论清代勘验制度与申状、申文、验文、详文发展演变

清代勘验是一种所涉范围广泛的政府行为,包括:官学考验,保举验看,捐纳验看,肃贪验赃,武备勘验,军兵勘验,刑法核验,工程勘验,仓库察验,盐、茶、漕验,民生核验。由此,诞生了专门的验勘机构及相应的验勘文书。从宋元申状发展到清代申文,是公文发展史上的一大变革。申状、申、验是一脉相传的文种。文章还分析了清代申文分解为“验文”“详文”的内在依据和外在特征。

补气降低射流泵汽蚀振动和噪声的实验研究

对喉管低压区补气来改善射流泵汽蚀性能的方案进行了实验研究,得出如下结论:1)补气会将射流泵汽蚀时的噪声降低1 dB-8.7 dB。补气量越大,噪声降低效果越明显;2)在同一汽蚀条件下,工作压力越大,汽蚀所产生的振动加速度也就越大;在轴线方向,振动加速度随着补气量的增大而降低,但在水平和竖直方向补气前后振动加速度变化不大;3)补气可以明显降低扩散管及其出口的压力脉动,有利于泵性能的稳定和延长泵的使用寿命;4)补气后,射流泵的流量比有所变化,但变化不大。工作压力越大,补气后汽蚀流量比下降的越少,在某些情况下,补气后反而可以增大流量比;5)补气会破坏严重汽蚀时的液汽两相临界流动,大大改善流动的阻塞情况。成果表明,在喉管低压区自然补气简单可靠,易于实现,具有明显的降噪减振效果,可有效改善泵的汽蚀性能,可在工程实践中得到广泛的应用。

医学硕士研究生生物化学实验带教的几点体会

教学实践是医学硕士研究生学习阶段的一个重要组成部分，是培养和发展硕士研究生教学能力的有效手段，实验教学是教学实践的一种有效形式。为了与广大医学硕士研究生交流实验教学体会，共同提高教学能力，从而提高教学质量，现针对在生物化学实验教学中应注意的一些问题总结了一些自身体会。

Optimization of PCR Reaction System for Random Single-strand DNA Pool in SELEX Technology

[Objective] This study aimed to optimize the PCR amplification conditions for random ssDNA pool in SELEX technology. [Method] L16（45） orthogonal experimental design was adopted for optimization of five important factors affecting PCR reaction system for random single-stranded DNA pool including Mg2＋ concentration, dNTP concentration, amount of Taq DNA polymerase, primer concentration and amount of random single-stranded DNA pool at four levels. Meanwhile, the annealing temperature and number of PCR reaction cycles were optimized to establish the optimal reaction system and PCR procedure. [Result] The optimal combination of PCR reaction system for random ssDNA pool was obtained, with a total system volume of 20 μl containing 2.0 μl of 10 × Buffer, 0.5 ng of random ssDNA pool, 2.5 mmol/L Mg2＋, 0.25 mmol/L dNTP Mixture, 0.6 μmol/L upstream and downstream primers and 1.5 U of Taq DNA polymerase; the optimal annealing temperature was 68 ℃ and the optimal number of cycles was 12. Under the above conditions, clear and stable bands with high specificity for random ssDNA pool were amplified. [Conclusion] This study laid the foundation for selection of parameters with higher specificity in SELEX technology.

Multimodality approach for locally advanced esophageal cancer

Carcinoma of the esophagus is an aggressive and lethal malignancy with an increasing incidence worldwide.Incidence rates vary internationally,with the highest rates found in Southern and Eastern Africa and Eastern Asia,and the lowest in Western and Middle Africa and Central America.Patients with locally advanced disease face a poor prognosis,with 5-year survival rates ranging from 15%-34%.Recent clinical trials have evaluated different strategies for management of locoregional cancer;however,because of stage migration and changes in disease epidemiology,applying these trials to clinical practice has become a daunting task.We searched Medline and conference abstracts for randomized studies published in the last 3 decades.We restricted our search to articles published in English.Neoadjuvant chemoradiotherapy followed by surgical resection is an accepted standard of care in the United States.Esophagectomy remains an essential component of treatment and can lead to improved overall survival,especially when performed at high volume institutions.The role of adjuvant chemotherapy following curative resection is still unclear.External beam radiation therapy alone is considered palliative and is typically reserved for patients with a poor performance status.

