AIM:To assess the validity of the Milan and University of California San Francisco(UCSF) criteria and examine the long-term outcome of orthotopic liver transplantation(OLT) in patients with hepatocellular carcinoma(HC...AIM:To assess the validity of the Milan and University of California San Francisco(UCSF) criteria and examine the long-term outcome of orthotopic liver transplantation(OLT) in patients with hepatocellular carcinoma(HCC) in a single-center study.METHODS:This study is a retrospective review of prospectively collected data.Between 1998 and 2009,56 of 356 OLTs were performed in patients with HCC.Based on pathological examination of liver explants,patients were retrospectively categorized into 3 groups:Milan +(n = 34),Milan-/UCSF +(n = 7) and UCSF-(n = 14).RESULTS:Median follow-up period was 39.5(1-124) mo.The 5-year overall survival rates in the Milan +,Milan-/UCSF + and UCSF-groups were 87.7%,53.6% and 33.3%,respectively(P < 0.000).Within these groups,tumor recurrence was determined in 5.8%,14.3% and 40% of patients,respectively(P < 0.011).Additionally,the presence of microvascular invasion within the explanted liver had a negative effect on the 5-year disease free survival(74.7% vs 46.7%,P < 0.044).CONCLUSION:The Milan criteria are reliable in the selection of suitable candidates for OLT for the treatment of HCC.For cases of OLT involving living donors,the UCSF criteria may be applied.展开更多
The leaders of the Meiji Restoration believed in their master, Yoshida Shoin （吉田松陰）, who claimed that in order for the islands of Japan not to be a colony of the powerful Western states, Japan had to conquer nea...The leaders of the Meiji Restoration believed in their master, Yoshida Shoin （吉田松陰）, who claimed that in order for the islands of Japan not to be a colony of the powerful Western states, Japan had to conquer nearby countries. This led to Japan’s invasion of the Ryukyu Islands, Taiwan, Korea, and Manchuria, which ultimately led to the Manchurian Incident of 1931, the Sino-Japanese War, and the Pacific War. Surprisingly, the subject and the timing of each and every one of these acts of war were in the same order of Yoshida Shoin’s proposal on preoccupancy. The Sino-Japanese war of 1894 was romanticized as clearing the barbaric culture by civilization, and the Russo-Japanese war of 1904 was romanticized as the realization of Eastern Peace. However, Japanese policies of aggressions were first deemed illegal by international law during the 1931 Manchurian Incident by the investigations of the League of Nations. The Japanese Empire received the recommendation by the League of Nations to restore to original state, but declined and exited from the League of Nations. Following their exit, they started the Sino-Japanese War and the Pacific War and eventually lost in 1945. The goal of the San Francisco Peace Treaty of 1951 was to punish Japan’s aggressions. However, as the Cold War between the East and the West started to arise in 1948, the punishment was eased, and their punishment for the aggressions on the Ryukyu Islands, Taiwan, and Korea was nearly unasked for. This paper examines the issues of the San Francisco Peace Treaty in the views of the international law of the League of Nations, established by Manley O. Hudson of Harvard University and others in U.S. academia and judiciary.展开更多
The California least tern （Sternula antillarum browni） is an endangered species. The two largest colonies of this bird species in the San Francisco Bay, California, USA, are located 23 km apart at Alameda Point and ...The California least tern （Sternula antillarum browni） is an endangered species. The two largest colonies of this bird species in the San Francisco Bay, California, USA, are located 23 km apart at Alameda Point and Hayward Regional Shoreline. The Alameda Point colony, on the former Naval Air Station, Alameda, has grown at an average rate of 9.2% per year since its discovery in 1976 and has a nesting density ranging from 1-153 nests per ha. Long-term breeding success at Alameda has averaged 0.86 fledglings per breeding pair. Least tems began appearing in 2003, at an island in Hayward enhanced with substrate mediums and social attraction devices. Successful breeding attempts have been observed at the Hayward colony since 2006. The Hayward colony has grown at an average rate of 51.5% per year, has a nesting density ranging from 33-333 nests per ha and long-term breeding success average of 0.87 fledglings per breeding pair. Dropped fish have been collected from both colonies, and silversides （family Atherinopsidae） are the dominant prey. Alameda terns forage on a greater variety of species than the Hayward terns. The regression results indicate the importance of Northern anchovy （Engraulis mordax） to the breeding success of the Alameda colony.展开更多
