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《晚明曲家年谱》金圣叹史实研究献疑 被引量:8
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作者 陆林 《文学遗产》 CSSCI 北大核心 2002年第1期68-78,共11页
《晚明曲家年谱·金圣叹年谱》,是金圣叹研究的重要成果。然受史料知见之限,于金氏有关史实间有语而未确、言而未详之处。本文就疑误、疑缺处试作商补,并对圣叹的交游、堂号、亲属、事迹和诗文系年等问题提出己见。
关键词 金圣叹 曲家 晚明 系年 交游 诗文 史实 年谱 事迹 史料
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泽曲明山复方对大鼠非酒精性脂肪性肝炎模型影响 被引量:1
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作者 郑佳连 张红 +1 位作者 卢秉久 张艳 《辽宁中医药大学学报》 CAS 2024年第9期6-11,共6页
目的泽曲明山复方是辽宁省名中医卢秉久教授治疗代谢相关性脂肪性肝病(metabolic associated fatty liver disease,MAFLD)的经验方。研究基于PI3K/AKT/mTOR通路探讨该经验方对大鼠非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NA... 目的泽曲明山复方是辽宁省名中医卢秉久教授治疗代谢相关性脂肪性肝病(metabolic associated fatty liver disease,MAFLD)的经验方。研究基于PI3K/AKT/mTOR通路探讨该经验方对大鼠非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)模型的影响。方法适应性饲养1周后,所有SD大鼠随机分为5组:对照组,模型组,中药低、高剂量组及水林佳组。对照组给予胆碱充足高脂饲料(choline-sufficient high fat diet,CSHF饲料)。其余4组大鼠给予胆碱缺乏高脂饲料(choline-deficiency high fat diet,CDHF饲料)8周建立NASH模型,建立模型同时给予对应药物干预。观察相应药物对模型大鼠血清生化学指标、肝脏病理学检查、PI3K/AKT/mTOR信号转导通路mRNA以及蛋白表达的影响。结果(1)体质量以及肝脏系数:5组大鼠体质量比较差异无统计学意义;与对照组比较,模型组大鼠肝脏系数显著升高;与模型组比较,各药物干预组大鼠肝脏系数不同程度下降,中药高剂量组疗效最为明显。(2)肝功能以及血脂:与对照组比较,模型组大鼠血清谷丙转氨酶(alanine aminotransferase,ALT)、谷草转氨酶(aspartate aminotransferase,AST)、甘油三酯(triglyceride,TG)、总胆固醇(cholesterol,CHOL)水平显著升高;与模型组比较,各药物干预组大鼠肝功能以及血脂指标水平不同程度降低,其中中药高剂量组疗效最为明显。(3)肝脏病理学检查:模型组大鼠肝脏HE染色可见胞质内大量脂肪空泡以及炎症细胞浸润;Sirius red染色可见中央静脉大量纤维组织沉积,证实造模成功;与模型组比较,各药物干预组大鼠肝脏HE以及Sirius red染色显示肝脏组织均有不同程度改善,中药高剂量组改善最为明显。(4)肝脏相关mRNA及蛋白表达:与对照组比较,模型组大鼠肝脏组织中PI3K、AKT以及mTOR mRNA表达明显升高;与模型组比较,各药物干预组mRNA表达有不同程度下调,其中中药高剂量组最为明显。与对照组比较,模型组大鼠肝脏组织中PI3K以及mTOR蛋白表达上调;与模型组比较,各药物干预组蛋白表达均有不同程度下降,其中中药高剂量组改善最为显著(P<0.01)。与对照组比较,模型组大鼠肝脏组织中PPARγ蛋白表达下降;与模型组比较,各药物干预组蛋白表达均有不同程度上调,其中水林佳组改善最为显著。免疫荧光方法检测肝脏组织中PPARγ蛋白表达,结果显示模型组荧光信号表达暗淡;中药组荧光信号表达略亮;水林佳组荧光信号表达较亮。结论泽曲明山复方通过保护肝功能、调节血脂、改善肝脏病理、抑制PI3K/AKT/mTOR通路表达、上调PPARγ表达等方面治疗NASH。 展开更多
关键词 泽曲明山复方 非酒精性脂肪性肝炎 PI3K/AKT/mTOR通路
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基于PI3K-AKT-mTOR通路探讨泽曲明山复方对大鼠非酒精性脂肪性肝炎模型的影响
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作者 郑佳连 张艳 +3 位作者 卢秉久 张红 韩永辉 付博 《中华中医药学刊》 CAS 北大核心 2024年第12期117-121,I0041-I0047,共12页
目的泽曲明山复方是临床治疗代谢相关性脂肪性肝病(MAFLD)的经验方。研究探讨该经验方对大鼠非酒精性脂肪性肝炎(NASH)模型的影响以及可能的机制。方法Sprague-Dawley大鼠给予胆碱缺乏高脂饲料(CDHFdiet)8周建立NASH模型。随机分为模型... 目的泽曲明山复方是临床治疗代谢相关性脂肪性肝病(MAFLD)的经验方。研究探讨该经验方对大鼠非酒精性脂肪性肝炎(NASH)模型的影响以及可能的机制。方法Sprague-Dawley大鼠给予胆碱缺乏高脂饲料(CDHFdiet)8周建立NASH模型。随机分为模型组,中药低、高剂量组以及水林佳组;建立模型同时给予对应药物干预。给予胆碱充足高脂饲料(CSHFdiet)作为对照组。观察相应药物对模型大鼠血清生化学、肝脏病理、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(PKB/AKT)/哺乳动物雷帕霉素靶蛋白(mTOR)通路信号转导通路mRNA、蛋白表达的影响。结果(1)体质量以及肝脏/体质量:5组大鼠体质量差异无统计学意义,模型组大鼠肝脏/体质量显著升高,各干预组大鼠肝脏/体质量不同程度下降,中药高剂量组疗效最为明显。