Objective To investigate whether repeated morphine exposure or prolonged withdrawal could influence operant and spatial learning differentially. Methods Animals were chronically treated with morphine or subjected to m...Objective To investigate whether repeated morphine exposure or prolonged withdrawal could influence operant and spatial learning differentially. Methods Animals were chronically treated with morphine or subjected to morphine withdrawal. Then, they were subjected to two kinds of learning: operant conditioning and spatial learning. Results The acquisition of both simple appetitive and cued operant learning was impaired after repeated morphine treatment. Withdrawal for 5 weeks alleviated the impairments. Single morphine exposure disrupted the retrieval of operant memory but had no effect on rats after 5-week withdrawal. Contrarily, neither chronic morphine exposure nor 5-week withdrawal influenced spatial learning task of the Morris water maze. Nevertheless, the retrieval of spatial memory was impaired by repeated morphine exposure but not by 5-week withdrawal. Conclusion These observations suggest that repeated morphine exposure can influence different types of learning at different aspects, implicating that the formation of opiate addiction may usurp memory mechanisms differentially.展开更多
Generally, different prevention measures should be taken according to spontaneous combustion propensities. The current methods to evaluate the propensity of coal spontaneous combustion, such as chromatographic method ...Generally, different prevention measures should be taken according to spontaneous combustion propensities. The current methods to evaluate the propensity of coal spontaneous combustion, such as chromatographic method of oxygen adsorption, oxidation kinetics method and activation energy method, are mostly affected by human factors. Their boundaries among different classes of propensities were all established by subjective judgments. A new evaluation method using catastrophe theory is introduced. This method can accurately depict the process of coal spontaneous combustion and the evaluation index, "catastrophe temperature", be obtained based on the model. In terms of catastrophe temperature, the spontaneous combustion propensity of different coals can be sequenced. Experimental data indicate that this method is appropriate to describe the spontaneous combustion process and to evaluate the propensity of coal svontaneous combustion.展开更多
This review discusses the pathophysiology,epidemiology,risk factors,classification,clinical evaluation,and current non-operative and operative treatment of hemorrhoids.Hemorrhoids are defined as the symptomatic enlarg...This review discusses the pathophysiology,epidemiology,risk factors,classification,clinical evaluation,and current non-operative and operative treatment of hemorrhoids.Hemorrhoids are defined as the symptomatic enlargement and distal displacement of the normal anal cushions.The most common symptom of hemorrhoids is rectal bleeding associated with bowel movement.The abnormal dilatation and distortion of the vascular channel,together with destructive changes in the supporting connective tissue within the anal cushion,is a paramount finding of hemorrhoids.It appears that the dysregulation of the vascular tone and vascular hyperplasia might play an important role in hemorrhoidal development,and could be a potential target for medical treatment.In most instances,hemorrhoids are treated conservatively,using many methods such as lifestyle modification,fiber supplement,suppositorydelivered anti-inflammatory drugs,and administration of venotonic drugs.Non-operative approaches include sclerotherapy and,preferably,rubber band ligation.An operation is indicated when non-operative approaches have failed or complications have occurred.Several surgical approaches for treating hemorrhoids have been introduced including hemorrhoidectomy and stapled hemorrhoidopexy,but postoperative pain is invariable.Some of the surgical treatments potentially cause appreciable morbidity such as anal stricture and incontinence.The applications and outcomes of each treatment are thoroughly discussed.展开更多
