知常明变者赢 守正创新者进

近日,我认真学习了徐有礼局长《思路决定出路 担当才有作为》的文章以及市委惠新安书记的批示意见,深受震撼与启发。 育英学校是一所具有 58 年建校历史的老校,学校见证着新中国成立后企业办社会的沧桑巨变。学校 2001 年改制为国办学校,2016 年加入 新华教育集团。集团成立伊始,新一届班子就提出了要用五年左右的时间把学校打造成白浪河东岸优质教育资源学校的奋斗目标。同年教 师节,我与全体教职员工面对国旗宣誓,立下了“我们热爱教育,终身无悔;我们献身教育,勤靡于劳;我们享受教育,各美其美”的铮 铮誓言。

Spatiotemporal dynamics of ecological variation of waterbird habitats in Dongtan area of Chongming Island

Based on Landsat TM images, we explored the pattern of variation of suitable waterbird habitats from 1990 to 2008 in the Dongtan area of Chongming Island at the Changjiang (Yangtze) River mouth. By applying our highly accurate indicator model (R=0.999, P<0.01), we quantified the variations of fluctuation intensity for local waterbird habitats during 1990-2008, and for the main waterbird groups (Anatidae, Charadriidae, Ardeidae and Laridae) from 2006 to 2008, to evaluate the impact of habitat quantity change on the waterbird habitat status and the population dynamics of the different waterbird groups. The results show that the aquaculture ponds (AP) and the Scirpus mariqueter zone (SMZ) underwent drastic habitat changes during certain periods (AP: 1997-2000, 2000-2003, 2005-2008; SMZ: 1997-2000), and the fluctuation intensity differed among habitat types in the order AP>SMZ>TSH (total suitable habitat)>BSA (bare mud flat and shallow water area). The abandonment of tracts of aquaculture ponds in Dongtan in mid-2006 brought about an intensive population fluctuation, caused by rapidly changing habitat with the population expanding to adjacent areas. At present, Anatidae and Ardeidae are threatened in the Dongtan area with declining populations because of their very "picky" habitat requirements (i.e., high reliance on AP). The Charadriidae experienced enormous population declines in the late 1990s, however, they have since recovered to normal levels as habitat change has stabilized. Our findings suggest that the current challenges for habitat management are the protection and stabilization of AP and SMZ habitats.

Dan Huang Ming Mu Recipe Suppresses the Progression of Streptozotocin-induced Diabetic Retinopathy After Retinal Laser Photocoagulation in Brown Norway Rats via Down-regulating Vascular Endothelial Growth Factor and Up-regulating Pigment Epithelium-derived

Objective To analyze the effects of Dan Huang Ming Mu Recipe(DHMMR)(a pharmaceutical preparation from herbs and having the function of replenishing vital essence,removing heat,promoting blood circulation and excreting pathogenic water) on diabetic retinopathy(DR) after retinal laser photocoagulation through regulating the expression of vascular endothelial growth factor(VEGF) and pigment epithelium-derived factor(PEDF).Methods Forty male Brown Norway(BN) rats were randomly divided into blank group(group A,10 BN rats) and model group(30 BN rats).DR models were induced by 40 mg/kg streptozotocin(STZ) and the body weight and blood glucose of rats were monitored.After 12-week injection,fluorescein fundus angiography(FFA) and histopathological examination were detected to confirm the successful establishment of DR models.Subsequently,the right eyes of model group rats were conducted retinal laser photocoagulation with the left eyes having no retinal laser photocoagulation and rats of the model group were randomly divided into group B(the model control group),group C(the positive control group),and group D(the DHMMR group),with 10 rats in each group.Rats of the group A and the group B were given vehicle,and the group C were given calcium dobesilate suspension by gavage,and the group D were given DHMMR by gavage.After 4-week gavage,FFA was carried out to observe the fundus microvascular change.Then,the rats were sacrificed to do histopathological examinations and the serum levels of P-selectin,cAMP,cGMP,and the relative expression of the protein of VEGF and PEDF in retina were detected.Results After 12-week STZ injection,the blood glucose of the model group were pronouncedly higher than the blank group(P < 0.01).Fundus micro-hemangioma changes were observed in the rats of the model group through FFA,and the rats of the blank group did not see any changes.The pictures of HE staining showed that the retinal structure of the model group was more disordered than the blank group.After 4-week gavage,treatments with DHMMR showed dramatic reduction of serum levels of Pselectin,cAMP and cGMP compared with the group B(P < 0.01).FFA and histopathological examinations of DHMMR-treated rats revealed significantly suppression of retinal edema,fundus microvascular destruction and retinal destruction distinguishing from the group B.And the relative expression of VEGF protein of the group D and the group A was markedly lower than that of the group B(P < 0.01).The relative expression of PEDF protein of the group D and the group A was dramatically higher than that of the group B to the contrary(P < 0.01).Conclusions DHMMR demonstrates pronounced suppressive effects on the progression of DR after retinal laser photocoagulation,through down-regulating VEGF and upregulating PEDF.

Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma:Case report with molecular analysis

Here we report a new case of clear cell adenocarcinoma (CCA) of the colon in a 54-year-old Caucasian man. Despite of the previous reported cases, the lesion was located in the right colon and was not associated with the conventional adenoma. We performed immunohistochemical and molecular analyses in order to explore whether the CCA had the molecular features generally associated with conventional colorectal carcinoma. The immunohistochemical and molecular analyses showed that the different morphology of CCA does not reflect a distinct biological entity but only an unusual morphological variant of intestinal carcinoma.

STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury

AIM To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODS We investigated thioacetamide(TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma(HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAAinduced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9(SOX9) and Yes-associated protein(YAP), which regulate the transdifferentiation of hepatocytes to cholangiocytes.RESULTS Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic STAT3-deficient mice as compared with control mice. STAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic STAT3-deficient livers as compared with control livers. SOX9 and YAP were upregulated in hepatic STAT3-deficient hepatocytes.CONCLUSION STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration.

Combating climate change calls for a global technological cooperation system built on the concept of ecological civilization

Climate change has been considered as the most paramount global environmental problem and the biggest externality throughout the history of human development. Accordingly, the world is facing unprecedented technological innovation and collaborative demands to deal with climate change. In the 2015 Paris Agreement, a long-term vision of technology development and transfer implementation was proposed, and policy and financial support for technological innovation in the area of climate change was advocated. These terms aim to enable developing countries to acquire the necessary technology in the early stage of the technology cycle to address climate change challenge. However, the traditional technological innovation and cooperation mode based on industrial civilization can hardly meet the technical demands of global climate protection. To ensure the continuous development and deployment of technology in a required scale and pace, a new global technical cooperation system is proposed to develop based on the philosophy of ecological civilization. The core contents of this system are supposed be as follows:to implement all-win cooperation targets, adhering to cooperation principles of Eco-man, adopt cooperation content that reflects synergy, pursue cooperation based on mutual trust, encourage participation of multiple actors, and promote sharing of cooperative outputs.

Molecular analysis of THH-induced mutations at HPRT locus in human promyelocytic leukemia cells with multiplex polymerase chain reaction

Objective: To study the genotoxicity and antitumor activity of a Chinese medicinal herb, Tripterygium Hypoglaucum (Level) Hutch (THH). Methods: The genotoxicity and antitumor activity of TH-H were investigated in human promyelocytic leukemia cells on the mutation of hypoxanthine-guanine phosphoribosyl transferase (HPRT) gene by using single cell clone culture, two-way screening counting, multiplex PCR amplification and gel electrophoresis. Results: The results showed that different mutant spectra existed between the spontaneous mutation and induced mutation by THH. Only 7. 7% (1/13) of spontaneous mutants showed deletion mutations, whereas the induced mutants included 46.6% (27/58) deletions. Mapping of all intragenic deletion breakpoints showed a random distribution in all 9 exons, but toward the 3'-end of the HPRT gene. Deletion of exon 1 only appeared when whole gene was deleted. Deletions of exon 7/8 and 9 often showed linkage deletions (71.4%). Conclusion: THH can induce the mutation, mainly deletions, of HPRT gene in human promyelocytic leukemia cells.

