目的:本文介绍等级结构保留失效时间模型(rank preserving structural failure time models,RPSFT)和BW法(the method of Branson and Whitehead)在临床试验转组研究中的应用,并对两种方法进行比较。方法:以部分对照组受试者在试验中途...目的:本文介绍等级结构保留失效时间模型(rank preserving structural failure time models,RPSFT)和BW法(the method of Branson and Whitehead)在临床试验转组研究中的应用,并对两种方法进行比较。方法:以部分对照组受试者在试验中途转至试验组为例,采用计算机模拟试验,查看不同截尾率、转组率水平下,RPSFT法和BW法估计试验药疗效的效果。以及探讨与传统的ITT法相比,RPSFT法和BW法的检验效能和Ⅰ类错误控制情况。结果:RPSFT法和BW法估计试验药疗效的准确性高,与传统的分析方法比较,引入的偏倚小。随着转组率和截尾率增大,RPSFT法与BW法的偏倚逐渐增大,估计的试验药疗效低于真实疗效,但RPSFT法的偏倚比BW法小。两种方法估计的均方误差(MSE)十分接近。当截尾率较大(40%)时,RPSFT法的MSE比BW小。随着转组率增大,两种方法的Ⅰ类错误不断升高,普遍高于0.05。与ITT法相比,RPSFT法与BW法的检验效能受转组率的影响小,下降趋势缓慢。结论:在估计试验药疗效的临床试验中,若存在对照组受试者转组到试验组的情况,统计分析以ITT法分析为主,RPSFT法和BW法作为辅助分析方法。RPSFT法和BW法相比,当截尾率和转组率均较高时,参数估计优先考虑选择使用RPSFT法。展开更多
Seasonal adjustment has been widely used in statistic analyses.Nowadays,the research on seasonal adjustment methods mainly concentrates on X-11,X-12 etc in China,lacking the whole understanding of foreign seasonal adj...Seasonal adjustment has been widely used in statistic analyses.Nowadays,the research on seasonal adjustment methods mainly concentrates on X-11,X-12 etc in China,lacking the whole understanding of foreign seasonal adjustment methods,and the latest progress of seasonal adjustment methods has been less introduced.In this article,various seasonal adjustment methods were introduced,and a comparison of their characteristics and applications was made.It is helpful that statistical organizations can develop appropriate seasonal adjustment methods,concerning different kinds of data.展开更多
We propose a novel model, based on two postulates, which provide new perspective on the fundamental forces using special and general relativity concepts. Many studies address the relations between the particles and th...We propose a novel model, based on two postulates, which provide new perspective on the fundamental forces using special and general relativity concepts. Many studies address the relations between the particles and the space time manifold, and the latter's physical structure, whether it is Continuous or Discrete. In the proposed model the properties of the particles are classical in the sense of general relativity, whereas their quantum properties are arises due to the experiments.展开更多
An integrated approach is proposed to predict the chromatographic retention time of oligonucleotides based on quantitative structure-retention relationships (QSRR) models. First, the primary base sequences of oligon...An integrated approach is proposed to predict the chromatographic retention time of oligonucleotides based on quantitative structure-retention relationships (QSRR) models. First, the primary base sequences of oligonucleotides are translated into vectors based on scores of generalized base properties (SGBP), involving physicochemical, quantum chemical, topological, spatial structural properties, etc.; thereafter, the sequence data are transformed into a uniform matrix by auto cross covariance (ACC). ACC accounts for the interactions between bases at a certain distance apart in an oligonucleotide sequence; hence, this method adequately takes the neighboring effect into account. Then, a genetic algorithm is used to select the variables related to chromatographic retention behavior of oligonuclcotides. Finally, a support vector machine is used to develop QSRR models to predict chromatographic retention behavior. The whole dataset is divided into pairs of training sets and test sets with different proportions; as a result, it has been found that the QSRR models using more than 26 training samples have an appropriate external power, and can accurately represent the relationship between the features of sequences and structures, and the retention times. The results indicate that the SGBP-ACC approach is a useful structural representation method in QSRR of oligonucleotides due to its many advantages such as plentiful structural information, easy manipulation and high characterization competence. Moreover, the method can further be applied to predict chromatographic retention behavior of oligonucleotides.展开更多
Community structure has an important influence on the structural and dynamic characteristics of the complex systems.So it has attracted a large number of researchers.However,due to its complexity,the mechanism of acti...Community structure has an important influence on the structural and dynamic characteristics of the complex systems.So it has attracted a large number of researchers.However,due to its complexity,the mechanism of action of the community structure is still not clear to this day.In this paper,some features of the community structure have been discussed.And a constraint model of the community has been deduced.This model is effective to identify the communities.And especially,it is effective to identify the overlapping nodes between the communities.Then a community detection algorithm,which has linear time complexity,is proposed based on this constraint model,a proposed node similarity model and the Modularity Q.Through some experiments on a series of real-world and synthetic networks,the high performances of the algorithm and the constraint model have been illustrated.展开更多
