Systematic research of the characteristics of late Quaternary activity of the middle part of Kouquan fault has been done through conducting 1∶50000 geologic mapping combining with remote sensing interpretation of spo...Systematic research of the characteristics of late Quaternary activity of the middle part of Kouquan fault has been done through conducting 1∶50000 geologic mapping combining with remote sensing interpretation of spot imaging, field validating and chronology research of the research area. Studies suggest that the middle part of Kouquan fault has had strong activity since the late Quaternary which controls the tectonic evolvement of the nearby mountains and Datong basin. The recent activity of this fault has faulted the sandy gravel layers of T1 terrace and the lower part of dark loessial soils over the terrace on the north of Chanfang village. The maximum vertical displacement is over 3m in the area between Xiaoyukou village and Louzikou village, and to the south of Dayukou village and the north of Emaokou village, the displacement decreases to 0.5m and 0.25m respectively. Based on the recent faulted landforms and combined with dating, we determined the age of recent activity of the fault in the research area to be between 7.71ka B.P. to 3.00 ka B.P. Discussions are made on this in combination with previous research.展开更多
To achieve a higher transfection efficiency and lower toxicity, a novel herringbone-like cationic lipid（2 ss HLL） composed of hydrophilic aspartic acid linked with two reduction-responsive cleavable hydrophobic olei...To achieve a higher transfection efficiency and lower toxicity, a novel herringbone-like cationic lipid（2 ss HLL） composed of hydrophilic aspartic acid linked with two reduction-responsive cleavable hydrophobic oleic acid tails was synthesized and assessed in this study. In our results, the cationic nanoplexes with a uniform spherical shape and a particle size of ~150 nm were successfully prepared by the electrostatic interaction between si RNAs and 2 ss HLL-based liposomes. From the results evaluated in Hep G2 cells, it was shown that the nanoplexes exhibited high cellular uptake of si RNA with a low cytotoxicity. Moreover, the significant down-regulation effects of 2 ss HLL/si EGFR nanoplexes on target m RNA were displayed by RT-PCR analysis, which were similar to those of Lipofectamine2000. It suggested that the enhanced si RNA gene silencing efficiency was probably attributed to the detachment of hydrophobic tail chains induced by reduction-responsive cleavage. This mechanism was also confirmed by the changes of size distribution and si RNA release of nanoplexes in the reductive environment and DTT-absence condition. Overall, we believed that the redox-active herringbone-like 2 ss HLL would be a potential nanocarrier towards si RNA delivery.展开更多
Dynamically crosslinked materials generally lose their self-healing ability and mechanical robustness in aqueous,acidic,and basic environments due to disruption of their dynamic interactions and bonds.Herein,a micelle...Dynamically crosslinked materials generally lose their self-healing ability and mechanical robustness in aqueous,acidic,and basic environments due to disruption of their dynamic interactions and bonds.Herein,a micelle-like structure with a hydrophobic outer layer is used to protect ionic interactions.This structure ensures the self-healing and long-term stability of the ionically crosslinked elastomers in aqueous,acidic,and basic environments.The elastomer possesses a tensile strength of 6.7 MPa and a strain at break of 1400%,which is superior to the existing waterproof selfhealing elastomers.The strain sensors and dielectric actuators based on the elastomer are highly stable and self-healable,even in extremely harsh environments.This design strategy of hydrophobic protection for dynamic interactions is quite general,allowing it to be extended to other self-healing materials.展开更多
基金jointly funded by the National Natural Science Foundation ( Grant No. 40972143)the Key Research Project of the 11th "Five-year Plan"of China Earthquake Administration( 1520945024)
文摘Systematic research of the characteristics of late Quaternary activity of the middle part of Kouquan fault has been done through conducting 1∶50000 geologic mapping combining with remote sensing interpretation of spot imaging, field validating and chronology research of the research area. Studies suggest that the middle part of Kouquan fault has had strong activity since the late Quaternary which controls the tectonic evolvement of the nearby mountains and Datong basin. The recent activity of this fault has faulted the sandy gravel layers of T1 terrace and the lower part of dark loessial soils over the terrace on the north of Chanfang village. The maximum vertical displacement is over 3m in the area between Xiaoyukou village and Louzikou village, and to the south of Dayukou village and the north of Emaokou village, the displacement decreases to 0.5m and 0.25m respectively. Based on the recent faulted landforms and combined with dating, we determined the age of recent activity of the fault in the research area to be between 7.71ka B.P. to 3.00 ka B.P. Discussions are made on this in combination with previous research.
基金National Natural Science Foundation of China(Grant No.81473158,81690264 and 81773650)the New Drug R&D program of China(Grant No.2018ZX09721003-004)the Opening Project of Key Laboratory of Drug Targeting and Drug Delivery System,Ministry of Education(Sichuan University)
文摘To achieve a higher transfection efficiency and lower toxicity, a novel herringbone-like cationic lipid（2 ss HLL） composed of hydrophilic aspartic acid linked with two reduction-responsive cleavable hydrophobic oleic acid tails was synthesized and assessed in this study. In our results, the cationic nanoplexes with a uniform spherical shape and a particle size of ~150 nm were successfully prepared by the electrostatic interaction between si RNAs and 2 ss HLL-based liposomes. From the results evaluated in Hep G2 cells, it was shown that the nanoplexes exhibited high cellular uptake of si RNA with a low cytotoxicity. Moreover, the significant down-regulation effects of 2 ss HLL/si EGFR nanoplexes on target m RNA were displayed by RT-PCR analysis, which were similar to those of Lipofectamine2000. It suggested that the enhanced si RNA gene silencing efficiency was probably attributed to the detachment of hydrophobic tail chains induced by reduction-responsive cleavage. This mechanism was also confirmed by the changes of size distribution and si RNA release of nanoplexes in the reductive environment and DTT-absence condition. Overall, we believed that the redox-active herringbone-like 2 ss HLL would be a potential nanocarrier towards si RNA delivery.
基金supported by the National Natural Science Foundation of China(51873110 and 51673120)State Key Laboratory of Polymer Materials Engineering(sklpme2019-2-14)the Fundamental Research Funds for Central Universities。
文摘Dynamically crosslinked materials generally lose their self-healing ability and mechanical robustness in aqueous,acidic,and basic environments due to disruption of their dynamic interactions and bonds.Herein,a micelle-like structure with a hydrophobic outer layer is used to protect ionic interactions.This structure ensures the self-healing and long-term stability of the ionically crosslinked elastomers in aqueous,acidic,and basic environments.The elastomer possesses a tensile strength of 6.7 MPa and a strain at break of 1400%,which is superior to the existing waterproof selfhealing elastomers.The strain sensors and dielectric actuators based on the elastomer are highly stable and self-healable,even in extremely harsh environments.This design strategy of hydrophobic protection for dynamic interactions is quite general,allowing it to be extended to other self-healing materials.
