Aim To study the effects of cyclovirobuxine D on inward rectifier K^- current(I_(k1) ) > transient outward K^+ current (I_(to)), L-type Ca^(2+) current (I_(Ca-L)), and actionpotential duration (APD) in isolated rat...Aim To study the effects of cyclovirobuxine D on inward rectifier K^- current(I_(k1) ) > transient outward K^+ current (I_(to)), L-type Ca^(2+) current (I_(Ca-L)), and actionpotential duration (APD) in isolated rat ventricular myocytes. Methods The whole cell patch-clamptechniques were used to study the changes of I_(k1), I_(to), I_(Ca-L) and APD in rat ventricularmyocytes. Results Cyclovirobuxine D (1-10 μmol·L^(-1)) significantly prolonged APD_(50) andAPD_(90) in isolated rat ventricular myocytes. Resting potential (RP) was decreased by 10μmol·L^(-1) of cyclovirobuxine D. Cyclovirobuxine D significantly decreased both inward andoutward components of I_(k1) . At - 100 mV, 1 and 10 μmol·L^(-1) of cyclovirobuxine D decreasedI_(k1), density from (-8.0+- 1.1) pA/pF to ( - 4.1 +- 0.7) pA/pF and ( - 3.4 +- 0.8) pA/pF,respectively, whereas at - 30 mV, I-(k1) density was decreased from (1.10 +-0.24) pA/pF to (0.61+-0.18) pA/pF and (0.36+- 0.11) pA/pF, respectively. 1_(to) was markedly inhibited bycyclovirobuxine D from the test potential of 0 mV to + 60 mV. At + 40 mV, 1 and 10μmol·L^(-1) ofcyclovirobuxine D decreased I_(to) density from (8.9+- 2.0) pA/pF to (5.5 +- 1.2) pA/pF and (4.9+-0.9) pA/pF, respectively. Cyclovirobuxine D inhibited I_(Ca-L) in a concentration-dependentmanner. At 10 mV, 1 and 10μmol·L^(-1) of cyclovirobuxine D decreased I_(Ca-L) density from ( - 9.9+- 1.8) pA/pF to ( - 6.4 +- 1.4) pA/pF and (-4.2+-0.6) pA/pF, respectively. ConclusionCyclovirobuxine D significantly prolonged APD and inhibited I_(k1), I_(to), and I_(Ca-L) in ratventricular myocytes. The inhibitory effects of cyclovirobuxine D on _(k1) and I_(to) are majormolecular mechanisms of APD prolongation in rat.展开更多
This study aims to figure out satellite imaging mechanisms for submerged sand ridges in the shallow water region in the case of the flow parallel to the topography corrugation.Solving the disturbance governing equatio...This study aims to figure out satellite imaging mechanisms for submerged sand ridges in the shallow water region in the case of the flow parallel to the topography corrugation.Solving the disturbance governing equations of the shear-flow yields the analytical solutions of the secondary circulation.The solutions indicate that a flow with a parabolic horizontal velocity shear and a sinusoidal vertical velocity shear will induce a pair of vortexes with opposite signs distributed symmetrically on the two sides of central line of a rectangular canal.In the case of the presence of surface Ekman layer with the direction of Ekman current opposite to(coincident with) the mean flow,the two vortexes converge(diverge) at the central line of canal in the upper layer and form a surface current convergent(divergent) zone along the central line of the canal.In the case of the absence of surface Ekman layer,there is no convergent(divergent) zone formed over the sea surface.The theoretical results are applied to interpretations of three convergent cases,one divergent case and statistics of 27 cases of satellite observations in the submerged sand ridge region of the Liaodong Shoal in the Bohai Sea.We found that the long,finger-like,bright patterns on SAR images are corresponding to the locations of the canals(or tidal channels) formed by two adjacent sand ridges rather than the sand ridges themselves.展开更多
