Several advances in genetics, diagnosis and palliation of pancreatic cancer (PC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. PC is relatively common as it ...Several advances in genetics, diagnosis and palliation of pancreatic cancer (PC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. PC is relatively common as it is the fourth leading cause of cancer related mortality. Most patients present with obstructive jaundice, epigastric or back pain, weight loss and anorexia. Despite improvements in diagnostic modalities, the majority of cases are still detected in advanced stages. The only curative treatment for PC remains surgical resection. No more than 20% of patients are candidates for surgery at the time of diagnosis and survival remains quite poor as adjuvant therapies are not very effective. A small percentage of patients with borderline non-resectable PC might benefit from neo-adjuvant chemoradiation therapy enabling them to undergo resection; however, randomized controlled studies are needed to prove the benefits of this strategy. Patients with unresectable PC benefit from palliative interventions such as biliary decompression and celiac plexus block. Further clinical trials to evaluate new chemo and radiation protocols as well as identification of genetic markers for PC are needed to improve the overall survival of patients affected by PC, as the current overall 5-year survival rate of patients affected by PC is still less than 5%. The aim of this article is to review the most recent high quality literature on this topic.展开更多
This paper presents a detailed analysis of the effects of noise (reverberation) on the focusing performance of de-composition of the time reversal operator (DORT) in a noise-limited case and in a reverberation-limited...This paper presents a detailed analysis of the effects of noise (reverberation) on the focusing performance of de-composition of the time reversal operator (DORT) in a noise-limited case and in a reverberation-limited case, respectively. Quantitative results obtained from simulations and experiments are presented. The results show the DORT method can be effi-ciently applied to target detection with enough source level to yield significant backscatter. For a target placed on the bottom, the influence of the reverberation on the focusing performance is slight. However, distinguishing between a target and constant backscattering returning from strong local clutter on the bottom (false alarms) needs further research.展开更多
文摘Several advances in genetics, diagnosis and palliation of pancreatic cancer (PC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. PC is relatively common as it is the fourth leading cause of cancer related mortality. Most patients present with obstructive jaundice, epigastric or back pain, weight loss and anorexia. Despite improvements in diagnostic modalities, the majority of cases are still detected in advanced stages. The only curative treatment for PC remains surgical resection. No more than 20% of patients are candidates for surgery at the time of diagnosis and survival remains quite poor as adjuvant therapies are not very effective. A small percentage of patients with borderline non-resectable PC might benefit from neo-adjuvant chemoradiation therapy enabling them to undergo resection; however, randomized controlled studies are needed to prove the benefits of this strategy. Patients with unresectable PC benefit from palliative interventions such as biliary decompression and celiac plexus block. Further clinical trials to evaluate new chemo and radiation protocols as well as identification of genetic markers for PC are needed to improve the overall survival of patients affected by PC, as the current overall 5-year survival rate of patients affected by PC is still less than 5%. The aim of this article is to review the most recent high quality literature on this topic.
基金Project supported by the National Natural Science Foundation of China (Nos. 60702022 and 60772094)the National Basic Re-search Program (973) of China (No. 5132103ZZT21B)
文摘This paper presents a detailed analysis of the effects of noise (reverberation) on the focusing performance of de-composition of the time reversal operator (DORT) in a noise-limited case and in a reverberation-limited case, respectively. Quantitative results obtained from simulations and experiments are presented. The results show the DORT method can be effi-ciently applied to target detection with enough source level to yield significant backscatter. For a target placed on the bottom, the influence of the reverberation on the focusing performance is slight. However, distinguishing between a target and constant backscattering returning from strong local clutter on the bottom (false alarms) needs further research.
