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阿魏酸结构改造新化合物对大鼠高脂血症的影响及机制 被引量:8
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作者 唐祯 许军 +1 位作者 徐彭 黄洪林 《时珍国医国药》 CAS CSCD 北大核心 2013年第6期1369-1371,共3页
目的观察阿魏酸结构改造物(对氯苯氧异丁酸甲氧基苯丙烯酸酯,AZ)对大鼠高脂血症的影响并探讨其作用机制。方法将60只SD大鼠随机分为正常对照组、高脂模型组、AZ高、中、低剂量组和非诺贝特阳性对照组,后5组制备高脂血症模型,测定AZ对TC... 目的观察阿魏酸结构改造物(对氯苯氧异丁酸甲氧基苯丙烯酸酯,AZ)对大鼠高脂血症的影响并探讨其作用机制。方法将60只SD大鼠随机分为正常对照组、高脂模型组、AZ高、中、低剂量组和非诺贝特阳性对照组,后5组制备高脂血症模型,测定AZ对TC、TG、HDL-C、LDL-C、HL、LPL、SOD、MDA、CAT、HSL和LCAT的影响。结果 AZ各剂量组和非诺贝特组均可显著降低高脂血症大鼠的血清TC、TG和LDL-C水平,AZ高剂量组可提高HDL-C水平;AZ剂量药组均可提高HL、LPL、SOD、CAT、LCAT的活性,降低MDA的活性。结论表明AZ对高脂饲料所致大鼠高脂血症有显著治疗作用;其机制可能包括①清除自由基,提高抗氧化活性。②加速甘油三酯与胆固醇的水解与转移。 展开更多
关键词 阿魏酸 阿魏酸结构改造化合物 高脂血症 机制
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新型合成抗菌药物研究新进展 被引量:19
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作者 袁勇 周成合 +1 位作者 刘嫱 宋春泽 《中国新药杂志》 CAS CSCD 北大核心 2007年第5期343-350,共8页
抗菌药物的耐药性问题日益严重。耐甲氧西林的金葡球菌(MRSA)引起的感染用传统的药物如青霉素治疗已相当困难,从而导致了临床并发症和死亡的急剧增加。研发具有新作用机制或新作用靶点的新结构化合物是解决耐药性问题的热点和重点领域,... 抗菌药物的耐药性问题日益严重。耐甲氧西林的金葡球菌(MRSA)引起的感染用传统的药物如青霉素治疗已相当困难,从而导致了临床并发症和死亡的急剧增加。研发具有新作用机制或新作用靶点的新结构化合物是解决耐药性问题的热点和重点领域,近年来发展迅速。现综述近年作用于细菌的蛋白质、DNA,RNA,细胞壁和脂肪酸等新型合成抗菌化合物的研究进展。 展开更多
关键词 抗菌药物 构效关系 酶抑制剂 新结构化合物
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Unfolding Evolution Strategically in Integrated Studios of Building and Design to Innovative Grasp of Design Creativity
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作者 Didem Bas Yanarates 《Journal of Environmental Science and Engineering(A)》 2015年第12期665-674,共10页
In emergence of design, it is undoubted to be informed from nature for how things get done. But in architecture, the students are not used to start up with biological investigation. Instead of analogues, it is permitt... In emergence of design, it is undoubted to be informed from nature for how things get done. But in architecture, the students are not used to start up with biological investigation. Instead of analogues, it is permitted to pursue an evolvability systematics for built emerge. The systematics relies upon the key assumptions of Kirschner who sought the characteristics of biological evolution. For an integrated design thinking of an architectural mind, this is a methodological study, which strategically adapts living forms' evolvability capacity to built-forms' structural emergence. The study outlines the evolution strategy with experimental studios of building and design. The preceding systematic is taught in distinguished courses. It is purposed to build an easy-to-apply framework for how to generate novel structures and how the spatial structure units are organized to emerge with an imagined nature as novel tectonic model. Besides, building up structural thinking into the consilience of evolution strategy, the study is also distinguished for understanding the value system of architectural mind to diagnose the genuine character of inventive built form. Strategy constructs processes. Thinking strategy concludes by the evolvability directives of studio assignments and they are given as flow-charts and project models. 展开更多
关键词 CREATIVITY innovative design EVOLVABILITY building and design teaching.
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Are the well-fed less thirsty?Effects of drought and salinity on New Zealand mangroves 被引量:1
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作者 Sridevi Ravi Martin K-FBader +4 位作者 Tim Young Mark Duxbury Michael Clearwater Cate Macinnis-Ng Sebastian Leuzinger 《Journal of Plant Ecology》 SCIE CSCD 2022年第1期85-99,共15页
Despite a large number of studies examining the effects of abiotic stress factors on plants,the mechanistic explanations of drought-induced tree mortality remain inconclusive and even less is known about how multiple ... Despite a large number of studies examining the effects of abiotic stress factors on plants,the mechanistic explanations of drought-induced tree mortality remain inconclusive and even less is known about how multiple stressors interact.The role of non-structural carbohydrates(NSCs)in preventing or postponing drought mortality is gaining attention.Here,we tested the role of NSCs in mitigating the effects of drought and salinity in New Zealand mangroves,Avicennia marina subsp.australasica.We experimentally manipulated plant NSC levels,prior to subjecting them to combinations of drought and salinity.Plant growth and survival rates were 2-and 3-fold higher in the high-NSC(H-NSC)group than in the low-NSC(L-NSC)group under high salinity and drought conditions,respectively.After 12 weeks under high salinity-high drought conditions,the H-NSC group showed higher stem hydraulic conductivity(281±50 mmol cm^(−1)s^(−1)MPa^(−1))compared with the L-NSC group(134±40 mmol cm^(−1)s^(−1)MPa^(−1)).Although starch levels remained relatively constant,we found a 20%increase in soluble sugars in the stems of H-NSC group under high drought and high salinity in week 8 compared with week 12.Our results suggest(i)an important role of NSCs in mitigating the effects of low soil water potential caused by drought and salinity,and(ii)sink-limited growth under conditions of combined salinity and drought. 展开更多
关键词 non-structural carbohydrates Avicennia marina subsp.australasica drought and salt tolerance carbon limitation temperate mangroves
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