A variable-charge (VC) and a permanent-charge paddy soil (PC) were selected to study nitrate-N (NO3^--N) and ammonium-N (NH4^+-N) leaching with N isotopes for one consecutive year. An irrigation and intermitt...A variable-charge (VC) and a permanent-charge paddy soil (PC) were selected to study nitrate-N (NO3^--N) and ammonium-N (NH4^+-N) leaching with N isotopes for one consecutive year. An irrigation and intermittent drainage pattern was adopted to mimic natural occurrence of rainfall during the upland crop season and drainage management during the flooded rice season. Treatments to each soil type were no-N controls (CK), ^15N-labeled (NH4)2SO4 (NS), and milk vetch (NV) applied at a rate equivalent to 238 kg N ha^-1 to unplanted lysimeters, totaling six treatments in triplicates. Results indicated that the soil type dominated N leaching characteristics. In the case of PC, NO3^--N accounted for 78% of the total leached inorganic N; NS was prone to leach three times more than the NV, being 8.2% and 2.4% of added ^15N respectively; and 〉 85% of leached NO3-N came from of the total inorganic N in leachate. Moreover, NH4^+-N native N in the soil. In the case of VC, NH4^+-N made up to 92% leaching was detected throughout the whole incubation, and was particularly high during the flooded season. NO3^--N leaching in VC occurred later at a lower rate compared to that in PC. The findings of this study indicate that NO3^--N leaching during the drained season in permanent-charge paddy soils and NH4^+-N leaching in variable-charge soils deserve more attention for regional environmental control.展开更多
Hepatitis C is recognized as a major threat to global public health. The current treatment of patients with chronic hepatitis C is the addition of ribavirin to interferon-based therapy which has limited efficacy, poor...Hepatitis C is recognized as a major threat to global public health. The current treatment of patients with chronic hepatitis C is the addition of ribavirin to interferon-based therapy which has limited efficacy, poor tolerability, and significant expense. New treatment options that are more potent and less toxic are much needed. Moreover, more effective treatment is an urgent priority for those who relapse or do not respond to current regimens. A major obstacle in combating hepatitis C virus (HCV) infection is that the fidelity of the viral replication machinery is notoriously low, thus enabling the virus to quickly develop mutations that resist compounds targeting viral enzymes. Therefore, an approach targeting the host cofactors, which are indispensable for the propagation of viruses, may be an ideal target for the development of antiviral agents because they have a lower rate of mutation than that of the viral genome, as long as they have no side effects to patients. Drugs targeting, for example, receptors of viral entry, host metabolism or nuclear receptors, which are factors required to complete the HCV life cycle, may be more effective in combating the viral infection. Targeting host cofactors of the HCV life cycle is an attractive concept because it imposes a higher genetic barrier for resistance than direct antiviral compounds. However the principle drawback of this strategy is the greater potential for cellular toxicity.展开更多
In China′s Loess Plateau area, gully head is the most active zone of a drainage system in gully areas. The differentiation of loess gully head follows geospatial patterns and reflects the process of the loess landfor...In China′s Loess Plateau area, gully head is the most active zone of a drainage system in gully areas. The differentiation of loess gully head follows geospatial patterns and reflects the process of the loess landform development and evolution of its drainage system to some extent. In this study, the geomorphic meaning, basic characteristics, morphological structure and the basic types of loess gully heads were systematically analysed. Then, the loess gully head′s conceptual model was established, and an extraction method based on Digital Elevation Model(DEM) for loess gully head features and elements was proposed. Through analysing the achieved statistics of loess gully head features, loess gully heads have apparently similar and different characteristics depending on the different loess landforms where they are found. The loess head characteristics reflect their growth period and evolution tendency to a certain degree, and they indirectly represent evolutionary mechanisms. In addition, the loess gully developmental stages and the evolutionary processes can be deduced by using loess gully head characteristics. This study is of great significance for development and improvement of the theoretical system for describing loess gully landforms.展开更多
