In view of the difficulty in determining remaining useful life of plant new variety right in economic analysis, Weibull Survival Analysis Method and Gaussian Model to were used to study how to accurately estimate the ...In view of the difficulty in determining remaining useful life of plant new variety right in economic analysis, Weibull Survival Analysis Method and Gaussian Model to were used to study how to accurately estimate the remaining useful life of plant new variety right. The results showed that the average life of the granted rice varieties was 10.013 years. With the increase of the age of plant variety rights, the probability of the same residual life Ttreaching x was smaller and smaller, the reliability lower and lower, while the probability of the variety rights becoming invalid became greater. The remaining useful life of a specific granted rice variety was closely related to the demonstration promotion age when the granted rice variety reached its maximum area and the appearance of alternative varieties, and when the demonstration promotion age of the granted rice variety reaching the one with the maximum area, the promotion area would be decreased once a new alternative variety appeared, correspondingly with the shortening of the remaining useful life of the variety. Therefore, Weibull Survival Analysis Method and Gaussian Model could describe the remaining useful life's time trend, as well as determine the remaining useful life of a concrete plant variety right, clarify the entire life time of varieties rights, and make the economic analysis of plant new varieties rights more accurate and reasonable.展开更多
AIM:To evaluate the correlations of plasma von Willebrand factor (vWF) level with the distant metastasis and prognosis of patients with colorectal cancer. METHODS: A total of 86 patients with historically confirmed me...AIM:To evaluate the correlations of plasma von Willebrand factor (vWF) level with the distant metastasis and prognosis of patients with colorectal cancer. METHODS: A total of 86 patients with historically confirmed metastatic colorectal cancers receiving treatment at Taipei Veterans General Hospital were enrolled. All patients had measurable metastatic lesions and life expectancies of more than 3 mo. Plasma vWF levels were measured by immuno-turbidimetric assay and compared with results from 40 non-metastatic colorectal cancer patients and 22 healthy controls. Patients with metastatic colorectal cancer were divided into two groups according to serum vWF levels and the differences between these two groups were analyzed using X2 test. Data on age, gender, performance status, location of primary tumor, extent of metastasis, site of metastases, histological differentiation, serum CEA and plasma vWF levels were analyzed to determine association with survival. Survival curves were constructed by Kaplan-Meier product limit method and the data was analyzed using log-rank test on a microcomputer. Multivariate analysis using the Cox's proportional hazards regression model was then performed to determine the independent prognostic indicators among all of the possible variables. RESULTS: Colorectal cancer patients were identified as having significantly higher plasma vWF concentrations than healthy controls (P<0.05). Moreover, higher vWF plasma levels were associated with advanced tumor stage (P<0.05) and the presence of multiple metastases (P=0.014). Patients with lower vWF plasma levels (≤160%) survived significantly longer than those with a higher plasma vWF level (log-rank test, P= 0.0043). By multivariate analysis, plasma vWF levels (P<0.001), the extent of metastasis (P= 0.012), and the performance status (P=0.014) were identified as independent prognostic factors. CONCLUSION: Our data indicates that high plasma vWF concentrations correlate with advanced diseases and significantly poor prognosis of patients with metastatic colorectal carcinoma. It may serve as a potential biological marker of disease progression in these patients.展开更多
Joyce began his literary career with strong discontent with his social condition. Ulysses is Joyce's optimum work, which takes 3 Dublin characters' experience in one day as the main line to show the paralysation and...Joyce began his literary career with strong discontent with his social condition. Ulysses is Joyce's optimum work, which takes 3 Dublin characters' experience in one day as the main line to show the paralysation and crisis of the whole Western society, people's emptiness on their minds, loneliness on their feelings and labefaction on their spirits, also, it showed the inextricable perplexity. To treat the theme of inextricable perplexity, this paper is trying to set about the inextricable Catholic Church and identity problems, with the ideas of Alick West-the outstanding English Marxist literary critic of the 20th century.展开更多