Objective To examine the expression of cell division cycle associated 2(CDCA 2) in pancreatic ductal adenocarcinoma(PDAC) and investigate its role in prognosis of PDAC patients.Methods This retrospective study include...Objective To examine the expression of cell division cycle associated 2(CDCA 2) in pancreatic ductal adenocarcinoma(PDAC) and investigate its role in prognosis of PDAC patients.Methods This retrospective study included 155 PDAC patients who underwent surgical treatment and complete post-operative follow-up.Clinicopathologic data were collected through clinical database.Tissue microarray was constructed and immunohistochemistry was performed to detect CDCA2 expression in the PDAC tumor tissues and adjacent non-tumor tissues.Clinicopathological characteristics between high and low CDCA2 expression were compared.Correlation of CDCA2 expressions with patients' survival was analyzed using Kaplan-Meier method and Cox regression analysis.Results Expression of CDCA2 in PDAC cells was significantly higher than that in adjacent non-tumor tissues(U=4056.5,P<0.001).Univariate analysis showed that CDCA2 expression [hazard ratio(HR)=1.574,95% confidence interval(CI)=1.014-2.443,P=0.043] and node metastasis(HR=1.704,95%CI=1.183-2.454,P=0.004) were significantly associated with prognosis.Cox regression analysis showed CDCA2 expression was not an independent prognostic risk factor(HR=1.418,95%CI=0.897-2.242,P=0.135) for PDCA patients.Stratification survival analysis demonstrated CDCA2 expression as an independent prognostic risk factor in male patients(HR=2.554,95%CI=1.446-4.511,P=0.003) or in non-perineural invasion patients(HR=2.290,95%CI=1.146-4.577,P=0.012).Conclusions CDCA2 is highly expressed in PDAC tumor tissue.Although CDCA2 is not an independent prognostic risk factor for PDAC patients,it might be used to help predict prognosis of male or non-perineural invasion patients of PDAC.展开更多
Tourism texts (shortened as TT) have become a principal means of promoting tourism in China. Cultural elements are abundant in those texts. Therefore, the proper understanding and rendering of such messages is the k...Tourism texts (shortened as TT) have become a principal means of promoting tourism in China. Cultural elements are abundant in those texts. Therefore, the proper understanding and rendering of such messages is the key to the quality of TT translation. Based on Skopos theory the paper focuses on the translating strategies of TT cultural elements.展开更多
Recently,the radial point interpolation meshfree method has gained popularity owing to its advantages in large deformation and discontinuity problems,however,the accuracy of this method depends on many factors and the...Recently,the radial point interpolation meshfree method has gained popularity owing to its advantages in large deformation and discontinuity problems,however,the accuracy of this method depends on many factors and their influences are not fully investigated yet.In this work,three main factors,i.e.,the shape parameters,the influence domain size,and the nodal distribution,on the accuracy of the radial point interpolation method(RPIM)are systematically studied and conclusive results are obtained.First,the effect of shape parameters(R,q)of the multi-quadric basis function on the accuracy of RPIM is examined via global search.A new interpolation error index,closely related to the accuracy of RPIM,is proposed.The distribution of various error indexes on the R q plane shows that shape parameters q[1.2,1.8]and R[0,1.5]can give good results for general 3-D analysis.This recommended range of shape parameters is examined by multiple benchmark examples in 3D solid mechanics.Second,through numerical experiments,an average of 30 40 nodes in the influence domain of a Gauss point is recommended for 3-D solid mechanics.Third,it is observed that the distribution of nodes has significant effect on the accuracy of RPIM although it has little effect on the accuracy of interpolation.Nodal distributions with better uniformity give better results.Furthermore,how the influence domain size and nodal distribution affect the selection of shape parameters and how the nodal distribution affects the choice of influence domain size are also discussed.展开更多
Starting from the thesis that translation always takes place in a certain social and cultural context and is therefore conditioned by certain contextual factors, this paper examines the particular role that poetics pl...Starting from the thesis that translation always takes place in a certain social and cultural context and is therefore conditioned by certain contextual factors, this paper examines the particular role that poetics played in Buddhist scripture translation that happened in ancient China. Buddhist poetics, in its associations with China's native poetics, did not work its way peacefully into the latter's embrace, to begin with. Instead, its appearance was first met with severe criticism and resistance. Aware of this