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显式迎流FEM在河口近海研究中的应用
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作者 耿兆铨 倪勇强 《河口与海岸工程》 1998年第1期1-12,共12页
河口特殊的地理形态和复杂的动力因素,使FEM在其数值研究中的应用越来越广,本文介绍的显式迎流FEM,既具有显式FEM省内存,省机时的优点,又具有边界适应性强,节点布设灵活且便于局部加密网格的特色,模式与计算前后处理技... 河口特殊的地理形态和复杂的动力因素,使FEM在其数值研究中的应用越来越广,本文介绍的显式迎流FEM,既具有显式FEM省内存,省机时的优点,又具有边界适应性强,节点布设灵活且便于局部加密网格的特色,模式与计算前后处理技术配套面成的软件包已广泛应用于潮汐河口,近海,港湾,湖泊及诸多岛汊的复杂水域的计算,除流场外,还成功应用际河口规划整治工程方案研究和污染浓度场,温度场,盐度,泥沙及事故溢油等计算模拟, 展开更多
关键词 有限元 河口 数值模拟 计算 水力学
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污点分析中的隐式污染检测方法
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作者 刘杰 张普含 +1 位作者 尹中旭 宋晓龙 《计算机工程》 CAS CSCD 2012年第23期28-32,共5页
隐式流对于污点分析方法的准确性有重要影响。为此,提出一种基于程序单静态赋值形式的隐式流检测方法。通过生成控制流图的必经节点树检测控制依赖关系,计算必经边界发现程序汇合点,引入虚拟取值函数获得汇合点变量的多个赋值,从而判别... 隐式流对于污点分析方法的准确性有重要影响。为此,提出一种基于程序单静态赋值形式的隐式流检测方法。通过生成控制流图的必经节点树检测控制依赖关系,计算必经边界发现程序汇合点,引入虚拟取值函数获得汇合点变量的多个赋值,从而判别变量取值分歧并标记污点属性。与人工审计结果的对比证明,该方法能够诊断2个污点分析工具的污染缺失和污染过度问题,有效降低隐式流分析的误报率和漏报率。 展开更多
关键词 污点分析 显式流 控制依赖 单静态赋值 必经边界
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杭州湾水动力特性研讨 被引量:31
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作者 倪勇强 耿兆铨 朱军政 《水动力学研究与进展(A辑)》 CSCD 北大核心 2003年第4期439-445,共7页
在分析、归纳前人对杭州湾流场研究成果的基础上 ,本文采用包含钱塘江河口、长江口及舟山群岛海域在内的大范围 ( 3 5 0 0 0km2 )数学模型 ,模拟 1981年夏季和 1983年冬季全国海岸带调查的大范围同步实测流场。在良好验证的基础上 ,就... 在分析、归纳前人对杭州湾流场研究成果的基础上 ,本文采用包含钱塘江河口、长江口及舟山群岛海域在内的大范围 ( 3 5 0 0 0km2 )数学模型 ,模拟 1981年夏季和 1983年冬季全国海岸带调查的大范围同步实测流场。在良好验证的基础上 ,就杭州湾入射潮波流路、涨落潮流矢分布、等潮位线、余流、盐度分布及无质量标记点迹线追踪等方面 ,分析、探讨杭州湾流场特性。成果可为更合理地规划整治。 展开更多
关键词 杭州湾 水动力 河口 数学模型 数值模拟 盐度 有限元
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Hepatoma cell line HepG2.2.15 demonstrates distinct biological features compared with parental HepG2 被引量:5
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作者 Ran Zhao Tian-Zhen Wang +6 位作者 Dan Kong Lei Zhang Hong-Xue Meng Yang Jiang Yi-Qi Wu Zu-Xi Yu Xiao-Ming Jin 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第9期1152-1159,共8页
AIM:To investigate the biological features of hepatitis B virus(HBV)-transfected HepG2.2.15 cells. METHODS:The cell ultrastructure,cell cycle and apoptosis,and the abilities of proliferation and invasion of HBV-transf... AIM:To investigate the biological features of hepatitis B virus(HBV)-transfected HepG2.2.15 cells. METHODS:The cell ultrastructure,cell cycle and apoptosis,and the abilities of proliferation and invasion of HBV-transfected HepG2.2.15 and the parent HepG2 cells were examined by electron microscopy,flow cytometry, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and trans-well assay.Oncogenicity of the two cell lines was compared via subcutaneous injection and orthotopic injection or implantation in nude mice,and the pathological analysis of tumor formation was performed.Two cytoskeletal proteins were detected by Western blotting. RESULTS:Compared with HepG2 cells,HepG2.2.15 cells showed organelle degeneration and filopodia disappearance under electron microscope.HepG2.2.15 cells proliferated and migrated slowly in vitro,and hardly formed tumor and lung metastasis in nude mice.Flow cytometry showed that the majority of HepG2.2.15 cells were arrested in G1 phase,and apoptosis was minor in both cell lines.Furthermore,the levels of cytoskeletal proteins F-actin and Ezrin were decreased in HepG2.2.15 cells. CONCLUSION:HepG2.2.15 cells demonstrated a lower proliferation and invasion ability than the HepG2 cells due to HBV transfection. 展开更多
关键词 HEPG2.2.15 HEPG2 Hepatitis B virus Biological feature Tumor
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Cardiotrophin-1 promotes cardiomyocyte differentiation from mouse induced pluripotent stem cells via JAK2/STAT3/Pim-1 signaling pathway 被引量:2
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作者 Tong LIU Ran ZHANG +8 位作者 Tao GUO Sai MA Dong HAN Xiu-Juan LI Yan JIN Miao-Miao FAN Ya-Bin WANG Yun-Dai CHEN Feng CAO 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2015年第6期591-599,共9页
