目的系统分析在确诊为COVID-19的儿童患者中,了解无症状COVID-19儿童发生率,为疫情的防控提供临床实践参考。方法搜索了英文数据库PubMed、Web of Science、Embase、约翰·霍普金斯大学公布数据,以及中文数据库CNKI、万方、重庆维...目的系统分析在确诊为COVID-19的儿童患者中,了解无症状COVID-19儿童发生率,为疫情的防控提供临床实践参考。方法搜索了英文数据库PubMed、Web of Science、Embase、约翰·霍普金斯大学公布数据,以及中文数据库CNKI、万方、重庆维普数据。回顾性分析2020年1月31至2021年4月30日关于COVID-19儿童临床特征的文献,采用R.3.6.3软件进行Meta分析,通过随机效应元分析来计算加权平均流行率和95%置信区间(CI)或加权平均均值及95%CI。结果一共56篇文献,包括15378人次患儿纳入研究。26篇研究来自国外研究,男女比例为1.10∶1,无症状儿童患者发生率24.12%(95%CI:20.41%~27.83%);按照中国与中国以外的亚组分析发现,中国无症状儿童发生率是24.97%(95%CI:18.37%~31.56%),欧洲国家发生率是23.83%(95%CI:16.79%~30.86%),美洲国家发生率是16.94%(95%CI:7.81%~26.06%),亚洲其他国家发生率是35.21%(95%CI:4.10%~66.32%)。而具有流行病学病史占89.37%(95%CI:84.73%~93.26%)。结论无症状COVID-19儿童发生率较高,无症状COVID-19儿童是最容易漏诊的,因此无症状COVID-19儿童是疫情防控的重点。展开更多
AIM: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS: Children at the age of 1-9 years were screened for HCV antibodies and a...AIM: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS: Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease.RESULTS: We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION: Asymptomatic HCV infection is detectable in 2.02% Egyptian children.展开更多
文摘目的系统分析在确诊为COVID-19的儿童患者中,了解无症状COVID-19儿童发生率,为疫情的防控提供临床实践参考。方法搜索了英文数据库PubMed、Web of Science、Embase、约翰·霍普金斯大学公布数据,以及中文数据库CNKI、万方、重庆维普数据。回顾性分析2020年1月31至2021年4月30日关于COVID-19儿童临床特征的文献,采用R.3.6.3软件进行Meta分析,通过随机效应元分析来计算加权平均流行率和95%置信区间(CI)或加权平均均值及95%CI。结果一共56篇文献,包括15378人次患儿纳入研究。26篇研究来自国外研究,男女比例为1.10∶1,无症状儿童患者发生率24.12%(95%CI:20.41%~27.83%);按照中国与中国以外的亚组分析发现,中国无症状儿童发生率是24.97%(95%CI:18.37%~31.56%),欧洲国家发生率是23.83%(95%CI:16.79%~30.86%),美洲国家发生率是16.94%(95%CI:7.81%~26.06%),亚洲其他国家发生率是35.21%(95%CI:4.10%~66.32%)。而具有流行病学病史占89.37%(95%CI:84.73%~93.26%)。结论无症状COVID-19儿童发生率较高,无症状COVID-19儿童是最容易漏诊的,因此无症状COVID-19儿童是疫情防控的重点。
基金Supported by the Sustainable Sciences Institute, United States as part of the small grants program
文摘AIM: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS: Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease.RESULTS: We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION: Asymptomatic HCV infection is detectable in 2.02% Egyptian children.
