AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Coliti...AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC.展开更多
In the spirit of black hole complementary principle, we have found the noncommutative membrane of Scharzchild black holes. In this paper we extend our results to Kerr black hole and see the same story. Also we make a ...In the spirit of black hole complementary principle, we have found the noncommutative membrane of Scharzchild black holes. In this paper we extend our results to Kerr black hole and see the same story. Also we make a conjecture that spacetimes are noncommutative on the stretched membrane of the more general Kerr-Newman black hole.展开更多
We investigate the gravitational time delay of light in the Schwarzschild black hole space-time surroundedby quintessence.With the analysis and numerical methods,we find that the gravitational time delay of light in t...We investigate the gravitational time delay of light in the Schwarzschild black hole space-time surroundedby quintessence.With the analysis and numerical methods,we find that the gravitational time delay of light in theSchwarzschild black hole space-time surrounded by quintessence increases when the normalization factor c increases,andthat the gravitational time delay also decreases when the quintessential state parameter ω_q increases.展开更多
High temperature treatment of tungsten alloy of W-5wt.% TM （transition metals, TM = Ni, Fe, Cu, Co） nanopowder was run under different temperatures to cover the oxidation rate at different temperatures. The correlat...High temperature treatment of tungsten alloy of W-5wt.% TM （transition metals, TM = Ni, Fe, Cu, Co） nanopowder was run under different temperatures to cover the oxidation rate at different temperatures. The correlation was developed for certain temperatures to find an equation for the relation between time and weight. The thermal treatment was done for different quantities at certain times. The proposed equation studies the correlation between temperature, time, and weight. For each temperature, a number of points were recorded from the measured oxidation curve. The shape of the curves is well-represented in this paper. The final results will present the highest temperature, the maximum weight, and the maximum time for full oxidation at high and low temperatures.展开更多
The lumped time distribution functions were proposed, which can be used for describing the dynamicsystems with two or more than two states of the end of growing polymer chain during chain addition polymerization.Numer...The lumped time distribution functions were proposed, which can be used for describing the dynamicsystems with two or more than two states of the end of growing polymer chain during chain addition polymerization.Numerical analysis of the lumped time distribution functions was carried out. The method for calculating molecularweight distribution of polymer in the stable free radical polymerization and more general cases was developed basedon the lumped time distribution functions.展开更多
AIM:To compare the natural history and course of acute diverticulitis in a younger age group with an older population and to evaluate whether younger patients should be managed differently. METHODS:This study was a re...AIM:To compare the natural history and course of acute diverticulitis in a younger age group with an older population and to evaluate whether younger patients should be managed differently. METHODS:This study was a retrospective review of 157 patients treated with acute diverticulitis between January 1,2004 and December 31,2007.Diverticulitis was stratified according to the Hinchey classification. Patients were divided into 2 populations:group A≤ 50 years(n=31) ;group B>50 years(n=126) .Mean patient follow-up was 15 mo. RESULTS:The median age was 60 years.A significantly higher proportion of patients in group B presented with complicated diverticulitis(36.5%vs 12.9%,P=0.01) .Recurrence was more frequent in group A(25.8%vs 11.1%,P=0.03) and the mean time-torecurrence was shorter(12 mo vs 28 mo,P=0.26) . The most severe recurrent episodes of acute diverticulitis were classified as Hinchey stageⅠand none of the patients required emergency surgery.In multivariate analysis,only age(P=0.024) was identified as an independent prognostic factor for recurrence. CONCLUSION:Based on the results of this study,we recommend that diverticulitis management should be based on the severity of the disease and not on the age of the patient.展开更多
Natural systems are typically nonlinear and complex, and it is of great interest to be able to reconstruct a system in order to understand its mechanism, which cannot only recover nonlinear behaviors but also predict ...Natural systems are typically nonlinear and complex, and it is of great interest to be able to reconstruct a system in order to understand its mechanism, which cannot only recover nonlinear behaviors but also predict future dynamics. Due to the advances of modern technology, big data becomes increasingly accessible and consequently the problem of reconstructing systems from measured data or time series plays a central role in many scientific disciplines. In recent decades, nonlinear methods rooted in state space reconstruction have been developed, and they do not assume any model equations but can recover the dynamics purely from the measured time series data. In this review, the development of state space reconstruction techniques will be introduced and the recent advances in systems prediction and causality inference using state space reconstruction will be presented. Particularly, the cutting-edge method to deal with short-term time series data will be focused on.Finally, the advantages as well as the remaining problems in this field are discussed.展开更多
The molecular characterization of the weighted atomic Hardy space Hw p,q,s is given. As an application, the boundedness of Hilbert transform on the weighted Hardy space is proved.