AIM: To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs (NSAIDs) or statins and colorectal cancer risk.METHODS: In a population-based case-control study in w...AIM: To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs (NSAIDs) or statins and colorectal cancer risk.METHODS: In a population-based case-control study in women, we examined the association between NSAIDs and statin use and the risk of colorectal cancers. We further investigated whether the use of statins modifies the protective effect of NSAIDs. Female cases (n = 669)of colorectal cancer aged 50-74 years were identified from a storewide registry in Wisconsin during 1999-2001. Community control women (n = 1375) were randomly selected from lists of licensed drivers and Medicare beneficiaries. Medication use and risk factor information were gathered during a structured telephone interview. A multivariable logistic regression model was used to calculate odds ratio (OR) and 95% confidence interval (CI).RESULTS: Overall, NSAIDs users had a 30% reduction in risk of colorectal cancer (95% CI: 0.56-0.88). Statin use was not associated with colorectal cancer risk (OR = 1.17, 95% CI: 0.74-1.85), regardless of structural type (lipophilic or hydrophilic), duration of use, or recency. There was no evidence of an interaction between NSAIDs and statins and colorectal cancer risk (P-interaction = 0.28).CONCLUSION: Although our results confirm the inverse association between NSAIDs use and colorectal cancer risk, they do not support a risk reduction in statin users, or an interaction effect of combined NSAIDs and statin use.展开更多
To compare liver proteolysis and proteasome activation in steatotic liver grafts conserved in University of Wisconsin (UW) and Institut Georges Lopez-1 (IGL-1) solutions.METHODSFatty liver grafts from male obese Z...To compare liver proteolysis and proteasome activation in steatotic liver grafts conserved in University of Wisconsin (UW) and Institut Georges Lopez-1 (IGL-1) solutions.METHODSFatty liver grafts from male obese Zücker rats were conserved in UW and IGL-1 solutions for 24 h at 4 °Cand subjected to “ex vivo” normo-thermic perfusion (2 h; 37 °C). Liver proteolysis in tissue specimens and perfusate was measured by reverse-phase high performance liquid chromatography. Total free amino acid release was correlated with the activation of the ubiquitin proteasome system (UPS: measured as chymotryptic-like activity and 20S and 19S proteasome), the prevention of liver injury (transaminases), mitochondrial injury (confocal microscopy) and inflammation markers (TNF 1 alpha, high mobility group box-1 (HGMB-1) and PPAR gamma), and liver apoptosis (TUNEL assay, cytochrome c and caspase 3).RESULTSProfiles of free AA (alanine, proline, leucine, isoleucine, methionine, lysine, ornithine, and threonine, among others) were similar for tissue and reperfusion effluent. In all cases, the IGL-1 solution showed a significantly higher prevention of proteolysis than UW (P < 0.05) after cold ischemia reperfusion. Livers conserved in IGL-1 presented more effective prevention of ATP-breakdown and more inhibition of UPS activity (measured as chymotryptic-like activity). In addition, the prevention of liver proteolysis and UPS activation correlated with the prevention of liver injury (AST/ALT) and mitochondrial damage (revealed by confocal microscopy findings) as well as with the prevention of inflammatory markers (TNF1alpha and HMGB) after reperfusion. In addition, the liver grafts preserved in IGL-1 showed a significant decrease in liver apoptosis, as shown by TUNEL assay and the reduction of cytochrome c, caspase 3 and P62 levels.CONCLUSIONOur comparison of these two preservation solutions suggests that IGL-1 helps to prevent ATP breakdown more effectively than UW and subsequently achieves a higher UPS inhibition and reduced liver proteolysis.展开更多
This study assesses vulnerability of agriculture to drought, using WINISAREG model and seasonal SPI2-index for eight climate regions (1951-2004). Results relative to Plovdiv show that in soils of large TAW (total a...This study assesses vulnerability of agriculture to drought, using WINISAREG model and seasonal SPI2-index for eight climate regions (1951-2004). Results relative to Plovdiv show that in soils of large TAW (total available water) net irrigation requirements NIRs range from 0 to 380 mm. In soils of small TAW, NIRs reach 440 mm in the very dry year. NIRs in Sofia/Silistra are about 100 mm smaller than in Plovdiv while in Sandanski they are 30-110 mm larger. Rainfed maize is associated with great yield variability (29% 〈 Cv 〈 72%). Considering an economical RYD (relative yield decrease) threshold, 32% of years are risky when TA Wis large in Plovdiv that is double than in Sofia and half than in Sandanski. In North Bulgaria the risky years are 10% in Pleven/Silistra that is half than in Lom. In Plovdiv region reliable relationships (R2 〉 91%) were found relating the SPI2 "July-Aug." with simulated RYD of rainfed maize while remaining relationships were less accurate (73% 〈 R2 〈 86%). Economical losses are produced when High Peak Season SPI2 〈 + 0.20 in Sandanski, SPI2 〈 - 0.50 in Plovdiv and SPI2 〈 - 0.90 in Sofia. In North Bulgaria the SPI2 threshold ranges from - 0.75 to - 1.50. Derived reliable relationships and SPl-thresholds are used for drought vulnerability mapping.展开更多