Composition of Starch and Protein in the Endosperm of Newly Generated Double Recessive Waxy and Opaque 2 Maize （Zea mays L.） Genotypes

Waxy maize with its pure amylopectin starch is the staple food of many ethnic minorities in hilly regions of Southeast Asia （SEA）. A combination of waxy and quality protein maize （QPM） traits would improve the quality of protein of waxy maize for human consumption. Double recessive waxy-QPM （wx-o2） genotypes had been generated from Southern Chinese material by haploid induction of crosses heterozygous for the two quality traits with an absolutely conserved waxy type and an improved amino acid profile. The vitreous kernel trait （due to the additional modifier genes present in QPM） was lost in the wx-o2 plant material; this may be due to the waxy mutation, this is anyhow desirable for acceptance as waxy maize is preferred due to its soft grains. The content of the quality limiting amino acid lysine was greatly increased in double recessive wx-o2 genotypes compared to standard waxy maize, but still with a high variation among genotypes for future improvement. Conclusively, it was indeed possible to combine two grain quality mutations successfully within one genotype and prototypes of double quality wx-o2 are available now to contribute to meet human requirements in essential amino acids and thus reduce malnutrition in various regions of Asia.

Permutation-substitution image encryption scheme based on a modified chaotic map in transform domain

A new chaotic image encryption scheme based on permutation and substitution in the Fourier domain is presented.Fractional Fourier Transform(FRFT)is used before the encryption scheme to get a large degree of randomization.The permutation is achieved by Baker map and the substitution by a key-related-to-plain-image algorithm based on the modified Logistic map.Modification of the Logistic map is developed to increase the space of the encryption key,and hence increase the security.The key of the encryption algorithm dependents on the plain image,and thus,the cipher image is sensitive to both the initial key and the plain image to resist known-plaintext and chosen plaintext attacks.The key space is large and hence the algorithm can effectively resist brute-force attacks.The proposed scheme is examined using different performance evaluation metrics and the results prove that the proposed scheme is highly secure,and it can effectively resist different attacks.

Night Vehicle Detection Using Variable Haar-Like Feature

This paper proposes a night-time vehicle detection method using variable Haar-like feature.The specific features of front vehicle cannot be obtained in road image at night-time because of light reflection and ambient light,and it is also difficult to define optimal brightness and color of rear lamp according to road conditions.In comparison,the difference of vehicle region and road surface is more robust for road illumination environment.Thus,we select the candidates of vehicles by analysing the difference,and verify the candidates using those brightness and complexity to detect vehicle correctly.The feature of brightness difference is detected using variable horizontal Haar-like mask according to vehicle size in the location of image.And the region occurring rapid change is selected as the candidate.The proposed method is evaluated by testing on the various real road conditions.

Water Conservancy and the Historical Evolvement of Lingnan Regional Culture

The history of the formation and development of Chinese civilization is also a civilization history of water conservancy. Water not only gives birth to Chinese civilization but also gives birth to the unique regional culture in Lingnan. In the past thousands of year, from the ancient myths and legends of Lingnan water conservancy culture to the digging of efficacious Canal＇s integration of the nationalities in Lingnan, to the blending of water and culture of the Xijiang River and the North River of the Zhujiang water system and the formation of urban river culture, development of its generation, deduction and inheritance has the mutual penetration with the formation of water system and the variation of water conservancy which mutually influence the historical evolvement of Lingnan regional culture.