Background The induced pluripotent stem cell (iPSC) has shown great potential in cellular therapy of myocardial infarction (MI), while its application is hampered by the low efficiency of cardiomyocyte differentia... Background The induced pluripotent stem cell (iPSC) has shown great potential in cellular therapy of myocardial infarction (MI), while its application is hampered by the low efficiency of cardiomyocyte differentiation. The present study was designed to investigate the effects of cardiotrophin-1 (CT-1) on cardiomyocyte differentiation from mouse induced pluripotent stem cells (miPSCs) and the underlying mechanisms involved. Methods The optimal treatment condition for cardiomyocyte differentiation from miPSCs was established with ideal concentration (10 ng/mL) and duration (from day 3 to day 14) of CT-1 administration. Up-regulated expression of cardiac specific genes that accounted for embryonic cardiogenesis was observed by quantitative RT-PCR. Elevated amount of a-myosin heavy chain (ct-MHC) and cardiac troponin I (cTn I) positive cells were detected by immunofluorescence staining and flow cytometry analysis in CT- 1 group. Results Transmission electron microscopic analysis revealed that cells treated with CT- 1 showed better organized sacromeric structure and more mitochondria, which are morphological characteristic of matured cardiomyocytes. Western blot demonstrated that CT-1 promotes cardiomyocyte differentiation from miPSCs partly via JAK2/STAT3/Pim-1 pathway as compared with control group. Conclusions These findings suggested that CT-1 could enhance the cardiomyocyte differentiation as well as the maturation of mouse induced pluripotent stem cell derived cardiomyocytes by regulating JAK2/STAT3/Pim-1 signaling pathway. 展开更多
关键词 Cardiac differentiation CARDIOTROPHIN-1 Mouse induced pluripotent stem cells PIM-1
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Modeling of the turbulent burning velocity for planar and Bunsen flames over a wide range of conditions
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作者 Zhen Lu Yue Yang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2022年第3期10-25,I0001,共17页
We develop and assess a model of the turbulent burning velocity ST over a wide range of conditions.The aim is to obtain an explicit ST model for turbulent combustion modeling and flame analysis.The model consists of s... We develop and assess a model of the turbulent burning velocity ST over a wide range of conditions.The aim is to obtain an explicit ST model for turbulent combustion modeling and flame analysis.The model consists of sub models of the stretch factor and the turbulent flame area.The stretch factor characterizes the flame response of turbulence stretch and incorporates detailed chemistry and transport effects with a lookup table of laminar counterflow flames.The flame area model captures the area growth based on Lagrangian statistics of propagating surfaces and considers the effects of turbulence length scales and fuel characteristics.The present model predicts sT via an algebraic expression without free parameters.We assess the model using 490 cases of the direct numerical simulation or experiment reported from various research groups on planar and Bunsen flames over a wide range of conditions,covering fuels from hydrogen to n-dodecane,pressures from 1 to 30 atm,lean and rich mixtures,turbulence intensity ratios from 0.1 to 177.6,and turbulence length ratios from 0.5 to 66.7.Despite the scattering sT data in the literature,the comprehensive comparison shows that the proposed ST model has an overall good agreement over the wide range of conditions,with the averaged modeling error of 28.1%. 展开更多
关键词 Turbulent burning velocity Turbulent premixed flame Flame speed
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