Bankruptcy Probability and Stock Prices： The Effect of Altman Z-Score Information on Stock Prices Through Panel Data

There is an extensive branch of literature that examines the success of Altman＇s Z-score in predicting bankruptcy or financial distress. The goal of this research paper is to investigate the stock price performance of firms that exhibit a large probability of bankruptcy according to the model of Airman. Regardless of the validity of Airman＇s Z-score, we utilize a new empirical design that relates stock price movements to Altman＇s Z-score. We focus and examine, through the methodology of panel data, whether stocks that have a high probability of bankruptcy underperform stocks with a low probability of bankruptcy or if there are differences in the way the markets react to the financial health of the sample firms.

Coupled modeling of land hydrology-regional climate including human carbon emission and water exploitation

Carbon emissions and water use are two major kinds of human activities. To reveal whether these two activities can modify the hydrological cycle and climate system in China, we conducted two sets of numerical experiments using regional climate model RegCM4. In the first experiment used to study the climatic responses to human carbon emissions, the model were configured over entire China because the impacts of carbon emissions can be detected across the whole country. Results from the first experiment revealed that near-surface air temperature may significantly increase from 2007 to 2059 at a rate exceeding 0.1 ~C per decade in most areas across the country; southwestern and southeastern China also showed increasing trends in summer precipitation, with rates exceeding 10 mm per decade over the same period. In summer, only northern China showed an increasing trend of evapotranspiration, with increase rates ranging from 1 to 5 mm per decade; in winter, increase rates ranging from 1 to 5 mm per decade were observed in most regions. These effects are believed to be caused by global warming from human carbon emissions. In the second experiment used to study the effects of human water use, the model were configured over a limited region-- Haihe River Basin in the northern China, because compared with the human carbon emissions, the effects of human water use are much more local and regional, and the Haihe River Basin is the most typical region in China that suffers from both intensive human groundwater exploitation and surface water diversion. We incorporated a scheme of human water regulation into RegCM4 and conducted the second experiment. Model outputs showed that the groundwater table severely declined by -10 m in 1971-2000 through human groundwater over- exploitation in the basin; in fact, current conditions are so extreme that even reducing the pumping rate by half cannot eliminate the ground- water depletion cones observed in the area. Other hydrological and climatic elements, such as soil moisture, runoff generation, air humidity, precipitation, wind field, and soil and air temperature, were also significantly affected by anthropogenic water withdrawal and consumption, although these effects could be mitigated by reducing the amount of water drawn for extraction and application.

Single-trial EEG-based emotion recognition using temporally regularized common spatial pattern

This study addresses the problem of classifying emotional words based on recorded electroencephalogram （EEG） signals by the single-trial EEG classification technique. Emotional two-character Chinese words are used as experimental materials. Positive words versus neutral words and negative words versus neutral words are classified, respectively, using the induced EEG signals. The method of temporally regularized common spatial patterns （TRCSP） is chosen to extract features from the EEG trials, and then single-trial EEG classification is achieved by linear discriminant analysis. Classification accuracies are between 55% and 65%. The statistical significance of the classification accuracies is confirmed by permutation tests, which shows the successful identification of emotional words and neutral ones, and also the ability to identify emotional words. In addition, 10 out of 15 subjects obtain significant classification accuracy for negative words versus neutral words while only 4 are significant for positive words versus neutral words, which demonstrate that negative emotions are more easily identified.

George Orwell＇s Experiment With the Ironic Narrative Structure in Nineteen Eighty-Four

This study seeks to establish the major relevance of the ironic vision embodied in the narrative structure in George Orwell＇s early novel Nineteen Eighty-Four. After providing a comprehensive satisfying examination of the cultural phenomenon that goes by the name of ＂Modernism＂, the world in which the young George Orwell began his literary career; the study will present a critical analyses exploring Orwell＇s novel concerning the past-war ironic dystopian vision, with special reference to his experiment with the ironic narrative techniques and structure.