(2)肝功能以及血脂:与对照组相比,模型组大鼠血清肝功能及血脂水平显著升高;各干预组大鼠肝功能以及血脂不同程度降低,其中中药高剂量组疗效最为明显。(3)肝脏病理:模型组大鼠肝脏HE染色可见胞浆内大量脂肪空泡以及炎性细胞浸润;Siriusred染色可见中央静脉大量纤维组织沉积,证实模型成立;各干预组肝脏HE以及Siriusred染色均有不同程度改善,中药高剂量组改善最为明显。(4)对肝组织固醇调节元件结合蛋白1(SREBP-1)、低密度脂蛋白受体(LDLR)mRNA表达的影响:与对照组相比,模型组SREBP-1mRNA表达明显升高;各干预组有不同程度下调,其中中药高剂量组最为明显。与对照组相比,模型组大鼠LDLRmRNA表达明显下降;各干预组表达有不同程度增加,其中中药高剂量组改善最为明显。(5)对肝组织SREBP-1、LDLR蛋白表达的影响:与对照组相比,模型组大鼠肝组织中SREBP-1蛋白染色深,各干预组较模型组染色浅,其中中药组效果更显著。与对照组相比,模型组大鼠肝组织中LDLR蛋白染色浅,各干预组较模型组染色深,其中中药高剂量组效果更显著。(6)对肝组织磷脂酰肌醇3-激酶(PI3K)、雷帕霉素靶蛋白(mTOR)、蛋白激酶B(PKB/AKT)蛋白表达的影响:通过免疫荧光染色观察,模型组样本细胞的荧光信号表达明亮且分布不均匀;对照组荧光信号表达暗淡;各干预组较模型组荧光信号表达亮度下调,中药干预组改善更明显。结论泽曲明山复方可能通过调控PI3K/AKT/mTOR通路,起到减轻肝脏炎症反应、减少肝内脂肪生成和聚集,改善NASH的目的,并在治疗过程中表现出剂量相关性。 展开更多
关键词 泽曲明山复方 非酒精性脂肪性肝炎 PI3K-AKT-mTOR通路
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周履靖词曲创作比较论 被引量:2
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作者 郑海涛 《西华师范大学学报(哲学社会科学版)》 2015年第1期16-20,共5页
周履靖是晚明时期所学甚杂的通才型文士,也是典型的"山人型"作家。他词曲兼作,其词作多一词一调之举,表现出乐于尝试不同调式的浓厚兴趣;但却对《渔歌子》一调有大量填制,这与他渴望隐逸山林、啸傲江湖的志趣相关。周履靖在... 周履靖是晚明时期所学甚杂的通才型文士,也是典型的"山人型"作家。他词曲兼作,其词作多一词一调之举,表现出乐于尝试不同调式的浓厚兴趣;但却对《渔歌子》一调有大量填制,这与他渴望隐逸山林、啸傲江湖的志趣相关。周履靖在散曲创作中几乎专作南曲套数,且多歌咏隐逸之乐,与词中主要题材内容相一致。因受明代曲体词化与词体曲化风习的浸渍,周履靖词曲的主体风格一同呈现出"清疏"的特征。无论从题材内容方面还是从审美风格方面看,周履靖的词曲创作都表现出一种趋同性特征,这与晚明词曲二体总的发展趋势是一致的。 展开更多
关键词 周履靖 明词 明曲 散曲 词曲
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Study on Growth and Development Rules and Growth Curve Fitting of Minghua Black Minks
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作者 荣敏 涂剑锋 +3 位作者 张志明 王淑茗 高峰 邢秀梅 《Agricultural Science & Technology》 CAS 2017年第2期285-286,302,共3页
Growth curves of Minghua black minks at 0-180 days old were fitted and analyzed by using two growth models Logistic and Gompertz. The results showed that the growth curves of Minghua black minks could be fitted very w... Growth curves of Minghua black minks at 0-180 days old were fitted and analyzed by using two growth models Logistic and Gompertz. The results showed that the growth curves of Minghua black minks could be fitted very well by Logistic model and Gompertz model (the degree of fitting FF≥0.99), but Gompertz model was better at fitting and predicting their weight. 展开更多
关键词 Minghua black minks Growth curve Non-lineared models Development rules FITTING
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Three-point bending performance of a new aluminum foam composite structure 被引量:6
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作者 王宁珍 陈祥 +3 位作者 李奡 李言祥 张华伟 刘源 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2016年第2期359-368,共10页
