Microglia,originating from primitive macrophages in the yolk sac,serves as both immune system defenders and regulators of homeostasis.These cells exhibit two primary polarization states:conventionally activated(M1)and...Microglia,originating from primitive macrophages in the yolk sac,serves as both immune system defenders and regulators of homeostasis.These cells exhibit two primary polarization states:conventionally activated(M1)and alternatively activated(M2).The polarization of microglia plays a crucial role in influencing inflammatory disorders,metabolic imbalances,and neural degeneration.This process is implicated in various aspects of ocular diseases,especially age-related macular degeneration(AMD),including inflammation,oxidative stress and pathological angiogenesis.The distinct functional phenotypes of microglia impact disease progression and prognosis.Thus,regulating the polarization or functional phenotype of microglia at different stages of AMD holds promise for personalized therapeutic approaches.This comprehensive review outlines the involvement of microglia polarization in both physiological and pathological conditions,emphasizing its relevance in AMD.The discussion underscores the potential of polarization as a foundation for personalized treatment strategies for AMD.展开更多
Thick debris flow deposits in the Hengduan Mountains of southwestern China record landscape instability at the close of the last glaciation and in the early Holocene. The deposits, ranging in thickness from 100 to 200...Thick debris flow deposits in the Hengduan Mountains of southwestern China record landscape instability at the close of the last glaciation and in the early Holocene. The deposits, ranging in thickness from 100 to 200 m, are common and in high magnitude in the valleys of this region. They are products of large debris flows induced by glacier and enabled by the presence of large amount of glacial debris on the landscape. The carbon 14 dating from Moxi Platform indicates that a period of catastrophic debris flows occurred at c. 7 kyr B.P., and was concurrent with other glacial-fluvial fans and terraces which tied to regional climatic oscillations elsewhere in the Himalaya. The comparable events suggest a strong climatic control on earth surface processes for the dynamics, magnitude, and frequency in this region.展开更多
The surface nature of fresh Mo2N/Al2O3, Mo2C/Al2O3 and/MoP/Al2O3 catalysts, which were synthesized directly in the IR cell to avoid passivation, were characterized by in situ IR spectroscopy with CO as a probe molecul...The surface nature of fresh Mo2N/Al2O3, Mo2C/Al2O3 and/MoP/Al2O3 catalysts, which were synthesized directly in the IR cell to avoid passivation, were characterized by in situ IR spectroscopy with CO as a probe molecule. CO adsorbed on fresh catalysts showed characteristic IR bands at 2045 cm-1 for Mo2N/Al2O3 catalyst, 2054 cm-1 for MozC/Al2O3 catalyst and 2037 cm-1 for MoP/Al2O3 catalyst, respectively. A strong band at 2200 cm-1 for Mo2N/Al2O3 catalyst, which could be ascribed to NCO species formed when CO reacted upon surface active nitrogen atoms, and a weak band at 2196 cm-1 for Mo2C/Al2O3 catalyst, which could be attributed to CCO species, were also detected. CO adsorbed on fresh Mo2N/Al2O3 catalyst, Mo2C/Al2O3 catalyst and MoP/Al2O3 catalyst, showed strong molecular adsorption, just like noble metals. Our experimental results are bolstered by direct IR evidence demonstrating the similarity in surface electronic property between the fresh Mo2N/Al2O3, Mo2C/Al2O3 and MoP/Al2O3 catalysts and noble metals.展开更多
Fashion continues to be an area that reflects the increasing popularity of different theoretical and practical approaches of researchers from different disciplines. Due to the rapid cycles of fashion, sustainable prod...Fashion continues to be an area that reflects the increasing popularity of different theoretical and practical approaches of researchers from different disciplines. Due to the rapid cycles of fashion, sustainable products and processes in terms of technical creativity and innovative approach are needed. In this context, fashion marketing emerges as an integrative marketing application with its both technical and social aspects by taking potential customers center that symbolize rapid change and creativity of fashion products. In this study, QFD-House of Brand was designed with Quality Function Deployment (QFD) approach. In this context, the experts (focus group) in Fashion Industry evaluated the selected fashion brand and its selected products by prioritizing the criteria. These evaluations were used in QFD-House of Brand. Thus, technical and social aspects of fashion industry were analysed together. By this technique, QFD-House of Brand established in relation to products and brand was interpreted and optimization suggestions were presented in accordance with the findings of the research. In addition, suggestions on sustainability and optimization of brand equity in fashion industry were provided.展开更多
