.She had been institutionalized for depression and senile dementia.Laboratory examinations disclosed a leucocytosis(WBC:12 500/μL) and elevated levels of serum C-reactive protein(2.8 mEq/L).Diagnosis of acute cecal volvulus was made from a"coffee bean sign"on an abdominal computed tomography and a"beak sign"on a gastrographin enema.An emergent laparotomy confirmed the diagnosis and an ileo-colectomy with primary anastomosis was carried out.The patient recovered after intensive respiratory care and fluid therapy, and then returned to her former institution.A review of Japanese literature disclosed that:(1) a marked increase of aged patients with mental disability presenting with cecal volvulus,(2) adoption of ileo-colectomy as the standard surgical procedure, and(3) improved survival of the patients, were observed in the last decade.

The Taiyuan Lianhualao History and the Present Situation, Problems and Thinking

Taiyuan lian hua lao is the local of unique Shangcun of Tai Yuan in Chinese folk rap art breed, it is not a matter cultural heritage directory so far by column for Shanxi Province in 2006. This paper describes the development of Taiyuan Lian hua lao from the aspects of present situation, problems and thinking, then puts forward the relevant suggestions.

Chinese Teachers＇ Understanding of Culture Teaching in ELT

In China, the teaching of culture was stipulated to be very important at the government level in the form of a curriculum in early 2000s. Now although the teachers seem to be fully aware of the significance of culture teaching, there are misunderstandings about it. A survey was conducted to find out how the teachers understand and meet the requirements of the curriculums. The results show even the teachers do not understand the objectives of ELT （English Language Teaching） stipulated in the curriculums. They need training and the requirements need clarification, so that the gap between what is expected and what is performed can be bridged.

A Perfect Combination of the Real Life and Literary World： An Analysis of The Old Man and the Sea

Being distinguished from many greatest American writers, Hemingway is noted as an iron man and his powerful philosophy： “Man can be destroyed, but not defeated”. Among all his works, The Old Man and the Sea is considered to be the masterpiece of Hemingway＇s works and the one that best demonstrates this powerful philosophy. And The Old Man and the Sea is a short novel about an old Cuban fisherman Santiago and his battle with a great marlin. In his masterpiece, Hemingway portrays Santiago with every dominant and strong characteristic, which is the prototype of an iron man. This is one of the basic characteristics of the novel which gives Ernest Hemingway great honor and makes him become one of the authors who define American literature. The Old Man and the Sea is the one that best represents American social life on the period Hemingway lived. In this short novel, a lot of facts are used. Most of the facts come from Hemingway＇s own experience. Reading up the masterpiece, it is evident that the story and the hero are the self-portray of the author himself. With the real life and the literary world perfectly combined, we read Hemingway＇s and we read through Hemingway and his inner world.

The Analysis of＂House-for-Pension＂ in China

As China has entered the aging society, the social and family are facing an increasing pressure in pension system. To explore diversified pension model for China has become the key to solve this problem. In 2013 the state council issued an document named Opinions to Speed Up the Derelopment of Pension Services, which clearly put forward that the government should promote the elderly housing reverse mortgage endowment insurance pilot ＂. ＂To implement housing endowment＂, practiced successfully in European and American countries, has proved a good way to solve the problem of lack of pension. This paper makes a analysis of the model, including the necessity,some practice and restricting factors promoting in our country, so as to explore countermeasures and Suggestions of the feasibility.

