BM-13 505 is a new type of thromboxane receptor antagonist developed firstabfoad and synthesized in our school.wita modife method recently。The resultS of our study showed that the occlusion time of carotid artery in ...BM-13 505 is a new type of thromboxane receptor antagonist developed firstabfoad and synthesized in our school.wita modife method recently。The resultS of our study showed that the occlusion time of carotid artery in experimental thrombosis rats was prolonged by BM-13505,0.45 and 0.23 mglkg iv fP<0.00 1 and <0.01 respectively).B·13505 2 mgjkg iv ef fectively prevented the cerebral thrombosis caused by AA 4 mg/kg in rats(P<0.01) BM-13505 10 mg/kg ip prevented the AA-induced pulmonary thrombosis in mice(P<0.01).Tail bleeding time of mice was prolonged by this dru.BM-13505 significantly inhibited the AA-induced rabbit platelet aggregation,with an IC￣(50) of0.17 μmol/L; ADp-and collagen-induced aggregations were not affected.TXB_2 level in platelets and that in mice plasma were decreased by BM-13505,but cAMP level inplatelets was not affected. BM-13505 may be possibly developed into a useful anti-platelet and anti-thromboti c drug。展开更多
Nowadays, over 300 tons of Au are used in electronic equipment each year with other precious and strategic metals such as Ag, Pt, Pd, Cu, Nb, Ta, etc.. After the use-phase, the electronic devices become electronic was...Nowadays, over 300 tons of Au are used in electronic equipment each year with other precious and strategic metals such as Ag, Pt, Pd, Cu, Nb, Ta, etc.. After the use-phase, the electronic devices become electronic waste （e-waste）; consequently it is important to consider e-waste as a secondary supply for the recovery of these metals. This paper presents the recovery ofAu, Ag, Cu and Nb from PCBs （printed circuit boards） of discarded computers using leaching column technique. The PCBs were crushed with a hammer mill until reaching a particle size between 3.33 mm to 0.43 mm, Then, it was leached with a sodium cyanide solution in a glass column using the following conditions： sodium cyanide concentration 4 g/L, flux 20 L/d kg PCBs day, pH between 10.5 to 11 and leaching time 15 days. Every day, after leaching, the pregnant solutions passed through a column with activated carbon to complete the closed loop system. The following recoveries were obtained： Au 46.6%, Ag 51.3%, Nb 47.2% and Cu 62.3%. A preliminary technical-economic study shows the feasibility to create a small-scale PCBs recycling plant. The initial investment is on the order of USS155,639, considering the recovered metals from the loaded carbon. The internal rate of return for a 10 years period IRR （internal rate of return） and NPV （net present value） estimated are 27% and US$105,926 respectively.展开更多
Objective To establish and evaluate a hypercoagulable animal model for the assessment of anticoagulants. Methods Forty mice, thirty-two rats, and twenty-four rabbits were randomly and equally divided into control grou...Objective To establish and evaluate a hypercoagulable animal model for the assessment of anticoagulants. Methods Forty mice, thirty-two rats, and twenty-four rabbits were randomly and equally divided into control group (saline) and three ellagic acid (EA)-treated groups (low, middle, and high doses). In the mice, bleeding time (BT) was estimated with tail transaction, and clotting time (CT) with template method. Prothrombin time (PT) and the activated partial thromboplastin time (APTT) in rats and rabbits were measured by means of Quick's one-stage assay and modified APTT assay respectively. In addition, thrombin activity was estimated in rats with PT assay using a hemagglutination analyzer. The circulating platelet aggregates were de- tected in rabbits through platelet counting and presented as the circulating platelet aggregate ratio (CPAR). Results EA shortened BT and CT in mice, PT and APTT in rats, and increased thrombin activity and CPAR, all in a dose-dependent manner. EA also brought reduction of PT and APTT in rabbits in dose- and time-dependent manners. Conclusion EA could induce hypercoagulable state through activating coagulation system and platelets in mice, rats, and rabbits.展开更多
Objective： The aim of this study was to analyze and compare the recent efficacy and toxicity of a three-drug platinum-based regimen （A regimen）： [cisplatin （DDP） ＋ gemcitabine （GEM） ＋ vinorelbine （NVB）] an...Objective： The aim of this study was to analyze and compare the recent efficacy and toxicity of a three-drug platinum-based regimen （A regimen）： [cisplatin （DDP） ＋ gemcitabine （GEM） ＋ vinorelbine （NVB）] and a two-drug combination without a platinum drug （B regimen）： GEM ＋ NVB, which were used to treat 55 advanced non-small cell lung cancer （NSCLC） patients, in a bid to provide a guidance for clinical treatment. Methods： Twenty-four cases of advanced NSCLC （stage Ill-IV） patients were treated with A regimen （DDP 35 mg/m^2 d1-3; GEM 1250 mg/m^2 d1, 8 ）. The other 31 cases were treated with B （GEM 1250 mg/m^2 d1,8; NVB 25 mg/m^2 d1, 8 ）. Repeat every 3 weeks for 6 courses. Results： In A regimen group, the overall