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理气化湿方对MAFLD大鼠肝细胞保护和糖脂代谢调节作用的研究 被引量:1
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作者 班亭玉 卢秉久 《辽宁中医杂志》 CAS 北大核心 2024年第1期192-200,I0007,共10页
目的探讨理气化湿方治疗MAFLD的作用机制。方法动物实验研究:以纯化高脂饲料喂养大鼠建立MAFLD模型,随机分为空白组、模型组、中药组和西药组,中药组和西药组分别给药予理气化湿方和水飞蓟宾葡甲胺,干预8周后对各组大鼠的体质量、肝湿... 目的探讨理气化湿方治疗MAFLD的作用机制。方法动物实验研究:以纯化高脂饲料喂养大鼠建立MAFLD模型,随机分为空白组、模型组、中药组和西药组,中药组和西药组分别给药予理气化湿方和水飞蓟宾葡甲胺,干预8周后对各组大鼠的体质量、肝湿重和肝指数,肝功能水平,血脂水平,FIN、FBG和IRI,肝组织一般情况和病理形态学改变,血清中脂肪因子及炎症因子的水平等指标进行比较分析。结果中药组和西药组大鼠的体质量比相比,中药组明显较低(P<0.05)。模型组大鼠的肝湿重显著高于正常组(P<0.01);干预后中药组和西药组大鼠的肝湿重均明显低于模型组(P<0.05)。干预后中药组和西药组大鼠的肝指数均有显著下降趋势(P<0.01)。模型组大鼠血清ALT和AST水平均显著高于正常组(P<0.01);干预后中药组和西药组大鼠血清ALT和AST水平较模型组均显著降低(P<0.01)。中药组干预后TG和LDL-C水平显著低于模型组(P<0.01)、TC水平明显低于模型组(P<0.05)、HDL-C水平明显高于模型组(P<0.05);西药组干预后TG和LDL-C水平显著低于模型组(P<0.01);中药组与西药组相比,大鼠血清TG、TC、LDL-C水平均明显较低(P<0.05)、HDL-C明显较高(P<0.05)。干预后中药组大鼠的血清FBG水平显著低于模型组(P<0.01);中药组和西药组大鼠的血清FBG水平比较,中药组显著降低(P<0.01)。干预后中药组和西药组大鼠的血清FINS水平均显著低于模型组(P<0.01)。模型组大鼠的IRI水平较正常组显著升高(P<0.01);干预后中药组大鼠的IRI水平较模型组显著改善(P<0.01);中药组与西药组大鼠IRI水平相比较,中药组显著低于西药组(P<0.01)。中药组和西药组大鼠肝脏组织与模型组相比,细胞体积、形态和排列层次均有明显改善,胞浆内沉积脂滴变小,仅可见少量小叶内炎症及气球样变。干预后中药组和西药组大鼠肝组织切片均可见肝细胞和肝内脂滴体积变小,小叶内炎症及肝细胞气球样变有明显改善,NAS积分均明显低于模型组(P<0.05)。中药组和西药组大鼠经干预后均可显示LEP浓度显著低于模型组,ADPN浓度显著高于模型组(P<0.01)。血清炎症因子水平:中药组和西药组大鼠经干预后血清中NF-κB、TNF-α、IL-1β浓度与模型组比较均显著降低(P<0.01);中药组与西药组组间比较,西药组大鼠血清NF-κB浓度较中药组更低(P<0.05)。结论理气化湿方能够降低MAFLD模型大鼠的体质量、肝湿重及肝指数,降低肝脏酶学水平、调节血脂异常水平、改善胰岛素抵抗进而调节糖脂代谢异常,以及调节血清中脂肪因子和炎症因子的异常浓度,这可能是理气化湿方治疗MAFLD的主要作用机制。 展开更多
关键词 代谢相关脂肪性肝病 理气化湿方 作用机制
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Nonholonomic Theory of Principal-direction Orthonormal Basis for a Layer of Surfaces
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作者 LI Jiayang XIE Xilin 《复旦学报(自然科学版)》 CAS CSCD 北大核心 2024年第4期415-437,442,共24页
In order to carry out tensor analysis in a neighborhood of a reference surface,the principal-direction orthogonal basis accompanying with Lame s coefficients or general curvilinear coordinate systems are widely used.A... In order to carry out tensor analysis in a neighborhood of a reference surface,the principal-direction orthogonal basis accompanying with Lame s coefficients or general curvilinear coordinate systems are widely used.A novel kind of field theory termed as the nonholonomic theory of the Principal-Direction Orthonormal Basis(PDOB)is presented systematically in the present paper,in which the formal Christoffel symbols are related directly to the principal and geodesic curvatures with respect to the principal directions of the surface.Furthermore,a systematic and simple way to determine the curvatures of the surface are presented with some examples.It provides a way to recognize qualitatively the bending property of a surface. 展开更多
关键词 nonholonomic theory principal-direction orthonormal basis principal curvature geodesic curvature
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疏肝理脾方治疗脾虚肝亢证抽动障碍疗效及神经免疫机制研究 被引量:3
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作者 史文丽 吴秋艳 +1 位作者 陈慧敏 马丙祥 《辽宁中医杂志》 CAS 2023年第7期124-127,共4页
目的观察疏肝理脾方治疗抽动障碍(脾虚肝亢证)的临床疗效,并从神经免疫角度探索该方的作用机制。方法选择59例抽动障碍(脾虚肝亢证)患儿作为试验组,予疏肝理脾方治疗12周,观察不同时间窗耶鲁综合抽动严重程度量表评分及脾虚肝亢证中医... 目的观察疏肝理脾方治疗抽动障碍(脾虚肝亢证)的临床疗效,并从神经免疫角度探索该方的作用机制。方法选择59例抽动障碍(脾虚肝亢证)患儿作为试验组,予疏肝理脾方治疗12周,观察不同时间窗耶鲁综合抽动严重程度量表评分及脾虚肝亢证中医证候量表积分变化。同期选择20例健康体检儿童作为对照组。采用酶联免疫吸附法分别检测试验组患儿治疗前后及对照组血清抗核抗体(ANAb)、白细胞介素-6(IL-6)、白细胞介素-12(IL-12)及肿瘤坏死因子α(TNF-α)水平。结果疾病临床疗效和中医临床疗效分别为84.7%(50/59)和88.1%(52/59),试验组治疗前血清ANAb、IL-6、IL-12、TNF-α含量较对照组明显增高(P<0.05),经疏肝理脾方治疗后,各指标含量降低(P<0.05)。结论疏肝理脾方治疗抽动障碍(脾虚肝亢证)疗效确切,其抗抽动的作用机制与降低血清中ANAb、IL-6、IL-12和TNF-a含量有关。 展开更多
关键词 疏肝理脾方 抽动障碍 脾虚肝亢证 临床疗效 神经免疫
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针刺联合理气润肠方治疗慢传输型便秘肺脾气虚证疗效观察
