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甘草及甘草酸类成分抗病毒性肺炎的药理作用研究进展 被引量:54
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作者 张明发 沈雅琴 《药物评价研究》 CAS 2020年第7期1452-1468,共17页
甘草及甘草酸类成分有抗冠状病毒、流感病毒、呼吸道合胞病毒和人巨细胞病毒等呼吸道病毒的作用,其机制可能与抑制病毒的蛋白合成,导致病毒复制受阻;改善免疫调控,上调一氧化氮表达,抑制血小板聚集,抑制炎症反应,保护宿主有关。甘草及... 甘草及甘草酸类成分有抗冠状病毒、流感病毒、呼吸道合胞病毒和人巨细胞病毒等呼吸道病毒的作用,其机制可能与抑制病毒的蛋白合成,导致病毒复制受阻;改善免疫调控,上调一氧化氮表达,抑制血小板聚集,抑制炎症反应,保护宿主有关。甘草及甘草酸类成分有止咳祛痰、平喘及肺保护和抗肺纤维化作用,其机制可能是通过上调过氧化物酶体增殖激活受体-γ(PPARγ)、血管紧张素转化酶2(ACE2)和IκB-α的表达,阻滞ERK/NF-κB信号通路,又能与高迁移率属蛋白B1(HMGB1)结合直接抑制HMGB1的化学趋化和促有丝分裂的活性,抑制炎性细胞因子表达、杯状细胞增生和黏蛋白过表达,以及上调水通道蛋白表达,减轻炎症反应;通过阻滞TLR-4/MyD88/NF-κB信号通路保护肺上皮细胞;通过阻滞IL-17/TGFβ1/Smad信号通路,抑制胶原合成和成纤维细胞增生,减轻肺纤维化形成;也可通过上调Smad7的表达,抑制气道重塑,改善肺功能。 展开更多
关键词 甘草 甘草酸 新冠病毒性肺炎 肺炎 哮喘 止咳祛痰
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苦参碱和氧化苦参碱对泌尿系统肿瘤的药理作用研究进展 被引量:4
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作者 张明发 沈雅琴 《抗感染药学》 2020年第10期1399-1404,共6页
苦参碱能抑制人肾癌ACHN细胞移植瘤在裸鼠体内生长,也能防治N-丁基-N-(4-羟丁基)亚硝基胺(BBN)诱发的大鼠膀胱癌。体外实验发现苦参碱也能与其浓度相关地抑制人肾癌ACHN细胞、GRC-1细胞、7860细胞、SK-NEP-1细胞、人膀胱癌T24细胞、T24/... 苦参碱能抑制人肾癌ACHN细胞移植瘤在裸鼠体内生长,也能防治N-丁基-N-(4-羟丁基)亚硝基胺(BBN)诱发的大鼠膀胱癌。体外实验发现苦参碱也能与其浓度相关地抑制人肾癌ACHN细胞、GRC-1细胞、7860细胞、SK-NEP-1细胞、人膀胱癌T24细胞、T24/ADM细胞、BIU-87细胞、BIU-87/ADM细胞、EJ细胞、人前列腺癌PC-3细胞、PC-3M细胞、LNCaP细胞和Du-145细胞的增殖并诱导凋亡。苦参碱还能增强顺铂抗SK-NEP-1细胞和阿霉素抗耐药T24/ADM细胞、BIU-87/ADM细胞的作用。氧化苦参碱也能抑制7860细胞、T24细胞、PC-3细胞增殖。本文中综述苦参碱和氧化苦参碱抗泌尿系统肿瘤的药理作用文献,并对其研究进展做了分析;还建议将其用于新冠病毒性肺炎(COVID-19)的治疗。 展开更多
关键词 苦参碱 氧化苦参碱 肾癌 膀胱癌 前列腺癌 新冠病毒性肺炎
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槐定碱和氧化槐定碱及拉马宁碱的药动学研究进展 被引量:3
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作者 张明发 沈雅琴 《抗感染药学》 2020年第6期777-781,共5页
槐定碱、氧化槐定碱和拉马宁碱均属苦参碱类生物碱。苦参碱类生物碱具有广泛的生物活性,如保护心、肝、肺、肾、脑、血管的作用,对心脏有正性肌力、负性频率、抗心律失常的作用,还有升高白细胞、平喘、抗溃疡、抗肝纤维化,以及镇静、催... 槐定碱、氧化槐定碱和拉马宁碱均属苦参碱类生物碱。苦参碱类生物碱具有广泛的生物活性,如保护心、肝、肺、肾、脑、血管的作用,对心脏有正性肌力、负性频率、抗心律失常的作用,还有升高白细胞、平喘、抗溃疡、抗肝纤维化,以及镇静、催眠、镇痛等中枢神经药理的作用,也具有抗肿瘤、免疫调节、抗菌、抗病毒、抗炎等药理作用。文中综述槐定碱、氧化槐定碱和拉马宁碱的药动学参数、体内过程文献,分析其药动学研究进展,为合理用药提供参考。并推荐将槐定碱用于新冠病毒性肺炎(COVID-19)的治疗。 展开更多
关键词 槐定碱 氧化槐定碱 拉马宁碱 药动学 药理作用 新冠病毒性肺炎
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Resilience of nurses at the epicenter of the COVID-19 pandemic in Lebanon 被引量:2
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作者 Mohamad Alameddine Karen Bou-Karroum +1 位作者 Wahida Ghalayini Firas Abiad 《International Journal of Nursing Sciences》 CSCD 2021年第4期432-438,I0005,共8页
Objective:The study aimed to investigate the level and factors associated with the resilience of nurses practicing at the main COVID-19 referral center in Lebanon.Methods:The study utilized a cross-sectional survey de... Objective:The study aimed to investigate the level and factors associated with the resilience of nurses practicing at the main COVID-19 referral center in Lebanon.Methods:The study utilized a cross-sectional survey design.Data were collected electronically in the spring of 2020 from 265 nurses.The questionnaire included five sections:demographic characteristics,job satisfaction,turnover intentions,exposure to violence,and resilience levels.Multiple linear regression was used to determine factors associated with resilience.Results:Results showed that the overall score of resilience among nurses was 66.91±13.34.Most nurses were satisfied with their job(67.8%),and most nurses reported that it is unlikely for them to quit their present work in the coming year(76.2%).Over the last year,three-quarters of nurses(74.7%)reported being ever exposed to a form of occupational violence.The resilience of nurses was directly associated with job satisfaction and male gender and inversely associated with intention-to-quit and exposure to violence(P<0.05).Conclusions:Enhancing the resilience of nurses at the frontline of the COVID-19 pandemic improves their job satisfaction and retention and would help support the effectiveness and efficiency of care services.Nurse managers can regularly investigate the resilience of nurses and offer interventions that would strengthen it,especially at times of crisis. 展开更多
关键词 COVID-19 Lebanon Nurses PSYCHOLOGICAL RESILIENCE
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Network pharmacology and molecular docking analysis on molecular targets and mechanism prediction of Huanglian Jiedu Decoction in the treatment of COVID-19