如何利用现有资源来拓展科学实验

精心设计实验，让学生通过亲自参加实验获得知识是搞好小学科学教学的关键。本文结合教学实践，从自己制作教学具，搞好实验仪器配备；选用替代品，配备实验器材；制作对比实验装置，实现事物变化规律的探究；联系当地条件，因地制宜选取器材；走进生活，扩展实验活动范围这五个方面进行了探索。

Instructions to authors

An informative, structured abstract of no more than 250 words should accompany each manuscript. Abstracts for original contributions should be structured into the following sections： AIM： Only the purpose should be included. METHODS： The materials, techniques, instruments and equipments, and the experimental procedures should be included. RESULTS： The observatory and experimental results, including data, effects, outcome, etc. should be included. Authors should present P value where necessary, and the significant data should accompany. CONCLUSION： Accurate view and the value of the results should be included. The format of structured abstracts is at： http：//www.wjgnet.com/wjg/help/11 .doc

Management of liver cirrhosis between primary care and specialists

This article discusses a practical, evidence-based approach to the diagnosis and management of liver cirrhosis by focusing on etiology, severity, presence of complications, and potential home-managed treatments. Relevant literature from 1985 to 2010 (PubMed) was reviewed. The search criteria were peer-reviewed full papers published in English using the following MESH headings alone or in combination: "ascites", "liver fibrosis", "cirrhosis", "chronic hepatitis", "chronic liver disease", "decompensated cirrhosis", "hepatic encephalopathy", "hypertransaminasemia", "liver transplantation" and "portal hypertension". Forty-nine papers were selected based on the highest quality of evidence for each section and type (original, randomized controlled trial, guideline, and review article), with respect to specialist setting (Gastroenterology, Hepatology, and Internal Medicine) and primary care. Liver cirrhosis from any cause represents an emerging health issue due to the increasing prevalence of the disease and its complications worldwide. Primary care physicians play a key role in early identification of risk factors, in the management of patients for improving quality and length of life, and for preventing complications. Specialists, by contrast, should guide specific treatments, especially in the case of complications and for selecting patient candidates for liver transplantation. An integrated approach between specialists and primary care physicians is essential for providing better outcomes and appropriate home care for patients with liver cirrhosis.

The Long-Term Field Experiment Observatory and Preliminary Analysis of Land-Atmosphere Interaction over Hilly Zone in the Subtropical Monsoon Region of Southern China

To improve current understanding of the water cycle,energy partitioning and CO2 exchange over hilly zone vegetative land surfaces in the subtropical monsoon environment of southern China,a long-term field experiment observatory was set up at Ningxiang,eastern Hunan Province.This paper presents a preliminary analysis of the field observations at the observatory collected from August to November 2012.Results show that significant diurnal variations in soil temperature occur only in shallow soil layers(0.05,0.10,and 0.20 m),and that heavy rainfall affects soil moisture in the deep layers(≥ 0.40 m).During the experimental period,significant diurnal variations in albedo,radiation components,energy components,and CO2 flux were observed,but little seasonal variation.Strong photosynthesis in the vegetation canopy enhanced the CO2 absorption and the latent heat released in daylight hours;Latent heat of evaporation was the main consumer of available energy in late summer.Because the field experiment data are demonstrably reliable,the observatory will provide reliable long-term measurements for future investigations of the land-atmosphere interaction over hilly land surfaces in the subtropical monsoon region of southern China.

Practice and experience of engineering culture development in the Sutong Bridge project

To keep up with the time,culture is integrated to large-scale construction project management in China,which will absolutely add more vitality into construction project management in our country.Engineering culture is an integration of project construction and engineering culture.However,engineering culture development enjoys its own particularity as a project is constructed once only within a limited period of time.This paper gives affirmative opinion that engineering culture development in large-scale projects backs project management on the basis of thorough investigation of engineering culture development in Sutong Bridge Project and after deepened analysis,proposes new thinking pattern of engineering culture development in large-scale projects in a systematic manner,including thorough understanding of the essence of engineering culture,principle and contents of engineering culture development as well as efficient method in respect of establishment and implementation of engineering culture,and therefore provides a standard reference and systematic thinking pattern for engineering culture development in future large-scale projects.

