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降钙素元结合SOFA评分在小儿脓毒症的诊断及预后的应用研究 被引量:3
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作者 时珺 《浙江临床医学》 2012年第3期289-291,共3页
目的 探讨血清降钙素元(PCT)及SOFA评分动态监测对小儿脓毒症的早期诊断并判断预后效果.方法 55例脓毒症患儿入院后24h内进行血常规、痰培养、外周血培养和X线胸片等常规检测;测定肝、肾功能,电解质,动脉血气;体温、白细胞计数、中性... 目的 探讨血清降钙素元(PCT)及SOFA评分动态监测对小儿脓毒症的早期诊断并判断预后效果.方法 55例脓毒症患儿入院后24h内进行血常规、痰培养、外周血培养和X线胸片等常规检测;测定肝、肾功能,电解质,动脉血气;体温、白细胞计数、中性粒细胞计数、中性粒细胞比例;测定血清C反应蛋白(CRP)、PCT;进行SOFA评分.并于入院后第4、7天同样采集上述指标,并随访28d.对照组患儿均来自PICU危重患儿.结果 入院后三组患儿相关炎症指标比较可见死亡组及存活组的WBC,中性粒细胞,CRP及PCT均显著高于对照组,但死亡组及存活组两组间差异均无统计学意义.存活组在第4天及第7天较死亡组炎症指标及SOFA评分均明显下降,差异有统计学意义(P〈0.05).结论 在早期小儿脓毒症中,PCT的大小与病情的轻重相关;在判断预后方面,需结合PCT及SOFA评分才能得到更准确的结果. 展开更多
关键词 降钙素元 SOFA评分 小儿脓毒症 早期诊断预后
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可溶性髓样细胞触发受体-1在呼吸机相关性肺炎的早期诊断及预后评估中的临床应用 被引量:30
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作者 陈少霖 张卫星 +3 位作者 张声 赖剑波 陈兴旺 黄静 《中华医院感染学杂志》 CAS CSCD 北大核心 2017年第13期2968-2971,共4页
目的探讨可溶性髓样细胞触发受体-1(sTREM-1)在呼吸机相关性肺炎(VAP)患者早期诊断及预后评估的临床应用价值。方法收集2014年1月-2016年10月患者60例,分为VAP组(26例)、非VAP组(34例);另选30名健康志愿者为对照组;在VAP组中根据其28天... 目的探讨可溶性髓样细胞触发受体-1(sTREM-1)在呼吸机相关性肺炎(VAP)患者早期诊断及预后评估的临床应用价值。方法收集2014年1月-2016年10月患者60例,分为VAP组(26例)、非VAP组(34例);另选30名健康志愿者为对照组;在VAP组中根据其28天存活与否分成生存组与死亡组;收集患者机械通气第1、3、5、7天血清和肺泡灌洗液标本,分别检测sTREM-1,血清降钙素原(PCT),血清C-反应蛋白(CRP);采用受试者工作特征(ROC)曲线分析血清CRP、PCT、sTREM-1和灌洗液sTREM-1对VAP的早期诊断价值;应用Logistic回归分析影响VAP患者预后的危险因素。结果 VAP发病率为43.33%,而VAP组28天死亡率高达46.15%;APACHEII评分和28天死亡率,VAP组较非VAP组显著升高(P<0.05);气管插管时间、机械通气时间、和ICU住院时间,VAP组较非VAP组的时间显著延长(P<0.01);ROC曲线分析CRP、CPT、sTREM-1水平对VAP早期诊断的意义;血清sTREM-1的AUC为0.73;敏感性是0.73,特异性是0.69,(95%CI:0.58~0.88);支气管肺泡灌液sTREM-1的AUC为0.90;敏感性是0.88,特异性是0.82,(95%CI:0.85~0.98)。28天死亡组(12例)的APACHE II评分、血清CRP、血清PCT、血清sTREM-1和灌洗液中sTREM-1均高于生存组(14例),多因素logistic回归分析后,其中支气管肺泡灌洗液中sTREM-1水平及APACHE II评分为预后独立危险因素(P<0.05)。结论支气管肺泡灌洗液sTREM-1可作为VAP早期诊断指标,其敏感性及特异性高于血清CRP、PCT、sTREM-1,而且其水平与APACHE II评分均可评估VAP预后。 展开更多
关键词 可溶性髓样细胞触发受体-1、呼吸机相关性肺炎、支气管肺泡灌洗液 早期诊断预后评估
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急性肾损伤生物标志物的研究进展 被引量:3
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作者 宋琼 李侃 +2 位作者 吴蓉 苏筠霞 李建华 《国际检验医学杂志》 CAS 2017年第8期1087-1089,共3页
急性肾损伤(AKI)指在多种病因引起的肾功能快速下降而出现的临床综合征,包括尚无肾衰竭和已有肾衰竭的不同损伤阶段,其诊断标准为:肾功能在48h内突然降低,至少2次血清肌酐(Scr)升高的绝对值≥0.3mg/dL(26.5μmol/L);或SCr较前一... 急性肾损伤(AKI)指在多种病因引起的肾功能快速下降而出现的临床综合征,包括尚无肾衰竭和已有肾衰竭的不同损伤阶段,其诊断标准为:肾功能在48h内突然降低,至少2次血清肌酐(Scr)升高的绝对值≥0.3mg/dL(26.5μmol/L);或SCr较前一次升高50%;或持续6h以上尿量〈0.5mL/(kg·h)。近年来AKI的发病率逐年升高[1], 展开更多
关键词 急性肾损伤 生物标志物 早期诊断预后
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Micro RNA与乳腺癌的相关研究进展
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作者 姚永山 陈爱军 《海南医学》 CAS 2013年第3期443-445,共3页
miRNA是天然反义寡核苷酸链,具有调节真核生物基因表达和细胞增殖的功能,其能通过与靶信使RNA(mRNA)特异的碱基配对,导致细胞信号调节因子的降解或翻译抑制,从而在转录后水平上调节细胞的蛋白表达。本文通过研究国内外相关文献,并结合... miRNA是天然反义寡核苷酸链,具有调节真核生物基因表达和细胞增殖的功能,其能通过与靶信使RNA(mRNA)特异的碱基配对,导致细胞信号调节因子的降解或翻译抑制,从而在转录后水平上调节细胞的蛋白表达。本文通过研究国内外相关文献,并结合笔者实践经验,就miRNA与乳腺癌的研究进展及发展趋势做一综述。 展开更多
关键词 MICRORNA 乳腺癌 早期诊断预后
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RASSFIA Promoter Hypermethylation as a Prognosis and Diagnosis for Breast Cancer in Vietnamese Population
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作者 Truong Kim Phuong Lao Duc Thuan +1 位作者 Doan Thi Phuong Thao Le Huyen Ai Thuy 《Journal of Life Sciences》 2014年第4期316-321,共6页