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作者 陈红霞 陈朝晖 +1 位作者 范永强 陈林 《辽宁中医药大学学报》 CAS 2023年第7期164-168,共5页
目的 探究针刺联合理气润肠方治疗慢传输型便秘肺脾气虚证的临床疗效。方法 选取2019年8月—2021年8月163例慢传输型便秘肺脾气虚证患者,依据随机数字表法将患者分为对照组(81例)与观察组(82例),对照组患者予以针刺治疗,观察组在此基础... 目的 探究针刺联合理气润肠方治疗慢传输型便秘肺脾气虚证的临床疗效。方法 选取2019年8月—2021年8月163例慢传输型便秘肺脾气虚证患者,依据随机数字表法将患者分为对照组(81例)与观察组(82例),对照组患者予以针刺治疗,观察组在此基础上联合理气润肠方治疗。比较两组患者临床疗效,中医证候积分,大肠内标记物数量,一氧化氮(nitric oxide,NO)、血清神经肽(neuropeptide Y,NPY)水平以及生活质量评分。结果 观察组治疗有效率显著高于对照组(P<0.05);治疗后两组患者粪便性状、排便间隔时间、排便难易程度、汗出气短、便后乏力以及中医证候总分均较治疗前显著降低(P<0.05),且组间比较观察组降低更显著(P<0.05);治疗后两组患者大肠内标记物数量、NO、NPY水平均较治疗前显著降低(P<0.05),且组间比较观察组降低更显著(P<0.05);治疗后两组患者生理状态、心理状态、担忧、满意度以及生活质量总分均较治疗前显著降低(P<0.05),且组间比较观察组降低更显著(P<0.05);两组不良反应发生率比较差异不具有统计学意义(P>0.05)。结论 针刺联合理气润肠方治疗慢传输型便秘肺脾气虚证可协同增效,显著缓解患者临床症状,在改善体内抑制性神经递质水平同时提高生活质量,安全性良好,具有临床应用价值。 展开更多
关键词 慢传输型便秘 脾气虚证 针刺 理气润肠方
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苍山理脾开胃方结合针刺四缝穴治疗儿童厌食症(脾失健运型)临床观察
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作者 周诗立 姚红梅 向正可 《辽宁中医杂志》 2023年第12期179-181,共3页
目的观察苍山理脾开胃方结合针刺四缝穴治疗儿童厌食症(脾失健运型)临床效果。方法研究纳入恩施州民族医院儿科收治的儿童厌食症(脾失健运型)共计92例(2021年1月—2022年6月),将92例患儿随机平均分为对照组与观察组,对照组46例患儿采取... 目的观察苍山理脾开胃方结合针刺四缝穴治疗儿童厌食症(脾失健运型)临床效果。方法研究纳入恩施州民族医院儿科收治的儿童厌食症(脾失健运型)共计92例(2021年1月—2022年6月),将92例患儿随机平均分为对照组与观察组,对照组46例患儿采取双歧四联活菌片治疗;观察组46例患儿采取双歧四联活菌片及苍山理脾开胃方、针刺四缝穴治疗。比较两组临床疗效、治疗前后儿童中医证候积分(厌恶进食、嗳气泛恶、胸脘痞闷、大便不调等)变化、胃排空1/2时间变化及药物不良反应。结果与对照组患儿(82.61%,38/46)比较,观察组患儿治疗总有效率(95.65%,44/46)更高(P<0.05);治疗前,两组患儿中医证候积分(厌恶进食、嗳气泛恶、胸脘痞闷、大便不调等)、胃排空1/2时间等指标比较(P>0.05),治疗后两组患儿中医证候积分(厌恶进食、嗳气泛恶、胸脘痞闷、大便不调等)、胃排空1/2时间、等指标均改善,观察组患儿治疗后中医证候积分(厌恶进食、嗳气泛恶、胸脘痞闷、大便不调等)、胃排空1/2时间等指标均比对照组更佳(P<0.05);对照组1例恶心,观察组1例腹泻(P>0.05)。结论儿童厌食症(脾失健运型)采取苍山理脾开胃方与针刺四缝穴结合治疗临床效果显著,患儿症状改善,恢复较好,且较为安全可靠,值得应用。 展开更多
关键词 儿童厌食症 苍山理脾开胃方 针刺四缝穴 脾失健运型 临床效果 中医证候积分
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Extrapolate well logs based on the constrained interpolation algorithm 被引量:3
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作者 刘红伟 刘洪 +1 位作者 秦月霜 首皓 《Applied Geophysics》 SCIE CSCD 2008年第4期307-313,共7页
Based on a detailed analysis of differences between seismic data and well logs, we discuss the problem of matching seismic traces and well logs and present a new matching method based on event search in instantaneous ... Based on a detailed analysis of differences between seismic data and well logs, we discuss the problem of matching seismic traces and well logs and present a new matching method based on event search in instantaneous phase which greatly improves seismic resolution. The method is based on flattening events in instantaneous phase to compare the seismic traces to the well log traces with the same phase. We calculate the coefficients using the singular value decomposition method to extrapolate the well logs. As a result, the events in the seismic profile are continuous and match well with well logs. We apply this method to the Mao-2 well in Daqing Oilfield with good results. 展开更多
关键词 events flattening SVD method instantaneous phase CORRELATION
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Prediction method of highway pavement rutting based on the grey theory 被引量:6
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作者 周岚 倪富健 赵岩荆 《Journal of Southeast University(English Edition)》 EI CAS 2015年第3期396-400,共5页