Influences of hydrological regime on heavy metal and salt ion concentrations in intertidal sediment from Chongming Dongtan, Changjiang River estuary, China

The tidal flat along the Changjiang(Yangtze) River estuary has long been reclaimed for the agricultural purposes, with the prevailing hydrological conditions during such pedogenic transformations being of great importance to their successful development. In this study, samples of surface sediment from Chongming Dongtan, situated at the mouth of the Changjiang River estuary, were collected and analyzed in order to understand how hydrological management can influence the concentrations of heavy metals and salt ions in pore water, and chemical fractionation of heavy metals during the reclamation process. We performed a series of experiments that simulated three dif ferent hydrological regimes: permanent flooding(R1), alternative five-day periods of wetting and drying(R2), continuous field capacity(R3). Our results exhibited good Pearson correlations coefficients between heavy metals and salt ions in the pore water for both R1 and R2. In particular, the concentrations of salt ions in the pore water decreased in all three regimes, but showed the biggest decline in R2. With this R2 experiment, the periodic concentration patterns in the pore water varied for Fe and Mn, but not for Cr, Cu, Pb and Zn. Neither the fractionation of Ni nor the residual fractions of any metals changed significantly in any regime. In R1, the reducible fractions of heavy metals(Cr, Cu, Zn and Pb) in the sediment decreased, while the acid extractable fractions increased. In R2, the acid extractable and the reducible fractions of Cr, Cu, Zn and Pb both decreased, as did the oxidizable fraction of Cu. These data suggest that an alternating hydrological regime can reduce both salinity and the availability of heavy metals in sediments.

Glass Substrates for OLED Lighting with High Out-coupling Efficiency

Glass substrates which realize high out-coupling efficiency OLEDs （organic light emitting diodes） were developed. A scattering layer whose matrix was made of high refractive index glass was formed on a glass substrate, and pores in the glass matrix work as scattering centers. The out-coupling efficiency of an OLED using this substrate is 1.8 times higher compared with an OLED using an untreated glass substrate. Furthermore angular dependency of the color and color variation between panels can be successfully suppressed.

FTIR Characterization of Gelatin from Chicken Feet

The objective of this study was characterizing the gelatin from the chicken feet by FTIR （Fourier transform infrared） spectroscopy. Two gelatin samples were prepared for the experiment which were extracted of 200 g of chicken feet by a thermal bath of 4% acetyl acid solution at 60 ℃. A commercial gelatin was used to compare the results. FTIR spectra of gelatin samples were recorded using a Nicolet iS5 FTIR spectrometer equipped with an ATR/iD3 with argon horizontal cell in which the spectra were varied in the range of 400-4,000 cm1 at 16 ~C. The results showed that FTIR spectra of the chicken feet gelatin had the most with the vibration peak at wave numbers of 1,652.01 cm~ to the amide I, of 1,539.87 cm1 to the amide II, of 1,241.29 cm~ to the amide III, of 2,923.72 cm-~ to the amide B and of 3,399.56 cm~ to the amide A. The collagen composition of the chicken feet gelatins was twotimes larger than the commercial gelatin and the vibration bands to beef gelatin have been different from chicken feet gelatins. This demonstrates that chicken feet gelatins are very good nutritional quality when compared to the commercial gelatin.

Institution and Change of the Public Economy:A New Interpretation of Early Modern Civilization Evolution

The causes of the evolution of human civilization have drawn much attention among social scientists. The new institutional economics （NIE） and its model of property rights explain the rise of the West Europe, but not the Industrial Revolution itself; nor have they addressed the causes for the rise and fall of civilizations in the East. By defining human civilization within the context of the public economic institution, we interpret this change in the public economic institution using swings in the demand structure of public goods. We see these swings as a contributing cause of the evolution of human civilization from traditional to modern. Our conclusions show that the shifts of public economic institutions between the mass democratic one and the elite constitutional one contributes to the current modem economic crisis and the stagnancy of modem civilization.

MAXIMUM SCORE CHANGE-POINT ESTIMATION IN BINARY RESPONSE MODEL

This paper is concerned with the estimation of change-point in a binary response model with the assumption that the conditional median of the error term, given the explanatory variable, is zero. We construct an estimation of change-point based on the maximum score function and give its exponential convergence rate under some mild conditions.