A Multicultural Interpretation of Jade Snow Wong＇s Fifth Chinese Daughter

Jade Snow Wong was one of the most famous literary writers to recount the complexity of cross-cultural experiences as Americans became sympathetic toward Chinese at the historic juncture of WWII. Her autobiography, Fifth Chinese Daughter, once represented early immigrants＇ assimilationist position, yet it was lately reread for the strength of her Chinese heritage in a multicultural American society. To interpret the cultural value of Chinese existence in America, this article analyzes the historic contexts of her story, and argues that her life experiences provide insights into fresh meanings of multiculturalism for various ethnic groups, as well as into the particular importance of Chinese American culture in connecting separate worlds within the world of America.

Two-stage vs single-stage management for concomitant gallstones and common bile duct stones

AIM:To evaluate the safety and effectiveness of twostage vs single-stage management for concomitant gallstones and common bile duct stones.METHODS:Four databases,including PubMed,Embase,the Cochrane Central Register of Controlled Trials and the Science Citation Index up to September 2011,were searched to identify all randomized controlled trials(RCTs).Data were extracted from the studies by two independent reviewers.The primary outcomes were stone clearance from the common bile duct,postoperative morbidity and mortality.The secondary outcomes were conversion to other procedures,number of procedures per patient,length of hospital stay,total operative time,hospitalization charges,patient acceptance and quality of life scores.RESULTS:Seven eligible RCTs [five trials(n = 621) comparing preoperative endoscopic retrograde cholangiopancreatography(ERCP)/endoscopic sphincterotomy(EST) + laparoscopic cholecystectomy(LC) with LC + laparoscopic common bile duct exploration(LCBDE);two trials(n = 166) comparing postoperative ERCP/EST + LC with LC + LCBDE],composed of 787 patients in total,were included in the final analysis.The metaanalysis detected no statistically significant difference between the two groups in stone clearance from the common bile duct [risk ratios(RR) =-0.10,95% confidence intervals(CI):-0.24 to 0.04,P = 0.17],postoperative morbidity(RR = 0.79,95% CI:0.58 to 1.10,P = 0.16),mortality(RR = 2.19,95% CI:0.33 to 14.67,P = 0.42),conversion to other procedures(RR = 1.21,95% CI:0.54 to 2.70,P = 0.39),length of hospital stay(MD = 0.99,95% CI:-1.59 to 3.57,P = 0.45),total operative time(MD = 12.14,95% CI:-1.83 to 26.10,P = 0.09).Two-stage(LC + ERCP/EST) management clearly required more procedures per patient than single-stage(LC + LCBDE) management.CONCLUSION:Single-stage management is equivalent to two-stage management but requires fewer procedures.However,patient's condition,operator's expertise and local resources should be taken into account in making treatment decisions.

Causes and Ramifications of the Xinjiang july 2009 Disturbances

In July 2009, serious ethnic disturbances took place in 0r^imqi, the capital of Xinjiang, in China＇s north-west. Although open to diverse interpretations, they embodied serious conflicts between the Oighurs--the most populous ethnic group of Xinjiang--and China＇s dominant Han nationality. This article seeks to identify the causes of the disturbances, including both those internal to China and those external to it, both short-term and long-term. The issue is important, because Chinese official sources largely blamed outside terrorist and extremist forces, especially those associated with the main Uighur diaspora organizations, while the Uighur diaspora itself, largely supported by Western journalists and scholars, put the responsibility on the Chinese state, charging it with injustices against the Uighurs. This article contributes to the literature by finding both internal and external contributing factors. It also looks at the ramifications of the disturbances, including both the aftermath of the incidents and prospects for the future, and adopts a fairly pessimistic stance concerning short-term ethnic relations. The methodology is textual analysis and personal experience.