response rate was 45.8% （CR ＋ PR = 11）, median response time was 5.5 months, median survival time was 11 months and 1-year survival rate was 41.7%. In B regimen group, the overall response rate was 48.4% （CR ＋ PR = 15） and median response time, survival time and 1-year survival rate were respectively 6.5 and 10 months and 41.9%. The major toxicities were nausea/vomiting, myelosuppression in A regimen group, myelosuppression and phlebitis in B regimen group, respectively. Conclusion： A regimen and B regimen for advanced NSCLC have similar response rate （P 〉 0.05）. B regimen, a two-drug combination without a platinum drug is of less toxicity and more safety than A regimen, a three-drug platinum-based regimen and is recommended to be a regimen in the first-line treatment for advanced NSCLC.展开更多
Hydrodynamic and turbulent structures in the trayed bubble column with 1.2 m inner diameter have been characterized from liquid-phase velocity-time series data obtained by the hot-film anemometer. Wavelet transform an...Hydrodynamic and turbulent structures in the trayed bubble column with 1.2 m inner diameter have been characterized from liquid-phase velocity-time series data obtained by the hot-film anemometer. Wavelet transform analysis was used for denoising the measured data and also for evaluating quantifiers of turbulence, viz., local intermittency measure, intermittency index and flatness factor. These quantifiers help in detecting the passage of bubbles and reveal the hidden structures and patterns in data. Also, the wavelet scalewise analysis of the turbulence at various locations in the column and under different operating conditions could be used to build a direct relationship between the local gas holdup and flatness factor. The methodology is therefore suitable for online evaluation of the trayed bubble column performance and shows promise for developing strategies for improving process performance.展开更多
Based on the Environmental Kuznets Curve theory, the authors choose provincial panel data of China in 1990-2007 and adopt panel trait root and co-integration testing method to study whether there is Environmental Kuzn...Based on the Environmental Kuznets Curve theory, the authors choose provincial panel data of China in 1990-2007 and adopt panel trait root and co-integration testing method to study whether there is Environmental Kuznets Curve for China＇s carbon emissions. The research results show that： carbon emissions per capita of the eastern region and the central region of China fit into Environmental Kuznets Curve, but that of the western region does not. On this basis, the authors carry out scenario analysis on the occurrence time of the inflection point of carbon emissions per capita of different regions, and describe a specific time path.展开更多
文摘BM-13 505 is a new type of thromboxane receptor antagonist developed firstabfoad and synthesized in our school.wita modife method recently。The resultS of our study showed that the occlusion time of carotid artery in experimental thrombosis rats was prolonged by BM-13505,0.45 and 0.23 mglkg iv fP<0.00 1 and <0.01 respectively).B·13505 2 mgjkg iv ef fectively prevented the cerebral thrombosis caused by AA 4 mg/kg in rats(P<0.01) BM-13505 10 mg/kg ip prevented the AA-induced pulmonary thrombosis in mice(P<0.01).Tail bleeding time of mice was prolonged by this dru.BM-13505 significantly inhibited the AA-induced rabbit platelet aggregation,with an IC￣(50) of0.17 μmol/L; ADp-and collagen-induced aggregations were not affected.TXB_2 level in platelets and that in mice plasma were decreased by BM-13505,but cAMP level inplatelets was not affected. BM-13505 may be possibly developed into a useful anti-platelet and anti-thromboti c drug。
文摘Nowadays, over 300 tons of Au are used in electronic equipment each year with other precious and strategic metals such as Ag, Pt, Pd, Cu, Nb, Ta, etc.. After the use-phase, the electronic devices become electronic waste （e-waste）; consequently it is important to consider e-waste as a secondary supply for the recovery of these metals. This paper presents the recovery ofAu, Ag, Cu and Nb from PCBs （printed circuit boards） of discarded computers using leaching column technique. The PCBs were crushed with a hammer mill until reaching a particle size between 3.33 mm to 0.43 mm, Then, it was leached with a sodium cyanide solution in a glass column using the following conditions： sodium cyanide concentration 4 g/L, flux 20 L/d kg PCBs day, pH between 10.5 to 11 and leaching time 15 days. Every day, after leaching, the pregnant solutions passed through a column with activated carbon to complete the closed loop system. The following recoveries were obtained： Au 46.6%, Ag 51.3%, Nb 47.2% and Cu 62.3%. A preliminary technical-economic study shows the feasibility to create a small-scale PCBs recycling plant. The initial investment is on the order of USS155,639, considering the recovered metals from the loaded carbon. The internal rate of return for a 10 years period IRR （internal rate of return） and NPV （net present value） estimated are 27% and US$105,926 respectively.
