Hepatitis C virus （HCV） is a global health concern, notably in Southeast Asia, and in Laos the presentation of the HCV- induced liver disease is poorly known. Our objective was thus to describe a comprehensive HCV i...Hepatitis C virus （HCV） is a global health concern, notably in Southeast Asia, and in Laos the presentation of the HCV- induced liver disease is poorly known. Our objective was thus to describe a comprehensive HCV infection pattern in order to guide national health policies. A study on a group of 1765 patients formerly diagnosed by rapid test in health centres was conducted at the Centre of Infectiology Lao Christophe Merieux in Vientiane. The demographic information of patients, their infection status （viral load： VL）, liver function （aminotransferases） and treatments were analysed. Results showed that gender distribution of infected people was balanced; with median ages of 53.8 for men and 51.6 years for women （13-86 years）. The majority of patients （72%） were confirmed positive （VL 〉 50 IU/mL） and 28% of them had high VL （〉 61oglo）. About 23% of patients had level of aminotransferases indicative of liver damage （〉 40 IU/mL）; but less than 20% of patients received treatment. Patients rarely received a second sampling or medical imaging. The survey also showed that cycloferon, pegylated interferon and ribavirin were the drugs prescribed preferentially by the medical staff, without following any international recommendations schemes. In conclusion, we recommend that a population screening policy and better management of patients should be urgently implemented in the country, respecting official guidelines. However, the cost of biological analysis and treatment are significant barriers that must be removed. Public health resolutions should be immediately enforced in the perspective of meeting the WHO HCV elimination deadline by 2030.展开更多
Many studies involving lexical access in picture-naming tasks have been undertaken at a point in time,mainly focusing on age of acquisition(AoA).To identify the real determinates of lexical access in recovery and thei...Many studies involving lexical access in picture-naming tasks have been undertaken at a point in time,mainly focusing on age of acquisition(AoA).To identify the real determinates of lexical access in recovery and their traces in the brain,we carried out a longitudinal study on a Chinese pure anomic patient using multiple logistic regression analysis.We found that AoA played an important role in early recovery but not in total recovery,whereas familiarity was significant in the whole process.From a new dynamic point of view,our results indicate that AoA and familiarity are the main determinants of lexical access in anomia recovery.We suggest that the changing effects of AoA during recovery may be related to the pathologic process;AoA and familiarity should be taken into account in constructing materials to assess and treat anomic patients.展开更多
基金supported by CILM, Institut de Recherche pour le Développement, Campus Francethe Fondation Mérieux
文摘Hepatitis C virus （HCV） is a global health concern, notably in Southeast Asia, and in Laos the presentation of the HCV- induced liver disease is poorly known. Our objective was thus to describe a comprehensive HCV infection pattern in order to guide national health policies. A study on a group of 1765 patients formerly diagnosed by rapid test in health centres was conducted at the Centre of Infectiology Lao Christophe Merieux in Vientiane. The demographic information of patients, their infection status （viral load： VL）, liver function （aminotransferases） and treatments were analysed. Results showed that gender distribution of infected people was balanced; with median ages of 53.8 for men and 51.6 years for women （13-86 years）. The majority of patients （72%） were confirmed positive （VL 〉 50 IU/mL） and 28% of them had high VL （〉 61oglo）. About 23% of patients had level of aminotransferases indicative of liver damage （〉 40 IU/mL）; but less than 20% of patients received treatment. Patients rarely received a second sampling or medical imaging. The survey also showed that cycloferon, pegylated interferon and ribavirin were the drugs prescribed preferentially by the medical staff, without following any international recommendations schemes. In conclusion, we recommend that a population screening policy and better management of patients should be urgently implemented in the country, respecting official guidelines. However, the cost of biological analysis and treatment are significant barriers that must be removed. Public health resolutions should be immediately enforced in the perspective of meeting the WHO HCV elimination deadline by 2030.
基金supported by the National Natural Science Foundation of China (No.30570582)the Science and Technology Foundation of Zhejiang Province (No.2007C33007),China
文摘Many studies involving lexical access in picture-naming tasks have been undertaken at a point in time,mainly focusing on age of acquisition(AoA).To identify the real determinates of lexical access in recovery and their traces in the brain,we carried out a longitudinal study on a Chinese pure anomic patient using multiple logistic regression analysis.We found that AoA played an important role in early recovery but not in total recovery,whereas familiarity was significant in the whole process.From a new dynamic point of view,our results indicate that AoA and familiarity are the main determinants of lexical access in anomia recovery.We suggest that the changing effects of AoA during recovery may be related to the pathologic process;AoA and familiarity should be taken into account in constructing materials to assess and treat anomic patients.
