We investigated the long-lasting effects of early postnatal tactile stimulation （TS） and maternal separation （MS） on the emotional behaviors of adult female rats. A split-litter design was introduced to remove con...We investigated the long-lasting effects of early postnatal tactile stimulation （TS） and maternal separation （MS） on the emotional behaviors of adult female rats. A split-litter design was introduced to remove confusing factors such as maternal disturbance. Pups of the non-tactile stimulation （NTS） group did not receive any handling. Pups subjected to the TS treatment were handled and marked for approximately 30 s daily from postnatal days （PND） 2 - 9 or from PND 10 - 17. Pups subjected to the MS treatment were handled and marked in the same way as the TS pups and then individually placed in a cup with familiar nest bedding for 1 h daily. At the age of 3 months, female rats with different neonatal experiences were employed in the light/dark box test and the one-trial passive avoidance response. Both PND 2 - 9 TS and PND 10 - 17 TS groups exhibited more time spent in the illuminated chamber of the light/dark box, and longer step-through latencies in the passive avoidance response when compared to the NTS group, indicating that early life TS treatment reduced novelty-induced anxious emotion and facilitated the retention of emotional memory in adult female rats. No significant effects were found on any behavioral measures between the MS groups and the TS groups, suggesting that neonatal short-time MS treatment was not intensive enough to alter the emotional behaviors, at least in female rats. Infantile age was not an effective factor for these measures. This result supports the hypothesis that neonatal tactile stimulation and maternal separation lead to different effects on the neural development of postnatal pups.展开更多
Previous studies carried out in the East China Sea （ECS） mud area focused on long-term environmental changes in sedimentary records during the Holoeene, especially during the mid-Holocene high-stand water levels per...Previous studies carried out in the East China Sea （ECS） mud area focused on long-term environmental changes in sedimentary records during the Holoeene, especially during the mid-Holocene high-stand water levels period. These results indicate that sensitive grain size groups can be used as a sedimentary proxy to reconstruct the evolution of the East Asian Winter Monsoon （EAWM）. The studies have been carried out mainly in the northern and middle portions of the Zhejiang-Fujian coastal mud, however, similar research in the southern portion and the comparison between sedimentary proxy and modern measured data of EAWM are lacking. In this paper, we focused on a sedimentary record of the past 100 years with an enhanced resolution of 1.8 years. Investigations of the southern end of the Zhejiang-Fujian coastal mud area were conducted on the basis of 21~Pb chronology, grain-size analysis and chemical element analysis. The correspondence between the mean grain size （Mz） of sediment sensitive grain size and the measured EAWM was confirmed for the first time. We found that during the recent 100 years, the variation of the mean grain size of the sensitive population in the southern portion of the Zhejiang-Fujian mud was mainly controlled by the EAWM intensity changes; and not directly related to changes in the sediment discharge from Datong station of the Changjiang River （DTSD）. Finally, recent changes in the content of heavy metals in study area reflect the impact of human activities on the environment.展开更多
A 350-cm-long sediment core sequence from Dahu Swamp situated in the eastern Nanling Mountains was selected for high-resolution paleoclimatic reconstruction since the Late Glacial period. The multi-proxy records of th...A 350-cm-long sediment core sequence from Dahu Swamp situated in the eastern Nanling Mountains was selected for high-resolution paleoclimatic reconstruction since the Late Glacial period. The multi-proxy records of this paper reveal several evidently dry and cold events that may coincide with the Oldest Dryas, the Older Dryas, the Younger Dryas in the late deglacial period. Two relatively wetter and warmer phases occurred in ca. 15,000-14,400 cal yr B.P. and 13,500-12,800 cal yr B.P. respectively may correspond to the Boiling and Allerod warming events. The Younger Dryas event （ca. 12,800-11,500 cal yr B.P.） revealed by multi-proxies was characterized by relatively colder and drier climate. A warmer and wetter climate, occurred in ca. 10,000~5000 cal yr B.P., was consistent with the Holoeene Optimum, which coincided with the maximum Northern Hemisphere insolation. The ＂8.2kyr cool event＂ and even the ＂8.8kyr cool event＂ were indicated as well from our sediment core. A dry mid-Holocene period （ca. 60000 3000 cal yr B.P.） indicated by multi-proxies does not follow the traditional concept of the wet mid-Holocene conditions observed in other regions in China.展开更多