Wordsworth's Prelude of 1799 is presenting a poetic voice of education through nature that goes beyond nature. This essay considers the cycles and developments in the poem under the four themes of Unity; Impression; ...Wordsworth's Prelude of 1799 is presenting a poetic voice of education through nature that goes beyond nature. This essay considers the cycles and developments in the poem under the four themes of Unity; Impression; Time, Age and Season; Revolution.展开更多
The article concerns the commission that was made by the Biennale di Venezia to Stravinsky in the 50s' which led to the composition of the Canticum Sacrum. The discovery of the correspondence between the composer, th...The article concerns the commission that was made by the Biennale di Venezia to Stravinsky in the 50s' which led to the composition of the Canticum Sacrum. The discovery of the correspondence between the composer, the artistic director Alessandro Piovesan and the organizers of the Venetian Festival allows to reconstruct the events that led Stravinsky to change his initial plans for a Passion selon Saint Marc in favour of a short Canticum. The objections, which concerned above all the limited size of the piece, were repeated several times by Piovesan, but were all disregarded by Stravinsky. In the light of the eight letters deposited in the Archivio Storico delle Arti Contemporanee (ASAC) of Venice (in Appendix), the circumstances bringing about Stravinsky's refusal can be fully understood. The references to recent studies by David H. Smyth, Akane Mori, and Jonathan Kramer regarding the identification of palindromic and proportional structures in the Canticum, offers further proof sustaining Stravinsky's declaration that to enlarge the piece would have been impossible. These events confirm the composer's unbending determination to undertake a new experimental stylistic direction already tried out in pieces like the Three Songs from William Shakespeare and Agon.展开更多
This research deals with an evaluation of the sink of greenhouse gas CO2 in a eutrophic area of the Venetian lagoon where fish is farmed ("Valle da pesca"). Following CDM UNFCCC (Clean Development Mechanism Unite...This research deals with an evaluation of the sink of greenhouse gas CO2 in a eutrophic area of the Venetian lagoon where fish is farmed ("Valle da pesca"). Following CDM UNFCCC (Clean Development Mechanism United Nations Framework Convention on Climate Change) criteria, this can be considered relevant to the international standard for the voluntary evaluation of carbon credits on the basis of Annex a of Kyoto Protocol. To identify the "Valle da pesca" brackish lagoon properties regulating the carbon dioxide (CO2), a survey has been performed during three seasons in one year and in four different locations. These places are located in the Italian Venetian Lagoon and in the Grado Lagoon in North Italy, Europe. To identify the CO2 sink capacity, a special index is calculated. The CO2 concentrations and sink are regulated by the balance of autotrophic and heterotrophic activities, and the sediment anoxic denitrification and macro algae are crucial tank of CO2 in the valley shallow waters. The ponds potential-CO2 yield of 80-124 kg/m2 per year and the value are related and proportional to the correct human environmental control (water flux control).展开更多
基金Supported by the National Natural Science Foundation of China(71273264)the Fundamental Research Funds for the Central Welfare Scientific Research Institutes of China(2015-14)~~
文摘In view of the difficulty in determining remaining useful life of plant new variety right in economic analysis, Weibull Survival Analysis Method and Gaussian Model to were used to study how to accurately estimate the remaining useful life of plant new variety right. The results showed that the average life of the granted rice varieties was 10.013 years. With the increase of the age of plant variety rights, the probability of the same residual life Ttreaching x was smaller and smaller, the reliability lower and lower, while the probability of the variety rights becoming invalid became greater. The remaining useful life of a specific granted rice variety was closely related to the demonstration promotion age when the granted rice variety reached its maximum area and the appearance of alternative varieties, and when the demonstration promotion age of the granted rice variety reaching the one with the maximum area, the promotion area would be decreased once a new alternative variety appeared, correspondingly with the shortening of the remaining useful life of the variety. Therefore, Weibull Survival Analysis Method and Gaussian Model could describe the remaining useful life's time trend, as well as determine the remaining useful life of a concrete plant variety right, clarify the entire life time of varieties rights, and make the economic analysis of plant new varieties rights more accurate and reasonable.