Radiotherapy combined with surgical treatment for gastric cancer:a meta-analysis

Objective:We carried out a meta-analysis to assess the effectiveness and safety of radiotherapy combined with surgery for gastric cancer.Methods:Randomized Clinical Trials (RCTs) in which radiotherapy (preoperative,intraoperative and postoperative),was compared with surgery alone in resectable gastric cancer were identified by searching Cochrane Library (Issue 2,2009),PubMed (Jan 1966-Jun 2009),EMBASE (Jan 1974-Jun 2009),Chinese Biomedical Literature Database (Jan 1978-Jun 2009),Chinese Science and Technology Periodicals Database (Jan 1989-Jun 2009),China National Knowledge Infrastructure (Jan 1994-Jun 2009) and Wanfang database (Jan 1997-Jun 2009) in English and Chinese languang.Two researchers assessed the quality of included randomized controlled trials (RCT) extracted data independently.The RevMan 5.0 software was used for meta-analysis.Our researchers assessed the quality of included randomized controlled trials (RCT) extracted data independently.The RevMan 5.0 software was used for meta-analysis.Results:Nine randomized controlled trials of 1 548 patients were selected for meta-analysis.Five randomized controlled trials were related with comparison of preoperative radiotherapy plus surgery with single surgery.Two randomized controlled trials were the comparative studies between surgery plus postoperative and single surgery.The meta-analysis results showed that:(1) compared with surgery alone,preoperative radiotherapy combined with surgery can increase 3 years (OR=1.78;95% CI 1.14-2.78,P=0.01),5 years (OR=1.67;95% CI 1.22-2.29,P=0.001),10 years (OR=1.64;95% CI 1.03-2.60,P=0.04) survival rate and resection rate (OR=2.15;95% CI 1.31-3.54,P=0.003);reduce the of tumor recurrence rate (OR=0.59;95% CI 0.37-0.92,P=0.02) and metastasis rate (OR=0.44;95% CI 0.27-0.73,P=0.001);(2) The tumor recurrent rates (OR=0.19,95% CI 0.03-1.14,P=0.07) and tumor metastasis rate (OR=0.09;95% CI 0.00-1.77,P=0.11) had no difference between single surgery group and peri-operative radiotherapy plus surgery group;(3) Postoperative radiotherapy compared with surgery alone had no significant effects on 1 year (OR=0.83;95% CI 0.60-1.15,P=0.26) and 3 years (OR=0.75;95% CI 0.51-1.11,P=0.15) survival rate compared with single surgery,but the 5-year survival rates (OR=0.57;95% CI 0.34-0.95,P=0.03) of the patients who received surgery alone was higher than those who received combined therapy.No difference of the tumor recurrence rate (OR=0.59;95% CI 0.33-1.05,P=0.07),tumor metestasis rate (OR=0.90;95% CI 0.51-1.59,P=0.71) and anastomotic leak (OR=0.98;95% CI 0.25-3.65,P=0.98) were observed between the two groups.Conclusion:Preoperative radiotherapy combined surgery is more rational and effective than surgery alone of gastric cancer.However,in terms of the clinical effects of perioperarive or postoperative radoiotherapy combined with surgery,much multicenter,largescale,high-quality,double-blind and rigorously designed studies would be needed than currently available in the future.

The development trend of paper-based media under the media convergence trend

The emergence of media convergence have so huge impact on paper-based media that paper-based media no longer has a monopoly. Some people assert that paper-based media will come to an end. However, the author believes that the paper media will not come to an end under the media convergence trend. It will develop parallel with media integration. The reason why the author has this view is that, on one hand, paper-based media has its unique physical characteristics. In the real world, paper media brought us the aesthetic experience by ＂five senses＂ . It cannot be replaced by the media convergence. The paper media will also make survival steering dimension; on the other hand, cultural heritage of the paper media make itself a unique appreciation of the value and not transcendent. Therefore, the paper media in the media convergence trend will continue to exist and turned to be ＂concept book＂ that admiring is the main part and reading supplemented.

Effects of Formulation Parameters and Process Variables on the Properties of Granules Obtained by Reactive Granulation

In this work, granulation between dodecyl-benzenesulfonic acid and sodium carbonate was investigated in a laboratory-scale high shear mixer. The effects offormulation parameters and process variables, including primary carbonate size, binder content, impeller speed, and operating temperature, were correlated to the properties ofthe product granules. Design ofexperiment and analysis ofvariance were combined to analyze the experimentaldata, and results showed that larger granule sizes with fewer fine particles can be obtained by employing higher binder contents and larger sodium carbonate sizes. The shear force ofthe impeller can extensively break oversized granules. The binder content exerted a contrasting effect on the flowability ofgranules formed with two kinds ofsodium carbonate, likely because ofdifferences in the liquid saturation ofthe solids. The dissolution rate determined by in-line size analysis showed that high binder contents were beneficialto dissolution performance, and the relationships between Hunter color and tested parameters were evaluated. The results ofthis work can be used as a reliable guidance for process controland optimization in powder detergent manufacturing.