目的:研究早期舌癌局灶性切除术患者给予加味黄连解毒汤治疗后的临床疗效和复发率。方法:将80例早期舌癌局灶性切除术患者随机分为两组。对照组40例,给予常规治疗;研究组40例,给予常规治疗及加味黄连解毒汤治疗。比较两组患者生存质量...目的:研究早期舌癌局灶性切除术患者给予加味黄连解毒汤治疗后的临床疗效和复发率。方法:将80例早期舌癌局灶性切除术患者随机分为两组。对照组40例,给予常规治疗;研究组40例,给予常规治疗及加味黄连解毒汤治疗。比较两组患者生存质量、缓解程度、不良反应、6～24个月复发率。结果:治疗后,研究组肿瘤缓解率75.00%,明显优于对照组缓解率60.00%,差异具有统计学意义(χ~2=5.128,P=0.024);两组卡氏功能状态(Karnofsky,KPS)评分比较,差异无统计学意义(t=0.149,P=0.149);研究组行为状况评分(performance status,PS)明显优于对照组,差异有统计学意义(t=2.079,P=0.041);研究组生存质量评分(quality of life,QOL)明显优于对照组,差异有统计学意义(t=6.904,P=0.000);研究组不良反应率为20.00%,对照组不良反应率为35.00%,两组比较,差异具有统计学意义(χ~2=5.643,P=0.039)。在6～24个月随访中,研究组有7例患者失访,对照组有5例患者失访,1例死亡,研究组6～24个月的复发率为27.27%(9/33),明显优于对照组的复发率44.12%(15/34),差异具有统计学意义(χ~2=6.185,P=0.013)。结论:早期舌癌局灶性切除术患者进行加味黄连解毒汤治疗,可有效提高患者肿瘤缓解率,减少近期复发率,并改善患者日常生活功能状态,从而提高生存质量。展开更多
纽约长老会医院-Weill Cornell医疗中心的Ashutosh Tewari博士及其同事在12月的《泌尿学》（Urology 2006；68：1268—1274.）杂志上报告，根据在美国Henry Ford Health System进行的一项大型研究的结果提示，对临床局灶性前列腺癌患者...纽约长老会医院-Weill Cornell医疗中心的Ashutosh Tewari博士及其同事在12月的《泌尿学》（Urology 2006；68：1268—1274.）杂志上报告，根据在美国Henry Ford Health System进行的一项大型研究的结果提示，对临床局灶性前列腺癌患者，根治性首列腺切除术和放疗似乎比保守治疗可显著提高生存率。展开更多
Objective: The predominant mechanism of early graft failure after coronary artery bypass grafting remains in doubt. Aspirin administered in the initial hours after coronary artery bypass grafting improves graft patenc...Objective: The predominant mechanism of early graft failure after coronary artery bypass grafting remains in doubt. Aspirin administered in the initial hours after coronary artery bypass grafting improves graft patency, implicating prostanoid synthesis in the pathogenesis. We hypothesized that synergy between endothelial disruption in the venous conduit and aspirin resistance would cause vein graft failure. Methods: Aspirin resistance, defined by diagnostic findings on at least two of three separate assays, was serially assessed in 225 patients undergoing off-pump coronary artery bypass grafting. Endothelial cell integrity was determined in surplus segments obtained from 408 vein grafts. The deposition of intraluminal thrombin within the vein was determined by comparing serum F1.2 levels between the coronary sinus and the aorta after grafting. Intraoperative blood flow in the grafts was measured with transit-time technology, and patency was assessed with electrocardiographically gated multichannel computed tomographic coronary angiography on day 5. Aspirin was the sole antithrombotic agent used during the study. Results: Thrombosed grafts(16/408) showed more endothelial cell loss at the time of grafting than did those grafts that remained patent(10.8% ± 21.5% vs 51.4% ± 39.1% integrity, P< .01). Aspirin resistance occurred in 67 patients(30% ). Graft thrombosis was associated with aspirin resistance(P< .04) and reduced endothelial integrity(P< .01). These factors coexisted in 14 of 16 grafts that failed and were associated with elevated coronary sinus F1.2 levels. Conclusion: Aspirin resistance and relatively compromised venous endothelial cell integrity together marked patients whose vein grafts failed within days after off-pump coronary artery bypass grafting. These observations form a basis for identifying patients at risk and developing approaches to prevent vein injury or to selectively intervene in high-risk circumstances.展开更多
