The Turpan-Hami basin, rich in coal and petroleum, is a superimposed basin of three types basins in different tectonic environments. This coal, oil and gas basin has undergone a complex tectonic-sedimentary evolution,...The Turpan-Hami basin, rich in coal and petroleum, is a superimposed basin of three types basins in different tectonic environments. This coal, oil and gas basin has undergone a complex tectonic-sedimentary evolution, in which two important stages were the negative inversion from a foredeep to a extensional basin during Early Mesozoic and the positive inversion to a thrust foreland basin in Late MesozoicEarly Cenozoic. The early normal faults residues are recognized with the addition of tectonic-sedimentary analysis to confirm the basin extension during Jurassic time and its tectonic inversion subsequently.展开更多
In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known t...In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known that the clinical features of metabolic diseases can manifest themselves with very different characteristics and escape early detection. Also, it is well known that the prognosis of many metabolic diseases is excellent if diagnosed and treated early. In this editorial we briefly summarized two groups of inherited metabolic diseases, the defects of cholesterol biosynthesis and those of bile acids. Both groups show variable clinical manifestations but some clinical signs and symptoms are common in both the defects of cholesterol and bile acids. The differential diagnosis can be made analyzing sterol profiles in blood and/or bile acids in blood and urine by chromatographic techniques(GC-MS and LC-MS/MS). Several defects of both biosynthetic pathways are treatable so early diagnosis is crucial. Unfortunately their diagnosis is made too late, due either to the clinical heterogeneity of the syndromes(severe, mild and very mild) that to the scarcity of scientific dissemination of these rare diseases. Therefore, the delay in diagnosis leads the patient to the medical observation when the disease has produced irreversible damages to the body. Here, we highlighted simple clinical and laboratory descriptions that can potentially make you to suspect a defect in cholesterol biosynthesis and/or bile acids, as well, we suggest appropriate request of the laboratory tests that along with common clinical features can help to diagnose these defects.展开更多
文摘The Turpan-Hami basin, rich in coal and petroleum, is a superimposed basin of three types basins in different tectonic environments. This coal, oil and gas basin has undergone a complex tectonic-sedimentary evolution, in which two important stages were the negative inversion from a foredeep to a extensional basin during Early Mesozoic and the positive inversion to a thrust foreland basin in Late MesozoicEarly Cenozoic. The early normal faults residues are recognized with the addition of tectonic-sedimentary analysis to confirm the basin extension during Jurassic time and its tectonic inversion subsequently.
文摘In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known that the clinical features of metabolic diseases can manifest themselves with very different characteristics and escape early detection. Also, it is well known that the prognosis of many metabolic diseases is excellent if diagnosed and treated early. In this editorial we briefly summarized two groups of inherited metabolic diseases, the defects of cholesterol biosynthesis and those of bile acids. Both groups show variable clinical manifestations but some clinical signs and symptoms are common in both the defects of cholesterol and bile acids. The differential diagnosis can be made analyzing sterol profiles in blood and/or bile acids in blood and urine by chromatographic techniques(GC-MS and LC-MS/MS). Several defects of both biosynthetic pathways are treatable so early diagnosis is crucial. Unfortunately their diagnosis is made too late, due either to the clinical heterogeneity of the syndromes(severe, mild and very mild) that to the scarcity of scientific dissemination of these rare diseases. Therefore, the delay in diagnosis leads the patient to the medical observation when the disease has produced irreversible damages to the body. Here, we highlighted simple clinical and laboratory descriptions that can potentially make you to suspect a defect in cholesterol biosynthesis and/or bile acids, as well, we suggest appropriate request of the laboratory tests that along with common clinical features can help to diagnose these defects.
