目的:总结显微镜高分辨率MRI在皮肤肿瘤病变评估中的研究进展。方法:在中国知网、万方数据、PubMed及Web of Science数据库,以“皮肤”“肿瘤”“高分辨率MRI”“显微镜线圈”及“skin”“dermal”“tumor”“high-resolution magnetic ...目的:总结显微镜高分辨率MRI在皮肤肿瘤病变评估中的研究进展。方法:在中国知网、万方数据、PubMed及Web of Science数据库,以“皮肤”“肿瘤”“高分辨率MRI”“显微镜线圈”及“skin”“dermal”“tumor”“high-resolution magnetic resonance imaging”“microscopy coil”等作为中、英文关键词,检索2003年1月—2024年1月发表的有关皮肤肿瘤病变显微镜高分辨率MRI评估的相关研究,共检索到133篇文献,排除内容不相符、无法获取全文、质量较低、证据等级不高、重复研究的文献,最终纳入26篇文献,对显微镜高分辨率MRI在良恶性皮肤肿瘤鉴别诊断及皮肤肿瘤侵犯深度、病变累及层面、肿瘤内血管评估方面的研究进行分析、总结。结果:显微镜线圈具有小视场、高信噪比的优点,显微镜高分辨率MRI非常适用于直径1~2 mm的体表皮肤肿瘤的检查。显微镜高分辨率MRI具有良好的软组织分辨力,可准确评估皮肤肿瘤的侵犯深度、病变累及层面,为皮肤肿瘤良恶性鉴别提供依据,进而辅助皮肤肿瘤的术前精准评估和指导外科治疗计划的制定。显微镜高分辨率MRI动态对比增强扫描及MR血管成像在观察肿瘤新生血管的动态变化、评估抗血管生成药物疗效等方面亦具有极大潜力。结论:显微镜高分辨率MRI具有无创、无辐射、软组织分辨率高及多参数、多相位成像的优势,能够为临床提供皮肤肿瘤病变性质、侵犯深度及其与周围结构关系等重要信息,对于皮肤肿瘤的诊断、术前评估、治疗方案制定、疗效评价等均有重要的临床价值。展开更多
ELF （extremely low frequency） magnetic fields from power-line current influence the yield of CMOS foundry. The poor yield happens because of ELF magnetic fields inducing directly the measurement or process equipment...ELF （extremely low frequency） magnetic fields from power-line current influence the yield of CMOS foundry. The poor yield happens because of ELF magnetic fields inducing directly the measurement or process equipment for cutting-edge chips below 28 nm process. The equipments of electron microscopes, including SEM （scanning electron microscope）, TEM （transmission electron microscopy）, STEM （scanning transmission electron microscopy） and EBLS （electron beam lithography system） are very susceptible to ELF magnetic fields emanating from various electrical power sources outside of the building and within next generation CMOS foundry recommends a maximum of 0.3 mG. The active canceling method uses active coils with current sensing field via sensor and inducing man-made electromagnetic field to reduce the stray magnetic field. Unfortunately, the conventional system takes more time to products field because of parasitical capacitance and resistance in long coil. The longer canceling coil the system construct, the more time it takes. Besides, canceling system should spend more time on calibrating non-linear current amplifier through software design. This research designs simpler anti-electro-magnetic system instead of typical frame and develops one turn canceling coil structure to reduce delaying time. Several parallel cells generate field up to 23.81 mG controlled by MPU （micro processor unit）. This system decreases the power-line inducing filed below 0.3 mG.展开更多
文摘目的:总结显微镜高分辨率MRI在皮肤肿瘤病变评估中的研究进展。方法:在中国知网、万方数据、PubMed及Web of Science数据库,以“皮肤”“肿瘤”“高分辨率MRI”“显微镜线圈”及“skin”“dermal”“tumor”“high-resolution magnetic resonance imaging”“microscopy coil”等作为中、英文关键词,检索2003年1月—2024年1月发表的有关皮肤肿瘤病变显微镜高分辨率MRI评估的相关研究,共检索到133篇文献,排除内容不相符、无法获取全文、质量较低、证据等级不高、重复研究的文献,最终纳入26篇文献,对显微镜高分辨率MRI在良恶性皮肤肿瘤鉴别诊断及皮肤肿瘤侵犯深度、病变累及层面、肿瘤内血管评估方面的研究进行分析、总结。结果:显微镜线圈具有小视场、高信噪比的优点,显微镜高分辨率MRI非常适用于直径1~2 mm的体表皮肤肿瘤的检查。显微镜高分辨率MRI具有良好的软组织分辨力,可准确评估皮肤肿瘤的侵犯深度、病变累及层面,为皮肤肿瘤良恶性鉴别提供依据,进而辅助皮肤肿瘤的术前精准评估和指导外科治疗计划的制定。显微镜高分辨率MRI动态对比增强扫描及MR血管成像在观察肿瘤新生血管的动态变化、评估抗血管生成药物疗效等方面亦具有极大潜力。结论:显微镜高分辨率MRI具有无创、无辐射、软组织分辨率高及多参数、多相位成像的优势,能够为临床提供皮肤肿瘤病变性质、侵犯深度及其与周围结构关系等重要信息,对于皮肤肿瘤的诊断、术前评估、治疗方案制定、疗效评价等均有重要的临床价值。
文摘ELF （extremely low frequency） magnetic fields from power-line current influence the yield of CMOS foundry. The poor yield happens because of ELF magnetic fields inducing directly the measurement or process equipment for cutting-edge chips below 28 nm process. The equipments of electron microscopes, including SEM （scanning electron microscope）, TEM （transmission electron microscopy）, STEM （scanning transmission electron microscopy） and EBLS （electron beam lithography system） are very susceptible to ELF magnetic fields emanating from various electrical power sources outside of the building and within next generation CMOS foundry recommends a maximum of 0.3 mG. The active canceling method uses active coils with current sensing field via sensor and inducing man-made electromagnetic field to reduce the stray magnetic field. Unfortunately, the conventional system takes more time to products field because of parasitical capacitance and resistance in long coil. The longer canceling coil the system construct, the more time it takes. Besides, canceling system should spend more time on calibrating non-linear current amplifier through software design. This research designs simpler anti-electro-magnetic system instead of typical frame and develops one turn canceling coil structure to reduce delaying time. Several parallel cells generate field up to 23.81 mG controlled by MPU （micro processor unit）. This system decreases the power-line inducing filed below 0.3 mG.
