Objective:To analyze the component law of Chinese patent medicines for anti-influenza and develop new prescriptions for anti-influenza by unsupervised data mining methods. Methods: Chinese patent medicine recipes for ...Objective:To analyze the component law of Chinese patent medicines for anti-influenza and develop new prescriptions for anti-influenza by unsupervised data mining methods. Methods: Chinese patent medicine recipes for anti-influenza were collected and recorded in the database, and then the correlation coefficient between herbs, core combinations of herbs and new prescriptions were analyzed by using modified mutual information, complex system entropy cluster and unsupervised hierarchical clustering, respectively. Results: Based on analysis of 126 Chinese patent medicine recipes, the frequency of each herb occurrence in these recipes, 54 frequently-used herb pairs, 34 core combinations were determined, and 4 new recipes for influenza were developed. Conclusion: Unsupervised data mining methods are able to mine the component law quickly and develop new prescriptions.展开更多
Droplet impacting liquid surface is not only the extremely prevalent phenomenon in the nature and industrial production but also the extremely complicated problem of strong non-linear transient impact and free-surface...Droplet impacting liquid surface is not only the extremely prevalent phenomenon in the nature and industrial production but also the extremely complicated problem of strong non-linear transient impact and free-surface flow. On the basis of the two-dimensional viscous incompressible N-S equations, this paper conducts a study of numerical simulation on the problem of droplet impacting liquid surface （water beads） of water container in certain initial velocity by the method of SPH （smoothed particle hydrodynamics）. The effect of surface tension is considered between surface particles by searching the free surface particles in the course of study; the effect of initial impact has been solved by use of artificial viscosity; at the same time, the side-wall virtual particles and image virtual particles are both introduced to deal with the boundary condition, which has solved the boundary defects quite well and eliminated the instability of real particles dropped to the comer of container. The calculated results form the distribution chart of particles, flow field chart, pressure chart and the displacement and velocity variation curve of different particles. The comparison between simulated results and experimental photos shows that the simulation is effective. This paper compares the variational curves for fluctuations of liquid surface qualitatively through adopting the methods of level-set, BEM and SPH, respectively at last. The simulated results show that it will produce strong non-linear phenomena, such as the splash of liquid, discrete liquid surface, and strong wave of free liquid surface, when the droplet impacts liquid surface; in the course of impacting, the movement of liquid particles exhibits the characteristic of oscillation; the method of SPH has certain advantages of dealing with the large deformation problem of free surface.展开更多
基金supported by Scientific Research Special Project of TCM Profession (200907001E)Science and Technology Special Major Project for "Significant New Drugs Formulation" (2009ZX09301-005-02)
文摘Objective:To analyze the component law of Chinese patent medicines for anti-influenza and develop new prescriptions for anti-influenza by unsupervised data mining methods. Methods: Chinese patent medicine recipes for anti-influenza were collected and recorded in the database, and then the correlation coefficient between herbs, core combinations of herbs and new prescriptions were analyzed by using modified mutual information, complex system entropy cluster and unsupervised hierarchical clustering, respectively. Results: Based on analysis of 126 Chinese patent medicine recipes, the frequency of each herb occurrence in these recipes, 54 frequently-used herb pairs, 34 core combinations were determined, and 4 new recipes for influenza were developed. Conclusion: Unsupervised data mining methods are able to mine the component law quickly and develop new prescriptions.
基金supported by the National Natural Science Foundation of China (Grant Nos. 51079095, 51021004)
文摘Droplet impacting liquid surface is not only the extremely prevalent phenomenon in the nature and industrial production but also the extremely complicated problem of strong non-linear transient impact and free-surface flow. On the basis of the two-dimensional viscous incompressible N-S equations, this paper conducts a study of numerical simulation on the problem of droplet impacting liquid surface （water beads） of water container in certain initial velocity by the method of SPH （smoothed particle hydrodynamics）. The effect of surface tension is considered between surface particles by searching the free surface particles in the course of study; the effect of initial impact has been solved by use of artificial viscosity; at the same time, the side-wall virtual particles and image virtual particles are both introduced to deal with the boundary condition, which has solved the boundary defects quite well and eliminated the instability of real particles dropped to the comer of container. The calculated results form the distribution chart of particles, flow field chart, pressure chart and the displacement and velocity variation curve of different particles. The comparison between simulated results and experimental photos shows that the simulation is effective. This paper compares the variational curves for fluctuations of liquid surface qualitatively through adopting the methods of level-set, BEM and SPH, respectively at last. The simulated results show that it will produce strong non-linear phenomena, such as the splash of liquid, discrete liquid surface, and strong wave of free liquid surface, when the droplet impacts liquid surface; in the course of impacting, the movement of liquid particles exhibits the characteristic of oscillation; the method of SPH has certain advantages of dealing with the large deformation problem of free surface.
