In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known t...In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known that the clinical features of metabolic diseases can manifest themselves with very different characteristics and escape early detection. Also, it is well known that the prognosis of many metabolic diseases is excellent if diagnosed and treated early. In this editorial we briefly summarized two groups of inherited metabolic diseases, the defects of cholesterol biosynthesis and those of bile acids. Both groups show variable clinical manifestations but some clinical signs and symptoms are common in both the defects of cholesterol and bile acids. The differential diagnosis can be made analyzing sterol profiles in blood and/or bile acids in blood and urine by chromatographic techniques(GC-MS and LC-MS/MS). Several defects of both biosynthetic pathways are treatable so early diagnosis is crucial. Unfortunately their diagnosis is made too late, due either to the clinical heterogeneity of the syndromes(severe, mild and very mild) that to the scarcity of scientific dissemination of these rare diseases. Therefore, the delay in diagnosis leads the patient to the medical observation when the disease has produced irreversible damages to the body. Here, we highlighted simple clinical and laboratory descriptions that can potentially make you to suspect a defect in cholesterol biosynthesis and/or bile acids, as well, we suggest appropriate request of the laboratory tests that along with common clinical features can help to diagnose these defects.展开更多
Industrial cluster has become an important part of regional economy,which status of global industry value chain is critical in the future, Innovation-based Cluster is the industrial cluster theory research at home and...Industrial cluster has become an important part of regional economy,which status of global industry value chain is critical in the future, Innovation-based Cluster is the industrial cluster theory research at home and abroad made to deepen the difference between the lower part of the Industrial cluster. Promoting innovative industrial cluster formation not only is one of the important means and carrier to cultivate strategic emerging industries, but also an important booster construction of national innovation system. According to the connotation,evolution process and characteristics of the Innovation-based Cluster, This paper from the perspective of three to analysis Innovation-based Clusters＇ innovative influence factors to find reasonable explanation to the creative industry cluster formation and more in-depth research.展开更多
文摘In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known that the clinical features of metabolic diseases can manifest themselves with very different characteristics and escape early detection. Also, it is well known that the prognosis of many metabolic diseases is excellent if diagnosed and treated early. In this editorial we briefly summarized two groups of inherited metabolic diseases, the defects of cholesterol biosynthesis and those of bile acids. Both groups show variable clinical manifestations but some clinical signs and symptoms are common in both the defects of cholesterol and bile acids. The differential diagnosis can be made analyzing sterol profiles in blood and/or bile acids in blood and urine by chromatographic techniques(GC-MS and LC-MS/MS). Several defects of both biosynthetic pathways are treatable so early diagnosis is crucial. Unfortunately their diagnosis is made too late, due either to the clinical heterogeneity of the syndromes(severe, mild and very mild) that to the scarcity of scientific dissemination of these rare diseases. Therefore, the delay in diagnosis leads the patient to the medical observation when the disease has produced irreversible damages to the body. Here, we highlighted simple clinical and laboratory descriptions that can potentially make you to suspect a defect in cholesterol biosynthesis and/or bile acids, as well, we suggest appropriate request of the laboratory tests that along with common clinical features can help to diagnose these defects.
文摘Industrial cluster has become an important part of regional economy,which status of global industry value chain is critical in the future, Innovation-based Cluster is the industrial cluster theory research at home and abroad made to deepen the difference between the lower part of the Industrial cluster. Promoting innovative industrial cluster formation not only is one of the important means and carrier to cultivate strategic emerging industries, but also an important booster construction of national innovation system. According to the connotation,evolution process and characteristics of the Innovation-based Cluster, This paper from the perspective of three to analysis Innovation-based Clusters＇ innovative influence factors to find reasonable explanation to the creative industry cluster formation and more in-depth research.