Aluminum spent potlining (SPL) was employed as both the fluxing agent and a source of carbonaceous reductant for the carbothermic reduction of chromite, aiming to allow effective separation of alloy from the slag comp...Aluminum spent potlining (SPL) was employed as both the fluxing agent and a source of carbonaceous reductant for the carbothermic reduction of chromite, aiming to allow effective separation of alloy from the slag component. The experimental results show that the carbonaceous component of the SPL is more reactive towards chromite reduction compared to graphite. The formation of refractory spinel (MgAl2O4) on chromite particles hinders further reduction and alloy growth. The slag-making components of the SPL (e.g. nepheline and NaF) form molten slags at low temperatures (~1300℃) and partly dissolve the refractory spinel as well as the chromite. Destruction of the spinel layer with enhanced mass transfer greatly improves the alloy growth, which can be further promoted by reduction at a higher temperature (e.g. 1500℃). Ferrochrome alloy particles grow large enough at 1500℃ in the presence of SPL, allowing effective separation from the slag component using elutriation separation.展开更多
Seismicity in northern Arizona is concentrated in a northwest-southeast trending belt that stretches from the Utah border south to the edge of the Colorado Plateau. Located within this NASB （Northern Arizona Seismic ...Seismicity in northern Arizona is concentrated in a northwest-southeast trending belt that stretches from the Utah border south to the edge of the Colorado Plateau. Located within this NASB （Northern Arizona Seismic Belt） is the San Francisco volcanic field, classified by the United States Geological Survey as potentially active. The last volcanic event in the field was located at Sunset Crater and occurred less than 1,000 years ago. Eruption intervals in the volcanic field are of the same order of length of time. Seismic monitoring of the volcanic field area has improved greatly since 1985 with the establishment of new network seismic stations. This has allowed for a lowered threshold of detection of seismic events and improved location capabilities. As an example of the result of this improved ability to locate smaller tremors, two swarms have been identified in the field, the 2009 Halloween swarm near Sunset Crater volcano and the 2011 swarm near Flagstaff, the largest urban community in northern Arizona.展开更多
The development of foils for racing boats has changed the strategy of sailing. Recently, the America＇s cup held in San Francisco, has been the theatre of a tragicomic history due to the foils. During the last round, ...The development of foils for racing boats has changed the strategy of sailing. Recently, the America＇s cup held in San Francisco, has been the theatre of a tragicomic history due to the foils. During the last round, the New-Zealand boat was winning by 8 to 1 against the defender USA. The winner is the first with 9 victories. USA team understood suddenly （may be） how to use the control of the pitching of the inain foils by adjusting the rake in order to stabilize the ship. And USA won by 9 victories against 8 to the challenger NZ. The goal in this paper is to point out few aspects which could be taken into account in order to improve this mysterious control law which is known as the key of the victory of the USA team. There are certainly many reasons and in particular the cleverness of the sailors and of all the engineering team behind this project. But it appears interesting to have a mathematical discussion, even if it is a partial one, on the mechanical behaviour of these extraordinary sailing boats. The nunlerical exanlples given here are not the true ones. They have just been invented in order to explain the theoretical developments concerning three points： The possibility of tacking on the foils for sailing upwind, the nature of foiling instabilities, if there are, when the boat is flying and the control laws.展开更多
Objective: Apios americana,a plant used as a staple ingredient of native American diets,has various properties,including anti-cancer,anti-hyperglycemic,hypotensive,and anti-inflammatory activity.In Japan,Apios is used...Objective: Apios americana,a plant used as a staple ingredient of native American diets,has various properties,including anti-cancer,anti-hyperglycemic,hypotensive,and anti-inflammatory activity.In Japan,Apios is used as a post-natal medication.After parturition,women undergo a period of recovery as they return to pre-pregnancy conditions.However,few health products that aid post-partum recovery are on the market.We explored whether Apios can accelerate the post-partum recovery process,in particular the involution of the uterus.Methods: Female rats kept in individual cages were mated with two male rats,with the exception of the control group(female rats without mating,on basal diet;n=6).After delivery,rats were divided into five groups based on their diet: basal diet(model;n=6);basal diet+oral intake at 5.4 g/kg of Chanfukang granules(a Chinese patent medicine preparation for post-partum lochia)(positive;n=6);basal diet containing 10% Apios powder(low;n=6);basal diet containing 20% Apios powder(medium;n=6);basal diet containing 40% Apios powder(high;n=6).Five days later,uteri and spleens were weighed.Uterus and spleen indices for each rat were calculated by dividing visceral weight by the total weight.Hormone and cytokine concentrations were measured using enzyme-linked immunosorbent assay(ELISA).Histological analysis