Satellite retrieval of atmospheric water vapor is intended to further understand the role played by the energy and water cycle to determine the Earth's weather and climate.The algorithm for operational retrieval o...Satellite retrieval of atmospheric water vapor is intended to further understand the role played by the energy and water cycle to determine the Earth's weather and climate.The algorithm for operational retrieval of total precipitable water (TPW) from the visible and infrared radiometer (VIRR) onboard Fengyun 3A (FY-3A) employs a split window technique for clear sky radiances over land and oceans during both day and night.The retrieved TPW is compared with that from the moderate resolution imaging spectroradiometer (MODIS) onboard the Terra satellite and data from radiosonde observations (RAOB).During the study period,comparisons show that the FY-3A TPW is in general agreement with the gradients and distributions from the Terra TPW.Their zonal mean difference over East Asia is smaller in the daytime than at night,and the main difference occurs in the complex terrain at mid latitude near 30°N.Compared with RAOB,the zonal FY-3A and the Terra TPW have a moist bias at low latitudes and a dry bias at mid and high latitudes;in addition,the FY-3A TPW performs slightly better in zonal mean biases and the diurnal cycle.The temporal variation of the FY-3A and the Terra TPW generally fits the RAOB TPW with the FY-3A more accurate at night while Terra TPW more accurate during the daytime.Comparisons of correlations,root mean square differences and standard deviations indicate that the FY-3A TPW series is more consistent with the RAOB TPW at selected stations.As a result,the FY-3A TPW has some advantages over East Asia in both spatial and temporal dimensions.展开更多
In this paper, a special three-step difference scheme is applied to the solution of nonlinear time-evolution equations, whose coefficients are determined according to accuracy constraints, necessary conditions of squa...In this paper, a special three-step difference scheme is applied to the solution of nonlinear time-evolution equations, whose coefficients are determined according to accuracy constraints, necessary conditions of square conservation, and historical observation information under the linear supposition. As in the linear case, the schemes also have obvious superiority in overall performance in the nonlinear case compared with traditional finite difference schemes, e.g., the leapfrog(LF) scheme and the complete square conservation difference(CSCD) scheme that do not use historical observations in determining their coefficients, and the retrospective time integration(RTI) scheme that does not consider compatibility and square conservation. Ideal numerical experiments using the one-dimensional nonlinear advection equation with an exact solution show that this three-step scheme minimizes its root mean square error(RMSE) during the first 2500 integration steps when no shock waves occur in the exact solution, while the RTI scheme outperforms the LF scheme and CSCD scheme only in the first 1000 steps and then becomes the worst in terms of RMSE up to the 2500th step. It is concluded that reasonable consideration of accuracy, square conservation, and historical observations is also critical for good performance of a finite difference scheme for solving nonlinear equations.展开更多
With experimental masses updated from AME11,the predictive power of relativistic mean-field(RMF) mass model is carefully examined and compared with HFB-17,FRDM,WS*,and DZ28 mass models.In the relativistic mean-field m...With experimental masses updated from AME11,the predictive power of relativistic mean-field(RMF) mass model is carefully examined and compared with HFB-17,FRDM,WS*,and DZ28 mass models.In the relativistic mean-field model,the calculation with the PC-PK1 has improved significantly in describing masses compared to the TMA,especially for the neutron-deficient nuclei.The corresponding rms deviation with respect to the known masses falls to 1.4 MeV.Furthermore,it is found that the RMF mass model better describes the nuclei with large deformations.The rms deviation for nuclei with the absolute value of quadrupole deformation parameter greater than 0.25 falls to 0.93,crossing the 1 MeV accuracy threshold for the PC-PK1,which may indicate the new model is more suitable for those largely-deformed nuclei.In addition,the necessity of new high-precision experimental data to evaluate and develop the nuclear mass models is emphasized as well.展开更多
In this work, the most detrimental missense mutations of aspartoacylase that cause Canavan's disease were identified computationally and the substrate binding efficiencies of those missense mutations were analyzed...In this work, the most detrimental missense mutations of aspartoacylase that cause Canavan's disease were identified computationally and the substrate binding efficiencies of those missense mutations were analyzed. Out of 30 missense mutations, I-Mutant 2.0, SIFT and PolyPhen programs identified 22 variants that were less stable, deleterious and damaging respectively. Subsequently, modeling of these 22 variants was performed to understand the change in their conformations with respect to the native aspartoacylase by computing their root mean squared deviation (RMSD). Furthermore, the native protein and the 22 mutants were docked with the substrate NAA (N-Acetyl-Aspartic acid) to explain the substrate binding efficiencies of those detrimental missense mutations. Among the 22 mutants, the docking studies identified that 15 mutants caused lower binding affinity for NAA than the native protein. Finally, normal mode analysis determined that the loss of binding affinity of these 15 mutants was caused by altered flexibility in the amino acids that bind to NAA compared with the native protein. Thus, the pre- sent study showed that the majority of the substrate-binding amino acids in those 15 mutants displayed loss of flexibility, which could be the theoretical explanation of decreased binding affinity between the mutant aspartoacylases and NAA.展开更多