文摘目的:研究早期舌癌局灶性切除术患者给予加味黄连解毒汤治疗后的临床疗效和复发率。方法:将80例早期舌癌局灶性切除术患者随机分为两组。对照组40例,给予常规治疗;研究组40例,给予常规治疗及加味黄连解毒汤治疗。比较两组患者生存质量、缓解程度、不良反应、6～24个月复发率。结果:治疗后,研究组肿瘤缓解率75.00%,明显优于对照组缓解率60.00%,差异具有统计学意义(χ~2=5.128,P=0.024);两组卡氏功能状态(Karnofsky,KPS)评分比较,差异无统计学意义(t=0.149,P=0.149);研究组行为状况评分(performance status,PS)明显优于对照组,差异有统计学意义(t=2.079,P=0.041);研究组生存质量评分(quality of life,QOL)明显优于对照组,差异有统计学意义(t=6.904,P=0.000);研究组不良反应率为20.00%,对照组不良反应率为35.00%,两组比较,差异具有统计学意义(χ~2=5.643,P=0.039)。在6～24个月随访中,研究组有7例患者失访,对照组有5例患者失访,1例死亡,研究组6～24个月的复发率为27.27%(9/33),明显优于对照组的复发率44.12%(15/34),差异具有统计学意义(χ~2=6.185,P=0.013)。结论:早期舌癌局灶性切除术患者进行加味黄连解毒汤治疗,可有效提高患者肿瘤缓解率,减少近期复发率,并改善患者日常生活功能状态,从而提高生存质量。
文摘纽约长老会医院-Weill Cornell医疗中心的Ashutosh Tewari博士及其同事在12月的《泌尿学》（Urology 2006；68：1268—1274.）杂志上报告，根据在美国Henry Ford Health System进行的一项大型研究的结果提示，对临床局灶性前列腺癌患者，根治性首列腺切除术和放疗似乎比保守治疗可显著提高生存率。
文摘Objective: The predominant mechanism of early graft failure after coronary artery bypass grafting remains in doubt. Aspirin administered in the initial hours after coronary artery bypass grafting improves graft patency, implicating prostanoid synthesis in the pathogenesis. We hypothesized that synergy between endothelial disruption in the venous conduit and aspirin resistance would cause vein graft failure. Methods: Aspirin resistance, defined by diagnostic findings on at least two of three separate assays, was serially assessed in 225 patients undergoing off-pump coronary artery bypass grafting. Endothelial cell integrity was determined in surplus segments obtained from 408 vein grafts. The deposition of intraluminal thrombin within the vein was determined by comparing serum F1.2 levels between the coronary sinus and the aorta after grafting. Intraoperative blood flow in the grafts was measured with transit-time technology, and patency was assessed with electrocardiographically gated multichannel computed tomographic coronary angiography on day 5. Aspirin was the sole antithrombotic agent used during the study. Results: Thrombosed grafts(16/408) showed more endothelial cell loss at the time of grafting than did those grafts that remained patent(10.8% ± 21.5% vs 51.4% ± 39.1% integrity, P< .01). Aspirin resistance occurred in 67 patients(30% ). Graft thrombosis was associated with aspirin resistance(P< .04) and reduced endothelial integrity(P< .01). These factors coexisted in 14 of 16 grafts that failed and were associated with elevated coronary sinus F1.2 levels. Conclusion: Aspirin resistance and relatively compromised venous endothelial cell integrity together marked patients whose vein grafts failed within days after off-pump coronary artery bypass grafting. These observations form a basis for identifying patients at risk and developing approaches to prevent vein injury or to selectively intervene in high-risk circumstances.
