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药用明胶微胶囊的研究进展
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作者 苏铭晖 《明胶科学与技术》 CAS 2019年第1期6-15,共10页
微胶囊技术是21世纪重点研究开发的高新技术之一,用途广泛。明胶具有无毒、稳定性强、成膜性和生物相容性等特点,也是在微胶囊技术中经常用作壁材的一种亲水性高分子胶体。它可以单独使用,也可以与其他材料一起经过复合形成囊壁。以药... 微胶囊技术是21世纪重点研究开发的高新技术之一,用途广泛。明胶具有无毒、稳定性强、成膜性和生物相容性等特点,也是在微胶囊技术中经常用作壁材的一种亲水性高分子胶体。它可以单独使用,也可以与其他材料一起经过复合形成囊壁。以药物为囊芯,明胶为囊壁的药用明胶微胶囊在药物存储和释放方面显示出独特的优势以及广阔的应用前景。近些年来,明胶药用微胶囊的研究成为医药行业中的前沿和热点。本文对以天然高分子材料明胶及其复合物作为微胶囊的壁材体系用于药用微胶囊的研究进展进行了简要的阐述,并且对药用明胶微胶囊的制备方法、功能以及在现阶段的应用进行了介绍。 展开更多
关键词 明胶微胶囊 药物用微胶囊
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Drying of Micro-Encapsulated Lactic Acid Bacteria—Effects of Trehalose and Immobilization on Cell Survival and Release Properties 被引量:2
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作者 LI Xiaoyan CHEN Xiguang 《Journal of Ocean University of China》 SCIE CAS 2009年第1期39-44,共6页
Lactic acid bacteria (LAB) were encapsulated with alginate, gelatin and trehalose additives by the extrusion method and dried at 4 ℃. The microcapsules were generally spherical and had a wrinkled surface with a siz... Lactic acid bacteria (LAB) were encapsulated with alginate, gelatin and trehalose additives by the extrusion method and dried at 4 ℃. The microcapsules were generally spherical and had a wrinkled surface with a size of 1.7mm± 0.2mm Trehalose as a carbohydrate source in the culture medium could reduce acid production and performed no function in the positive proliferation of LAB. Using trehalose as a carbohydrate source and protective medittm simultaneously had a benefit in the protection of LAB cells during the storage at 4 ℃. The density of live LAB cells could be 10^7 CFU g^-1 after 8weeks of storage. Cells of LAB could be continuously released from the capsules from the acidic (pH 1.2) to neutral conditions (pH 6.8). The release amounts and proliferation speeds of LAB cells in neutral medium were much larger and faster than those in acidic conditions. Additionally, nxtmobilization of LAB could improve the survival of cells when they were exposed to acidic medium (pH 1.2) with a survival rate of 76%. 展开更多
关键词 ALGINATE GELATIN MICROCAPSULE TREHALOSE survival release tolerance
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