A new method for determining the incremental cohesion △Cm of surrounding rock due to prestressed cable anchor is presented, and the formulas for △Cm are deduced and △Cm distributions also are discussed, based on th...A new method for determining the incremental cohesion △Cm of surrounding rock due to prestressed cable anchor is presented, and the formulas for △Cm are deduced and △Cm distributions also are discussed, based on the two anchorage effects, one is the effect with the prestressed vaIue △σ3 of cable anchor improving the stress state of surrounding rock and increasing the surrounding rock strength, the other is the fully encapsulated effect. The determined incremental cohesion △Cm is subiected to the model test and field measurement in the references, and coincides well with those tested results. The formulas for △Cm can be used in designing supoport parameters and related numerical analyses of prestressed cable anchor.展开更多
The absence of effective therapies for castration-resistant prostate cancer(CRPC) establishes the need to develop novel therapeutic modality, such as targeted gene therapy, which is ideal for the treatment of CRPC. Bu...The absence of effective therapies for castration-resistant prostate cancer(CRPC) establishes the need to develop novel therapeutic modality, such as targeted gene therapy, which is ideal for the treatment of CRPC. But its application has been limited due to lack of favorable gene vector and the reduction of "bystander effect". Consequently, scientists all over the world focus their main experimental research on the following four aspects: targeted gene, vector, transfer means and comprehensive therapy. In this paper, we reviewed the latest advances of experimental research on targeted gene therapy for prostate cancer.展开更多
The spatial reticulated shell structure with cables (RSC) is a kind of coupling working system, which consists of flexible cables, reticulated shell structure (RS) and tower columns. The dynamic analysis of RSC based ...The spatial reticulated shell structure with cables (RSC) is a kind of coupling working system, which consists of flexible cables, reticulated shell structure (RS) and tower columns. The dynamic analysis of RSC based on the coupling model was carried out. Three kinds of elements such as the spatial bar element, cable element and beam element were introduced to analyze the reticulated shell, cable and tower column respectively. Furthermore, such parameter influences as structural boundary conditions, grid configuration, the span-to-depth ratio and the arrangement of cable system upon structural dynamics were analyzed. The structural vibration modes can be divided into four groups based on some numerical examples. And the frequencies in the same group are very close while the frequencies in different groups are different from each other obviously. It is clear that the sequence of the appearance of the each mode group heavily depends on the comparative stiffness of the tower column system, RS and cables.展开更多
Improving daylighting strategy is a mandatory step to achieve visual enjoyment and energy saving in buildings. Psycho, physiological effects and energy performance have to be investigated in order to define a range of...Improving daylighting strategy is a mandatory step to achieve visual enjoyment and energy saving in buildings. Psycho, physiological effects and energy performance have to be investigated in order to define a range of different daylighting strategies, thanks to daylighting devices and climate based daylight modeling. Daylighting optimization ensures indoor healthier rooms, reduces electric light consumption and cuts the risk of glare. The best way to achieve these targets is to define users lighting needs, based on visual targets and to draw up some green measures to reduce electricity demands. Involving new climate-based daylight modeling metrics aims at defining proper illumination targets, in order to drastically reduce electrical lights, as well as reducing thermal loads deriving from cooling and HVAC （heating, ventilation and air conditioning） systems.展开更多
Based on eddy covariance measurements over two kinds of land surfaces(a degraded grassland and a maize cropland)in a semiarid area of China in 2005 and 2008,the effects of different gap filling methods,energy balance ...Based on eddy covariance measurements over two kinds of land surfaces(a degraded grassland and a maize cropland)in a semiarid area of China in 2005 and 2008,the effects of different gap filling methods,energy balance closure and friction velocity threshold(u*)on annual net ecosystem exchange(NEE)were analyzed.Six gap filling methods,including mean diurnal variation(MDV),marginal distribution sampling(MDS),and nonlinear regressions method,were investigated by generating secondary datasets with four different artificial gap lengths(ranging in length from single half-hours to 12 consecutive days).The MDS generally showed a good overall performance especially for long gaps,with an annual sum bias error less than 5 g C m-2 yr-1.There was a large positive annual sum bias error for