To determine whether the concentration of hCG in cervical fluid can predict miscarriage during early pregnancy. Design: Prospective clinical study. Setting: University hospital. Patient(s): Ninety-nine women with sing...To determine whether the concentration of hCG in cervical fluid can predict miscarriage during early pregnancy. Design: Prospective clinical study. Setting: University hospital. Patient(s): Ninety-nine women with singleton pregnancies, 17 of whom suffered a miscarriage. Intervention(s): None. Main Outcome Measure(s): Miscarriage and the cervical fluid/- serum hCG concentration ratio. Result(s): With a cutoff value of 1.0, the sensitivity, specificity, and positive and negative predictive values of the cervical fluid/serum hCG concentration ratio for predicting miscarriage were 88.2% , 94.9% , 83.3% , and 96.6% , respectively. Conclusion(s): The cervical fluid/serum hCG concentration ratio might be a useful predictor of miscarriage during early pregnancy.展开更多
文摘To determine whether the concentration of hCG in cervical fluid can predict miscarriage during early pregnancy. Design: Prospective clinical study. Setting: University hospital. Patient(s): Ninety-nine women with singleton pregnancies, 17 of whom suffered a miscarriage. Intervention(s): None. Main Outcome Measure(s): Miscarriage and the cervical fluid/- serum hCG concentration ratio. Result(s): With a cutoff value of 1.0, the sensitivity, specificity, and positive and negative predictive values of the cervical fluid/serum hCG concentration ratio for predicting miscarriage were 88.2% , 94.9% , 83.3% , and 96.6% , respectively. Conclusion(s): The cervical fluid/serum hCG concentration ratio might be a useful predictor of miscarriage during early pregnancy.
文摘目的分析凝血功能指标凝血酶原时间(prothrombin time,PT)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、D-二聚体(D-Dimer,D-D)、纤维蛋白原(fibrinogen,FIB)、凝血酶时间(thrombin time,TT)在早孕期先兆流产中的临床意义。方法回顾性收集2019年1月至2021年12月宜兴市第二人民医院(宜兴市职业病防治院)收治的120例先兆流产患者作为研究对象,根据患者不同的妊娠结局分为保胎成功组(n=71)和流产组(n=49),另收集同期正常妊娠孕妇120例为对照组。对比三组入院时的凝血PT,APTT,D-D,FIB,TT表达,偏回归分析凝血功能指标与早孕期先兆流产的关联性,并分析其对早孕期先兆流产患者妊娠结局的预测价值。结果三组入院时的凝血功能指标PT,APTT,D-D,FIB,TT水平比较,保胎成功组高于流产组、对照组(P<0.05);回归分析显示,入院时的凝血PT,APTT,D-D,FIB,TT指标为早孕期先兆流产的危险因素(P<0.05);入院时的凝血PT,APTT,D-D,FIB,TT水平联合预测早孕期先兆流产患者妊娠结局的曲线下面积(area under the curve,AUC)为0.788。结论凝血功能指标PT,APTT,D-D,FIB,TT与早期先兆流产患者妊娠结局存在相关性,其表达可辅助临床诊疗。