In frame of the asteroid-comet hazard problem study, a qualitative analysis of some methods for the effect on a celestial near-Earth object (NEO)-an asteroid, a comet — is carried out. The goal of the effect is a cor...In frame of the asteroid-comet hazard problem study, a qualitative analysis of some methods for the effect on a celestial near-Earth object (NEO)-an asteroid, a comet — is carried out. The goal of the effect is a correction of this object’s orbit, its deflection from the Earth to prevent their collision. There are studied a mechanical impact-kinetic effect of the spacecraft (SC), a thermonuclear effect, an effect on a cometary nucleus for a controlled change of its dusty mantle and, therefore, its sublimation activity. Qualitative models of these effects are developed. Numerical analysis results are given for a group of NEOs such as some asteroids from the Apollo family (Apollo, Castalia, Nereus, Orpheus, Phaethon, Toutatis, etc.) and from the Aten family (Aten, Hathor, Khufu, etc.) as well as some short-periodic comets like the comet P/Biela. There are studied some characteristics of the effects on the NEOs such as the velocity impulse (or acceleration) applied to the celestial body, its deflection from the Earth. The study is supported by the Russian Foundation of Basic Studies (Grant N 01-01-00133).展开更多
In this study, two deep convective cloud cases were analyzed in detail to study their initiation and evolution. In both cases, all deep convective clouds were positioned at the rear of the cold front cloud bands and p...In this study, two deep convective cloud cases were analyzed in detail to study their initiation and evolution. In both cases, all deep convective clouds were positioned at the rear of the cold front cloud bands and propagated backward. Satellite data showed that prior to initiation of the deep convective clouds, thermodynamic and moist conditions were favorable for their formation. In the morning, a deep convective cloud at the rear of cold front cloud band propagated backward, the outflow boundary of which created favorable conditions for initiation. An additional deep convective cloud cluster moved in from the west and interacted with the outflow boundary to develop a mesoscale convective system(MCS) with large, ellipse-shaped deep convective clouds that brought strong rainfall. The initiation and evolution of these clouds are shown clearly in satellite data and provide significant information for nowcasting and short-term forecasting.展开更多
By making use of the decomposition of U（1） gauge potential theory and the C-mapping method we discuss a mixture of interacting neutral and charged Bose condensates, which is supposed being realized in the interior o...By making use of the decomposition of U（1） gauge potential theory and the C-mapping method we discuss a mixture of interacting neutral and charged Bose condensates, which is supposed being realized in the interior of neutron stars in the form of a coexistent neutron superfluid and protonic superconductor. We propose that this system possesses vortex lines and two classes of knotted solitons. The topological charge of the vortex lines are characterized by the Hopf indices and the Brower degrees of φ-mapping, and the knotted solitons are described by nontrivial Hopf invariant and the BF action respectively.展开更多
A winter onshore warm tongue extending from the Yellow Sea Warm Current to the southern Jiangsu coast, and an of fshore cold tongue extending from the southern Jiangsu coast to the southwest of Jeju Island(South Korea...A winter onshore warm tongue extending from the Yellow Sea Warm Current to the southern Jiangsu coast, and an of fshore cold tongue extending from the southern Jiangsu coast to the southwest of Jeju Island(South Korea), are newly identified based on the sea-surface temperature from satellite remote sensing, and further confirmed by the distribution of suspended sediments. In addition, there are two obvious thermal fronts associated with the onshore warm tongue and off shore cold tongue. The narrow gap between the two thermal fronts is supposed to be the pathway for the off shore transport of cold coastal water and suspended sediments. The concurrence of onshore warm and of fshore cold tongues suggests the concurrence of onshore and off shore currents in the western Yellow Sea in winter, which seems to be inconsistent with the previously accepted view that, in winter, the Yellow Sea Coastal Current flows from the Old Huanghe Delta to the southwest of Jeju Island. This distinctive phenomenon helps establish an updated view of the circulation in the western Yellow Sea in winter.展开更多