The Translation of a Few Words With Old-Fashioned Meanings in Pride and Prejudice

Word meanings change with time. This paper analyzes the meanings of three language units from Jane Austen＇s Pride and Prejudice and their Chinese renderings by seven translators. These three units are recollect, handsome, and come upon the town. By studying the linguistic, situational, or cultural contexts of each language unit, the analysis shows that of the renderings of these three language units, the accuracy rate is three out of seven, one out of seven, and two out of seven respectively. The paper points out that one of the most important causes of the low accuracy rates is that these language units denote old-fashioned meanings. Another cause of the low accuracy rates is that some of the translators are not careful enough in their identification of the meanings of these language units. The paper suggests that in the translation of a classic novel like Pride and Prejudice, translators need to analyze carefully the linguistic, situational, or cultural contexts of a tricky language unit in the novel for very likely it denotes an old-fashioned meaning. Translators could also consult and compare what a tricky language unit means in other places of the novel, use an encyclopedic dictionary instead of a dictionary of contemporary English, and study the notes on tricky words in the novel made by established scholars.

Advances in applying somatosensory interaction technology in geriatric care:A bibliometric analysis

Objectives:Somatosensory Interaction Technology(SIT)is used in various aspects of geriatric care.We aimed to conduct a bibliometric analysis to summarize relevant publications and visualize publication characteristics,current hotspots,and development trends,thereby inspiring subsequent researches.Methods:We searched theWeb of Science Core Collection database for publications on the application of SIT in geriatric care.Bibliometric visualization and clustering analysis were performed using VOSviewer V1.6.18 Software,while keywords burst detection analysis was conducted with CiteSpace 6.1.R6 Software.Results:After screening,a total of 1,019 publications were included.The number of publications on SIT in geriatric care is gradually increasing,exhibiting a rapid growth rate.The United States,Canada,and Australia led in terms of publication volume.Keyword clustering analysis identified major research hotspots:crisis warning,somatic abilities,rehabilitation training and psychosocial support.Initial studies primarily explored themes such as recovery,movement,systems,and later shifted towards gait analysis,muscle strength,parameters,and home-based care.More recently,research themes have evolved to dementia,machine learning,and gamification.Conclusions:SIT is innovative for promoting active aging,advancing intelligent healthcare,and elevating the daily quality of life for older adults in clinical and domestic settings.Applications of SIT can be categorized into early warning systems for crises,detailed analyses of physical conditions,rehabilitation enhancement,and support for psychosocial health.Research trends have transitioned from whole-body recognition to precise feedback,from a focus on physical health to mental health,and from technical feasibility to user-friendliness.Future research should focus on developing accessible and user-friendly devices,fostering interdisciplinary collaborations for innovation,expanding research to address both the physical and mental health needs of diverse older adults,and integrating emerging technologies to enhance data precision and accelerate the development of intelligent platforms.

Pharmacist-led interventions in older adults:A bibliometric analysis of scientific literature

Pharmacist-led interventions have demonstrated significant benefits for older adults,with a plethora of studies dedicated to this subject.A bibliometric study was conducted to assess the current state of research and summarize key themes in the domain of pharmacist-led interventions for older adults.The analysis encompassed publications available in the Web of Science Core Collection from its inception until September 8,2022.To perform the bibliometric analysis,VOSviewer and CiteSpace software were employed.The initial query yielded a substantial 6084 relevant documents spanning the period from 1995 to September 8,2022.Of these,5496(constituting 90.34%)were categorized as“Article”.Notably,the yearly output of publications displayed an upward trajectory.This body of work emanated from 120 countries and regions,with the United States being the foremost contributor,accounting for the majority of publications(n=2637).The University of Sydney in Australia emerged as the institution with the highest number of publications(n=155).Timothy F Chen,affiliated with the University of Sydney,was the most prolific author,boasting 35 publications.Joseph T Hanlon,a scholar affiliated with the University of the Sciences in Philadelphia,emerged as the most frequently co-cited author.When considering journal productivity,The Journal of Managed Care&Specialty Pharmacy stood out as the most prolific journal(n=251).Conversely,the Journal of the American Geriatrics Society garnered the highest number of co-citations(n=5293).The predominant research themes encompassed the development of new criteria,updates to existing criteria,the utilization of criteria for identifying potentially inappropriate medications in older populations,concerns surrounding inappropriate polypharmacy in this demographic,and the evaluation of the positive impact of pharmacist-led interventions for older adults.In conclusion,this comprehensive bibliometric analysis offers a panoramic view of pharmacist-led interventions for older adults,providing valuable insights into the field’s evolution over the past three decades.