In order to make a scientific pavement maintenance decision, a grey-theory-based prediction methodological framework is proposed to predict pavement performance. Based on the field pavement rutting data,analysis of va... In order to make a scientific pavement maintenance decision, a grey-theory-based prediction methodological framework is proposed to predict pavement performance. Based on the field pavement rutting data,analysis of variance (ANOVA)was first used to study the influence of different factors on pavement rutting. Cluster analysis was then employed to investigate the rutting development trend.Based on the clustering results,the grey theory was applied to build pavement rutting models for each cluster, which can effectively reduce the complexity of the predictive model.The results show that axial load and asphalt binder type play important roles in rutting development.The prediction model is capable of capturing the uncertainty in the pavement performance prediction process and can meet the requirements of highway pavement maintenance,and,therefore,has a wide application prospects. 展开更多
关键词 prediction method grey theory cluster analysis analysis of variance pavement rutting
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Elastic Kirchhoff migration of vectorial wave-fields 被引量:4
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作者 杜启振 侯波 《Applied Geophysics》 SCIE CSCD 2008年第4期284-293,共10页
Based on Kuo and Dai's vectorial wave-field extrapolation equations, we derive new Kirchhoff migration equations by introducing unit vectors which represent the ray directions at the imaging points of the reflected P... Based on Kuo and Dai's vectorial wave-field extrapolation equations, we derive new Kirchhoff migration equations by introducing unit vectors which represent the ray directions at the imaging points of the reflected P- and PS converted-waves. Furthermore, using the slope of the events on shot records and a ray racing procedure, mirror-image reflection points are found and the reflection data are smeared along the Fresnel zone. The migration method proposed in this paper solves two troublesome imaging problems caused by limited receiving aperture and migration artifacts resulting from wave propagation at the velocities of non original wave type. The migration method is applied successfully with model data, demonstrating that the new method is effective and correct. 展开更多
关键词 Elastic Kirchhoff migration vectorial wave-field Fresnel zone P-WAVE PSconverted wave POLARIZATION
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对归脾汤的再研究 被引量:7
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作者 杨纯新 《中国医药科学》 2012年第17期95-95,100,共2页
目的探讨古方归脾汤的理论与应用。方法通过查阅古文献和现代文献,并结合自己的应用体会,对归脾汤的方源、方理、药理、现代药物实验以及临床应用等相关内容进行归纳、整理、分析、探讨。结果归脾汤处方合理,广泛应用于内科、外科、儿... 目的探讨古方归脾汤的理论与应用。方法通过查阅古文献和现代文献,并结合自己的应用体会,对归脾汤的方源、方理、药理、现代药物实验以及临床应用等相关内容进行归纳、整理、分析、探讨。结果归脾汤处方合理,广泛应用于内科、外科、儿科、妇科、男科等临床各科,疗效显著。结论古方归脾汤,未来前景广阔。 展开更多
关键词 归脾汤 方源 方理 实验 应用
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Analysis of rock physics response of gas-bearing volcanic reservoir based on three-phase poroelastic theory 被引量:3
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作者 吴清岭 赵海波 +1 位作者 李来林 范兴才 《Applied Geophysics》 SCIE CSCD 2008年第4期277-283,共7页
Unlike previous theories with velocity and/or elastic modulus averaging, we use a three-phase porous rock physics model developed by Santos for analyzing the seismic response of two immiscible fluids in saturated poro... Unlike previous theories with velocity and/or elastic modulus averaging, we use a three-phase porous rock physics model developed by Santos for analyzing the seismic response of two immiscible fluids in saturated porous media. Considering reservoir reference pressure and coupling drag of two fluids in pores, the effects of frequency, porosity, and gas saturation on the phase velocities of the P-and S-waves are discussed in detail under field conditions. The effects of porosity and gas saturation on Vp/Vs are also provided. The data for our numerical experiments are from a sample of deep volcanic rock from Daqing. The numerical results show that the frequency dispersion effect can be ignored for deep volcanic rocks with low porosity and low permeability. It is concluded that for deep volcanic rocks the effect of gas content in pores on Vp/Vs is negligible but the effect of porosity is significant when there is a certain amount of water contained in the pores. The accurate estimate of lithology and porosity in this case is relatively more important. 展开更多
