Korean ＂picture brides＂ who migrated to Hawaii a century ago are reborn in stories through literary works produced in 21 st-century Korea and the USA. The literary value of picture bride stories is an important star...Korean ＂picture brides＂ who migrated to Hawaii a century ago are reborn in stories through literary works produced in 21 st-century Korea and the USA. The literary value of picture bride stories is an important starting point for raising awareness of the reality of Korean migration to the US a century ago and for understanding the status of the 20th-century Korean diaspora beyond national borders and cultural boundaries. This study aimed to investigate the historical background of picture brides in Hawaii in the early 20th century so as to research that the life of Korean picture brides was much harder than those of other Asian picture brides. The stories of picture brides, gleaned from various oral narratives, news articles, poems, plays, and novels, not only represent in great detail the patriarchal and nationalistic discourse prevalent in the period in the US on Korean and Asian picture brides, but also provide important details on these women＇s daily living, independent efforts to make new lives in Hawaii, and the transboundary hybrid culture that emerged as a result. The comparative-literary approach of the study also captures the value of the transnationalist thread in the literary works under study.展开更多
To explore the target of action of LHQW-XYS on the main components of COVID-19 olfactory impairment by using network pharmacological methods and try to reveal its mechanism of action in the treatment related to COVID-...To explore the target of action of LHQW-XYS on the main components of COVID-19 olfactory impairment by using network pharmacological methods and try to reveal its mechanism of action in the treatment related to COVID-19 induced olfactory impairment,we used the TCMSP platform to obtain potential active ingredients through oral utilization and drug-like properties screening;the Swiss TargetPrediction platform to predict the targets of the active ingredients and construct a drug-ingredient-target network,and then obtained the gene targets of COVID-19 olfactory injury through GeneCards,OMIM,and TTD platforms to intersect the drug targets and disease genes to obtain common targets.The drug targets and disease genes were intersected to obtain common targets.STRING and Cytoscape 3.8.2 software were used to construct the target-disease gene PPI network,screen the key targets and core gene clusters,and analyze the key targets by GO and KEGG enrichment analyses with the help of the Metascape platform,and then map the screened core active ingredients and their targets into the pathway to construct the core active ingredients-targets-pathway network.The core active ingredient-target-pathway network was constructed,and finally,molecular docking was carried out.The results showed that there were 4669 potential targets,5609 disease targets,and 17 drug-disease cross-targets for the active ingredients of LHQW-XYS.The GO and KEGG enrichment analyses indicated that the mechanism of LHQW-XYS in the treatment of olfactory impairment in COVID-19 may be due to the regulation of related signaling pathways,such as Serotonergic synapse and Regulation of lipolysis in adipocytes.Molecular docking showed that six active components(quercetin,luteolin,kaempferol,7-methoxy-2-methylisoflavone,wogonin,medicarpin)and two key genes(PTGS2,PPARG)had good binding properties.In the end,we conclude that LHQW-XYS may act on Serotonergic synapse and Regulation of lipolysis in adipocyte pathways to achieve anti-COVID-19 olfactory impairment-associated effects.展开更多
文摘Korean ＂picture brides＂ who migrated to Hawaii a century ago are reborn in stories through literary works produced in 21 st-century Korea and the USA. The literary value of picture bride stories is an important starting point for raising awareness of the reality of Korean migration to the US a century ago and for understanding the status of the 20th-century Korean diaspora beyond national borders and cultural boundaries. This study aimed to investigate the historical background of picture brides in Hawaii in the early 20th century so as to research that the life of Korean picture brides was much harder than those of other Asian picture brides. The stories of picture brides, gleaned from various oral narratives, news articles, poems, plays, and novels, not only represent in great detail the patriarchal and nationalistic discourse prevalent in the period in the US on Korean and Asian picture brides, but also provide important details on these women＇s daily living, independent efforts to make new lives in Hawaii, and the transboundary hybrid culture that emerged as a result. The comparative-literary approach of the study also captures the value of the transnationalist thread in the literary works under study.
基金National Natural Science Foundation of China General Project(Grant No.82374195).
文摘To explore the target of action of LHQW-XYS on the main components of COVID-19 olfactory impairment by using network pharmacological methods and try to reveal its mechanism of action in the treatment related to COVID-19 induced olfactory impairment,we used the TCMSP platform to obtain potential active ingredients through oral utilization and drug-like properties screening;the Swiss TargetPrediction platform to predict the targets of the active ingredients and construct a drug-ingredient-target network,and then obtained the gene targets of COVID-19 olfactory injury through GeneCards,OMIM,and TTD platforms to intersect the drug targets and disease genes to obtain common targets.The drug targets and disease genes were intersected to obtain common targets.STRING and Cytoscape 3.8.2 software were used to construct the target-disease gene PPI network,screen the key targets and core gene clusters,and analyze the key targets by GO and KEGG enrichment analyses with the help of the Metascape platform,and then map the screened core active ingredients and their targets into the pathway to construct the core active ingredients-targets-pathway network.The core active ingredient-target-pathway network was constructed,and finally,molecular docking was carried out.The results showed that there were 4669 potential targets,5609 disease targets,and 17 drug-disease cross-targets for the active ingredients of LHQW-XYS.The GO and KEGG enrichment analyses indicated that the mechanism of LHQW-XYS in the treatment of olfactory impairment in COVID-19 may be due to the regulation of related signaling pathways,such as Serotonergic synapse and Regulation of lipolysis in adipocytes.Molecular docking showed that six active components(quercetin,luteolin,kaempferol,7-methoxy-2-methylisoflavone,wogonin,medicarpin)and two key genes(PTGS2,PPARG)had good binding properties.In the end,we conclude that LHQW-XYS may act on Serotonergic synapse and Regulation of lipolysis in adipocyte pathways to achieve anti-COVID-19 olfactory impairment-associated effects.
