Objective:To explore the pharmacological basis of the Compound Xintahua (XTH) action in Atherosclerosis (AS) therapy, a network interaction analysis was conducted at the molecular level. Methods:TCMSP database and lit...Objective:To explore the pharmacological basis of the Compound Xintahua (XTH) action in Atherosclerosis (AS) therapy, a network interaction analysis was conducted at the molecular level. Methods:TCMSP database and literature mining were used to analyze the main effective components in XTH, and the targets were predicted by Swiss Target Prediction server according to AS mechanism. The potential targets were introduced into the FunRich database for target annotation and analysis, the path analysis was finally performed based on the FunRich databases. To determine the mechanism of action of XTH. Results:A total of 316 compounds, 117 targets, and 290 signaling pathways were identified. And 16 effective compounds, 39 common targets, and 43 pathways were associated with AS. Conclusions:The results showed that the flavonoids, phenols, organic acids and terpenoids of XTH could participate in the process of lipid metabolism, angiogenesis, oxidation, inflammation, endocrine metabolism, cell proliferation and apoptosis, It was further found that they could play the role of anti-Atherosclerosis through multi-component, multi-target, and multi-channel synergistically.展开更多
文摘Objective:To explore the pharmacological basis of the Compound Xintahua (XTH) action in Atherosclerosis (AS) therapy, a network interaction analysis was conducted at the molecular level. Methods:TCMSP database and literature mining were used to analyze the main effective components in XTH, and the targets were predicted by Swiss Target Prediction server according to AS mechanism. The potential targets were introduced into the FunRich database for target annotation and analysis, the path analysis was finally performed based on the FunRich databases. To determine the mechanism of action of XTH. Results:A total of 316 compounds, 117 targets, and 290 signaling pathways were identified. And 16 effective compounds, 39 common targets, and 43 pathways were associated with AS. Conclusions:The results showed that the flavonoids, phenols, organic acids and terpenoids of XTH could participate in the process of lipid metabolism, angiogenesis, oxidation, inflammation, endocrine metabolism, cell proliferation and apoptosis, It was further found that they could play the role of anti-Atherosclerosis through multi-component, multi-target, and multi-channel synergistically.