By combining Argos drifter buoys and TOPEX/POSEIDON altimeter data, the time series of sea-surface velocity fields in the Kuroshio Current (KC) and adjacent regions are established. And the variability of the KC from ...By combining Argos drifter buoys and TOPEX/POSEIDON altimeter data, the time series of sea-surface velocity fields in the Kuroshio Current (KC) and adjacent regions are established. And the variability of the KC from the Luzon Strait to the Tokara Strait is studied based on the velocity fields. The results show that the dominant variability period varies in different segments of the KC: The primary period near the Luzon Strait and to the east of Taiwan Island is the intra-seasonal time scale; the KC on the continental shelf of the ECS is the steadiest segment without obvious periodicity, while the Tokara Strait shows the period of seasonal variability. The diverse periods are caused by the Rossby waves propagating from the interior ocean, with adjustments in topography of island chain and local wind stress.展开更多
The temporal and spatial variations of surface latent heat flux(SLHF)and diagnostic air temperature at 2m before and after the M_S5.7 earthquake occurring on November 26,2005 in the area between Ruichang City and Jiuj...The temporal and spatial variations of surface latent heat flux(SLHF)and diagnostic air temperature at 2m before and after the M_S5.7 earthquake occurring on November 26,2005 in the area between Ruichang City and Jiujiang City,Jiangxi Province are summarized in this paper.It is found that before the earthquake significant SLHF anomalies and air temperature anomalies occurred in the epicentral area and its vicinity.The air temperature anomalies appeared from the 2nd to the 13th of November,2005 and were concentrated at the epicentral area and in its southern part.Then two days later,that is,from the 4th to the 15th of November 2005,significant SLHF anomalies occurred in the epicentral area and to its northern area where many lakes are distributed along the active faults.During the anomalous period,the SLHF and air temperature at 2m exceeded the sum of average daily value over 26 years and 1.5 times of its mean square deviation.Both anomalies had maintained for 12 days with a peculiar distribution related to the tectonic active zone.It is considered that both of air temperature anomalies and SLHF anomalies are correlated to the movement of thermal flux from underground prior to earthquake.SLHF anomalies occurred over wide regions covered with abundant water,whereas air temperature anomalies occurred over land.展开更多
文摘Aim To study the effects of cyclovirobuxine D on inward rectifier K^- current(I_(k1) ) > transient outward K^+ current (I_(to)), L-type Ca^(2+) current (I_(Ca-L)), and actionpotential duration (APD) in isolated rat ventricular myocytes. Methods The whole cell patch-clamptechniques were used to study the changes of I_(k1), I_(to), I_(Ca-L) and APD in rat ventricularmyocytes. Results Cyclovirobuxine D (1-10 μmol·L^(-1)) significantly prolonged APD_(50) andAPD_(90) in isolated rat ventricular myocytes. Resting potential (RP) was decreased by 10μmol·L^(-1) of cyclovirobuxine D. Cyclovirobuxine D significantly decreased both inward andoutward components of I_(k1) . At - 100 mV, 1 and 10 μmol·L^(-1) of cyclovirobuxine D decreasedI_(k1), density from (-8.0+- 1.1) pA/pF to ( - 4.1 +- 0.7) pA/pF and ( - 3.4 +- 0.8) pA/pF,respectively, whereas at - 30 mV, I-(k1) density was decreased from (1.10 +-0.24) pA/pF to (0.61+-0.18) pA/pF and (0.36+- 0.11) pA/pF, respectively. 1_(to) was markedly inhibited bycyclovirobuxine D from the test potential of 0 mV to + 60 mV. At + 40 mV, 1 and 10μmol·L^(-1) ofcyclovirobuxine D decreased I_(to) density from (8.9+- 2.0) pA/pF to (5.5 +- 1.2) pA/pF and (4.9+-0.9) pA/pF, respectively. Cyclovirobuxine D inhibited I_(Ca-L) in a concentration-dependentmanner. At 10 mV, 1 and 10μmol·L^(-1) of cyclovirobuxine D decreased I_(Ca-L) density from ( - 9.9+- 1.8) pA/pF to ( - 6.4 +- 1.4) pA/pF and (-4.2+-0.6) pA/pF, respectively. ConclusionCyclovirobuxine D significantly prolonged APD and inhibited I_(k1), I_(to), and I_(Ca-L) in ratventricular myocytes. The inhibitory effects of cyclovirobuxine D on _(k1) and I_(to) are majormolecular mechanisms of APD prolongation in rat.