关键词 rock physics three-phase porous media seismic response and volcanic rock
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Screening of Preprocessing Method of Biolog for Soil Microbial Community Functional Diversity 被引量:2
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作者 党雯 郜春花 +4 位作者 张强 李建华 卢朝东 靳东升 卢晋晶 《Agricultural Science & Technology》 CAS 2015年第10期2247-2251,2255,共6页
As one of the main methods of microbial community functional diversity measurement, biolog method was favored by many researchers for its simple oper- ation, high sensitivity, strong resolution and rich data. But the ... As one of the main methods of microbial community functional diversity measurement, biolog method was favored by many researchers for its simple oper- ation, high sensitivity, strong resolution and rich data. But the preprocessing meth- ods reported in the literatures were not the same. In order to screen the best pre- processing method, this paper took three typical treatments to explore the effect of different preprocessing methods on soil microbial community functional diversity. The results showed that, method B's overall trend of AWCD values was better than A and C's. Method B's microbial utilization of six carbon sources was higher, and the result was relatively stable. The Simpson index, Shannon richness index and Car- bon source utilization richness index of the two treatments were B〉C〉A, while the Mclntosh index and Shannon evenness were not very stable, but the difference of variance analysis was not significant, and the method B was always with a smallest variance. Method B's principal component analysis was better than A and C's. In a word, the method using 250 r/min shaking for 30 minutes and cultivating at 28 ℃ was the best one, because it was simple, convenient, and with good repeatability. 展开更多
关键词 Biolog method Preprocessing method Soil microbial community Func- tional diversity AWCD values
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Damage failure of cemented backfill and its reasonable match with rock mass 被引量:31
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作者 刘志祥 兰明 +1 位作者 肖思友 郭虎强 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2015年第3期954-959,共6页
In order to study the failure mechanism of backfill and the reasonable matches between backfill and rock mass, and to achieve the object of safe and efficient mining in metal mine, four types of backfills were tested ... In order to study the failure mechanism of backfill and the reasonable matches between backfill and rock mass, and to achieve the object of safe and efficient mining in metal mine, four types of backfills were tested under uniaxial compression loading, with cement?tailing ratios of 0.250:1, 0.125:1, 0.100:1 and 0.083:1, respectively. With the help of the stress?strain curves, the deformation and failure characteristics of different backfills with differing cement?tailing ratios were analyzed. Based on the experimental results, the damage constitutive equations of cemented backfills with four cement?tailing ratios were proposed on the basis of damage mechanics. Moreover, comparative