problem, Buddhist translators in ancient China made continuous efforts in adapting Buddhist translations to the reading habits of the local people, which helped to ensure an easier acceptance of Buddhist philosophy by the Chinese people. With the growth and advancement of Buddhism in China, Buddhist poetics was no longer regarded as an enemy by its Chinese counterpart, and the style of Buddhist scripture translation was therefore able to stick closer to that of the original texts. The conclusion is that the poetics of one foreign literary system, when it comes to a new cultural environment, instead of remaining unaltered, usually goes through a complicated process of clashing and confl cfing with the native poetics before they two become reconciled and compatible with each other.展开更多
基金This work was supported by grants from the National Natural Science Foundation of China (No. 30470549)the National Basic Research Priorities Programme (973) of China (No.2006CBS00800)
文摘Objective To investigate whether repeated morphine exposure or prolonged withdrawal could influence operant and spatial learning differentially. Methods Animals were chronically treated with morphine or subjected to morphine withdrawal. Then, they were subjected to two kinds of learning: operant conditioning and spatial learning. Results The acquisition of both simple appetitive and cued operant learning was impaired after repeated morphine treatment. Withdrawal for 5 weeks alleviated the impairments. Single morphine exposure disrupted the retrieval of operant memory but had no effect on rats after 5-week withdrawal. Contrarily, neither chronic morphine exposure nor 5-week withdrawal influenced spatial learning task of the Morris water maze. Nevertheless, the retrieval of spatial memory was impaired by repeated morphine exposure but not by 5-week withdrawal. Conclusion These observations suggest that repeated morphine exposure can influence different types of learning at different aspects, implicating that the formation of opiate addiction may usurp memory mechanisms differentially.
文摘Generally, different prevention measures should be taken according to spontaneous combustion propensities. The current methods to evaluate the propensity of coal spontaneous combustion, such as chromatographic method of oxygen adsorption, oxidation kinetics method and activation energy method, are mostly affected by human factors. Their boundaries among different classes of propensities were all established by subjective judgments. A new evaluation method using catastrophe theory is introduced. This method can accurately depict the process of coal spontaneous combustion and the evaluation index, "catastrophe temperature", be obtained based on the model. In terms of catastrophe temperature, the spontaneous combustion propensity of different coals can be sequenced. Experimental data indicate that this method is appropriate to describe the spontaneous combustion process and to evaluate the propensity of coal svontaneous combustion.
基金Supported by Faculty of Medicine Siriraj Hospital,Mahidol University,Bangkok,Thailand
文摘This review discusses the pathophysiology,epidemiology,risk factors,classification,clinical evaluation,and current non-operative and operative treatment of hemorrhoids.Hemorrhoids are defined as the symptomatic enlargement and distal displacement of the normal anal cushions.The most common symptom of hemorrhoids is rectal bleeding associated with bowel movement.The abnormal dilatation and distortion of the vascular channel,together with destructive changes in the supporting connective tissue within the anal cushion,is a paramount finding of hemorrhoids.It appears that the dysregulation of the vascular tone and vascular hyperplasia might play an important role in hemorrhoidal development,and could be a potential target for medical treatment.In most instances,hemorrhoids are treated conservatively,using many methods such as lifestyle modification,fiber supplement,suppositorydelivered anti-inflammatory drugs,and administration of venotonic drugs.Non-operative approaches include sclerotherapy and,preferably,rubber band ligation.An operation is indicated when non-operative approaches have failed or complications have occurred.Several surgical approaches for treating hemorrhoids have been introduced including hemorrhoidectomy and stapled hemorrhoidopexy,but postoperative pain is invariable.Some of the surgical treatments potentially cause appreciable morbidity such as anal stricture and incontinence.The applications and outcomes of each treatment are thoroughly discussed.