Ultrafast quasiparticle dynamics of single crystalline LaOFeAs were investigated by pump-probe measurement.The compound experiences structural and spin-density-wave(SDW)phase transitions at 150 K(TS1)and 130 K(TS2),re...Ultrafast quasiparticle dynamics of single crystalline LaOFeAs were investigated by pump-probe measurement.The compound experiences structural and spin-density-wave(SDW)phase transitions at 150 K(TS1)and 130 K(TS2),respectively.The relaxation time of quasiparticles was somewhat temperature independent at high temperature but exhibited a sharp upturn at TS1and reached the maximum at approximately TS2.The remarkable slowing down of quasiparticle relaxation time is caused by the formation of energy gap.By employing the Rothwarf-Taylor model analysis,we found that there should be already energy gaps opening just below the structural transition.The magnitude of SDW gap was identified to be 72 meV.展开更多
In studies of auditory perception, a dichotomy between envelope and temporal fine structure(TFS) has been emphasized. It has been shown that frequency-following responses(FFRs) in the rat inferior colliculus can be di...In studies of auditory perception, a dichotomy between envelope and temporal fine structure(TFS) has been emphasized. It has been shown that frequency-following responses(FFRs) in the rat inferior colliculus can be divided into the envelope component(FFREnv)and the temporal fine structure component(FFRTFS). However, the existing FFR models cannot successfully separate FFREnv and FFRTFS. This study was to develop a new FFR model to effectively distinguish FFREnv from FFRTFS by both combining the advantages of the two existing FFR models and simultaneously adding cellular properties of inferior colliculus neurons. To evaluate the validity of the present model, correlations between simulated FFRs and experimental data from the rat inferior colliculus were calculated. Different model parameters were tested, FFRs were calculated, and the parameters with highest prediction were chosen to establish an ideal FFR model. The results indicate that the new FFR model can provide reliable predictions for experimentally obtained FFREnv and FFRTFS.展开更多
ZnS:Mn2+ nanocrystals(NCs) with particle size from 1.9 nm to 3.2 nm are synthesized via chemical precipitation method with different [S2-]/[Zn2+] ratios.The size-dependent decay for Mn emission exhibits a double expon...ZnS:Mn2+ nanocrystals(NCs) with particle size from 1.9 nm to 3.2 nm are synthesized via chemical precipitation method with different [S2-]/[Zn2+] ratios.The size-dependent decay for Mn emission exhibits a double exponential behavior.And two lifetime values,in millisecond time domain,can both be shortened with size increasing,which is attributed to enhanced interaction between host and Mn2+ impurity.A molecular structure model is proposed to interpret the tendency of two lifetime components,which is correlated to the number of S vacancy(Vs) defects around Mn2+.展开更多
文摘目的:本文介绍等级结构保留失效时间模型(rank preserving structural failure time models,RPSFT)和BW法(the method of Branson and Whitehead)在临床试验转组研究中的应用,并对两种方法进行比较。方法:以部分对照组受试者在试验中途转至试验组为例,采用计算机模拟试验,查看不同截尾率、转组率水平下,RPSFT法和BW法估计试验药疗效的效果。以及探讨与传统的ITT法相比,RPSFT法和BW法的检验效能和Ⅰ类错误控制情况。结果:RPSFT法和BW法估计试验药疗效的准确性高,与传统的分析方法比较,引入的偏倚小。随着转组率和截尾率增大,RPSFT法与BW法的偏倚逐渐增大,估计的试验药疗效低于真实疗效,但RPSFT法的偏倚比BW法小。两种方法估计的均方误差(MSE)十分接近。当截尾率较大(40%)时,RPSFT法的MSE比BW小。随着转组率增大,两种方法的Ⅰ类错误不断升高,普遍高于0.05。与ITT法相比,RPSFT法与BW法的检验效能受转组率的影响小,下降趋势缓慢。结论:在估计试验药疗效的临床试验中,若存在对照组受试者转组到试验组的情况,统计分析以ITT法分析为主,RPSFT法和BW法作为辅助分析方法。RPSFT法和BW法相比,当截尾率和转组率均较高时,参数估计优先考虑选择使用RPSFT法。
文摘Seasonal adjustment has been widely used in statistic analyses.Nowadays,the research on seasonal adjustment methods mainly concentrates on X-11,X-12 etc in China,lacking the whole understanding of foreign seasonal adjustment methods,and the latest progress of seasonal adjustment methods has been less introduced.In this article,various seasonal adjustment methods were introduced,and a comparison of their characteristics and applications was made.It is helpful that statistical organizations can develop appropriate seasonal adjustment methods,concerning different kinds of data.
文摘We propose a novel model, based on two postulates, which provide new perspective on the fundamental forces using special and general relativity concepts. Many studies address the relations between the particles and the space time manifold, and the latter's physical structure, whether it is Continuous or Discrete. In the proposed model the properties of the particles are classical in the sense of general relativity, whereas their quantum properties are arises due to the experiments.