A new composite structure based on aluminum foam sandwich and fiber metal laminate was proposed. A layer of glass fiber was provided at the interface between the metal panel and the aluminum foam core in this composit... A new composite structure based on aluminum foam sandwich and fiber metal laminate was proposed. A layer of glass fiber was provided at the interface between the metal panel and the aluminum foam core in this composite structure, using adhesive technology to bond the materials together by organic glue in the sequence of metal panel, glass fiber, aluminum foam core, glass fiber and metal panel. The experimental results show that the new composite structure has an improved comprehensive performance compared with the traditional aluminum foam sandwiches. The optimized parameters for the fabrication of the new aluminum foam composite structure with best bending strength were obtained. The epoxy resin and low porosity aluminum foams are preferred, the thickness of aluminum sheets should be at least 1.5 mm, and the type of glass fiber has little effect on the bending strength. The main failure modes of the new composite structures with two types of glues were discussed. 展开更多
关键词 composite structure three-point bending strength aluminum foam sandwich glass fiber
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Innovative Proof for Elastic Flexure Formulas
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作者 Hamed Jamshidi Pooya Djamshidi Sina Haji Saffar 《Journal of Mechanics Engineering and Automation》 2013年第7期424-427,共4页
The basic problem in teaching mechanics of materials is that some subjects discussed in the reference books are not easy to understand for most of the students. Using experience of many years teaching mechanics of mat... The basic problem in teaching mechanics of materials is that some subjects discussed in the reference books are not easy to understand for most of the students. Using experience of many years teaching mechanics of materials, we have been continuously trying to find easier methods to help the students get a better understanding of fundamental concepts. This effort and investigation has led to innovative and simple approaches to prove the equations much easier than the existing ones and also to clarify complicated concept. In this paper, we are offering our innovative proof for elastic flexure formulas as well as an interesting model for the moment sign convention in the cross section of a beam. In this method, considering a portion of a beam under pure bending and obtaining the stress distribution in the cross section and applying the balance of the considered portion, we prove the Elastic Flexure Formulas much easier than the existing methods. Emphasizing on deeper understanding, some notes and a new model are offered during this proof. 展开更多
关键词 Innovative proof elastic flexure formulas UNDERSTAND bending moment.