nonlinear regressions,indicating an overestimate on net ecosystem respiration.The offset in the annual sum NEE for four nonlinear regressions was from 8.0 to 30.8 g C m-2 yr-1.As soil water content was a limiting factor in the semiarid area,the nonlinear regressions considering both soil temperature and soil water content as controlling variables had a better performance than others.The performance of MDV was better in daytime than in nighttime,with an annual sum bias error falling between-2.6 and-13.4 g C m-2 yr-1.Overall,the accuracy of the gap filling method was dependent on the type of the land surface,gap length,and the time of day when the data gap occurred.The energy balance ratio for the two ecosystems was nearly 80%.Turbulent intensity had a large impact on energy balance ratio.Low energy balance ratio was observed under low friction velocity during the night.When there was a large fetch distance in a wind direction,a low energy balance ratio was caused by mismatch of the footprints between the available energy and turbulent fluxes.The effect of energy balance correction on CO2 flux was evaluated by assuming the imbalance caused by the underestimation of sensible heat flux and latent heat flux.The results showed an average increase of 10 g C m-2 yr-1 for annual NEE in both ecosystems with an energy balance correction.On the other hand,the u*threshold also have a large impact on annual sum NEE.Net carbon emission increased 37.5 g C m-2 yr-1 as u*threshold increased from 0.1 to 0.2 m s-1,indicating a large impact of imposing u*threshold on net ecosystem carbon exchange.展开更多
In this paper, we provide determinant representation of the n-th order rogue wave solutions for a higherorder nonlinear Schr6dinger equation （HONLS） by the Darboux transformation and confirm the decomposition rule o...In this paper, we provide determinant representation of the n-th order rogue wave solutions for a higherorder nonlinear Schr6dinger equation （HONLS） by the Darboux transformation and confirm the decomposition rule of the rogue wave solutions up to fourth-order. These solutions have two parameters a and ;3 which denote the contribution of the higher-order terms （dispersions and nonlinear effects） included in the HONLS equation. Two localized properties, i.e., length and width of the first-order rogue wave solution are expressed by above two parameters, which show analytically a remarkable influence of higher-order terms on the rogue wave. Moreover, profiles of the higher-order rogue wave solutions demonstrate graphically a strong compression effect along t-direction given by higher-order terms.展开更多
文摘A new method for determining the incremental cohesion △Cm of surrounding rock due to prestressed cable anchor is presented, and the formulas for △Cm are deduced and △Cm distributions also are discussed, based on the two anchorage effects, one is the effect with the prestressed vaIue △σ3 of cable anchor improving the stress state of surrounding rock and increasing the surrounding rock strength, the other is the fully encapsulated effect. The determined incremental cohesion △Cm is subiected to the model test and field measurement in the references, and coincides well with those tested results. The formulas for △Cm can be used in designing supoport parameters and related numerical analyses of prestressed cable anchor.
文摘The absence of effective therapies for castration-resistant prostate cancer(CRPC) establishes the need to develop novel therapeutic modality, such as targeted gene therapy, which is ideal for the treatment of CRPC. But its application has been limited due to lack of favorable gene vector and the reduction of "bystander effect". Consequently, scientists all over the world focus their main experimental research on the following four aspects: targeted gene, vector, transfer means and comprehensive therapy. In this paper, we reviewed the latest advances of experimental research on targeted gene therapy for prostate cancer.
基金NationalNaturalScience Foundation ofChina (No. 5 0 2 780 5 4) and the KeyProject of Chinese Ministry of Education(No.10 40 79)
文摘The spatial reticulated shell structure with cables (RSC) is a kind of coupling working system, which consists of flexible cables, reticulated shell structure (RS) and tower columns. The dynamic analysis of RSC based on the coupling model was carried out. Three kinds of elements such as the spatial bar element, cable element and beam element were introduced to analyze the reticulated shell, cable and tower column respectively. Furthermore, such parameter influences as structural boundary conditions, grid configuration, the span-to-depth ratio and the arrangement of cable system upon structural dynamics were analyzed. The structural vibration modes can be divided into four groups based on some numerical examples. And the frequencies in the same group are very close while the frequencies in different groups are different from each other obviously. It is clear that the sequence of the appearance of the each mode group heavily depends on the comparative stiffness of the tower column system, RS and cables.