This study sought to answer the following question: The empirical model in which strategic planning affects innovation and competitive advantage and how does this influence corporate performance perceived by the CEOs...This study sought to answer the following question: The empirical model in which strategic planning affects innovation and competitive advantage and how does this influence corporate performance perceived by the CEOs of companies in Monterrey, Nuevo LEon, does this have an acceptable outcome in regards of the theoretical fit model? This study was empirical, quantitative, descriptive, exploratory, explicative and transversal in nature. The studied population consisted of executives who attended the training sessions of the Institute of Public Accountants of Nuevo Le6n (IPANL). For this study, a sample of 134 executives was selected by convenience sampling. For the data collection, an instrument of 94 indicators was elaborated and the indicators within the study were the following: 31 indicators for strategic planning, 15 indicators for innovation, 24 indicators for competitive advantage, and 24 indicators for corporate performance. The null hypotheses were analyzed using multivariate analysis denominated as a structural equation model, utilizing maximum plausibility methods. According to the selected structural equation indexes, the obtained results show that the proposed model had an acceptable goodness of fit index.展开更多
Nurses' unintentional medication errors during treatment are relatively frequent and yet inevitable. Errors provoke emotions which influence the nurses' professional careers. Little is known about the relationship b...Nurses' unintentional medication errors during treatment are relatively frequent and yet inevitable. Errors provoke emotions which influence the nurses' professional careers. Little is known about the relationship between nurses' supervisors constructive listening (CL) and the emotional reactions of nurses who committed an error and its relation to patients' safety. Our purpose was to explore the relationship between nurses' perceptions regarding their supervisors' CL and their emotional experiences after committing an error related to patient care. Dependent variables included of guilt, empathy towards the patient, general and professional self-assessment, shame, and Negative and Positive Affect (NA/PA). In this descriptive study, we used a snowball sampling method. Participants were asked to sign an informed-consent form and complete the questionnaire before or after work. No compensation (material or otherwise) was offered to participants. The study was approved by the ethics committee of the academic institution involved. A total of 162 nurses participated: 103 (63.6%) held a registered and 40 (25%) held a managerial role. Seniority had high variability, ranging from 3 months to 45 years (M=1 3.54, SD=0.78). The majority of errors reported (67.7%) concerned the administration of medications. We used Structural Equation Modeling to measure relationships between the main variables (X2(9)=14.52, p=.105, CFI=.911, RMSEA=.062 (90% CI=.00-. 11). The main findings were: a high rating of perceived supervisor's CL led to high state-guilt (β=. 15, p=.04). Next, higher state-guilt led to high PA (β=.18, p=.02) and to high NA (β=.45, p〈.001). High PA led to reporting the error (β=.17, p=.03), whereas high NA led to a high degree of empathy towards the patient (β=.17, p=.03). Our findings show the importance of CL, which led to reporting error and to empathy towards patients, mediated by increased state-guilt and by increased positive and negative effect. Supervisor nurses should use CL to create an atmosphere of trust which fosters the reporting of errors and improves patients' safety.展开更多
基金Project supported by the National Natural Science Foundation of China (No. 30390080)the Nanjing Science and Technology Bureau,China (No. 200901063)
文摘A variable-charge (VC) and a permanent-charge paddy soil (PC) were selected to study nitrate-N (NO3^--N) and ammonium-N (NH4^+-N) leaching with N isotopes for one consecutive year. An irrigation and intermittent drainage pattern was adopted to mimic natural occurrence of rainfall during the upland crop season and drainage management during the flooded rice season. Treatments to each soil type were no-N controls (CK), ^15N-labeled (NH4)2SO4 (NS), and milk vetch (NV) applied at a rate equivalent to 238 kg N ha^-1 to unplanted lysimeters, totaling six treatments in triplicates. Results indicated that the soil type dominated N leaching characteristics. In the case of PC, NO3^--N accounted for 78% of the total leached inorganic N; NS was prone to leach three times more than the NV, being 8.2% and 2.4% of added ^15N respectively; and 〉 85% of leached NO3-N came from of the total inorganic N in leachate. Moreover, NH4^+-N native N in the soil. In the case of VC, NH4^+-N made up to 92% leaching was detected throughout the whole incubation, and was particularly high during the flooded season. NO3^--N leaching in VC occurred later at a lower rate compared to that in PC. The findings of this study indicate that NO3^--N leaching during the drained season in permanent-charge paddy soils and NH4^+-N leaching in variable-charge soils deserve more attention for regional environmental control.