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Nature of Valuational Consciousness in Good Life
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作者 Kumar Neeraj Sachdev 《Journal of Philosophy Study》 2012年第10期767-771,共5页
I make an attempt in the paper to argue in favor of the person-centered view of good life, where becoming a good person involves seeking to qualitatively transform oneself into a worthy human being. I maintain that be... I make an attempt in the paper to argue in favor of the person-centered view of good life, where becoming a good person involves seeking to qualitatively transform oneself into a worthy human being. I maintain that becoming fully a person and respecting others as persons are achievements that are not assured for all of us. Thus, for the purpose I prepare the ground for an account of good life that rests on valuational consciousness. I propose that one may ascribe valuational consciousness to a person who is a value-sensitive rational being striving to attain a kind of inner transparency. Evidently, to say that a person has valuational consciousness is to stress the values, which are built into personal consciousness. The life of a person, whether that of truth, courage, nobility, justice, kindness, is a life marked by ego transcending personal consciousness that reaches out to humanity at large. And such a repository of values enables a human being to attain the ideal of good life. The ideal of good life, I contend, consists of attaining the higher order posture of selflessness--a posture of inner transparency. It is to shake off the egocentric partiality that characterizes our usual attitudinal stance towards one another. 展开更多
关键词 good life CONSCIOUSNESS valuational consciousness strong evaluation SELFLESSNESS
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A Public Verifiable Identity Based Signcryption in the Random Oracle Model
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作者 陈雯 潘峰 +1 位作者 郭放 雷飞宇 《Journal of Donghua University(English Edition)》 EI CAS 2009年第4期368-373,共6页
Since Libert and Quisquater's identity based signcryption scheme cannot provide public verifiability after research, the paper proposes a new identity based signcryption scheme. The scheme uses quadratic residue a... Since Libert and Quisquater's identity based signcryption scheme cannot provide public verifiability after research, the paper proposes a new identity based signcryption scheme. The scheme uses quadratic residue and pairings over elliptic curves to realize public verifiability. By analysis the scheme is proved to be more efficient than Libert and Quisquater's scheme. Moreover, a security proof of the original scheme is presented in the random oracle model. 展开更多
关键词 identity based signcrvption public verifiability random oracle
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The mean curvature flow in Minkowski spaces 被引量:1
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作者 Fanqi Zeng Qun He Bin Chen 《Science China Mathematics》 SCIE CSCD 2018年第10期1833-1850,共18页
Studying the geometric flow plays a powerful role in mathematics and physics. In this paper, we introduce the mean curvature flow on Finsler manifolds and give a number of examples of the mean curvature flow. For Mink... Studying the geometric flow plays a powerful role in mathematics and physics. In this paper, we introduce the mean curvature flow on Finsler manifolds and give a number of examples of the mean curvature flow. For Minkowski spaces, a special case of Finsler manifolds, we prove the short time existence and uniqueness for solutions of the mean curvature flow and prove that the flow preserves the convexity and mean convexity.We also derive some comparison principles for the mean curvature flow. 展开更多
关键词 anisotropic mean curvature mean curvature flow Finsler manifold Minkowski space CONVEXITY
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Torsion in the Cohomology of Torus Orbifolds
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作者 Hideya KUWATA Mikiya MASUDA Haozhi ZENG 《Chinese Annals of Mathematics,Series B》 SCIE CSCD 2017年第6期1247-1268,共22页
The authors study torsion in the integral cohomology of a certain family of2 n-dimensional orbifolds X with actions of the n-dimensional compact torus. Compact simplicial toric varieties are in our family. For a prime... The authors study torsion in the integral cohomology of a certain family of2 n-dimensional orbifolds X with actions of the n-dimensional compact torus. Compact simplicial toric varieties are in our family. For a prime number p, the authors find a necessary condition for the integral cohomology of X to have no p-torsion. Then it is proved that the necessary condition is sufficient in some cases. The authors also give an example of X which shows that the necessary condition is not sufficient in general. 展开更多