It has been suggested that the narrow cores of the Fe Ka emission lines in Active Galactic Nuclei （AGNs） are likely produced in the torus, the inner radius of which can be measured by observing the lag time between ...It has been suggested that the narrow cores of the Fe Ka emission lines in Active Galactic Nuclei （AGNs） are likely produced in the torus, the inner radius of which can be measured by observing the lag time between the V and K band flux variations. In this paper, we compare the virial products of the infrared time lags, and the narrow Fe Ka widths for 10 type 1 AGNs, with the black hole masses from other techniques. We found the narrow Fe Ka line width is in average 2.6＋0.9-0.4 times broader than expected, assuming an isotropic velocity distribution of the torus at the distance measured by the infrared lags. We propose the thick disk model of the torus may explain the observed larger line width. Another possibility is the contamination by emission from the broad line region or the outer accretion disk. Alternatively, the narrow iron line might originate from the inner most part of the obscuring torus within the sublimation radius, while the infrared emission may be from the outer cooler part. We note the correlations between the black hole masses based on this new technique and those based on other known techniques are statistically insignificant. We argue that this could be attributed to the small sample size and the very large uncertainties in the measurements of iron K line widths. The next generation of X-ray observatories could help verify the origin of the narrow iron Ka line and the reliability of this new technique.展开更多
A so-called ghost dark energy was recently proposed to explain the present acceleration of the universe.The energy density of ghost dark energy,which originates from Veneziano ghost of Quantum Chromodynamics(QCD),in a...A so-called ghost dark energy was recently proposed to explain the present acceleration of the universe.The energy density of ghost dark energy,which originates from Veneziano ghost of Quantum Chromodynamics(QCD),in a time dependent background,can be written in the form,ρD=αH + βH^2 where H is the Hubble parameter.We investigate the generalized ghost dark energy(GGDE) model in the setup of loop quantum Cosmology(LQC) and Galileon Cosmology.We study the cosmological implications of the models.We also obtain the equation of state and the deceleration parameters and differential equations governing the evolution of this dark energy model for LQC and Galileon Cosmology.展开更多
基金Supported by Danish Innovation Law Grant,J.nr.3414-06-01530from the Danish Food Industry Agency under the Ministry of Food,Agriculture and FisheriesNordisk Rebalance,who developed and manufactured Profermin,and partly financed the study
文摘AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC.
基金The project supported by the Knowledge Innovation Project of the Ghinese Academy of Sciences. We are thankful for the discussions with Prof. M. Li and Dr. Q.G. Huang. We are also grateful to Prof. R.G. Cai and Dr. Fei Wang for valuable suggestions.
文摘In the spirit of black hole complementary principle, we have found the noncommutative membrane of Scharzchild black holes. In this paper we extend our results to Kerr black hole and see the same story. Also we make a conjecture that spacetimes are noncommutative on the stretched membrane of the more general Kerr-Newman black hole.
基金the State Key Basic Research Program of China under Grant No.2003CB716300National Natural Science Foundation of China under Grant No.10547114Scientific Research Fund of Hunan Normal University
文摘We investigate the gravitational time delay of light in the Schwarzschild black hole space-time surroundedby quintessence.With the analysis and numerical methods,we find that the gravitational time delay of light in theSchwarzschild black hole space-time surrounded by quintessence increases when the normalization factor c increases,andthat the gravitational time delay also decreases when the quintessential state parameter ω_q increases.
文摘High temperature treatment of tungsten alloy of W-5wt.% TM （transition metals, TM = Ni, Fe, Cu, Co） nanopowder was run under different temperatures to cover the oxidation rate at different temperatures. The correlation was developed for certain temperatures to find an equation for the relation between time and weight. The thermal treatment was done for different quantities at certain times. The proposed equation studies the correlation between temperature, time, and weight. For each temperature, a number of points were recorded from the measured oxidation curve. The shape of the curves is well-represented in this paper. The final results will present the highest temperature, the maximum weight, and the maximum time for full oxidation at high and low temperatures.
文摘The lumped time distribution functions were proposed, which can be used for describing the dynamicsystems with two or more than two states of the end of growing polymer chain during chain addition polymerization.Numerical analysis of the lumped time distribution functions was carried out. The method for calculating molecularweight distribution of polymer in the stable free radical polymerization and more general cases was developed basedon the lumped time distribution functions.