analysis of constitutive model and experimental results were made to verify the reliability of the damage model. In addition, an energy model using catastrophe theory to obtain the instability criteria of system was established to study the interaction between backfill and rock mass, and then the system instability criterion was deduced. The results show that there are different damage characteristics for different backfills, backfills with lower cement?tailing ratio tend to have a lower damage value when stress reaches peak value, and damage more rapidly and more obviously in failure process after peak value of stress; the stiffness and elastic modulus of rock mass with lower strength are more likely to lead to system instability. The results of this work provide a scientific basis for the rational strength design of backfill mine. 展开更多
关键词 cemented tailings backfill rock mass damage constitutive equation catastrophe theory MATCH instability criterion
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《伤寒论》栀子豉汤“得吐”探析 被引量:1
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作者 黄仁礼 《国医论坛》 2004年第5期2-3,共2页
关键词 《伤寒论》 栀子豉汤 吐剂 方理辨析
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LOW MACH NUMBER FLOW COMPUTATION USING PRECONDITIONING METHODS AND COMPRESSIBLE NAVIER-STOKES EQUATIONS
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作者 刘学强 李青 +1 位作者 柴建忠 伍贻兆 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2007年第4期271-275,共5页
The preconditioning method is used to solve the low Mach number flow. The space discritisation scheme is the Roe scheme and the DES turbulence model is used. Then, the low Mach number turbulence flow around the NACA00... The preconditioning method is used to solve the low Mach number flow. The space discritisation scheme is the Roe scheme and the DES turbulence model is used. Then, the low Mach number turbulence flow around the NACA0012 airfoil is used to verify the efficiency of the proposed method. Two cases of the low Mach number flows around the multi-element airfoil and the circular cylinder are also used to test the proposed method. Numerical results show that the methods combined the preconditioning method and compressible Navier-Stokes equations are efficient to solve low Mach number flows. 展开更多
关键词 Navier-Stokes equations preconditioning method turbulence model
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Inorganic Carbon Utilization in Some Marine Phytoplankton Species 被引量:2
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作者 缪晓玲 吴庆余 《Acta Botanica Sinica》 CSCD 2002年第4期395-399,共5页
In order to learn the ways and possible utilization mechanisms of dissolved inorganic carbon (DIC) in marine phytoplankton species under carbon-replete or -limited conditions, the activity of extracellular carbonic an... In order to learn the ways and possible utilization mechanisms of dissolved inorganic carbon (DIC) in marine phytoplankton species under carbon-replete or -limited conditions, the activity of extracellular carbonic anhydrase (CA) was assayed in different pH, CO 2 and DIC concentrations. Extracellular CA in Amphidinium carterae and Prorocentrum minimum was detected under carbon-replete conditions, while in Melosira sp., Phaeodactylum tricornutum, Skeletonema costatum, Thalassiosira rotula, Emiliania huxleyi and Pleurochrysis carterae, CA activity was assayed under conditions of carbon limitation. No CA activity was found even under carbon-limited conditions in Chaetoceros compressus, Glenodinium foliaceum, Coccolithus pelagicus, Gephrocapsa oceanica and Heterosigma akashiwo. In species without extracellular CA activity, the direct HCO - 3 uptake was investigated using a pH drift technique and the anion exchange inhibitor 4′4′-diisothiocyanatostilbene-2,2-disulfonic acid (DIDS) in a closed system. The result showed that direct HCO - 3 transport might occur by an anion exchange mechanism in species Coc. pelagicus and G. oceanica. Of the 13 species investigated, only H. akashiwo did not have the potential for direct uptake or extracellular CA-catalyzed HCO - 3 utilization. 展开更多