锃亮的水烟壶

一东文老头的那把水烟壶是很有些年头的,听说已经传了好几代人。那是一把纯黄铜制作的水烟壶,做工非常考究。烟壶的构造由三个部分组成。主体是一个圆柱形的容器,容器上端的一边流线型地缩小成一根上翘的弯管,管头便是烟嘴;容器的另一边则是一个竖起的空心小圆柱,圆柱中插有一根更小的圆柱形铜管,就像一根空心的铜栓,这根空心栓子的端头大小与外管一致,端头的中间是一个空窝。

耄耋老人陈义文的“木版年华”

年画,是儿时过年贴在墙上的彩色记忆,当空空的白墙上贴上五彩缤纷的年画,顿时给家里并不宽敞富裕的小屋增添了很多喜庆浓郁的新年气氛。如今,物质生活逐渐丰裕,年画也渐渐被人们所遗忘。然而,在湖北省老河口市光化街道拦马河社区,却有一位耄耋之年的老人,用一把刻刀、一生的时光,雕刻着属于自己的那份坚持与理想,演绎了一曲＂木版年华＂。他叫陈义文,今年90岁高龄,从事木版雕刻已经有70余年了。

Identification of aeolian loess deposits on the Indo-Gangetic Plain(India)and their significance

Aeolian loess deposits contain abundant information about the evolution of the paleoenvironment.For example,paleoclimate changes recorded in Chinese loess area obtained significant achievement in the past few decades.Compared to Chinese loess,research on Indian loess is lacking.Currently,most studies focus on the Kashmir area located in the southern Himalayas,and studies on other areas are rare.However,field observations demonstrate that the sediments around the New Delhi-Agra-Jaipur Plain are similar to Chinese loess-paleosol sequences.For example,the boundary between two strata is transitional and without horizontal bedding.Moreover,obvious pedogenic horizons developed among sediment sequences,probably indicating unrecognised aeolian deposits in the Indo-Gangetic Plain(IGP).To confirm this,pilot samples were obtained from the IGP and detailed indoor measurements conducted.The results indicate that the distribution patterns of particle size and rare earth elements(REE) of the pilot samples are similar to Chinese loess.Furthermore,the scanning electronic microscopy(SEM) images of pilot samples show obvious conchoidal fractures,dash-shaped concavities,and abundant small pits that usually form through mechanical impact.These are typical characteristics of aeolian particles.In addition,environmental and rock magnetic measurements indicate that the dominant magnetic minerals in the pilot samples are magnetite and maghemite,and that they likely contain small amounts of hematite.Furthermore,conventional magnetic parameters are comparable with Chinese loess.Based on this,aeolian loess deposits are widely distributed in the IGP,which may have promoted the development of Indian farming and contributed towards the prosperity of ancient Indian civilisation.This study also provides a new and valuable record for the research on paleoclimate changes in the study area in the future.

Society's support for the aged in China:a cultural perspective

This article is concerned with the influence of welfare culture on society＇s old age support institutions and practice. It examines the development of old age support programs in contemporary China from a cultural perspective in an attempt to reveal the interaction between social welfare patterns for the elderly and social policy-makers＇ conception of social welfare and traditional social welfare culture. What stands in the way of the transition of Chinese social welfare for the elderly fi＇om a residual to an institutional model is a value system founded on restrictions and lack of awareness of civil fights. These factors limit the role of social welfare in narrowing the gaps between different social strata in the aged population and lead to inequitable welfare resource distribution. Although an aging population and the diffusion of welfare state culture are pushing the Chinese social welfare system toward diversified development, its final establishment still depends on a reexamination by the public and policy-makers of the relationship between individual citizens and the state.