文摘Hepatitis C is recognized as a major threat to global public health. The current treatment of patients with chronic hepatitis C is the addition of ribavirin to interferon-based therapy which has limited efficacy, poor tolerability, and significant expense. New treatment options that are more potent and less toxic are much needed. Moreover, more effective treatment is an urgent priority for those who relapse or do not respond to current regimens. A major obstacle in combating hepatitis C virus (HCV) infection is that the fidelity of the viral replication machinery is notoriously low, thus enabling the virus to quickly develop mutations that resist compounds targeting viral enzymes. Therefore, an approach targeting the host cofactors, which are indispensable for the propagation of viruses, may be an ideal target for the development of antiviral agents because they have a lower rate of mutation than that of the viral genome, as long as they have no side effects to patients. Drugs targeting, for example, receptors of viral entry, host metabolism or nuclear receptors, which are factors required to complete the HCV life cycle, may be more effective in combating the viral infection. Targeting host cofactors of the HCV life cycle is an attractive concept because it imposes a higher genetic barrier for resistance than direct antiviral compounds. However the principle drawback of this strategy is the greater potential for cellular toxicity.
基金Under the auspices of National Youth Science Foundation of China(No.41001294)Key Project of National Natural Science Foundation of China(No.40930531)Research Fund of State Key Laboratory Resources and Environment Information System(No.2010KF0002SA)
文摘In China′s Loess Plateau area, gully head is the most active zone of a drainage system in gully areas. The differentiation of loess gully head follows geospatial patterns and reflects the process of the loess landform development and evolution of its drainage system to some extent. In this study, the geomorphic meaning, basic characteristics, morphological structure and the basic types of loess gully heads were systematically analysed. Then, the loess gully head′s conceptual model was established, and an extraction method based on Digital Elevation Model(DEM) for loess gully head features and elements was proposed. Through analysing the achieved statistics of loess gully head features, loess gully heads have apparently similar and different characteristics depending on the different loess landforms where they are found. The loess head characteristics reflect their growth period and evolution tendency to a certain degree, and they indirectly represent evolutionary mechanisms. In addition, the loess gully developmental stages and the evolutionary processes can be deduced by using loess gully head characteristics. This study is of great significance for development and improvement of the theoretical system for describing loess gully landforms.
文摘This study sought to answer the following question: The empirical model in which strategic planning affects innovation and competitive advantage and how does this influence corporate performance perceived by the CEOs of companies in Monterrey, Nuevo LEon, does this have an acceptable outcome in regards of the theoretical fit model? This study was empirical, quantitative, descriptive, exploratory, explicative and transversal in nature. The studied population consisted of executives who attended the training sessions of the Institute of Public Accountants of Nuevo Le6n (IPANL). For this study, a sample of 134 executives was selected by convenience sampling. For the data collection, an instrument of 94 indicators was elaborated and the indicators within the study were the following: 31 indicators for strategic planning, 15 indicators for innovation, 24 indicators for competitive advantage, and 24 indicators for corporate performance. The null hypotheses were analyzed using multivariate analysis denominated as a structural equation model, utilizing maximum plausibility methods. According to the selected structural equation indexes, the obtained results show that the proposed model had an acceptable goodness of fit index.
文摘Nurses' unintentional medication errors during treatment are relatively frequent and yet inevitable. Errors provoke emotions which influence the nurses' professional careers. Little is known about the relationship between nurses' supervisors constructive listening (CL) and the emotional reactions of nurses who committed an error and its relation to patients' safety. Our purpose was to explore the relationship between nurses' perceptions regarding their supervisors' CL and their emotional experiences after committing an error related to patient care. Dependent variables included of guilt, empathy towards the patient, general and professional self-assessment, shame, and Negative and Positive Affect (NA/PA). In this descriptive study, we used a snowball sampling method. Participants were asked to sign an informed-consent form and complete the questionnaire before or after work. No compensation (material or otherwise) was offered to participants. The study was approved by the ethics committee of the academic institution involved. A total of 162 nurses participated: 103 (63.6%) held a registered and 40 (25%) held a managerial role. Seniority had high variability, ranging from 3 months to 45 years (M=1 3.54, SD=0.78). The majority of errors reported (67.7%) concerned the administration of medications. We used Structural Equation Modeling to measure relationships between the main variables (X2(9)=14.52, p=.105, CFI=.911, RMSEA=.062 (90% CI=.00-. 11). The main findings were: a high rating of perceived supervisor's CL led to high state-guilt (β=. 15, p=.04). Next, higher state-guilt led to high PA (β=.18, p=.02) and to high NA (β=.45, p〈.001). High PA led to reporting the error (β=.17, p=.03), whereas high NA led to a high degree of empathy towards the patient (β=.17, p=.03). Our findings show the importance of CL, which led to reporting error and to empathy towards patients, mediated by increased state-guilt and by increased positive and negative effect. Supervisor nurses should use CL to create an atmosphere of trust which fosters the reporting of errors and improves patients' safety.