关键词 dissolved inorganic carbon (DIC) extracellular carbonic anhydrase (CA) 4′4′-diisothiocyanatostilbene-2 2-disulfonic acid (DIDS) dextran-bound sulfonamide (DBS)
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Modeling and analysis of azimuthal AVO responses from a viscoelastic anisotropic reflector 被引量:3
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作者 郭智奇 刘喜武 +1 位作者 符伟 李向阳 《Applied Geophysics》 SCIE CSCD 2015年第3期441-452,470,共13页
We propose a method for mOdeling azimuthal AVO responses from a fractured i reflector. The method calculates the integrated reflected wavetrains, and the wavetrains contain elastodynamic information including the con... We propose a method for mOdeling azimuthal AVO responses from a fractured i reflector. The method calculates the integrated reflected wavetrains, and the wavetrains contain elastodynamic information including the contrast in impedance and anelasticity i across interfaces, the intemal anisotropic propagation, the dispersion and attenuation along i the wave path, and tuning and interference. The results suggest that for large angles of incidence, the velocity dispersion and attenuation increase the amplitudes of PP waves from the top and decrease those from the bottom. For azimuthal responses at specific angles of incidence, the reflected wavetrains of PP waves tend to have longer duration with increasing azimuth. In contrast, model-converted PSV and PSH reflections show stable azimuthal features and are less affected by the reflector thickness. The amplitudes of PSV reflections increase with increasing azimuth; moreover, the waves have no reflection energy at 0° and 90° azimuth and maximum amplitude at 45° azimuth. 展开更多
关键词 REFLECTOR viscoelastic and anisotropic dispersion and attenuation generalized anisotropic Zoelopritz theory azimuthal AVO
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Effect of Protective Cultivation Patterns of Rice in Cold Areas on Soil Physiological and Biochemical Status in Paddy Field 被引量:8
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作者 汪秀志 钱永德 +4 位作者 张德远 刘崇文 刘丽华 吕艳东 郑桂萍 《Agricultural Science & Technology》 CAS 2010年第2期183-188,共6页
[Objective] The research aimed to explore how to use the soil reasonably,prevent the degradation of soil fertility,maintain soil fertility,improve the ecological environment of paddy field and improve the soil product... [Objective] The research aimed to explore how to use the soil reasonably,prevent the degradation of soil fertility,maintain soil fertility,improve the ecological environment of paddy field and improve the soil productivity of paddy field from the cultivation aspect.[Method] Taking kenjiandao 10 as the material,the variation laws of root weight,soil physical and chemical characteristics,soil enzyme,straw decomposition rate,soil temperature,microorganism of rice under the planting patterns of water-saving pro... 展开更多
关键词 Tillage methods Paddy field Soil physics and chemistry Soil microorganism Soil enzyme activity
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杏苏散之议 被引量:1
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作者 邓丽芳 《中国民间疗法》 2013年第7期6-7,共2页
