Objective： Tibial shaft fractures are straightforward to treat but when associated with soft tissue injury particularly at the nail entry/plate insertion site or there is significant comminution proximally or a large...Objective： Tibial shaft fractures are straightforward to treat but when associated with soft tissue injury particularly at the nail entry/plate insertion site or there is significant comminution proximally or a large butterfly fragment/a second split component in the posterior coronal plane, it is a challenge to the treating surgeon. The aim of the present report is to describe the technique of posterior coronal plating in such a scenario and its ad- vantages. Methods： Between July 2008 and June 2011, 12 patients were prospectively treated by this approach using 4.5 mm broad dynamic compression plates. Results： The time of bony consolidation and full weight bearing averaged 21.7 weeks （range, 16-26 weeks）. Patients were followed up for at least 24 months （range, 24-48 months）. At 1 year postoperatively, no loss in reduction or alignment was observed. Mean Hospital for Lower Extremity Measurement Functional Score was 72.8 （range, 64-78）. All patients were satisfied with their treatment outcomes. Conclusion： Direct posterior approach and fixation using prone position helps to visualise the fracture fragments and provide rigid fixation. The approach is simple and extensile easily, apart from advantages of less soft tissue and hardware problems compared to standard medial or lateral plating.展开更多
Many interacting biomolecular components in cells form different positive or negative feedback loops. When biological signals transduce through cascades consisting of various loops they will be affected or even distor...Many interacting biomolecular components in cells form different positive or negative feedback loops. When biological signals transduce through cascades consisting of various loops they will be affected or even distorted. Especially, how to process various signals buried in various intrinsic and extrinsic noises is an important issue. This paper analyzes how the response time influences noise filtering ability and how to enhance the ability by coupling different feedback loops. A parameter to measure the response time of the signal transduction, i.e., τ0.9, and its relationship between the response time and noise filtering will be discussed. The authors show clearly that the longer the response time is, the better the ability to filter noises will be. Therefore, to enhance the ability to filter noises, the authors can prolong the response time by coupling different positive or negative feedback loops. The results provide a possible approach to enhance the ability to filter noises in larger biomolecular networks.展开更多
文摘Objective： Tibial shaft fractures are straightforward to treat but when associated with soft tissue injury particularly at the nail entry/plate insertion site or there is significant comminution proximally or a large butterfly fragment/a second split component in the posterior coronal plane, it is a challenge to the treating surgeon. The aim of the present report is to describe the technique of posterior coronal plating in such a scenario and its ad- vantages. Methods： Between July 2008 and June 2011, 12 patients were prospectively treated by this approach using 4.5 mm broad dynamic compression plates. Results： The time of bony consolidation and full weight bearing averaged 21.7 weeks （range, 16-26 weeks）. Patients were followed up for at least 24 months （range, 24-48 months）. At 1 year postoperatively, no loss in reduction or alignment was observed. Mean Hospital for Lower Extremity Measurement Functional Score was 72.8 （range, 64-78）. All patients were satisfied with their treatment outcomes. Conclusion： Direct posterior approach and fixation using prone position helps to visualise the fracture fragments and provide rigid fixation. The approach is simple and extensile easily, apart from advantages of less soft tissue and hardware problems compared to standard medial or lateral plating.
基金This research is supported by the National Natural Science Foundation of China under Grant No. 10832006, Youth Research under Grant No. 10701052, and Shanghai Pujiang Program.
文摘Many interacting biomolecular components in cells form different positive or negative feedback loops. When biological signals transduce through cascades consisting of various loops they will be affected or even distorted. Especially, how to process various signals buried in various intrinsic and extrinsic noises is an important issue. This paper analyzes how the response time influences noise filtering ability and how to enhance the ability by coupling different feedback loops. A parameter to measure the response time of the signal transduction, i.e., τ0.9, and its relationship between the response time and noise filtering will be discussed. The authors show clearly that the longer the response time is, the better the ability to filter noises will be. Therefore, to enhance the ability to filter noises, the authors can prolong the response time by coupling different positive or negative feedback loops. The results provide a possible approach to enhance the ability to filter noises in larger biomolecular networks.
