Wireless Mesh Networks (WMNs) are vulnerable to various security threats because of their special infrastructure and communication mode, wherein insider attacks are the most challenging issue. To address this proble...Wireless Mesh Networks (WMNs) are vulnerable to various security threats because of their special infrastructure and communication mode, wherein insider attacks are the most challenging issue. To address this problem and protect innocent users from malicious attacks, it is important to encourage cooperation and deter malicious behaviors. Reputation systems constitute a major category of techniques used for managing trust in distributed networks, and they are effective in characterizing and quantifying a node's behavior for WMNs. However, conventional layered reputation mechanisms ignore several key factors of reputation in other layers; therefore, they cannot provide optimal performance and accurate malicious node identification and isolation for WMNs. In this paper, we propose a novel dynamic reputation mechanism, SLCRM, which couples reputation systems with a cross-layer design and node-security-rating classification techniques to dynamically detect and restrict insider attacks. Simulation results show that in terms of network throughput, packet delivery ratio, malicious nodes' identification, and success rates, SI_CRM imple- ments security protection against insider attacks in a more dynamic, effective, and efficient manner than the subjective logic and uncertainty-based reputation model and the familiarity-based reputation model.展开更多
In this paper we put forward a new solution of the well-known problem of relevant logics, i.e., we construct an atomic entailment. Hence, we construct a system of predicate calculus based on the atomic entailment. Nex...In this paper we put forward a new solution of the well-known problem of relevant logics, i.e., we construct an atomic entailment. Hence, we construct a system of predicate calculus based on the atomic entailment. Next, we establish the definition of atomic inconsistency. The atomic inconsistency establishes an infinite class of inconsistent, but non-trivial systems. In this paper we construct the new definition of the classical entailment, into the bargain.展开更多
Empirical, formal, and speculative understandings of logic as identified by Hegel will be formalized. Being formalized the propositions will be deduced from how probabilities can be used to make decisions by appropria...Empirical, formal, and speculative understandings of logic as identified by Hegel will be formalized. Being formalized the propositions will be deduced from how probabilities can be used to make decisions by appropriating Hegel's concept of being two-sided for inferences. This will work for what I will call grounded as opposed to ungrounded probability functions. The domain of their values will be decided by a three-valued modal relation of the binomial probability function. Keynes (1920, Ch. IV ~17) and Popper's (1959, Ch. 59) solution to the problem of unknown proportions will be challenged by an understanding of logic that puts the content of what the axioms mean for making rational decisions before their mere being. What is true for the different types inferences will then work for the principle of the dialectic in contrast to the two proposed by Hume and the one proposed by David Lewis. In this way, it will be demonstrated that Hegel's understanding of logic is still more advanced than one that fails to recognize it falls within the scope of the dialectic. Dialectic as such will be a principle where the different understandings of a predicated logic will have a modal value within a higher standpoint of system.展开更多
Background:Infliximab(IFX)is effective at inducing and maintaining clinical remission and mucosal healing in patients with Crohn’s disease(CD);however,9%–40%of patients do not respond to primary IFX treatment.This s...Background:Infliximab(IFX)is effective at inducing and maintaining clinical remission and mucosal healing in patients with Crohn’s disease(CD);however,9%–40%of patients do not respond to primary IFX treatment.This study aimed to construct and validate nomograms to predict IFX response in CD patients.Methods:A total of 343 patients diagnosed with CD who had received IFX induction from four tertiary centers between September 2008 and September 2019 were enrolled in this study and randomly classified into a training cohort(n=240)and a validation cohort(n=103).The primary outcome was primary non-response(PNR)and the secondary outcome was mucosal healing(MH).Nomograms were constructed from the training cohort using multivariate logistic regression.Performance of nomograms was evaluated by area under the receiver-operating characteristic curve(AUC)and calibration curve.The clinical usefulness of nomograms was evaluated by decision-curve analysis.Results:The nomogram for PNR was developed based on four independent predictors:age,C-reactive protein(CRP)at week 2,body mass index,and non-stricturing,non-penetrating behavior(B1).AUC was 0.77 in the training cohort and 0.76 in the validation cohort.The nomogram for MH included four independent factors:baseline Crohn’s Disease Endoscopic Index of Severity,CRP at week 2,B1,and disease duration.AUC was 0.79 and 0.72 in the training and validation cohorts,respectively.The two nomograms showed good calibration in both cohorts and were superior to single factors and an existing matrix model.The decision curve indicated the clinical usefulness of the PNR nomogram.Conclusions:We established and validated nomograms for the prediction of PNR to IFX and MH in CD patients.This graphical tool is easy to use and will assist physicians in therapeutic decision-making.展开更多