of uteri was completed using hematoxylin and eosin(H&E) staining.Expression of matrix metalloproteinases and inhibitors in uteri was measured by western blotting.Results: Our results showed that Apios treatment reduced the post-partum uterus index and regulated the hormone concentrations.Moreover,we found that the process of uterine involution was accelerated,based on morphological changes in the uterus.In addition,our results indicated that Apios alleviated the inflammatory response induced by the involution process.Transforming growth factor β was also found to be regulated by Apios.There were significant downregulation of matrix metalloproteinases and upregulation of their inhibitors by Apios,which suggested that Apios increased the rate of the collagen clearance process.Conclusions: These results,based on experimental observations at the molecular and protein levels,verified our hypothesis that Apios can improve uterine involution,and demonstrated the potential application of Apios in post-partum care.展开更多
文摘AIM:To assess the validity of the Milan and University of California San Francisco(UCSF) criteria and examine the long-term outcome of orthotopic liver transplantation(OLT) in patients with hepatocellular carcinoma(HCC) in a single-center study.METHODS:This study is a retrospective review of prospectively collected data.Between 1998 and 2009,56 of 356 OLTs were performed in patients with HCC.Based on pathological examination of liver explants,patients were retrospectively categorized into 3 groups:Milan +(n = 34),Milan-/UCSF +(n = 7) and UCSF-(n = 14).RESULTS:Median follow-up period was 39.5(1-124) mo.The 5-year overall survival rates in the Milan +,Milan-/UCSF + and UCSF-groups were 87.7%,53.6% and 33.3%,respectively(P < 0.000).Within these groups,tumor recurrence was determined in 5.8%,14.3% and 40% of patients,respectively(P < 0.011).Additionally,the presence of microvascular invasion within the explanted liver had a negative effect on the 5-year disease free survival(74.7% vs 46.7%,P < 0.044).CONCLUSION:The Milan criteria are reliable in the selection of suitable candidates for OLT for the treatment of HCC.For cases of OLT involving living donors,the UCSF criteria may be applied.
文摘The leaders of the Meiji Restoration believed in their master, Yoshida Shoin （吉田松陰）, who claimed that in order for the islands of Japan not to be a colony of the powerful Western states, Japan had to conquer nearby countries. This led to Japan’s invasion of the Ryukyu Islands, Taiwan, Korea, and Manchuria, which ultimately led to the Manchurian Incident of 1931, the Sino-Japanese War, and the Pacific War. Surprisingly, the subject and the timing of each and every one of these acts of war were in the same order of Yoshida Shoin’s proposal on preoccupancy. The Sino-Japanese war of 1894 was romanticized as clearing the barbaric culture by civilization, and the Russo-Japanese war of 1904 was romanticized as the realization of Eastern Peace. However, Japanese policies of aggressions were first deemed illegal by international law during the 1931 Manchurian Incident by the investigations of the League of Nations. The Japanese Empire received the recommendation by the League of Nations to restore to original state, but declined and exited from the League of Nations. Following their exit, they started the Sino-Japanese War and the Pacific War and eventually lost in 1945. The goal of the San Francisco Peace Treaty of 1951 was to punish Japan’s aggressions. However, as the Cold War between the East and the West started to arise in 1948, the punishment was eased, and their punishment for the aggressions on the Ryukyu Islands, Taiwan, and Korea was nearly unasked for. This paper examines the issues of the San Francisco Peace Treaty in the views of the international law of the League of Nations, established by Manley O. Hudson of Harvard University and others in U.S. academia and judiciary.
文摘The California least tern （Sternula antillarum browni） is an endangered species. The two largest colonies of this bird species in the San Francisco Bay, California, USA, are located 23 km apart at Alameda Point and Hayward Regional Shoreline. The Alameda Point colony, on the former Naval Air Station, Alameda, has grown at an average rate of 9.2% per year since its discovery in 1976 and has a nesting density ranging from 1-153 nests per ha. Long-term breeding success at Alameda has averaged 0.86 fledglings per breeding pair. Least tems began appearing in 2003, at an island in Hayward enhanced with substrate mediums and social attraction devices. Successful breeding attempts have been observed at the Hayward colony since 2006. The Hayward colony has grown at an average rate of 51.5% per year, has a nesting density ranging from 33-333 nests per ha and long-term breeding success average of 0.87 fledglings per breeding pair. Dropped fish have been collected from both colonies, and silversides （family Atherinopsidae） are the dominant prey. Alameda terns forage on a greater variety of species than the Hayward terns. The regression results indicate the importance of Northern anchovy （Engraulis mordax） to the breeding success of the Alameda colony.