文摘Objective To establish and evaluate a hypercoagulable animal model for the assessment of anticoagulants. Methods Forty mice, thirty-two rats, and twenty-four rabbits were randomly and equally divided into control group (saline) and three ellagic acid (EA)-treated groups (low, middle, and high doses). In the mice, bleeding time (BT) was estimated with tail transaction, and clotting time (CT) with template method. Prothrombin time (PT) and the activated partial thromboplastin time (APTT) in rats and rabbits were measured by means of Quick's one-stage assay and modified APTT assay respectively. In addition, thrombin activity was estimated in rats with PT assay using a hemagglutination analyzer. The circulating platelet aggregates were de- tected in rabbits through platelet counting and presented as the circulating platelet aggregate ratio (CPAR). Results EA shortened BT and CT in mice, PT and APTT in rats, and increased thrombin activity and CPAR, all in a dose-dependent manner. EA also brought reduction of PT and APTT in rabbits in dose- and time-dependent manners. Conclusion EA could induce hypercoagulable state through activating coagulation system and platelets in mice, rats, and rabbits.
文摘Objective： The aim of this study was to analyze and compare the recent efficacy and toxicity of a three-drug platinum-based regimen （A regimen）： [cisplatin （DDP） ＋ gemcitabine （GEM） ＋ vinorelbine （NVB）] and a two-drug combination without a platinum drug （B regimen）： GEM ＋ NVB, which were used to treat 55 advanced non-small cell lung cancer （NSCLC） patients, in a bid to provide a guidance for clinical treatment. Methods： Twenty-four cases of advanced NSCLC （stage Ill-IV） patients were treated with A regimen （DDP 35 mg/m^2 d1-3; GEM 1250 mg/m^2 d1, 8 ）. The other 31 cases were treated with B （GEM 1250 mg/m^2 d1,8; NVB 25 mg/m^2 d1, 8 ）. Repeat every 3 weeks for 6 courses. Results： In A regimen group, the overall response rate was 45.8% （CR ＋ PR = 11）, median response time was 5.5 months, median survival time was 11 months and 1-year survival rate was 41.7%. In B regimen group, the overall response rate was 48.4% （CR ＋ PR = 15） and median response time, survival time and 1-year survival rate were respectively 6.5 and 10 months and 41.9%. The major toxicities were nausea/vomiting, myelosuppression in A regimen group, myelosuppression and phlebitis in B regimen group, respectively. Conclusion： A regimen and B regimen for advanced NSCLC have similar response rate （P 〉 0.05）. B regimen, a two-drug combination without a platinum drug is of less toxicity and more safety than A regimen, a three-drug platinum-based regimen and is recommended to be a regimen in the first-line treatment for advanced NSCLC.
文摘Hydrodynamic and turbulent structures in the trayed bubble column with 1.2 m inner diameter have been characterized from liquid-phase velocity-time series data obtained by the hot-film anemometer. Wavelet transform analysis was used for denoising the measured data and also for evaluating quantifiers of turbulence, viz., local intermittency measure, intermittency index and flatness factor. These quantifiers help in detecting the passage of bubbles and reveal the hidden structures and patterns in data. Also, the wavelet scalewise analysis of the turbulence at various locations in the column and under different operating conditions could be used to build a direct relationship between the local gas holdup and flatness factor. The methodology is therefore suitable for online evaluation of the trayed bubble column performance and shows promise for developing strategies for improving process performance.
文摘Based on the Environmental Kuznets Curve theory, the authors choose provincial panel data of China in 1990-2007 and adopt panel trait root and co-integration testing method to study whether there is Environmental Kuznets Curve for China＇s carbon emissions. The research results show that： carbon emissions per capita of the eastern region and the central region of China fit into Environmental Kuznets Curve, but that of the western region does not. On this basis, the authors carry out scenario analysis on the occurrence time of the inflection point of carbon emissions per capita of different regions, and describe a specific time path.