文摘Improving daylighting strategy is a mandatory step to achieve visual enjoyment and energy saving in buildings. Psycho, physiological effects and energy performance have to be investigated in order to define a range of different daylighting strategies, thanks to daylighting devices and climate based daylight modeling. Daylighting optimization ensures indoor healthier rooms, reduces electric light consumption and cuts the risk of glare. The best way to achieve these targets is to define users lighting needs, based on visual targets and to draw up some green measures to reduce electricity demands. Involving new climate-based daylight modeling metrics aims at defining proper illumination targets, in order to drastically reduce electrical lights, as well as reducing thermal loads deriving from cooling and HVAC （heating, ventilation and air conditioning） systems.
基金supported by the National Natural Science Foundation of China(Grant Nos.41275023,41021004))Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA05110102)
文摘Based on eddy covariance measurements over two kinds of land surfaces(a degraded grassland and a maize cropland)in a semiarid area of China in 2005 and 2008,the effects of different gap filling methods,energy balance closure and friction velocity threshold(u*)on annual net ecosystem exchange(NEE)were analyzed.Six gap filling methods,including mean diurnal variation(MDV),marginal distribution sampling(MDS),and nonlinear regressions method,were investigated by generating secondary datasets with four different artificial gap lengths(ranging in length from single half-hours to 12 consecutive days).The MDS generally showed a good overall performance especially for long gaps,with an annual sum bias error less than 5 g C m-2 yr-1.There was a large positive annual sum bias error for nonlinear regressions,indicating an overestimate on net ecosystem respiration.The offset in the annual sum NEE for four nonlinear regressions was from 8.0 to 30.8 g C m-2 yr-1.As soil water content was a limiting factor in the semiarid area,the nonlinear regressions considering both soil temperature and soil water content as controlling variables had a better performance than others.The performance of MDV was better in daytime than in nighttime,with an annual sum bias error falling between-2.6 and-13.4 g C m-2 yr-1.Overall,the accuracy of the gap filling method was dependent on the type of the land surface,gap length,and the time of day when the data gap occurred.The energy balance ratio for the two ecosystems was nearly 80%.Turbulent intensity had a large impact on energy balance ratio.Low energy balance ratio was observed under low friction velocity during the night.When there was a large fetch distance in a wind direction,a low energy balance ratio was caused by mismatch of the footprints between the available energy and turbulent fluxes.The effect of energy balance correction on CO2 flux was evaluated by assuming the imbalance caused by the underestimation of sensible heat flux and latent heat flux.The results showed an average increase of 10 g C m-2 yr-1 for annual NEE in both ecosystems with an energy balance correction.On the other hand,the u*threshold also have a large impact on annual sum NEE.Net carbon emission increased 37.5 g C m-2 yr-1 as u*threshold increased from 0.1 to 0.2 m s-1,indicating a large impact of imposing u*threshold on net ecosystem carbon exchange.
基金Supported by the National Natural Science Foundation of China under Grant No.11271210the K.C.Wong Magna Fund in Ningbo University
文摘In this paper, we provide determinant representation of the n-th order rogue wave solutions for a higherorder nonlinear Schr6dinger equation （HONLS） by the Darboux transformation and confirm the decomposition rule of the rogue wave solutions up to fourth-order. These solutions have two parameters a and ;3 which denote the contribution of the higher-order terms （dispersions and nonlinear effects） included in the HONLS equation. Two localized properties, i.e., length and width of the first-order rogue wave solution are expressed by above two parameters, which show analytically a remarkable influence of higher-order terms on the rogue wave. Moreover, profiles of the higher-order rogue wave solutions demonstrate graphically a strong compression effect along t-direction given by higher-order terms.