基金supported by Academician Foundation of China (for Yuan and Zheng)Shanghai Science and Technology Committee Program - Special for EXPO under Grant No.10DZ0581600 and Grant SHUES2011A07 from Shanghai Institute of Urban Ecology and Sustainability(for Zhao)+1 种基金partially supported by US National Sci-ence Foundation Award 0962107 (for Zheng and Liu)Award 1061998 (for Zheng)
文摘This study aims to figure out satellite imaging mechanisms for submerged sand ridges in the shallow water region in the case of the flow parallel to the topography corrugation.Solving the disturbance governing equations of the shear-flow yields the analytical solutions of the secondary circulation.The solutions indicate that a flow with a parabolic horizontal velocity shear and a sinusoidal vertical velocity shear will induce a pair of vortexes with opposite signs distributed symmetrically on the two sides of central line of a rectangular canal.In the case of the presence of surface Ekman layer with the direction of Ekman current opposite to(coincident with) the mean flow,the two vortexes converge(diverge) at the central line of canal in the upper layer and form a surface current convergent(divergent) zone along the central line of the canal.In the case of the absence of surface Ekman layer,there is no convergent(divergent) zone formed over the sea surface.The theoretical results are applied to interpretations of three convergent cases,one divergent case and statistics of 27 cases of satellite observations in the submerged sand ridge region of the Liaodong Shoal in the Bohai Sea.We found that the long,finger-like,bright patterns on SAR images are corresponding to the locations of the canals(or tidal channels) formed by two adjacent sand ridges rather than the sand ridges themselves.
文摘In frame of the asteroid-comet hazard problem study, a qualitative analysis of some methods for the effect on a celestial near-Earth object (NEO)-an asteroid, a comet — is carried out. The goal of the effect is a correction of this object’s orbit, its deflection from the Earth to prevent their collision. There are studied a mechanical impact-kinetic effect of the spacecraft (SC), a thermonuclear effect, an effect on a cometary nucleus for a controlled change of its dusty mantle and, therefore, its sublimation activity. Qualitative models of these effects are developed. Numerical analysis results are given for a group of NEOs such as some asteroids from the Apollo family (Apollo, Castalia, Nereus, Orpheus, Phaethon, Toutatis, etc.) and from the Aten family (Aten, Hathor, Khufu, etc.) as well as some short-periodic comets like the comet P/Biela. There are studied some characteristics of the effects on the NEOs such as the velocity impulse (or acceleration) applied to the celestial body, its deflection from the Earth. The study is supported by the Russian Foundation of Basic Studies (Grant N 01-01-00133).
基金supported by the National Natural Science Foundation of China"Study of Characteristics of the Environmental Field before the Deep Convective Cloud Initiated Using Geostational Meteorological Satellite Data"(Grant No.41005026)
文摘In this study, two deep convective cloud cases were analyzed in detail to study their initiation and evolution. In both cases, all deep convective clouds were positioned at the rear of the cold front cloud bands and propagated backward. Satellite data showed that prior to initiation of the deep convective clouds, thermodynamic and moist conditions were favorable for their formation. In the morning, a deep convective cloud at the rear of cold front cloud band propagated backward, the outflow boundary of which created favorable conditions for initiation. An additional deep convective cloud cluster moved in from the west and interacted with the outflow boundary to develop a mesoscale convective system(MCS) with large, ellipse-shaped deep convective clouds that brought strong rainfall. The initiation and evolution of these clouds are shown clearly in satellite data and provide significant information for nowcasting and short-term forecasting.