Aberrant tumor suppressor gene promoter methylation was associated with the several cancers, including breast cancer, which was the common female deaths in most countries involved in Vietnam. The methylation in tumor ... Aberrant tumor suppressor gene promoter methylation was associated with the several cancers, including breast cancer, which was the common female deaths in most countries involved in Vietnam. The methylation in tumor suppressor genes, including RASSFIA, were the key targets of establishing the potential biomarkers for prognosis and early diagnosis of breast cancer. In present study, with the aim towards using the hypermethylation at CpG islands of promoter of RASSFIA as the biomarker for breast cancer in Vietnamese population, MSP (methyl specific PCR) was carried out to analyze the hypermethylation status ofRASSFIA gene in 115 samples including 95 breast cancer specimens and 20 normal breast tissues from another disease (not breast cancer). All samples were obtained from Ho Chi Minh City Medical Hospital, Vietnam. The known predictive and prognostic factors: HER2/neu overexpression was immunohistochemistry stained as input value for breast cancer specimens. For input value confirmed, the overexpression of p53 protein was also analyzed together with prior immunochemical assay. The results indicated that the hypermethylation of frequencies for methylation of given gene reached 42.1% (P 〈 0.05). In addition, the DNA hypermethylation of RASSFIA gene increased the possibility to be breast cancer with high incidence via calculated of odd ratio (P 〈 0.05). In conclusion, the hypermethylation of candidate genes could be used as the promising biomarkers applying in Vietnamese breast cancer patients. 展开更多
关键词 RASSFIA HYPERMETHYLATION MSP bisulfite modification breast cancer.
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SIOOB protein and its clinical effect on craniocerebra injury 被引量:8
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作者 袁雪松 卞晓星 《Chinese Journal of Traumatology》 CAS 2008年第1期54-57,共4页
Objective: To explore the role of S100B protein in the early diagnosis, treatment, and prognosis judgement of craniocerebral injury. Methods: In this study, we reviewed the domestic and foreign research reports abo... Objective: To explore the role of S100B protein in the early diagnosis, treatment, and prognosis judgement of craniocerebral injury. Methods: In this study, we reviewed the domestic and foreign research reports about the relationship between S100B protein and craniocerebral injury. Results: The concentration of S100B protein had a different increase based on the degree of injury in early stage after craniocerebral injury, and the increasing degree of S100B protein showed a positive correlation with the grading of pathogenetic condition and prognosis of craniocerebral injury. Conclusions: S100B protein may be taken as a specific index of early diagnosis, grading of pathogenetic condition, and prognosis judgement after craniocerebral injury. To grasp and regulate the mechanism of neurotoxicity and to elucidate the therapeutic effect of S100B protein will be a research direction in clinical treatment of craniocerebral injury. 展开更多
关键词 Craniocerebral trauma Early diagnosis PROGNOSIS S100B protein
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