基金supported by the Program for Changjiang Scholars and Innovative Research Team in University under Grant No.IRT1078the Key Program of NSFC-Guangdong Union Foundation under Grant No.U1135002+1 种基金Major National S&T Program under Grant No.2011ZX03005-002the Fundamental Research Funds for the Central Universities under Grant No.JY10000903001
文摘Wireless Mesh Networks (WMNs) are vulnerable to various security threats because of their special infrastructure and communication mode, wherein insider attacks are the most challenging issue. To address this problem and protect innocent users from malicious attacks, it is important to encourage cooperation and deter malicious behaviors. Reputation systems constitute a major category of techniques used for managing trust in distributed networks, and they are effective in characterizing and quantifying a node's behavior for WMNs. However, conventional layered reputation mechanisms ignore several key factors of reputation in other layers; therefore, they cannot provide optimal performance and accurate malicious node identification and isolation for WMNs. In this paper, we propose a novel dynamic reputation mechanism, SLCRM, which couples reputation systems with a cross-layer design and node-security-rating classification techniques to dynamically detect and restrict insider attacks. Simulation results show that in terms of network throughput, packet delivery ratio, malicious nodes' identification, and success rates, SI_CRM imple- ments security protection against insider attacks in a more dynamic, effective, and efficient manner than the subjective logic and uncertainty-based reputation model and the familiarity-based reputation model.
文摘In this paper we put forward a new solution of the well-known problem of relevant logics, i.e., we construct an atomic entailment. Hence, we construct a system of predicate calculus based on the atomic entailment. Next, we establish the definition of atomic inconsistency. The atomic inconsistency establishes an infinite class of inconsistent, but non-trivial systems. In this paper we construct the new definition of the classical entailment, into the bargain.
文摘Empirical, formal, and speculative understandings of logic as identified by Hegel will be formalized. Being formalized the propositions will be deduced from how probabilities can be used to make decisions by appropriating Hegel's concept of being two-sided for inferences. This will work for what I will call grounded as opposed to ungrounded probability functions. The domain of their values will be decided by a three-valued modal relation of the binomial probability function. Keynes (1920, Ch. IV ~17) and Popper's (1959, Ch. 59) solution to the problem of unknown proportions will be challenged by an understanding of logic that puts the content of what the axioms mean for making rational decisions before their mere being. What is true for the different types inferences will then work for the principle of the dialectic in contrast to the two proposed by Hume and the one proposed by David Lewis. In this way, it will be demonstrated that Hegel's understanding of logic is still more advanced than one that fails to recognize it falls within the scope of the dialectic. Dialectic as such will be a principle where the different understandings of a predicated logic will have a modal value within a higher standpoint of system.
基金supported by grants from the National Natural Science Foundation of China(#81870374,#81670498)Guangdong Science and Technology(#2017A030306021)+1 种基金Science and Technology Innovation Young Talents of Guangdong Special Support Plan(#2016TQ03R296)the Fundamental Research Funds for the Central Universities(#19ykzd11).
文摘Background:Infliximab(IFX)is effective at inducing and maintaining clinical remission and mucosal healing in patients with Crohn’s disease(CD);however,9%–40%of patients do not respond to primary IFX treatment.This study aimed to construct and validate nomograms to predict IFX response in CD patients.Methods:A total of 343 patients diagnosed with CD who had received IFX induction from four tertiary centers between September 2008 and September 2019 were enrolled in this study and randomly classified into a training cohort(n=240)and a validation cohort(n=103).The primary outcome was primary non-response(PNR)and the secondary outcome was mucosal healing(MH).Nomograms were constructed from the training cohort using multivariate logistic regression.Performance of nomograms was evaluated by area under the receiver-operating characteristic curve(AUC)and calibration curve.The clinical usefulness of nomograms was evaluated by decision-curve analysis.Results:The nomogram for PNR was developed based on four independent predictors:age,C-reactive protein(CRP)at week 2,body mass index,and non-stricturing,non-penetrating behavior(B1).AUC was 0.77 in the training cohort and 0.76 in the validation cohort.The nomogram for MH included four independent factors:baseline Crohn’s Disease Endoscopic Index of Severity,CRP at week 2,B1,and disease duration.AUC was 0.79 and 0.72 in the training and validation cohorts,respectively.The two nomograms showed good calibration in both cohorts and were superior to single factors and an existing matrix model.The decision curve indicated the clinical usefulness of the PNR nomogram.Conclusions:We established and validated nomograms for the prediction of PNR to IFX and MH in CD patients.This graphical tool is easy to use and will assist physicians in therapeutic decision-making.