基金Supported by National Natural Science Foundation of China under Grant No.10275030
文摘By making use of the decomposition of U（1） gauge potential theory and the C-mapping method we discuss a mixture of interacting neutral and charged Bose condensates, which is supposed being realized in the interior of neutron stars in the form of a coexistent neutron superfluid and protonic superconductor. We propose that this system possesses vortex lines and two classes of knotted solitons. The topological charge of the vortex lines are characterized by the Hopf indices and the Brower degrees of φ-mapping, and the knotted solitons are described by nontrivial Hopf invariant and the BF action respectively.
基金Supported by the Strategy Program of Chinese Academy of Sciences(Nos.XDA10020104,XDA10020305)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.41421005)+2 种基金the National Natural Science Foundation of China(Nos.41476019,41606040)the NSFC-Shandong Joint Fund for Marine Science Research Centers(No.U1406401)the High Performance Computing Center,Institute of Oceanology,Chinese Academy of Sciences in Qingdao
文摘A winter onshore warm tongue extending from the Yellow Sea Warm Current to the southern Jiangsu coast, and an of fshore cold tongue extending from the southern Jiangsu coast to the southwest of Jeju Island(South Korea), are newly identified based on the sea-surface temperature from satellite remote sensing, and further confirmed by the distribution of suspended sediments. In addition, there are two obvious thermal fronts associated with the onshore warm tongue and off shore cold tongue. The narrow gap between the two thermal fronts is supposed to be the pathway for the off shore transport of cold coastal water and suspended sediments. The concurrence of onshore warm and of fshore cold tongues suggests the concurrence of onshore and off shore currents in the western Yellow Sea in winter, which seems to be inconsistent with the previously accepted view that, in winter, the Yellow Sea Coastal Current flows from the Old Huanghe Delta to the southwest of Jeju Island. This distinctive phenomenon helps establish an updated view of the circulation in the western Yellow Sea in winter.
基金Supported by the National Basic Research Program of China (973 Program, Nos. 2007CB411804, 2005CB422303)the NSFC (No. 40706006)+2 种基金the Key Project of International Science and Technology Cooperation Program of China (No. 2006DFB21250)the "111 Project" (B07036)the Program for New Century Excellent Talents in University (NECT-07-0781)
文摘By combining Argos drifter buoys and TOPEX/POSEIDON altimeter data, the time series of sea-surface velocity fields in the Kuroshio Current (KC) and adjacent regions are established. And the variability of the KC from the Luzon Strait to the Tokara Strait is studied based on the velocity fields. The results show that the dominant variability period varies in different segments of the KC: The primary period near the Luzon Strait and to the east of Taiwan Island is the intra-seasonal time scale; the KC on the continental shelf of the ECS is the steadiest segment without obvious periodicity, while the Tokara Strait shows the period of seasonal variability. The diverse periods are caused by the Rossby waves propagating from the interior ocean, with adjustments in topography of island chain and local wind stress.
基金This research was jointly sponsored by the National 11th"Five-Year Plan"of Key Technology R & D Program of Ministry of Science and Technology (Grant No.2006BAC01B030203)the National Natural Science Foundation of Chin (40372131).
文摘The temporal and spatial variations of surface latent heat flux(SLHF)and diagnostic air temperature at 2m before and after the M_S5.7 earthquake occurring on November 26,2005 in the area between Ruichang City and Jiujiang City,Jiangxi Province are summarized in this paper.It is found that before the earthquake significant SLHF anomalies and air temperature anomalies occurred in the epicentral area and its vicinity.The air temperature anomalies appeared from the 2nd to the 13th of November,2005 and were concentrated at the epicentral area and in its southern part.Then two days later,that is,from the 4th to the 15th of November 2005,significant SLHF anomalies occurred in the epicentral area and to its northern area where many lakes are distributed along the active faults.During the anomalous period,the SLHF and air temperature at 2m exceeded the sum of average daily value over 26 years and 1.5 times of its mean square deviation.Both anomalies had maintained for 12 days with a peculiar distribution related to the tectonic active zone.It is considered that both of air temperature anomalies and SLHF anomalies are correlated to the movement of thermal flux from underground prior to earthquake.SLHF anomalies occurred over wide regions covered with abundant water,whereas air temperature anomalies occurred over land.
