AIM:To evaluate retrospectively the correlation between enhancement patterns on dynamic computed tomography (CT) and angiogenesis and fibrosis in pancreatic adenocarcinoma.METHODS: Twenty-three patients with pancreati...AIM:To evaluate retrospectively the correlation between enhancement patterns on dynamic computed tomography (CT) and angiogenesis and fibrosis in pancreatic adenocarcinoma.METHODS: Twenty-three patients with pancreatic adenocarcinoma underwent dynamic CT and tumor resection. In addition to the absolute and relative enhanced value that was calculated by subtracting the attenuation value on pre-contrast from those on contrast-enhanced CT in each phase, we defined one parameter, "tumor-aorta enhancement ratio", which was calculated by dividing enhancement of pancreatic cancer by enhancement of abdominal aorta in each phase. These enhancement patterns were correlated with the level of vascular endothelial growth factor (VEGF), microvessel density (MVD), and extent of fibrosis.RESULTS: The absolute enhanced value in the arterial phase correlated with the level of VEGF and MVD (P=0.047, P=0.001). The relative enhanced value in arterial phase and tumor-aorta enhancement ratio (arterial) correlated with MVD (P=0.003, P=0.022). Tumor-aorta enhancement ratio (arterial) correlated negatively with the extent of fibrosis (P=0.004). The tumors with greater MVD and higher expression of VEGF tended to show high enhancement in the arterial dominant phase. On the other hand, the tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase.CONCLUSION: Enhancement patterns on dynamic CT correlated with angiogenesis and may be modified by the extent of fibrosis.展开更多
To get fiber motion in condensing zone of compact spinning,velocity of this area is achieved by simulation,and then a bead-elastic rod fiber model is established.Based on simulation and dynamic analysis on this zone,g...To get fiber motion in condensing zone of compact spinning,velocity of this area is achieved by simulation,and then a bead-elastic rod fiber model is established.Based on simulation and dynamic analysis on this zone,governing equations are constructed and Runge-Kutta approach is used.Lastly,trajectories of fibers are calculated by specially designed Matlab procedure according to the principles mentioned above.Results show that fiber motions at different initial positions are different;X-axis velocity component makes fibers gathering on sides of suction slot;Y-axis airflow gets fibers gradually close and then stick to the surface of lattice apron.Fiber motions also reflect that the compact spinning process in condensing zone can be divided into three parts:fast convergence zone,adjustment convergence zone,and steady convergence zone.展开更多
AIM： To investigate the relationship between urinary peptide changes and Helicobacter pylori （H. pylorl） infection using urinary peptidome profiling. METHODS： The study was performed in volunteers （n = 137） who ...AIM： To investigate the relationship between urinary peptide changes and Helicobacter pylori （H. pylorl） infection using urinary peptidome profiling. METHODS： The study was performed in volunteers （n = 137） who gave informed consent. Urinary peptides were enriched by magnetic beads based weak cation exchange chromatography＇and spectrums acquired by matrix-assisted laser desorption/ionization time-of-flight （MALDI-TOF） mass spectrometry （MS）. ClinProTools bioinformatics software was used for statistical analysis and the recognition of peptide patterns. The marker peptides were identified by LTQ Obitrap XL tandem MS. RESULTS： Approximately 50 proteins or peptides which loaded onto the magnetic beads were detected by MAL-DI-TOF MS. By optimizing the parameters of the model, the Genetic Algorithm model had good recognition capability （97%） and positive predictive value （94%）. Based on the model, 2 markers with molecular masses of 6788 and 1912 Da were found that differentiated between H. pylori positive and negative volunteers. The m/z 1912 sequence was parsed as SKQFTSSTSYN- RGDSTF. The peptide was identified as isoform 1 of the fibrinogen a chain precursor, whose concentration in urine was markedly higher in H. pylori infected volunteers than in H. pylori non-infected ones. CONCLUSION： The appearance of urinary fibrinogen degradation products is caused by an active H. pyloriinduced process.展开更多
The generalized noncommutative torus Tkp of rank n was defined in [4] by the crossed product Am/k ×a3 Z ×a4 … ×an Z, where the actions ai of Z on the fibre Mk(C) of a rational rotation algebra Am/k are...The generalized noncommutative torus Tkp of rank n was defined in [4] by the crossed product Am/k ×a3 Z ×a4 … ×an Z, where the actions ai of Z on the fibre Mk(C) of a rational rotation algebra Am/k are trivial, and C*(kZ × kZ) ×a3 Z ×a4 ... ×an Z is a completely irrational noncommutative torus Ap of rank n. It is shown in this paper that Tkp is strongly Morita equivalent to Ap, and that Tkp (?) Mp∞ is isomorphic to Ap (?) Mk(C) (?) Mp∞ if and only if the set of prime factors of k is a subset of the set of prime factors of p.展开更多
The mode theory is the main way to study the propagation characteristics of light in fiber so far,but it is not suitable for analysis of light in duct.By using ray-tracing method,the rotary propagation characteristics...The mode theory is the main way to study the propagation characteristics of light in fiber so far,but it is not suitable for analysis of light in duct.By using ray-tracing method,the rotary propagation characteristics of light in multimode-single mode-multimode(MSM) fiber structures are analyzed in this paper.Firstly,the light ray in fiber can propagate around an inscribed circle,and the central axis of this fiber is the propagation axis.Secondly,the radius of the inscribed circle is decided by both incident angle and incident position,and its variation is between 0 and RM,where RM is the radius of the multimode fiber.Lastly,the bigger the ratio of core and cladding diameter is,the higher the propagation efficiency is.展开更多
