Model driven architecture(MDA) is an evolutionary step in software development.Model transformation forms a key part of MDA.The transformation from computation independent model(CIM) to platform independent model(PIM)...Model driven architecture(MDA) is an evolutionary step in software development.Model transformation forms a key part of MDA.The transformation from computation independent model(CIM) to platform independent model(PIM) is the first step of the transformation.This paper proposes an approach for this transformation with pattern.In this approach, we take advantage of"reuse"from various standpoints.Feature model is used to describe the requirement of the application.This can help us bring"reuse"into effect at requirement level.Moreover we use pattern to transform CIM to PIM.This can help us bring"reuse"into effect at development level.Meanwhile, pattern was divided into four hierarchies.Different hierarchies of pattern are used to help us utilize reuse at different phase of development.From another standpoint, feature model describes the problem of a domain while pattern describe the problem across domains.This can help us reuse the element in and across domains.Finally, the detailed process of the transformation is given.展开更多
New generation passive optical network aims at providing more than 100 Gb/s capacity. Thanks to recent progress enabling a variety of optical transceivers up to 40 Gb/s, many evolution possibilities to 200G PONs （pas...New generation passive optical network aims at providing more than 100 Gb/s capacity. Thanks to recent progress enabling a variety of optical transceivers up to 40 Gb/s, many evolution possibilities to 200G PONs （passive optical network） could be investigated. This work proposes two directly deployable cases of evolution to 200G PON based on the combination of these improved optical transceivers and WDM （wavelength division multiplexing）. The physical layer of the optical network has been simulated with OptiSystem software to show the communication links performances behavior when considering key components parameters in order to achieve good network design for a given area. The complexity of the proposed architectures and financial cost comparisons are also discussed.展开更多
Previous analyses have reported that the human monocytic cell line THP1 can be differentiated into cells with macrophage-like characteristics by phorbol 12-myristate 13-acetate(PMA). However, little is known about the...Previous analyses have reported that the human monocytic cell line THP1 can be differentiated into cells with macrophage-like characteristics by phorbol 12-myristate 13-acetate(PMA). However, little is known about the mechanism responsible for regulating this differentiation process. Here, we performed high-throughput RNA-Seq analysis to investigate the genes differently expressed in THP1 cells treated with and without PMA and examined those that may be responsible for the PMA-induced differentiation of monocytes into macrophages. We found 3,000 genes to be differentially expressed after PMA treatment. Gene ontology analysis revealed that genes related to cellular processes and regulation of biological processes were significantly enriched. KEGG analysis also demonstrated that the differentially expressed genes(DEGs) were significantly enriched in the PI3K/AKT signaling pathway and phagosome pathway. Importantly, we reveal an important role of the PI3K/AKT pathway in PMA-induced THP1 cell differentiation. The identified DEGs and pathways may facilitate further study of the detailed molecular mechanisms of THP1 differentiation. Thus, our results provide numerous potential therapeutic targets for modulation of the differentiation of this disease.展开更多
基金supported by the National Natural Science Foundation of China (Grant No.601730301)the National BasicResearch Program of China (973 Program) (Grant No.2002CB312001)
文摘Model driven architecture(MDA) is an evolutionary step in software development.Model transformation forms a key part of MDA.The transformation from computation independent model(CIM) to platform independent model(PIM) is the first step of the transformation.This paper proposes an approach for this transformation with pattern.In this approach, we take advantage of"reuse"from various standpoints.Feature model is used to describe the requirement of the application.This can help us bring"reuse"into effect at requirement level.Moreover we use pattern to transform CIM to PIM.This can help us bring"reuse"into effect at development level.Meanwhile, pattern was divided into four hierarchies.Different hierarchies of pattern are used to help us utilize reuse at different phase of development.From another standpoint, feature model describes the problem of a domain while pattern describe the problem across domains.This can help us reuse the element in and across domains.Finally, the detailed process of the transformation is given.
文摘New generation passive optical network aims at providing more than 100 Gb/s capacity. Thanks to recent progress enabling a variety of optical transceivers up to 40 Gb/s, many evolution possibilities to 200G PONs （passive optical network） could be investigated. This work proposes two directly deployable cases of evolution to 200G PON based on the combination of these improved optical transceivers and WDM （wavelength division multiplexing）. The physical layer of the optical network has been simulated with OptiSystem software to show the communication links performances behavior when considering key components parameters in order to achieve good network design for a given area. The complexity of the proposed architectures and financial cost comparisons are also discussed.
基金supported by funds from the National Natural Science Foundation of China(81400102)the Chinese Postdoctoral Science Foundation(2015M570751)+1 种基金the National Undergraduate Training Program for Innovation and Entrepreneurship(201510559043)the Medical Scientific Research Foundation of Guangdong Province,China(A2015420)
文摘Previous analyses have reported that the human monocytic cell line THP1 can be differentiated into cells with macrophage-like characteristics by phorbol 12-myristate 13-acetate(PMA). However, little is known about the mechanism responsible for regulating this differentiation process. Here, we performed high-throughput RNA-Seq analysis to investigate the genes differently expressed in THP1 cells treated with and without PMA and examined those that may be responsible for the PMA-induced differentiation of monocytes into macrophages. We found 3,000 genes to be differentially expressed after PMA treatment. Gene ontology analysis revealed that genes related to cellular processes and regulation of biological processes were significantly enriched. KEGG analysis also demonstrated that the differentially expressed genes(DEGs) were significantly enriched in the PI3K/AKT signaling pathway and phagosome pathway. Importantly, we reveal an important role of the PI3K/AKT pathway in PMA-induced THP1 cell differentiation. The identified DEGs and pathways may facilitate further study of the detailed molecular mechanisms of THP1 differentiation. Thus, our results provide numerous potential therapeutic targets for modulation of the differentiation of this disease.
