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注射剂车间无菌灌装的验证方法 被引量:4
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作者 梁玉仪 梁勇坤 卢喆胜 《中国药业》 CAS 2004年第4期25-26,共2页
以无菌试验用培养基作为活性物模拟整个生产工艺的试验,探讨对注射剂车间无菌生产过程(无菌配液、灌装过程)验证的方法,证实无菌灌装试验是用以评价无菌保证水平的重要依据,是对无菌生产工艺进行在线验证的重要手段。
关键词 无菌灌装过程 验证 培养基 GMP
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Effects of Process and Storage Temperature on Browning Index, Furosine, and HMF of Aseptic Cold Break Tomato Paste during Storage Time
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作者 Hye Won Yeom Joseph Conte Rasheed Mohammed Steve DeMuri 《Journal of Food Science and Engineering》 2016年第5期237-244,共8页
Effects of process and storage temperature on concentration of Maillard compounds in aseptic cold break tomato paste were evaluated during 12 months of storage time. Cold break tomato paste was processed at 104 ℃ or ... Effects of process and storage temperature on concentration of Maillard compounds in aseptic cold break tomato paste were evaluated during 12 months of storage time. Cold break tomato paste was processed at 104 ℃ or 112℃, aseptically filled into 5 liter bags, and stored at 21 ℃ and 33 ℃. Level of Browning Index, Furosine, and HMF was monitored in the aseptic cold break tomato paste during the storage time. Browning Index, Furosine, and HMF significantly increased in the aseptic cold break tomato paste during storage at 33℃, and there was linear correlation between Browning Index and Furosine (or HMF). At the lower storage temperature of 21℃, no significant increases were observed. Effects of the process temperature on Browning Index, Furosine, and HMF of aseptic cold break tomato paste were less significant than the storage temperature. 展开更多
关键词 Aseptic cold break tomato paste process temperature storage temperature Browning Index FUROSINE HMF.
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