基金Supported by a Grant From the Yen Tjing-Ling Medical Foundation
文摘AIM:To evaluate the correlations of plasma von Willebrand factor (vWF) level with the distant metastasis and prognosis of patients with colorectal cancer. METHODS: A total of 86 patients with historically confirmed metastatic colorectal cancers receiving treatment at Taipei Veterans General Hospital were enrolled. All patients had measurable metastatic lesions and life expectancies of more than 3 mo. Plasma vWF levels were measured by immuno-turbidimetric assay and compared with results from 40 non-metastatic colorectal cancer patients and 22 healthy controls. Patients with metastatic colorectal cancer were divided into two groups according to serum vWF levels and the differences between these two groups were analyzed using X2 test. Data on age, gender, performance status, location of primary tumor, extent of metastasis, site of metastases, histological differentiation, serum CEA and plasma vWF levels were analyzed to determine association with survival. Survival curves were constructed by Kaplan-Meier product limit method and the data was analyzed using log-rank test on a microcomputer. Multivariate analysis using the Cox's proportional hazards regression model was then performed to determine the independent prognostic indicators among all of the possible variables. RESULTS: Colorectal cancer patients were identified as having significantly higher plasma vWF concentrations than healthy controls (P<0.05). Moreover, higher vWF plasma levels were associated with advanced tumor stage (P<0.05) and the presence of multiple metastases (P=0.014). Patients with lower vWF plasma levels (≤160%) survived significantly longer than those with a higher plasma vWF level (log-rank test, P= 0.0043). By multivariate analysis, plasma vWF levels (P<0.001), the extent of metastasis (P= 0.012), and the performance status (P=0.014) were identified as independent prognostic factors. CONCLUSION: Our data indicates that high plasma vWF concentrations correlate with advanced diseases and significantly poor prognosis of patients with metastatic colorectal carcinoma. It may serve as a potential biological marker of disease progression in these patients.
文摘Joyce began his literary career with strong discontent with his social condition. Ulysses is Joyce's optimum work, which takes 3 Dublin characters' experience in one day as the main line to show the paralysation and crisis of the whole Western society, people's emptiness on their minds, loneliness on their feelings and labefaction on their spirits, also, it showed the inextricable perplexity. To treat the theme of inextricable perplexity, this paper is trying to set about the inextricable Catholic Church and identity problems, with the ideas of Alick West-the outstanding English Marxist literary critic of the 20th century.
文摘AIM: To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs (NSAIDs) or statins and colorectal cancer risk.METHODS: In a population-based case-control study in women, we examined the association between NSAIDs and statin use and the risk of colorectal cancers. We further investigated whether the use of statins modifies the protective effect of NSAIDs. Female cases (n = 669)of colorectal cancer aged 50-74 years were identified from a storewide registry in Wisconsin during 1999-2001. Community control women (n = 1375) were randomly selected from lists of licensed drivers and Medicare beneficiaries. Medication use and risk factor information were gathered during a structured telephone interview. A multivariable logistic regression model was used to calculate odds ratio (OR) and 95% confidence interval (CI).RESULTS: Overall, NSAIDs users had a 30% reduction in risk of colorectal cancer (95% CI: 0.56-0.88). Statin use was not associated with colorectal cancer risk (OR = 1.17, 95% CI: 0.74-1.85), regardless of structural type (lipophilic or hydrophilic), duration of use, or recency. There was no evidence of an interaction between NSAIDs and statins and colorectal cancer risk (P-interaction = 0.28).CONCLUSION: Although our results confirm the inverse association between NSAIDs use and colorectal cancer risk, they do not support a risk reduction in statin users, or an interaction effect of combined NSAIDs and statin use.
基金Supported by Instituto de Salud Carlos III(ISCIII)through the FIS project PI12/0056,co-funded by FEDER from Regional Development European Funds(European Union)
文摘To compare liver proteolysis and proteasome activation in steatotic liver grafts conserved in University of Wisconsin (UW) and Institut Georges Lopez-1 (IGL-1) solutions.METHODSFatty liver grafts from male obese Zücker rats were conserved in UW and IGL-1 solutions for 24 h at 4 °Cand subjected to “ex vivo” normo-thermic perfusion (2 h; 37 °C). Liver proteolysis in tissue specimens and perfusate was measured by reverse-phase high performance liquid chromatography. Total free amino acid release was correlated with the activation of the ubiquitin proteasome system (UPS: measured as chymotryptic-like activity and 20S and 19S proteasome), the prevention of liver injury (transaminases), mitochondrial injury (confocal microscopy) and inflammation markers (TNF 1 alpha, high mobility group box-1 (HGMB-1) and PPAR gamma), and liver apoptosis (TUNEL assay, cytochrome c and caspase 3).RESULTSProfiles of free AA (alanine, proline, leucine, isoleucine, methionine, lysine, ornithine, and threonine, among others) were similar for tissue and reperfusion effluent. In all cases, the IGL-1 solution showed a significantly higher prevention of proteolysis than UW (P < 0.05) after cold ischemia reperfusion. Livers conserved in IGL-1 presented more effective prevention of ATP-breakdown and more inhibition of UPS activity (measured as chymotryptic-like activity). In addition, the prevention of liver proteolysis and UPS activation correlated with the prevention of liver injury (AST/ALT) and mitochondrial damage (revealed by confocal microscopy findings) as well as with the prevention of inflammatory markers (TNF1alpha and HMGB) after reperfusion. In addition, the liver grafts preserved in IGL-1 showed a significant decrease in liver apoptosis, as shown by TUNEL assay and the reduction of cytochrome c, caspase 3 and P62 levels.CONCLUSIONOur comparison of these two preservation solutions suggests that IGL-1 helps to prevent ATP breakdown more effectively than UW and subsequently achieves a higher UPS inhibition and reduced liver proteolysis.