The Wadi Sharis orogenic gold deposit in northwestern Yemen is related to the fault and shear zones vein at medium depth in the crust in the Neoprotcrozoic meta-sedimentary and meta-volcanosedimentary succes- sion of ...The Wadi Sharis orogenic gold deposit in northwestern Yemen is related to the fault and shear zones vein at medium depth in the crust in the Neoprotcrozoic meta-sedimentary and meta-volcanosedimentary succes- sion of greenschist to amphibolite facies metamorphism. Three distinct fluid inclusion types have been identified in the gold-bearing quartz sulphide veins of the deposit: (1) type I: vapour-liquid two-phase (VH2O-LH2O ), (2) type II : three-phase CO2 ( VCO2 - LH2O - LCO2 ) and (3) type III: vapour-rich (LCO2 - VCO2 ) inclusions. Six analysis of individual fluid inclusion indicate the fluid inclusions comprise mainly of H2O and CO2. Forma- tion P-T conditions recorded by fluid inclusions in quartz crystals correspond to 180℃-380℃ and up to 130 MPa, as indicated by high-density CO2 bubbles (up to 0. 98 g/cm3 ) observed in some inclusions. The esti- mated crystallization pressures correspond to approximately 4-10 km of overburden, assuming a lithostatic load. The salinity ranges from 0 to 22 wt%. The deposit holds at 0.2-5 g/t Au and contains low-moderate salinity.展开更多
In the field of intangible cultural heritage' s digital protection, a lot of research work has been made by all countries in the world, while the research on the digital commuuication of intangible cultural heritage ...In the field of intangible cultural heritage' s digital protection, a lot of research work has been made by all countries in the world, while the research on the digital commuuication of intangible cultural heritage is few and especially rarely seen in China. Under the premise, in this paper, the factors influencing intangible cultural heritage in the communication process are analyzed based on the information characteristics of intangible cultural heritage and the advantages of I-Space framework model in researching information transfer. Also, combined with the birch bark making technology in Heilongjiang province, the knowledge-based and signified communication strategy of intangible cultural heritage is proposed, aiming at providing new ideas for the researches on the digital communication of intangible cultural heritage.展开更多
Major oxides,as well as trace elements (including rare earth elements) compositions have been analyzed for the mixosedimentites from Neoproterozoic Jiayuan Formation in northern Anhui,China. The results show that the ...Major oxides,as well as trace elements (including rare earth elements) compositions have been analyzed for the mixosedimentites from Neoproterozoic Jiayuan Formation in northern Anhui,China. The results show that the concentrations of elements are closely related to the relative proportions of carbonates and terrigenous detritus (varying from 2/3 to 1/9 based on petrographic study). The ratios between some immobile elements (e.g. La,Th,Zr and Sc) are constant and then can be used as tracers for the discrimination of provenance and tectonic setting of terrigenous detritus. The results indicate that the terrigenous detritus mainly came from the felsic volcanics related to continental arc,with minor contribution from the old basement. Combined with recent research progresses,these mixosedimentites imply that the Neoproterozoic sedimentation in northern Anhui was probably taken place in a back arc basin during the convergence of Rodinia super continent between 1.0 and 0.8 Ga.展开更多
Chemomics is an interdisciplinary study using approaches from chemoinformatics,bioinformatics,synthetic chemistry,and other related disciplines.Biological systems make natural products from endogenous small molecules ...Chemomics is an interdisciplinary study using approaches from chemoinformatics,bioinformatics,synthetic chemistry,and other related disciplines.Biological systems make natural products from endogenous small molecules (natural product building blocks) through a sequence of enzyme catalytic reactions.For each reaction,the natural product building blocks may contribute a group of atoms to the target natural product.We describe this group of atoms as a chemoyl.A chemome is the complete set of chemoyls in an organism.Chemomics studies chemomes and the principles of natural product syntheses and evolutions.Driven by survival and reproductive demands,biological systems have developed effective protocols to synthesize natural products in order to respond to environmental changes;this results in biological and chemical diversity.In recent years,it has been realized that one of the bottlenecks in drug discovery is the lack of chemical resources for drug screening.Chemomics may solve this problem by revealing the rules governing the creation of chemical diversity in biological systems,and by developing biomimetic synthesis approaches to make quasi natural product libraries for drug screening.This treatise introduces chemomics and outlines its contents and potential applications in the fields of drug innovation.展开更多