杏苏散之理,众家无异议于其宣肺散寒、化痰止咳之功,争议的焦点是杏苏散所治“凉燥”病邪是否存在?杏苏散可否治燥?根据《方剂学》教材所载,杏苏散的药物组成是:杏仁、紫苏叶、前胡、桔梗、甘草、枳壳、茯苓、橘红、半夏、生姜、... 杏苏散之理,众家无异议于其宣肺散寒、化痰止咳之功,争议的焦点是杏苏散所治“凉燥”病邪是否存在?杏苏散可否治燥?根据《方剂学》教材所载,杏苏散的药物组成是:杏仁、紫苏叶、前胡、桔梗、甘草、枳壳、茯苓、橘红、半夏、生姜、大枣。功用:轻宣凉燥,宣肺化痰。主治:外感凉燥证。症见:头微痛,恶寒无汗,咳嗽痰稀,鼻塞嗌干,苔白,脉弦。 展开更多
关键词 杏苏散 方理 争议
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Combined effect of hydroxypropyl-β-cyclodextrin and media pH on the solubility of prostaglandin E_1 被引量:1
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作者 谷福根 吴春芝 高永良 《Journal of Chinese Pharmaceutical Sciences》 CAS 2007年第2期112-115,共4页
Aim To investigate the combined effect of hydroxypropyl-β-cyclodextrin (HP-β-CD) and media pH on the solubility of prostaglandin E1 (PGE1) and construct a theoretical equation for the drug solubility as a functi... Aim To investigate the combined effect of hydroxypropyl-β-cyclodextrin (HP-β-CD) and media pH on the solubility of prostaglandin E1 (PGE1) and construct a theoretical equation for the drug solubility as a function of HP-β-CD concentration and media pH. Methods The solubility of PGE1 under different pH conditions was determined. Then, the drug solubility in different concentrations of HP-β-CD acidic or pH neutral solutions was measured, respectively. Finally, a theoretical solubility equation for the drug as a function of HP-β-CD concentration and media pH was deduced and confirmed in experiment. Results PGEs was solubilized by HP-β-CD or by increasing media pH. The drug solubility as a function of HP-β-CD concentration was found to follow the AL-type complexation model in acidic or neutral pH media, suggesting that both the ionized and neutral drugs form 1:1 molecular ratio complexes. Conclusions The solubility of PGE1 may be improved by increasing media pH or by using HP-β-CD as a solubilizer. HP-β-CD and media pH can produce combined effect on the solubility of PGE1. The deduced equation for the drug solubility in this study effectively characterizes the roles of HP-β-CD and media pH in determining total solubility of the drug. 展开更多
关键词 PGE1 HP-β-CD PH SOLUBILITY COMPLEXATION Theoretical equation
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Formation mechanism and criterion of linear segregation in ZL205A alloy 被引量:9
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作者 王晔 吴士平 +3 位作者 薛祥 陈瑞润 张建兵 肖文峰 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第11期3632-3638,共7页
The experiments and numerical simulation were conducted for ZL205A aluminum alloy cylindrical shell casting. The formation mechanism of the linear segregation produced by the low pressure die casting (LPDC) process wa... The experiments and numerical simulation were conducted for ZL205A aluminum alloy cylindrical shell casting. The formation mechanism of the linear segregation produced by the low pressure die casting (LPDC) process was investigated. And the heat transfer of the casting during solidification process was analyzed by simulation technique, resulting from the information of linear segregation obtained by plenty of experiments. The new linear segregation criterion was proposed through the simulation and experimental results. It was found that the melting metal with high Cu contents was feeding the crack shrinkage formed by the tearing under the effect of feeding pressure during the later solidification, which led to the formation of linear segregation. The control methods for the linear segregation were suggested based on the proposed mechanism. Finally, the criterion of linear segregation was confirmed by the production of the actual castings. 展开更多
关键词 cylindrical shell casting linear segregation formation mechanism CRITERION control method
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