基金supported by the National Natural Science Foundation of China (10901169)National 111 Programme of Introducing Talents of Discipline to Universities (0507111106)+2 种基金Innovation Ability Training Foundation of Chongqing University (CDCX008)Innovative Group Program for Graduates of Chongqing University,ScienceInnovation Fund (200711C1A0010260)
文摘An integrated approach is proposed to predict the chromatographic retention time of oligonucleotides based on quantitative structure-retention relationships (QSRR) models. First, the primary base sequences of oligonucleotides are translated into vectors based on scores of generalized base properties (SGBP), involving physicochemical, quantum chemical, topological, spatial structural properties, etc.; thereafter, the sequence data are transformed into a uniform matrix by auto cross covariance (ACC). ACC accounts for the interactions between bases at a certain distance apart in an oligonucleotide sequence; hence, this method adequately takes the neighboring effect into account. Then, a genetic algorithm is used to select the variables related to chromatographic retention behavior of oligonuclcotides. Finally, a support vector machine is used to develop QSRR models to predict chromatographic retention behavior. The whole dataset is divided into pairs of training sets and test sets with different proportions; as a result, it has been found that the QSRR models using more than 26 training samples have an appropriate external power, and can accurately represent the relationship between the features of sequences and structures, and the retention times. The results indicate that the SGBP-ACC approach is a useful structural representation method in QSRR of oligonucleotides due to its many advantages such as plentiful structural information, easy manipulation and high characterization competence. Moreover, the method can further be applied to predict chromatographic retention behavior of oligonucleotides.
基金Supported by the National Natural Science Foundation of China under Grant No. 60974090the Specialized Research Fund for the Doctoral Program of Higher Education of China under Grant No. 200806110016
文摘Community structure has an important influence on the structural and dynamic characteristics of the complex systems.So it has attracted a large number of researchers.However,due to its complexity,the mechanism of action of the community structure is still not clear to this day.In this paper,some features of the community structure have been discussed.And a constraint model of the community has been deduced.This model is effective to identify the communities.And especially,it is effective to identify the overlapping nodes between the communities.Then a community detection algorithm,which has linear time complexity,is proposed based on this constraint model,a proposed node similarity model and the Modularity Q.Through some experiments on a series of real-world and synthetic networks,the high performances of the algorithm and the constraint model have been illustrated.
基金supported by the National Science Foundation of China(Grant No.2011CB921701)the National Basic Research Program of China(Grant No.2012CB821403)
文摘Ultrafast quasiparticle dynamics of single crystalline LaOFeAs were investigated by pump-probe measurement.The compound experiences structural and spin-density-wave(SDW)phase transitions at 150 K(TS1)and 130 K(TS2),respectively.The relaxation time of quasiparticles was somewhat temperature independent at high temperature but exhibited a sharp upturn at TS1and reached the maximum at approximately TS2.The remarkable slowing down of quasiparticle relaxation time is caused by the formation of energy gap.By employing the Rothwarf-Taylor model analysis,we found that there should be already energy gaps opening just below the structural transition.The magnitude of SDW gap was identified to be 72 meV.
基金supported by the National Natural Science Foundation of China(Grant No.31470987)the National Basic Research Development Program of China(Grant No.2015CB351800)“985”grants from Peking University for Physiological Psychology and China Postdoctoral Science Foundation(Grant No.2016M601066)
文摘In studies of auditory perception, a dichotomy between envelope and temporal fine structure(TFS) has been emphasized. It has been shown that frequency-following responses(FFRs) in the rat inferior colliculus can be divided into the envelope component(FFREnv)and the temporal fine structure component(FFRTFS). However, the existing FFR models cannot successfully separate FFREnv and FFRTFS. This study was to develop a new FFR model to effectively distinguish FFREnv from FFRTFS by both combining the advantages of the two existing FFR models and simultaneously adding cellular properties of inferior colliculus neurons. To evaluate the validity of the present model, correlations between simulated FFRs and experimental data from the rat inferior colliculus were calculated. Different model parameters were tested, FFRs were calculated, and the parameters with highest prediction were chosen to establish an ideal FFR model. The results indicate that the new FFR model can provide reliable predictions for experimentally obtained FFREnv and FFRTFS.
基金supported by the National Natural Science Foundation of China(Nos.60877029,10904109,60977035 and 60907021)the Natural Science Foundation of Tianjin(No.09JCYBJC01400)the Tianjin Key Subject for Materials Physics and Chemistry
文摘ZnS:Mn2+ nanocrystals(NCs) with particle size from 1.9 nm to 3.2 nm are synthesized via chemical precipitation method with different [S2-]/[Zn2+] ratios.The size-dependent decay for Mn emission exhibits a double exponential behavior.And two lifetime values,in millisecond time domain,can both be shortened with size increasing,which is attributed to enhanced interaction between host and Mn2+ impurity.A molecular structure model is proposed to interpret the tendency of two lifetime components,which is correlated to the number of S vacancy(Vs) defects around Mn2+.