基金supported by the National High Technology Research and Development Program of China(Grant No. 2007AA12Z144)the Professional Projects (Grant Nos.GYHY200706005 and GYHY200906036)the China Meteoro-logical Administration New Technology Promotion Project (GrantNo. CMATG2008Z04)
文摘Satellite retrieval of atmospheric water vapor is intended to further understand the role played by the energy and water cycle to determine the Earth's weather and climate.The algorithm for operational retrieval of total precipitable water (TPW) from the visible and infrared radiometer (VIRR) onboard Fengyun 3A (FY-3A) employs a split window technique for clear sky radiances over land and oceans during both day and night.The retrieved TPW is compared with that from the moderate resolution imaging spectroradiometer (MODIS) onboard the Terra satellite and data from radiosonde observations (RAOB).During the study period,comparisons show that the FY-3A TPW is in general agreement with the gradients and distributions from the Terra TPW.Their zonal mean difference over East Asia is smaller in the daytime than at night,and the main difference occurs in the complex terrain at mid latitude near 30°N.Compared with RAOB,the zonal FY-3A and the Terra TPW have a moist bias at low latitudes and a dry bias at mid and high latitudes;in addition,the FY-3A TPW performs slightly better in zonal mean biases and the diurnal cycle.The temporal variation of the FY-3A and the Terra TPW generally fits the RAOB TPW with the FY-3A more accurate at night while Terra TPW more accurate during the daytime.Comparisons of correlations,root mean square differences and standard deviations indicate that the FY-3A TPW series is more consistent with the RAOB TPW at selected stations.As a result,the FY-3A TPW has some advantages over East Asia in both spatial and temporal dimensions.
基金the Ministry of Science and Technology of China for the National Basic Research Program of China(973 Program,Grant No.2011CB309704)
文摘In this paper, a special three-step difference scheme is applied to the solution of nonlinear time-evolution equations, whose coefficients are determined according to accuracy constraints, necessary conditions of square conservation, and historical observation information under the linear supposition. As in the linear case, the schemes also have obvious superiority in overall performance in the nonlinear case compared with traditional finite difference schemes, e.g., the leapfrog(LF) scheme and the complete square conservation difference(CSCD) scheme that do not use historical observations in determining their coefficients, and the retrospective time integration(RTI) scheme that does not consider compatibility and square conservation. Ideal numerical experiments using the one-dimensional nonlinear advection equation with an exact solution show that this three-step scheme minimizes its root mean square error(RMSE) during the first 2500 integration steps when no shock waves occur in the exact solution, while the RTI scheme outperforms the LF scheme and CSCD scheme only in the first 1000 steps and then becomes the worst in terms of RMSE up to the 2500th step. It is concluded that reasonable consideration of accuracy, square conservation, and historical observations is also critical for good performance of a finite difference scheme for solving nonlinear equations.
基金supported by the 211 Project of Anhui University (Grant No.02303319-33190135)the Key Research Foundation of Education Ministry of Anhui Province of China(Grant No.KJ2012A021)+1 种基金the Program for New Century Excellent Talents in University of Ministry of Education of China(Grant No.NCET-09-0031)the National Natural Science Foundation of China(Grant Nos.10975008,11105010,11035007, 11128510,11175001 and 11205004)
文摘With experimental masses updated from AME11,the predictive power of relativistic mean-field(RMF) mass model is carefully examined and compared with HFB-17,FRDM,WS*,and DZ28 mass models.In the relativistic mean-field model,the calculation with the PC-PK1 has improved significantly in describing masses compared to the TMA,especially for the neutron-deficient nuclei.The corresponding rms deviation with respect to the known masses falls to 1.4 MeV.Furthermore,it is found that the RMF mass model better describes the nuclei with large deformations.The rms deviation for nuclei with the absolute value of quadrupole deformation parameter greater than 0.25 falls to 0.93,crossing the 1 MeV accuracy threshold for the PC-PK1,which may indicate the new model is more suitable for those largely-deformed nuclei.In addition,the necessity of new high-precision experimental data to evaluate and develop the nuclear mass models is emphasized as well.
文摘In this work, the most detrimental missense mutations of aspartoacylase that cause Canavan's disease were identified computationally and the substrate binding efficiencies of those missense mutations were analyzed. Out of 30 missense mutations, I-Mutant 2.0, SIFT and PolyPhen programs identified 22 variants that were less stable, deleterious and damaging respectively. Subsequently, modeling of these 22 variants was performed to understand the change in their conformations with respect to the native aspartoacylase by computing their root mean squared deviation (RMSD). Furthermore, the native protein and the 22 mutants were docked with the substrate NAA (N-Acetyl-Aspartic acid) to explain the substrate binding efficiencies of those detrimental missense mutations. Among the 22 mutants, the docking studies identified that 15 mutants caused lower binding affinity for NAA than the native protein. Finally, normal mode analysis determined that the loss of binding affinity of these 15 mutants was caused by altered flexibility in the amino acids that bind to NAA compared with the native protein. Thus, the pre- sent study showed that the majority of the substrate-binding amino acids in those 15 mutants displayed loss of flexibility, which could be the theoretical explanation of decreased binding affinity between the mutant aspartoacylases and NAA.