文摘AIM:To evaluate retrospectively the correlation between enhancement patterns on dynamic computed tomography (CT) and angiogenesis and fibrosis in pancreatic adenocarcinoma.METHODS: Twenty-three patients with pancreatic adenocarcinoma underwent dynamic CT and tumor resection. In addition to the absolute and relative enhanced value that was calculated by subtracting the attenuation value on pre-contrast from those on contrast-enhanced CT in each phase, we defined one parameter, "tumor-aorta enhancement ratio", which was calculated by dividing enhancement of pancreatic cancer by enhancement of abdominal aorta in each phase. These enhancement patterns were correlated with the level of vascular endothelial growth factor (VEGF), microvessel density (MVD), and extent of fibrosis.RESULTS: The absolute enhanced value in the arterial phase correlated with the level of VEGF and MVD (P=0.047, P=0.001). The relative enhanced value in arterial phase and tumor-aorta enhancement ratio (arterial) correlated with MVD (P=0.003, P=0.022). Tumor-aorta enhancement ratio (arterial) correlated negatively with the extent of fibrosis (P=0.004). The tumors with greater MVD and higher expression of VEGF tended to show high enhancement in the arterial dominant phase. On the other hand, the tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase.CONCLUSION: Enhancement patterns on dynamic CT correlated with angiogenesis and may be modified by the extent of fibrosis.
文摘To get fiber motion in condensing zone of compact spinning,velocity of this area is achieved by simulation,and then a bead-elastic rod fiber model is established.Based on simulation and dynamic analysis on this zone,governing equations are constructed and Runge-Kutta approach is used.Lastly,trajectories of fibers are calculated by specially designed Matlab procedure according to the principles mentioned above.Results show that fiber motions at different initial positions are different;X-axis velocity component makes fibers gathering on sides of suction slot;Y-axis airflow gets fibers gradually close and then stick to the surface of lattice apron.Fiber motions also reflect that the compact spinning process in condensing zone can be divided into three parts:fast convergence zone,adjustment convergence zone,and steady convergence zone.
基金Supported by The National Science and Technology Pillar Program of the Ministry of Science and Technology of the People’s Republic of China during the Eleventh Five-Year plan period,No. 2007BAID4B02
文摘AIM： To investigate the relationship between urinary peptide changes and Helicobacter pylori （H. pylorl） infection using urinary peptidome profiling. METHODS： The study was performed in volunteers （n = 137） who gave informed consent. Urinary peptides were enriched by magnetic beads based weak cation exchange chromatography＇and spectrums acquired by matrix-assisted laser desorption/ionization time-of-flight （MALDI-TOF） mass spectrometry （MS）. ClinProTools bioinformatics software was used for statistical analysis and the recognition of peptide patterns. The marker peptides were identified by LTQ Obitrap XL tandem MS. RESULTS： Approximately 50 proteins or peptides which loaded onto the magnetic beads were detected by MAL-DI-TOF MS. By optimizing the parameters of the model, the Genetic Algorithm model had good recognition capability （97%） and positive predictive value （94%）. Based on the model, 2 markers with molecular masses of 6788 and 1912 Da were found that differentiated between H. pylori positive and negative volunteers. The m/z 1912 sequence was parsed as SKQFTSSTSYN- RGDSTF. The peptide was identified as isoform 1 of the fibrinogen a chain precursor, whose concentration in urine was markedly higher in H. pylori infected volunteers than in H. pylori non-infected ones. CONCLUSION： The appearance of urinary fibrinogen degradation products is caused by an active H. pyloriinduced process.
基金Project supported by Grant No.1999-2-102-001-3 from the Interdisciplinary Research Program Year of the KOSEF.
文摘The generalized noncommutative torus Tkp of rank n was defined in [4] by the crossed product Am/k ×a3 Z ×a4 … ×an Z, where the actions ai of Z on the fibre Mk(C) of a rational rotation algebra Am/k are trivial, and C*(kZ × kZ) ×a3 Z ×a4 ... ×an Z is a completely irrational noncommutative torus Ap of rank n. It is shown in this paper that Tkp is strongly Morita equivalent to Ap, and that Tkp (?) Mp∞ is isomorphic to Ap (?) Mk(C) (?) Mp∞ if and only if the set of prime factors of k is a subset of the set of prime factors of p.
基金supported by the National Natural Science Foundation of China(No.61177076)the Fundamental Research Funds for the Central Universities(Nos.2013-Ia-038 and 2013-Ia-006)
文摘The mode theory is the main way to study the propagation characteristics of light in fiber so far,but it is not suitable for analysis of light in duct.By using ray-tracing method,the rotary propagation characteristics of light in multimode-single mode-multimode(MSM) fiber structures are analyzed in this paper.Firstly,the light ray in fiber can propagate around an inscribed circle,and the central axis of this fiber is the propagation axis.Secondly,the radius of the inscribed circle is decided by both incident angle and incident position,and its variation is between 0 and RM,where RM is the radius of the multimode fiber.Lastly,the bigger the ratio of core and cladding diameter is,the higher the propagation efficiency is.