基金Supported by the National High Technology Research and Development Program of China(863 Program)(2012AA02A212)
文摘Objective To examine the expression of cell division cycle associated 2(CDCA 2) in pancreatic ductal adenocarcinoma(PDAC) and investigate its role in prognosis of PDAC patients.Methods This retrospective study included 155 PDAC patients who underwent surgical treatment and complete post-operative follow-up.Clinicopathologic data were collected through clinical database.Tissue microarray was constructed and immunohistochemistry was performed to detect CDCA2 expression in the PDAC tumor tissues and adjacent non-tumor tissues.Clinicopathological characteristics between high and low CDCA2 expression were compared.Correlation of CDCA2 expressions with patients' survival was analyzed using Kaplan-Meier method and Cox regression analysis.Results Expression of CDCA2 in PDAC cells was significantly higher than that in adjacent non-tumor tissues(U=4056.5,P<0.001).Univariate analysis showed that CDCA2 expression [hazard ratio(HR)=1.574,95% confidence interval(CI)=1.014-2.443,P=0.043] and node metastasis(HR=1.704,95%CI=1.183-2.454,P=0.004) were significantly associated with prognosis.Cox regression analysis showed CDCA2 expression was not an independent prognostic risk factor(HR=1.418,95%CI=0.897-2.242,P=0.135) for PDCA patients.Stratification survival analysis demonstrated CDCA2 expression as an independent prognostic risk factor in male patients(HR=2.554,95%CI=1.446-4.511,P=0.003) or in non-perineural invasion patients(HR=2.290,95%CI=1.146-4.577,P=0.012).Conclusions CDCA2 is highly expressed in PDAC tumor tissue.Although CDCA2 is not an independent prognostic risk factor for PDAC patients,it might be used to help predict prognosis of male or non-perineural invasion patients of PDAC.
文摘Tourism texts (shortened as TT) have become a principal means of promoting tourism in China. Cultural elements are abundant in those texts. Therefore, the proper understanding and rendering of such messages is the key to the quality of TT translation. Based on Skopos theory the paper focuses on the translating strategies of TT cultural elements.
基金Project(2010CB732103)supported by the National Basic Research Program of ChinaProject(51179092)supported by the National Natural Science Foundation of ChinaProject(2012-KY-02)supported by the State Key Laboratory of Hydroscience and Engineering,China
文摘Recently,the radial point interpolation meshfree method has gained popularity owing to its advantages in large deformation and discontinuity problems,however,the accuracy of this method depends on many factors and their influences are not fully investigated yet.In this work,three main factors,i.e.,the shape parameters,the influence domain size,and the nodal distribution,on the accuracy of the radial point interpolation method(RPIM)are systematically studied and conclusive results are obtained.First,the effect of shape parameters(R,q)of the multi-quadric basis function on the accuracy of RPIM is examined via global search.A new interpolation error index,closely related to the accuracy of RPIM,is proposed.The distribution of various error indexes on the R q plane shows that shape parameters q[1.2,1.8]and R[0,1.5]can give good results for general 3-D analysis.This recommended range of shape parameters is examined by multiple benchmark examples in 3D solid mechanics.Second,through numerical experiments,an average of 30 40 nodes in the influence domain of a Gauss point is recommended for 3-D solid mechanics.Third,it is observed that the distribution of nodes has significant effect on the accuracy of RPIM although it has little effect on the accuracy of interpolation.Nodal distributions with better uniformity give better results.Furthermore,how the influence domain size and nodal distribution affect the selection of shape parameters and how the nodal distribution affects the choice of influence domain size are also discussed.
文摘Starting from the thesis that translation always takes place in a certain social and cultural context and is therefore conditioned by certain contextual factors, this paper examines the particular role that poetics played in Buddhist scripture translation that happened in ancient China. Buddhist poetics, in its associations with China's native poetics, did not work its way peacefully into the latter's embrace, to begin with. Instead, its appearance was first met with severe criticism and resistance. Aware of this problem, Buddhist translators in ancient China made continuous efforts in adapting Buddhist translations to the reading habits of the local people, which helped to ensure an easier acceptance of Buddhist philosophy by the Chinese people. With the growth and advancement of Buddhism in China, Buddhist poetics was no longer regarded as an enemy by its Chinese counterpart, and the style of Buddhist scripture translation was therefore able to stick closer to that of the original texts. The conclusion is that the poetics of one foreign literary system, when it comes to a new cultural environment, instead of remaining unaltered, usually goes through a complicated process of clashing and confl cfing with the native poetics before they two become reconciled and compatible with each other.