Adaptive Illumination Normalization Approach Based on Denoising Technique for Face Recognition

A novel adaptive illumination normalization approach is proposed to eliminate the effects caused by illumination variations for face recognition. The proposed method divides an image into blocks and performs discrete cosine transform(DCT) in blocks independently in the logarithm domain. For each block-DCT coefficient except the direct current(DC) component, we take the illumination as main signal and take the reflectance as "noise". A data-driven and adaptive soft-thresholding denoising technique is employed in each block-DCT coefficient except the DC component. Illumination is estimated by applying the inverse DCT in the block-DCT coefficients, and the indirectly obtained reflectance can be used in further recognition task. Experimental results show that the proposed approach outperforms other existing methods. Moreover, the proposed method does not need any prior information, and none of the parameters can be determined by experience.

A proof of a weak version of the Bieberbach conjecture in several complex variables

In this paper, the sharp estimates of all homogeneous expansions for a subclass of starlike mappings on the unit ball in complex Banach spaces are first established. Meanwhile, the sharp estimates of all homogeneous expansions for the above generalized mappings on the unit polydisk in Cnare also obtained. Our results show that a weak version of the Bieberbach conjecture in several complex variables is proved, and the obtained conclusions reduce to the classical results in one complex variable.

Effect of manual acupuncture on bowel motility in normal kunming mouse

OBJECTIVE:To observe the effects of acupuncture on motility of jejunum and distal colon at different acupoints on normal Kunming mice.METHODS:The jejunal and colorectal motor activity of forty Kunming mice were recorded by the intra-intestinal capsule.The capsules contained with distilled water were placed into the cavities of jejunum and distal colon.The changes of bowel were compared with the background activity recorded before any stimulation.The chosen acupoints were as follows:Zusanli(ST 36) on the lower legs,Tianshu(ST 25) on the mid-lower abdomen.RESULTS:Manual acupuncture(MA) at Zusanli(ST36) significantly promoted the motility of jejunum and distal colon(manifested as increased change rate of average amplitude and increased change rate of mean area under the contractile curve) of normal Kunming mice(P < 0.01).MA atTianshu(ST25) significantly inhibited the motility of jejunum(manifested as decreased change rate of average amplitude,decreased change rate of mean area under the contractile curve,and the reduced frequency) of normal Kunming mice(P < 0.01),while significantly increased the distal colonic motility(manifested as increased amplitude and increased mean area under the contractile curve) of normal Kunming mice(P < 0.01).CONCLUSION:MA at specific acupoints[Zusanli(ST 36),Tianshu(ST 25)]has different effects on the motility of jejunum and distal colon,which might involve the segmental innervations of the related nerve.

Salvianolic acids improve liver lipid metabolism in ovariectomized rats via blocking STAT-3/SREBP1 signaling

Postmenopausal women, who have reduced circulating estrogen levels, are more prone to develop obesity and related metabolic diseases than premenopausal women. The absence of safe and effective treatments for postmenopausal obesity has changed the focus to natural products as alternative remedies. Total salvianolic acids(TSA) are the major water-soluble ingredients of Danshen. Salvianolic acid(SA) is the major constituent of the TSA. Salvianolic acids, including TSA and SA, are widely used in traditional Chinese medicine. In the present study, ovariectomized rats and LO2 cells were used to study the effects of salvianolic acids on body weight gain and hepatic steatosis. Salvianolic acids reduced ovariectomy(OVX)-induced body weight gain, attenuated the expressions of hepatic lipogenic genes, such as sterol regulatory element binding protein(SREBP)1, fatty acid synthase(FAS), and stearoyl-CoA desaturase(SCD)1, and decreased the liver triglyceride(TG) and total cholesterol(TC). For the molecular mechanisms, OVX and high glucose-induced phosphorylation of signal transducer and activator of transcription(STAT)-3 was inhibited by salvianolic acids treatment. In LO2 cells, inhibition of STAT-3 by siRNA attenuated the increased expression of SREBP1 and TG induced by high glucose. Salvianolic acids reduced the upregulation of SREBP1 and TG induced by high glucose in LO2 cells. In conclusion, these findings illustrated that salvianolic acids markedly alleviated the lipid metabolism disorders and protected against the postmenopausal obesity. The underlying mechanism was probably associated with the regulation of STAT-3 signaling.