文摘Microglia,originating from primitive macrophages in the yolk sac,serves as both immune system defenders and regulators of homeostasis.These cells exhibit two primary polarization states:conventionally activated(M1)and alternatively activated(M2).The polarization of microglia plays a crucial role in influencing inflammatory disorders,metabolic imbalances,and neural degeneration.This process is implicated in various aspects of ocular diseases,especially age-related macular degeneration(AMD),including inflammation,oxidative stress and pathological angiogenesis.The distinct functional phenotypes of microglia impact disease progression and prognosis.Thus,regulating the polarization or functional phenotype of microglia at different stages of AMD holds promise for personalized therapeutic approaches.This comprehensive review outlines the involvement of microglia polarization in both physiological and pathological conditions,emphasizing its relevance in AMD.The discussion underscores the potential of polarization as a foundation for personalized treatment strategies for AMD.
文摘Thick debris flow deposits in the Hengduan Mountains of southwestern China record landscape instability at the close of the last glaciation and in the early Holocene. The deposits, ranging in thickness from 100 to 200 m, are common and in high magnitude in the valleys of this region. They are products of large debris flows induced by glacier and enabled by the presence of large amount of glacial debris on the landscape. The carbon 14 dating from Moxi Platform indicates that a period of catastrophic debris flows occurred at c. 7 kyr B.P., and was concurrent with other glacial-fluvial fans and terraces which tied to regional climatic oscillations elsewhere in the Himalaya. The comparable events suggest a strong climatic control on earth surface processes for the dynamics, magnitude, and frequency in this region.
基金supported by the National Nature Science Foundation of China(No.20903054).
文摘The surface nature of fresh Mo2N/Al2O3, Mo2C/Al2O3 and/MoP/Al2O3 catalysts, which were synthesized directly in the IR cell to avoid passivation, were characterized by in situ IR spectroscopy with CO as a probe molecule. CO adsorbed on fresh catalysts showed characteristic IR bands at 2045 cm-1 for Mo2N/Al2O3 catalyst, 2054 cm-1 for MozC/Al2O3 catalyst and 2037 cm-1 for MoP/Al2O3 catalyst, respectively. A strong band at 2200 cm-1 for Mo2N/Al2O3 catalyst, which could be ascribed to NCO species formed when CO reacted upon surface active nitrogen atoms, and a weak band at 2196 cm-1 for Mo2C/Al2O3 catalyst, which could be attributed to CCO species, were also detected. CO adsorbed on fresh Mo2N/Al2O3 catalyst, Mo2C/Al2O3 catalyst and MoP/Al2O3 catalyst, showed strong molecular adsorption, just like noble metals. Our experimental results are bolstered by direct IR evidence demonstrating the similarity in surface electronic property between the fresh Mo2N/Al2O3, Mo2C/Al2O3 and MoP/Al2O3 catalysts and noble metals.
文摘Fashion continues to be an area that reflects the increasing popularity of different theoretical and practical approaches of researchers from different disciplines. Due to the rapid cycles of fashion, sustainable products and processes in terms of technical creativity and innovative approach are needed. In this context, fashion marketing emerges as an integrative marketing application with its both technical and social aspects by taking potential customers center that symbolize rapid change and creativity of fashion products. In this study, QFD-House of Brand was designed with Quality Function Deployment (QFD) approach. In this context, the experts (focus group) in Fashion Industry evaluated the selected fashion brand and its selected products by prioritizing the criteria. These evaluations were used in QFD-House of Brand. Thus, technical and social aspects of fashion industry were analysed together. By this technique, QFD-House of Brand established in relation to products and brand was interpreted and optimization suggestions were presented in accordance with the findings of the research. In addition, suggestions on sustainability and optimization of brand equity in fashion industry were provided.