Objective.This study aimed to compare the accuracy of rectal cancer restaging after neoadjuvant therapy with 3D CUBE sequence with 2D T2-weighted fast spin-echo(FSE)sequence.Methods.This retrospective study comprised ...Objective.This study aimed to compare the accuracy of rectal cancer restaging after neoadjuvant therapy with 3D CUBE sequence with 2D T2-weighted fast spin-echo(FSE)sequence.Methods.This retrospective study comprised 72 patients with rectal cancer confirmed by colonoscopy and biopsy.After neoadjuvant therapy,all patients underwent pelvic magnetic resonance imaging(MRI)examination at 1.5T MRI sequences including a single coronal 3D CUBE T2-weighted FSE sequence with 1.4mmthickness and a 2D T2-weighted FSE sequence in the sagittal,coronal and axial planes with 5mmthickness.The total acquisition time of the two sequences was recorded.Results were compared with postsurgical pathology(gold standard).The diagnostic accuracy was evaluated;and receiver operating characteristic(ROC)curves and the area under the curves(AUC)were calculated.Results.The T category staging accuracy of 3D T2WI and 2D T2WI was 81.9% and 72.2%,respectively,for reviewer 1 and 86.1% and 75.0% for reviewer 2.The AUC of 3D was higher than that of 2D(0.878 vs.0.783 for reader 1 and 0.905 vs.0.796 for reader 2;both P<0.05)when judging whether the tumor broke through themuscle layer.There was no significant difference between 3D and 2D in judging whether lymph nodes weremalignant(AUC 0.719 vs.0.698 for reader 1 and 0.740 vs.0.698 for reader 2;both P>0.05).There were no significant differences in the visibility of the rectal wall layer,tumor lesion and the overall image quality(all P>0.05).Compared with 2D sequences,the 3D sequence had shorter acquisition time and higher signal intensity ratio(both P<0.05).Conclusion.3D CUBE T2-weighted sequences offer better diagnostic accuracy in rectal cancer restaging after neoadjuvant therapy when compared with 2D T2-weighted FSE sequences;it has a shorter scanning time and more versatility of orientation reconstruction.展开更多
文摘We investigated the long-lasting effects of early postnatal tactile stimulation （TS） and maternal separation （MS） on the emotional behaviors of adult female rats. A split-litter design was introduced to remove confusing factors such as maternal disturbance. Pups of the non-tactile stimulation （NTS） group did not receive any handling. Pups subjected to the TS treatment were handled and marked for approximately 30 s daily from postnatal days （PND） 2 - 9 or from PND 10 - 17. Pups subjected to the MS treatment were handled and marked in the same way as the TS pups and then individually placed in a cup with familiar nest bedding for 1 h daily. At the age of 3 months, female rats with different neonatal experiences were employed in the light/dark box test and the one-trial passive avoidance response. Both PND 2 - 9 TS and PND 10 - 17 TS groups exhibited more time spent in the illuminated chamber of the light/dark box, and longer step-through latencies in the passive avoidance response when compared to the NTS group, indicating that early life TS treatment reduced novelty-induced anxious emotion and facilitated the retention of emotional memory in adult female rats. No significant effects were found on any behavioral measures between the MS groups and the TS groups, suggesting that neonatal short-time MS treatment was not intensive enough to alter the emotional behaviors, at least in female rats. Infantile age was not an effective factor for these measures. This result supports the hypothesis that neonatal tactile stimulation and maternal separation lead to different effects on the neural development of postnatal pups.