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作者 XU Xinyi LIU Leping +3 位作者 CAO Xueshuai LONG Xi PENG Sujuan ZHANG Guomin 《Digital Chinese Medicine》 2022年第1期18-32,共15页
Objective To investigate and predict the molecular targets and mechanism of Huanglian Jiedu Decoction(黄连解毒汤,HLJDD)in the treatment of Corona Virus Disease 2019(COV-ID-19)through network pharmacology and molecular... Objective To investigate and predict the molecular targets and mechanism of Huanglian Jiedu Decoction(黄连解毒汤,HLJDD)in the treatment of Corona Virus Disease 2019(COV-ID-19)through network pharmacology and molecular docking analysis.Methods The chemical constituents and action targets of HLJDD were retrieved on Tradi-tional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),SymMap v2,Encyclopedia of Traditional Chinese Medicine(ETCM),a High-throughput Ex-periment-and Reference-guided Database of Traditional Chinese Medicine(HERB),and Tra-ditional Chinese Medicine Integrated Database(TCMID).UniProt and GeneCards were used to query the target genes that corresponding to the active compounds,and then a compound-target network was constructed using Cytoscape 3.7.2.Gene Ontology(GO)database was used to annotate GO functions.Kyoto Encyclopedia of Genes and Genomes(KEGG)was used to predict the possible mechanisms of active compounds.The Database for Annotation,Visu-alization and Integrated Discovery(DAVID)was used to analysis the tissue enrichment.The main active compounds in HLJDD are molecularly docked with their corresponding related targets.Results Seventy-six compounds were screened and 458 corresponding targets in the network were obtained.Gene annotation showed that the targets were involved mainly in 1953 biolo-gical processes.884 signaling pathways was enriched,involving signaling by interleukins,cy-tokine signaling in immune system,generic transcription pathway,and RNA polymerase II transcription.The targets mainly distributed in the lung,liver,and placenta,involving a vari-ety of immune cells,such as T cells and B cells.The molecular docking results showed that core compounds such as wogonin,berberine,and baicalein had high affinity with tumor nec-rosis factor(TNF),insulin(INS),and tumor protein 53(TP53).Conclusion The active compounds in HLJDD may have a therapeutic effect on COVID-19 through regulating multiple signal pathways by targeting genes such as vascular endothelial growth factor A(VEGFA),INS,interleukin-6(IL-6),TNF,caspase-3,TP53,and mitogen-activ-ated protein kinase 3(MAPK3). 展开更多
关键词 Huanglian Jiedu Decoction(黄连解毒汤 HLJDD) Active compounds Corona Virus Disease 2019(COVID-19) Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) Network pharmacology Molecular docking
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Weathering the storm:COVID-19 infection in patients with hematological malignancies 被引量:1
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作者 Lin-qin WANG Elaine TAN SU YIN +3 位作者 Guo-qing WEI Yong-xian HU Arnon NAGLER He HUANG 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2020年第12期921-939,共19页
The coronavirus disease 2019(COVID-19)is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Within a matter of months,this highly contagious novel virus has led to a g... The coronavirus disease 2019(COVID-19)is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Within a matter of months,this highly contagious novel virus has led to a global outbreak and is still spreading rapidly across continents.In patients with COVID-19,underlying chronic diseases and comorbidities are associated with dismal treatment outcomes.Owing to their immunosuppressive status,patients with hematological malignancies(HMs)are at an increased risk of infection and have a worse prognosis than patients without HMs.Accordingly,intensive attention should be paid to this cohort.In this review,we summarize and analyze specific clinical manifestations for patients with coexisting COVID-19 and HMs.Furthermore,we briefly de-scribe customized management strategies and interventions for this susceptible cohort.This review is intended to guide clinical practice. 展开更多
关键词 Coronavirus disease 2019(COVID-19) Hematological malignancies Immunosuppressive status Management strategies Treatment regimen
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