文摘The Wadi Sharis orogenic gold deposit in northwestern Yemen is related to the fault and shear zones vein at medium depth in the crust in the Neoprotcrozoic meta-sedimentary and meta-volcanosedimentary succes- sion of greenschist to amphibolite facies metamorphism. Three distinct fluid inclusion types have been identified in the gold-bearing quartz sulphide veins of the deposit: (1) type I: vapour-liquid two-phase (VH2O-LH2O ), (2) type II : three-phase CO2 ( VCO2 - LH2O - LCO2 ) and (3) type III: vapour-rich (LCO2 - VCO2 ) inclusions. Six analysis of individual fluid inclusion indicate the fluid inclusions comprise mainly of H2O and CO2. Forma- tion P-T conditions recorded by fluid inclusions in quartz crystals correspond to 180℃-380℃ and up to 130 MPa, as indicated by high-density CO2 bubbles (up to 0. 98 g/cm3 ) observed in some inclusions. The esti- mated crystallization pressures correspond to approximately 4-10 km of overburden, assuming a lithostatic load. The salinity ranges from 0 to 22 wt%. The deposit holds at 0.2-5 g/t Au and contains low-moderate salinity.
文摘In the field of intangible cultural heritage' s digital protection, a lot of research work has been made by all countries in the world, while the research on the digital commuuication of intangible cultural heritage is few and especially rarely seen in China. Under the premise, in this paper, the factors influencing intangible cultural heritage in the communication process are analyzed based on the information characteristics of intangible cultural heritage and the advantages of I-Space framework model in researching information transfer. Also, combined with the birch bark making technology in Heilongjiang province, the knowledge-based and signified communication strategy of intangible cultural heritage is proposed, aiming at providing new ideas for the researches on the digital communication of intangible cultural heritage.
基金supported by the National Nature Sciences Foundation of China( 40873015)the Science Research Fundation ( Ph.D) of Suzhou University ( 2009jb04)the Out-standing Young Talent Foundation of Colleges and Universities in Anhui ( 2010SQRL190)
文摘Major oxides,as well as trace elements (including rare earth elements) compositions have been analyzed for the mixosedimentites from Neoproterozoic Jiayuan Formation in northern Anhui,China. The results show that the concentrations of elements are closely related to the relative proportions of carbonates and terrigenous detritus (varying from 2/3 to 1/9 based on petrographic study). The ratios between some immobile elements (e.g. La,Th,Zr and Sc) are constant and then can be used as tracers for the discrimination of provenance and tectonic setting of terrigenous detritus. The results indicate that the terrigenous detritus mainly came from the felsic volcanics related to continental arc,with minor contribution from the old basement. Combined with recent research progresses,these mixosedimentites imply that the Neoproterozoic sedimentation in northern Anhui was probably taken place in a back arc basin during the convergence of Rodinia super continent between 1.0 and 0.8 Ga.
基金supported by the National Science and Technology Major Project of China (2010ZX09102-305)the National High-tech R&D Program of China (863 Program,2012AA020307)+1 种基金the Introduction of Innovative R&D Team Program of Guangdong Province (2009010058)the National Natural Science Foundation of China (81173470)
文摘Chemomics is an interdisciplinary study using approaches from chemoinformatics,bioinformatics,synthetic chemistry,and other related disciplines.Biological systems make natural products from endogenous small molecules (natural product building blocks) through a sequence of enzyme catalytic reactions.For each reaction,the natural product building blocks may contribute a group of atoms to the target natural product.We describe this group of atoms as a chemoyl.A chemome is the complete set of chemoyls in an organism.Chemomics studies chemomes and the principles of natural product syntheses and evolutions.Driven by survival and reproductive demands,biological systems have developed effective protocols to synthesize natural products in order to respond to environmental changes;this results in biological and chemical diversity.In recent years,it has been realized that one of the bottlenecks in drug discovery is the lack of chemical resources for drug screening.Chemomics may solve this problem by revealing the rules governing the creation of chemical diversity in biological systems,and by developing biomimetic synthesis approaches to make quasi natural product libraries for drug screening.This treatise introduces chemomics and outlines its contents and potential applications in the fields of drug innovation.