关键词 Toric orbifold COHOMOLOGY TORSION
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Effect of manual acupuncture on bowel motility in normal kunming mouse 被引量:7
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作者 Zhao Yuxue Cui Changxiang +4 位作者 Qin Qingguang Ben Hui Gao Junhong Yu Xiaochun Zhu Bing 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2015年第2期227-233,共7页
OBJECTIVE:To observe the effects of acupuncture on motility of jejunum and distal colon at different acupoints on normal Kunming mice.METHODS:The jejunal and colorectal motor activity of forty Kunming mice were record... OBJECTIVE:To observe the effects of acupuncture on motility of jejunum and distal colon at different acupoints on normal Kunming mice.METHODS:The jejunal and colorectal motor activity of forty Kunming mice were recorded by the intra-intestinal capsule.The capsules contained with distilled water were placed into the cavities of jejunum and distal colon.The changes of bowel were compared with the background activity recorded before any stimulation.The chosen acupoints were as follows:Zusanli(ST 36) on the lower legs,Tianshu(ST 25) on the mid-lower abdomen.RESULTS:Manual acupuncture(MA) at Zusanli(ST36) significantly promoted the motility of jejunum and distal colon(manifested as increased change rate of average amplitude and increased change rate of mean area under the contractile curve) of normal Kunming mice(P < 0.01).MA atTianshu(ST25) significantly inhibited the motility of jejunum(manifested as decreased change rate of average amplitude,decreased change rate of mean area under the contractile curve,and the reduced frequency) of normal Kunming mice(P < 0.01),while significantly increased the distal colonic motility(manifested as increased amplitude and increased mean area under the contractile curve) of normal Kunming mice(P < 0.01).CONCLUSION:MA at specific acupoints[Zusanli(ST 36),Tianshu(ST 25)]has different effects on the motility of jejunum and distal colon,which might involve the segmental innervations of the related nerve. 展开更多
关键词 Hand acupuncture Point ST 36(Zusanli) Point ST 25(Tianshu) Gastrointestinal motility
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A new method in highway route design:joining circular arcs by a single C-Bézier curve with shape parameter 被引量:4
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作者 Hua-hui CAI Guo-jin WANG 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2009年第4期562-569,共8页
We constructed a single C-Bezier curve with a shape parameter for G^2 joining two circular arcs. It was shown that an S-shaped transition curve, which is able to manage a broader scope about two circle radii than the ... We constructed a single C-Bezier curve with a shape parameter for G^2 joining two circular arcs. It was shown that an S-shaped transition curve, which is able to manage a broader scope about two circle radii than the Bezier curves, has no curvature extrema, while a C-shaped transition curve has a single curvature extremum. Regarding the two kinds of curves, specific algorithms were presented in detail, strict mathematical proofs were given, and the effectiveness of the method was shown by examples This method has the following three advantages: (1) the pattern is unified; (2) the parameter able to adjust the shape of the transition curve is available; (3) the transition curve is only a single segment, and the algorithm can be formulated as a low order equation to be solved for its positive root. These advantages make the method simple and easy to implement. 展开更多
关键词 Transition curve C-Bezier curve Monotone curvature Shape parameter
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Stability of hypersurface sections of quadric threefolds 被引量:1
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作者 BYUN SangHo LEE YongNam 《Science China Mathematics》 SCIE CSCD 2015年第3期479-486,共8页
Let S be a complete intersection of a smooth quadric 3-fold Q and a hypersurface of degree d in P4.We analyze GIT stability of S with respect to the natural G=SO(5,C)-action.We prove that if d 4 and S has at worst sem... Let S be a complete intersection of a smooth quadric 3-fold Q and a hypersurface of degree d in P4.We analyze GIT stability of S with respect to the natural G=SO(5,C)-action.We prove that if d 4 and S has at worst semi-log canonical singularities then S is G-stable.Also,we prove that if d 3 and S has at worst semi-log canonical singularities then S is G-semistable. 展开更多
关键词 quadric threefold hypersurface section STABILITY geometric invariant theory