文摘AIM:To compare the natural history and course of acute diverticulitis in a younger age group with an older population and to evaluate whether younger patients should be managed differently. METHODS:This study was a retrospective review of 157 patients treated with acute diverticulitis between January 1,2004 and December 31,2007.Diverticulitis was stratified according to the Hinchey classification. Patients were divided into 2 populations:group A≤ 50 years(n=31) ;group B>50 years(n=126) .Mean patient follow-up was 15 mo. RESULTS:The median age was 60 years.A significantly higher proportion of patients in group B presented with complicated diverticulitis(36.5%vs 12.9%,P=0.01) .Recurrence was more frequent in group A(25.8%vs 11.1%,P=0.03) and the mean time-torecurrence was shorter(12 mo vs 28 mo,P=0.26) . The most severe recurrent episodes of acute diverticulitis were classified as Hinchey stageⅠand none of the patients required emergency surgery.In multivariate analysis,only age(P=0.024) was identified as an independent prognostic factor for recurrence. CONCLUSION:Based on the results of this study,we recommend that diverticulitis management should be based on the severity of the disease and not on the age of the patient.
基金supported by the National Key Research and Development Program of China (Grant No. 2017YFA0505500)Japan Society for the Promotion of Science KAKENHI Program (Grant No. JP15H05707)National Natural Science Foundation of China (Grant Nos. 11771010,31771476,91530320, 91529303,91439103 and 81471047)
文摘Natural systems are typically nonlinear and complex, and it is of great interest to be able to reconstruct a system in order to understand its mechanism, which cannot only recover nonlinear behaviors but also predict future dynamics. Due to the advances of modern technology, big data becomes increasingly accessible and consequently the problem of reconstructing systems from measured data or time series plays a central role in many scientific disciplines. In recent decades, nonlinear methods rooted in state space reconstruction have been developed, and they do not assume any model equations but can recover the dynamics purely from the measured time series data. In this review, the development of state space reconstruction techniques will be introduced and the recent advances in systems prediction and causality inference using state space reconstruction will be presented. Particularly, the cutting-edge method to deal with short-term time series data will be focused on.Finally, the advantages as well as the remaining problems in this field are discussed.
基金This work was supported by the National Natural Science Foundation of China (Grant Nos. 19631080, 69735020)
文摘The molecular characterization of the weighted atomic Hardy space Hw p,q,s is given. As an application, the boundedness of Hilbert transform on the weighted Hardy space is proved.
基金supported by the National Natural Science Foundation of China (Grant Nos. 10773010 and 10825312)support from the "Chuang Xin" Foundation operated by the Graduate School of University of Science and Technology of China
文摘It has been suggested that the narrow cores of the Fe Ka emission lines in Active Galactic Nuclei （AGNs） are likely produced in the torus, the inner radius of which can be measured by observing the lag time between the V and K band flux variations. In this paper, we compare the virial products of the infrared time lags, and the narrow Fe Ka widths for 10 type 1 AGNs, with the black hole masses from other techniques. We found the narrow Fe Ka line width is in average 2.6＋0.9-0.4 times broader than expected, assuming an isotropic velocity distribution of the torus at the distance measured by the infrared lags. We propose the thick disk model of the torus may explain the observed larger line width. Another possibility is the contamination by emission from the broad line region or the outer accretion disk. Alternatively, the narrow iron line might originate from the inner most part of the obscuring torus within the sublimation radius, while the infrared emission may be from the outer cooler part. We note the correlations between the black hole masses based on this new technique and those based on other known techniques are statistically insignificant. We argue that this could be attributed to the small sample size and the very large uncertainties in the measurements of iron K line widths. The next generation of X-ray observatories could help verify the origin of the narrow iron Ka line and the reliability of this new technique.
文摘A so-called ghost dark energy was recently proposed to explain the present acceleration of the universe.The energy density of ghost dark energy,which originates from Veneziano ghost of Quantum Chromodynamics(QCD),in a time dependent background,can be written in the form,ρD=αH + βH^2 where H is the Hubble parameter.We investigate the generalized ghost dark energy(GGDE) model in the setup of loop quantum Cosmology(LQC) and Galileon Cosmology.We study the cosmological implications of the models.We also obtain the equation of state and the deceleration parameters and differential equations governing the evolution of this dark energy model for LQC and Galileon Cosmology.