基金Supported by the National Natural Science Foundation of China(No.41030856)the Taishan Scholar Project
文摘Previous studies carried out in the East China Sea （ECS） mud area focused on long-term environmental changes in sedimentary records during the Holoeene, especially during the mid-Holocene high-stand water levels period. These results indicate that sensitive grain size groups can be used as a sedimentary proxy to reconstruct the evolution of the East Asian Winter Monsoon （EAWM）. The studies have been carried out mainly in the northern and middle portions of the Zhejiang-Fujian coastal mud, however, similar research in the southern portion and the comparison between sedimentary proxy and modern measured data of EAWM are lacking. In this paper, we focused on a sedimentary record of the past 100 years with an enhanced resolution of 1.8 years. Investigations of the southern end of the Zhejiang-Fujian coastal mud area were conducted on the basis of 21~Pb chronology, grain-size analysis and chemical element analysis. The correspondence between the mean grain size （Mz） of sediment sensitive grain size and the measured EAWM was confirmed for the first time. We found that during the recent 100 years, the variation of the mean grain size of the sensitive population in the southern portion of the Zhejiang-Fujian mud was mainly controlled by the EAWM intensity changes; and not directly related to changes in the sediment discharge from Datong station of the Changjiang River （DTSD）. Finally, recent changes in the content of heavy metals in study area reflect the impact of human activities on the environment.
基金Under the auspices of National Natural Science Foundation of China (No. 40671189)Natural Science Foundation of Guangdong Province (No. 8151063101000044, 06025042)the Fok Ying Tung Education Foundation (No. 91021)
文摘A 350-cm-long sediment core sequence from Dahu Swamp situated in the eastern Nanling Mountains was selected for high-resolution paleoclimatic reconstruction since the Late Glacial period. The multi-proxy records of this paper reveal several evidently dry and cold events that may coincide with the Oldest Dryas, the Older Dryas, the Younger Dryas in the late deglacial period. Two relatively wetter and warmer phases occurred in ca. 15,000-14,400 cal yr B.P. and 13,500-12,800 cal yr B.P. respectively may correspond to the Boiling and Allerod warming events. The Younger Dryas event （ca. 12,800-11,500 cal yr B.P.） revealed by multi-proxies was characterized by relatively colder and drier climate. A warmer and wetter climate, occurred in ca. 10,000~5000 cal yr B.P., was consistent with the Holoeene Optimum, which coincided with the maximum Northern Hemisphere insolation. The ＂8.2kyr cool event＂ and even the ＂8.8kyr cool event＂ were indicated as well from our sediment core. A dry mid-Holocene period （ca. 60000 3000 cal yr B.P.） indicated by multi-proxies does not follow the traditional concept of the wet mid-Holocene conditions observed in other regions in China.
基金This study was supported by grants from the Guangdong Science and Technology Department of China(No.2015A030313109).
文摘Objective.This study aimed to compare the accuracy of rectal cancer restaging after neoadjuvant therapy with 3D CUBE sequence with 2D T2-weighted fast spin-echo(FSE)sequence.Methods.This retrospective study comprised 72 patients with rectal cancer confirmed by colonoscopy and biopsy.After neoadjuvant therapy,all patients underwent pelvic magnetic resonance imaging(MRI)examination at 1.5T MRI sequences including a single coronal 3D CUBE T2-weighted FSE sequence with 1.4mmthickness and a 2D T2-weighted FSE sequence in the sagittal,coronal and axial planes with 5mmthickness.The total acquisition time of the two sequences was recorded.Results were compared with postsurgical pathology(gold standard).The diagnostic accuracy was evaluated;and receiver operating characteristic(ROC)curves and the area under the curves(AUC)were calculated.Results.The T category staging accuracy of 3D T2WI and 2D T2WI was 81.9% and 72.2%,respectively,for reviewer 1 and 86.1% and 75.0% for reviewer 2.The AUC of 3D was higher than that of 2D(0.878 vs.0.783 for reader 1 and 0.905 vs.0.796 for reader 2;both P<0.05)when judging whether the tumor broke through themuscle layer.There was no significant difference between 3D and 2D in judging whether lymph nodes weremalignant(AUC 0.719 vs.0.698 for reader 1 and 0.740 vs.0.698 for reader 2;both P>0.05).There were no significant differences in the visibility of the rectal wall layer,tumor lesion and the overall image quality(all P>0.05).Compared with 2D sequences,the 3D sequence had shorter acquisition time and higher signal intensity ratio(both P<0.05).Conclusion.3D CUBE T2-weighted sequences offer better diagnostic accuracy in rectal cancer restaging after neoadjuvant therapy when compared with 2D T2-weighted FSE sequences;it has a shorter scanning time and more versatility of orientation reconstruction.