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Optimal constant in an L^2 extension problem and a proof of a conjecture of Ohsawa 被引量:10
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作者 GUAN Qi'An ZHOU Xiang Yu 《Science China Mathematics》 SCIE CSCD 2015年第1期35-59,共25页
In this paper,we solve the optimal constant problem in the setting of Ohsawa’s generalized L2extension theorem.As applications,we prove a conjecture of Ohsawa and the extended Suita conjecture,we also establish some ... In this paper,we solve the optimal constant problem in the setting of Ohsawa’s generalized L2extension theorem.As applications,we prove a conjecture of Ohsawa and the extended Suita conjecture,we also establish some relations between Bergman kernel and logarithmic capacity on compact and open Riemann surfaces. 展开更多
关键词 L2 extension theorem optimal L2 estimate Bergman kernel a conjecture of Ohsawa extendedSuita conjecture
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Comparisons of Metrics on Teichmller Space
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作者 Zongliang SUN Lixin LIU 《Chinese Annals of Mathematics,Series B》 SCIE CSCD 2010年第1期71-84,共14页
For a Riemann surface X of conformally finite type (g, n), let dT, dL and dpi (i = 1, 2) be the Teichmuller metric, the length spectrum metric and Thurston's pseudometrics on the Teichmutler space T(X), respect... For a Riemann surface X of conformally finite type (g, n), let dT, dL and dpi (i = 1, 2) be the Teichmuller metric, the length spectrum metric and Thurston's pseudometrics on the Teichmutler space T(X), respectively. The authors get a description of the Teichmiiller distance in terms of the Jenkins-Strebel differential lengths of simple closed curves. Using this result, by relatively short arguments, some comparisons between dT and dL, dpi (i = 1, 2) on Tε(X) and T(X) are obtained, respectively. These comparisons improve a corresponding result of Li a little. As applications, the authors first get an alternative proof of the topological equivalence of dT to any one of dL, dp1 and dp2 on T(X). Second, a new proof of the completeness of the length spectrum metric from the viewpoint of Finsler geometry is given. Third, a simple proof of the following result of Liu-Papadopoulos is given: a sequence goes to infinity in T(X) with respect to dT if and only if it goes to infinity with respect to dL (as well as dpi (i = 1, 2)). 展开更多
关键词 Length spectrum metric Teichmuller metric Thurston's pseudo-metrics
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The reason of Hopf’s and Oleinik’s proofs for countability of shocks being wrong
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作者 LI BangHe Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing 100190,China 《Science China Mathematics》 SCIE 2012年第4期727-729,共3页
For the number of complete shock curves of a conservation law with one space variable,Hopf in 1950 for the Burger equation,and Oleinik in 1956 for the general,stated that it is at most countable.In 1979,the present au... For the number of complete shock curves of a conservation law with one space variable,Hopf in 1950 for the Burger equation,and Oleinik in 1956 for the general,stated that it is at most countable.In 1979,the present author published an example to show that the statement of Hopf and Oleinik is wrong.But after so long time,the wrong statement for countability still appeared in some publications,which is at least partly due to that some ones felt difficult to understand Hopf and Oleinik’s proofs being wrong.So,pointing out where they went wrong becomes very necessary. 展开更多
关键词 countability of shocks uncountability of shocks conservation law
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Hyperbolicity of unitary involutions
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作者 KARPENKO Nikita A. 《Science China Mathematics》 SCIE 2012年第5期937-945,共9页
We prove the so-called Unitary Hyperbolicity Theorem,a result on hyperbolicity of unitary involutions.The analogous previously known results for the orthogonal and symplectic involutions are formal consequences of the... We prove the so-called Unitary Hyperbolicity Theorem,a result on hyperbolicity of unitary involutions.The analogous previously known results for the orthogonal and symplectic involutions are formal consequences of the unitary one.While the original proofs in the orthogonal and symplectic cases were based on the incompressibility of generalized Severi-Brauer varieties,the proof in the unitary case is based on the incompressibility of their Weil transfers. 展开更多
关键词 algebraic groups INVOLUTIONS projective homogeneous varieties Chow groups and motives Steenrod operations
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