基金funded by NRCan under the Rare Earth Elements and Chromite R&D Program
文摘Aluminum spent potlining (SPL) was employed as both the fluxing agent and a source of carbonaceous reductant for the carbothermic reduction of chromite, aiming to allow effective separation of alloy from the slag component. The experimental results show that the carbonaceous component of the SPL is more reactive towards chromite reduction compared to graphite. The formation of refractory spinel (MgAl2O4) on chromite particles hinders further reduction and alloy growth. The slag-making components of the SPL (e.g. nepheline and NaF) form molten slags at low temperatures (~1300℃) and partly dissolve the refractory spinel as well as the chromite. Destruction of the spinel layer with enhanced mass transfer greatly improves the alloy growth, which can be further promoted by reduction at a higher temperature (e.g. 1500℃). Ferrochrome alloy particles grow large enough at 1500℃ in the presence of SPL, allowing effective separation from the slag component using elutriation separation.
文摘Seismicity in northern Arizona is concentrated in a northwest-southeast trending belt that stretches from the Utah border south to the edge of the Colorado Plateau. Located within this NASB （Northern Arizona Seismic Belt） is the San Francisco volcanic field, classified by the United States Geological Survey as potentially active. The last volcanic event in the field was located at Sunset Crater and occurred less than 1,000 years ago. Eruption intervals in the volcanic field are of the same order of length of time. Seismic monitoring of the volcanic field area has improved greatly since 1985 with the establishment of new network seismic stations. This has allowed for a lowered threshold of detection of seismic events and improved location capabilities. As an example of the result of this improved ability to locate smaller tremors, two swarms have been identified in the field, the 2009 Halloween swarm near Sunset Crater volcano and the 2011 swarm near Flagstaff, the largest urban community in northern Arizona.
文摘The development of foils for racing boats has changed the strategy of sailing. Recently, the America＇s cup held in San Francisco, has been the theatre of a tragicomic history due to the foils. During the last round, the New-Zealand boat was winning by 8 to 1 against the defender USA. The winner is the first with 9 victories. USA team understood suddenly （may be） how to use the control of the pitching of the inain foils by adjusting the rake in order to stabilize the ship. And USA won by 9 victories against 8 to the challenger NZ. The goal in this paper is to point out few aspects which could be taken into account in order to improve this mysterious control law which is known as the key of the victory of the USA team. There are certainly many reasons and in particular the cleverness of the sailors and of all the engineering team behind this project. But it appears interesting to have a mathematical discussion, even if it is a partial one, on the mechanical behaviour of these extraordinary sailing boats. The nunlerical exanlples given here are not the true ones. They have just been invented in order to explain the theoretical developments concerning three points： The possibility of tacking on the foils for sailing upwind, the nature of foiling instabilities, if there are, when the boat is flying and the control laws.
基金Project supported by the Zhejiang Provincial Natural Science Foundation of China(No.LZ14C200001)
文摘Objective: Apios americana,a plant used as a staple ingredient of native American diets,has various properties,including anti-cancer,anti-hyperglycemic,hypotensive,and anti-inflammatory activity.In Japan,Apios is used as a post-natal medication.After parturition,women undergo a period of recovery as they return to pre-pregnancy conditions.However,few health products that aid post-partum recovery are on the market.We explored whether Apios can accelerate the post-partum recovery process,in particular the involution of the uterus.Methods: Female rats kept in individual cages were mated with two male rats,with the exception of the control group(female rats without mating,on basal diet;n=6).After delivery,rats were divided into five groups based on their diet: basal diet(model;n=6);basal diet+oral intake at 5.4 g/kg of Chanfukang granules(a Chinese patent medicine preparation for post-partum lochia)(positive;n=6);basal diet containing 10% Apios powder(low;n=6);basal diet containing 20% Apios powder(medium;n=6);basal diet containing 40% Apios powder(high;n=6).Five days later,uteri and spleens were weighed.Uterus and spleen indices for each rat were calculated by dividing visceral weight by the total weight.Hormone and cytokine concentrations were measured using enzyme-linked immunosorbent assay(ELISA).Histological analysis of uteri was completed using hematoxylin and eosin(H&E) staining.Expression of matrix metalloproteinases and inhibitors in uteri was measured by western blotting.Results: Our results showed that Apios treatment reduced the post-partum uterus index and regulated the hormone concentrations.Moreover,we found that the process of uterine involution was accelerated,based on morphological changes in the uterus.In addition,our results indicated that Apios alleviated the inflammatory response induced by the involution process.Transforming growth factor β was also found to be regulated by Apios.There were significant downregulation of matrix metalloproteinases and upregulation of their inhibitors by Apios,which suggested that Apios increased the rate of the collagen clearance process.Conclusions: These results,based on experimental observations at the molecular and protein levels,verified our hypothesis that Apios can improve uterine involution,and demonstrated the potential application of Apios in post-partum care.