文摘This study assesses vulnerability of agriculture to drought, using WINISAREG model and seasonal SPI2-index for eight climate regions (1951-2004). Results relative to Plovdiv show that in soils of large TAW (total available water) net irrigation requirements NIRs range from 0 to 380 mm. In soils of small TAW, NIRs reach 440 mm in the very dry year. NIRs in Sofia/Silistra are about 100 mm smaller than in Plovdiv while in Sandanski they are 30-110 mm larger. Rainfed maize is associated with great yield variability (29% 〈 Cv 〈 72%). Considering an economical RYD (relative yield decrease) threshold, 32% of years are risky when TA Wis large in Plovdiv that is double than in Sofia and half than in Sandanski. In North Bulgaria the risky years are 10% in Pleven/Silistra that is half than in Lom. In Plovdiv region reliable relationships (R2 〉 91%) were found relating the SPI2 "July-Aug." with simulated RYD of rainfed maize while remaining relationships were less accurate (73% 〈 R2 〈 86%). Economical losses are produced when High Peak Season SPI2 〈 + 0.20 in Sandanski, SPI2 〈 - 0.50 in Plovdiv and SPI2 〈 - 0.90 in Sofia. In North Bulgaria the SPI2 threshold ranges from - 0.75 to - 1.50. Derived reliable relationships and SPl-thresholds are used for drought vulnerability mapping.
文摘Wordsworth's Prelude of 1799 is presenting a poetic voice of education through nature that goes beyond nature. This essay considers the cycles and developments in the poem under the four themes of Unity; Impression; Time, Age and Season; Revolution.
文摘The article concerns the commission that was made by the Biennale di Venezia to Stravinsky in the 50s' which led to the composition of the Canticum Sacrum. The discovery of the correspondence between the composer, the artistic director Alessandro Piovesan and the organizers of the Venetian Festival allows to reconstruct the events that led Stravinsky to change his initial plans for a Passion selon Saint Marc in favour of a short Canticum. The objections, which concerned above all the limited size of the piece, were repeated several times by Piovesan, but were all disregarded by Stravinsky. In the light of the eight letters deposited in the Archivio Storico delle Arti Contemporanee (ASAC) of Venice (in Appendix), the circumstances bringing about Stravinsky's refusal can be fully understood. The references to recent studies by David H. Smyth, Akane Mori, and Jonathan Kramer regarding the identification of palindromic and proportional structures in the Canticum, offers further proof sustaining Stravinsky's declaration that to enlarge the piece would have been impossible. These events confirm the composer's unbending determination to undertake a new experimental stylistic direction already tried out in pieces like the Three Songs from William Shakespeare and Agon.
文摘This research deals with an evaluation of the sink of greenhouse gas CO2 in a eutrophic area of the Venetian lagoon where fish is farmed ("Valle da pesca"). Following CDM UNFCCC (Clean Development Mechanism United Nations Framework Convention on Climate Change) criteria, this can be considered relevant to the international standard for the voluntary evaluation of carbon credits on the basis of Annex a of Kyoto Protocol. To identify the "Valle da pesca" brackish lagoon properties regulating the carbon dioxide (CO2), a survey has been performed during three seasons in one year and in four different locations. These places are located in the Italian Venetian Lagoon and in the Grado Lagoon in North Italy, Europe. To identify the CO2 sink capacity, a special index is calculated. The CO2 concentrations and sink are regulated by the balance of autotrophic and heterotrophic activities, and the sediment anoxic denitrification and macro algae are crucial tank of CO2 in the valley shallow waters. The ponds potential-CO2 yield of 80-124 kg/m2 per year and the value are related and proportional to the correct human environmental control (water flux control).